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Trpm4 Ion Channels In Pre-Bötzinger Complex Interneurons Are Essential For Breathing Motor Pattern But Not Rhythm, Maria Cristina D. Picardo, Yae K. Sugimura, Kaitlyn E. Dorst, Prajkta S. Kallurkar, Victoria T. Akins, Xingru Ma, Ryoichi Teruyama, Romain Guinamard, Kaiwen Kam, Margaret S. Saha, Christopher A. Del Negro Feb 2019

Trpm4 Ion Channels In Pre-Bötzinger Complex Interneurons Are Essential For Breathing Motor Pattern But Not Rhythm, Maria Cristina D. Picardo, Yae K. Sugimura, Kaitlyn E. Dorst, Prajkta S. Kallurkar, Victoria T. Akins, Xingru Ma, Ryoichi Teruyama, Romain Guinamard, Kaiwen Kam, Margaret S. Saha, Christopher A. Del Negro

Faculty Publications

© 2019 Picardo et al. Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca 2+ )-activated nonselective cationic current (I CAN ) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing I CAN is predicted to slow down or stop breathing; its contributions to motor pattern would be reflected in the magnitude of movements (output). We tested the role(s) of I CAN using reverse genetic techniques to diminish its putative ion channels Trpm4 or Trpc3 in preBötC neurons in vivo. Adult mice transduced with Trpm4-targeted short hairpin RNA (shRNA) progressively decreased the tidal volume of …

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Host Sex, Size, And Hemoparasite Infection Influence The Effects Of Ectoparasitic Burdens On Free-Ranging Iguanas, Christine Lattin Feb 2019

Host Sex, Size, And Hemoparasite Infection Influence The Effects Of Ectoparasitic Burdens On Free-Ranging Iguanas, Christine Lattin

Faculty Publications

Investigations focusing on host-ectoparasite interactions in animals have revealed asymptomatic to severe health and fitness consequences suggesting that species mobilize different interspecific response mechanisms. Fewer studies, however, have examined intraspecific responses to ectoparasitic burdens. In this study, we analyzed host health and fitness responses to increasing ectoparasite burdens along with the presence/absence of hemoparasites of free-ranging insular rock iguanas (Cyclura cychlura) in The Bahamas. Using hematology, plasma biochemistry, as well as body condition and growth rate comparisons, we failed to find significant associations of tick burdens with annual growth rate, corticosterone, packed cell volume, total white blood cell, and heterophil, …

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Workshop Report: Cryopreservation Of Aquatic Biomedical Models, Mary Hagedorn, Zoltan Varga, Ronald B. Walter, Terrence R. Tiersch Feb 2019

Workshop Report: Cryopreservation Of Aquatic Biomedical Models, Mary Hagedorn, Zoltan Varga, Ronald B. Walter, Terrence R. Tiersch

Faculty Publications

The genetic resources of aquatic biomedical model organisms are the products of millions of years of evolution, decades of scientific development, and hundreds of millions of dollars of research funding investment. Genetic resources (e.g., specific alleles, transgenes, or combinations) of each model organism can be considered a form of scientific wealth that can be accumulated and exchanged, typically in the form of live animals or germplasm. Large-scale maintenance of live aquatic organisms that carry these genetic resources is inefficient, costly, and risky. In situ maintenance may be substantially enhanced and backed up by combining cryopreserved germplasm repositories and genetic information …

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Gobbling Chronology Of Eastern Wild Turkeys In South Carolina, Patrick H. Wightman, John C. Kilgo, Mark Vukovich, Jay R. Cantrell, Charles R. Ruth, Bradley S. Cohen, Michael J. Chamberlain, Bret A. Collier Feb 2019

Gobbling Chronology Of Eastern Wild Turkeys In South Carolina, Patrick H. Wightman, John C. Kilgo, Mark Vukovich, Jay R. Cantrell, Charles R. Ruth, Bradley S. Cohen, Michael J. Chamberlain, Bret A. Collier

Faculty Publications

Eastern wild turkeys (Meleagris gallopavo silvestris) use a polygynous-promiscuous mating system, wherein males compete for mating opportunities and communicate with females via courtship behaviors. One courtship behavior is vocalization (gobbling), which attracts females and signals dominance to other males. However, temporal variation in gobbling activity may be influenced by external stimuli, environmental variation, and hunter activity. Gobbling activity is a key determinant of hunter satisfaction, and gobbling chronology is often used by state agencies to inform regulatory processes. To identify factors influencing gobbling activity, we evaluated daily gobbling chronology on 3 sites in South Carolina, USA (Webb Wildlife Management Area …

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Metal Levels In Whales From The Gulf Of Maine: A One Environmental Health Approach, John Pierce Wise, James T.F. Wise, Catherine F. Wise, Sandra S. Wise, Cairong Zhu, Cynthia L. Browning, Tongzhang Zheng, Christopher Perkins, Christy Gianios, Hong Xie, John Pierce Wise Feb 2019

Metal Levels In Whales From The Gulf Of Maine: A One Environmental Health Approach, John Pierce Wise, James T.F. Wise, Catherine F. Wise, Sandra S. Wise, Cairong Zhu, Cynthia L. Browning, Tongzhang Zheng, Christopher Perkins, Christy Gianios, Hong Xie, John Pierce Wise

Faculty Publications

One Environmental Health has emerged as an important area of research that considers the interconnectedness of human, animal and ecosystem health with a focus on toxicology. The great whales in the Gulf of Maine are important species for ecosystem health, for the economies of the Eastern seaboard of the United States, and as sentinels for human health. The Gulf of Maine is an area with heavy coastal development, industry, and marine traffic, all of which contribute chronic exposures to environmental chemicals that can bioaccumulate in tissues and may gradually diminish an individual whale's or a population's fitness. We biopsied whales …

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B Cell Homeostasis Is Maintained During Long-Duration Spaceflight, Guillaume Spielmann, Nadia Agha, Hawley Kunz, Richard J. Simpson, Brian Crucian, Satish Mehta, Mitzi Laughlin, John Campbell Feb 2019

B Cell Homeostasis Is Maintained During Long-Duration Spaceflight, Guillaume Spielmann, Nadia Agha, Hawley Kunz, Richard J. Simpson, Brian Crucian, Satish Mehta, Mitzi Laughlin, John Campbell

Faculty Publications

Long-duration spaceflights reportedly induce immune dysregulation, which is considered a risk to astronaut safety and mission success. Recent studies have examined the impact of spaceflight on markers of adaptive and innate immunity, but no study, to date, has comprehensively evaluated humoral immunity and serological markers of B cell function. The aim of this study was to characterize changes in B cell numbers and phenotypes, along with plasma Igs and polyclonal free light chains (FLCs)—near-“real-time” biomarkers of Ig synthesis—in response to an ~6-mo mission to the International Space Station (ISS). Whole-blood samples were collected before flight, during flight (“Early flight,” “Mid-flight,” …

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The Comparative Genomics And Complex Population History Of Papio Baboons, Jeffrey Rogers, Muthuswamy Raveendran, R. Alan Harris, Thomas Mailund, Kalle Leppälä, Georgios Athanasiadis, Mikkel Heide Schierup, Jade Cheng, Kasper Munch, Jerilyn A. Walker, Miriam K. Konkel, Vallmer E. Jordan, Cody J. Steely, Thomas O. Beckstrom, Christina Bergey, Andrew Burrell, Dominik Schrempf, Angela Noll, Maximillian Kothe, Gisela H. Kopp, Yue Liu, Shwetha Murali, Konstantinos Billis, Fergal J. Martin, Matthieu Muffato, Laura A. Cox, James Else, Todd Disotell, Donna M. Muzny, Jane Phillips-Conroy, Bronwen Aken, Evan E. Eichler, Tomas Marques-Bonet, Carolin Kosiol Jan 2019

The Comparative Genomics And Complex Population History Of Papio Baboons, Jeffrey Rogers, Muthuswamy Raveendran, R. Alan Harris, Thomas Mailund, Kalle Leppälä, Georgios Athanasiadis, Mikkel Heide Schierup, Jade Cheng, Kasper Munch, Jerilyn A. Walker, Miriam K. Konkel, Vallmer E. Jordan, Cody J. Steely, Thomas O. Beckstrom, Christina Bergey, Andrew Burrell, Dominik Schrempf, Angela Noll, Maximillian Kothe, Gisela H. Kopp, Yue Liu, Shwetha Murali, Konstantinos Billis, Fergal J. Martin, Matthieu Muffato, Laura A. Cox, James Else, Todd Disotell, Donna M. Muzny, Jane Phillips-Conroy, Bronwen Aken, Evan E. Eichler, Tomas Marques-Bonet, Carolin Kosiol

Faculty Publications

Copyright © 2019 The Authors, Recent studies suggest that closely related species can accumulate substantial genetic and phenotypic differences despite ongoing gene flow, thus challenging traditional ideas regarding the genetics of speciation. Baboons (genus Papio) are Old World monkeys consisting of six readily distinguishable species. Baboon species hybridize in the wild, and prior data imply a complex history of differentiation and introgression. We produced a reference genome assembly for the olive baboon (Papio anubis) and whole-genome sequence data for all six extant species. We document multiple episodes of admixture and introgression during the radiation of Papio baboons, thus demonstrating their …

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Habitat Usage Patterns Of Bottlenose Dolphins (Tursiops Truncatus) In Terrebonne And Timbalier Bays, Louisiana, Mary Allison Manning Jan 2019

Habitat Usage Patterns Of Bottlenose Dolphins (Tursiops Truncatus) In Terrebonne And Timbalier Bays, Louisiana, Mary Allison Manning

LSU Master's Theses

I coupled fine-scale environmental data with observed behavior and group composition data to examine overall distribution within the bay system and to characterize the habitat associated with foraging and the presence of calves. Semi-isolated populations of bottlenose dolphins (Tursiops truncatus) along Louisiana’s coast are undergoing increased risks from boat traffic, oil spills, land subsidence, and planned water diversions (CPRA 2017). Characterizing the habitat use of bottlenose dolphins in Terrebonne and Timbalier bays, Louisiana, is important given the likely high site fidelity, small home ranges, and low exchange of individuals with nearby coastal populations (Lane et al. 2015, McDonald …

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Effects Of Red Raspberry Polyphenols And Metabolites On Biomarkers Of Inflammation And Insulin Resistance In Prediabetes And Type 2 Diabetes, Reynaldo Moreno Ucles Jan 2019

Effects Of Red Raspberry Polyphenols And Metabolites On Biomarkers Of Inflammation And Insulin Resistance In Prediabetes And Type 2 Diabetes, Reynaldo Moreno Ucles

LSU Doctoral Dissertations

Berry fruits are rich sources of polyphenolic compounds (PCs), which can promote health benefits. Anthocyanin concentrations of red raspberry (RR)(Rubus idaeus) extracts were determined to be a total of 887.6 ± 262.8 μg/g cyanidin-3-sophoroside (C3S) equivalents with C3S being the most prevalent. Ellagitannin analysis by MALDI-TOF indicated sanguiin H-6 and lambertianin C were the major ellagitannins present in RR. To explore the efficacy of RR in modulating diabetes, seven type 2 diabetes mellitus (T2DM) and two pre-diabetic patients were given drinks delivering one RR serving (123 g) per day in a smoothie for two weeks. Blood samples were …

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Predictability Of Ocean Heat Content From Electrical Conductance, D. S. Trossman, R. H. Tyler Jan 2019

Predictability Of Ocean Heat Content From Electrical Conductance, D. S. Trossman, R. H. Tyler

Faculty Publications

No abstract provided.

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Conditional Knock-Out Of Mglur5 From Astrocytes During Epilepsy Development Impairs High-Frequency Glutamate Uptake, Anthony D. Umpierre, Peter J. West, John A. White, Karen S. Wilcox Jan 2019

Conditional Knock-Out Of Mglur5 From Astrocytes During Epilepsy Development Impairs High-Frequency Glutamate Uptake, Anthony D. Umpierre, Peter J. West, John A. White, Karen S. Wilcox

Faculty Publications

No abstract provided.

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The Genetic And Epigenetic Effects Of Pre-Treatment With The Small Molecule Inhibitors Chir99021, Pd0325901, And Nup0178 On Bovine Fetal Fibroblast Cells, Laura Whitney Coley Jan 2019

The Genetic And Epigenetic Effects Of Pre-Treatment With The Small Molecule Inhibitors Chir99021, Pd0325901, And Nup0178 On Bovine Fetal Fibroblast Cells, Laura Whitney Coley

LSU Doctoral Dissertations

The ability to produce genetically superior livestock has established somatic cell nuclear transfer (SCNT) as an invaluable tool in commercial livestock production. Successful reprogramming of somatic cells towards pluripotency requires the epigenetic marks characteristic of the differentiated cell type first be erased in order to inactivate the somatic cell program and activate the embryonic program. Several small molecules have been shown to improve both the kinetics and efficiency of reprogramming. These chemical modifiers aid in overcoming the “roadblocks” encountered during the reprogramming process by inducing the necessary epigenetic modifications needed to silence the somatic cell genome and completely reactivate the …

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Composition And Ecology Of Avian Communities Along Elevational Gradients In Borneo, Ryan Christian Burner Jan 2019

Composition And Ecology Of Avian Communities Along Elevational Gradients In Borneo, Ryan Christian Burner

LSU Doctoral Dissertations

A primary goal of ecology is to explain the diversity and distribution of organisms. Species distributions can be a function of abiotic factors, species interactions, dispersal limitations, and history, but the relative importance of these factors is widely debated. Elevational gradients are useful systems for studying these effects because many of these factors vary predictably with elevation, and because elevational gradients are replicated many times across the earth. However, few quantitative surveys of Southeast Asian bird communities have been conducted along elevational gradients. In this study, I surveyed birds using point counts and measured habitat and temperature across primary forest …

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Etoxpred: A Machine Learning-Based Approach To Estimate The Toxicity Of Drug Candidates 11 Medical And Health Sciences 1115 Pharmacology And Pharmaceutical Sciences 03 Chemical Sciences 0305 Organic Chemistry 03 Chemical Sciences 0304 Medicinal And Biomolecular Chemistry, Limeng Pu, Misagh Naderi, Tairan Liu, Hsiao Chun Wu, Supratik Mukhopadhyay, Michal Brylinski Jan 2019

Etoxpred: A Machine Learning-Based Approach To Estimate The Toxicity Of Drug Candidates 11 Medical And Health Sciences 1115 Pharmacology And Pharmaceutical Sciences 03 Chemical Sciences 0305 Organic Chemistry 03 Chemical Sciences 0304 Medicinal And Biomolecular Chemistry, Limeng Pu, Misagh Naderi, Tairan Liu, Hsiao Chun Wu, Supratik Mukhopadhyay, Michal Brylinski

Faculty Publications

© 2019 The Author(s). Background: The efficiency of drug development defined as a number of successfully launched new pharmaceuticals normalized by financial investments has significantly declined. Nonetheless, recent advances in high-throughput experimental techniques and computational modeling promise reductions in the costs and development times required to bring new drugs to market. The prediction of toxicity of drug candidates is one of the important components of modern drug discovery. Results: In this work, we describe eToxPred, a new approach to reliably estimate the toxicity and synthetic accessibility of small organic compounds. eToxPred employs machine learning algorithms trained on molecular fingerprints to …

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Trophodynamics And Mercury Bioaccumulation In Reef And Open-Ocean Fishes From The Bahamas With A Focus On Two Teleost Predators, Oliver N. Shipley, Cheng Shiuan Lee, Nicholas S. Fisher, Georgiana Burruss, Michael G. Frisk, Edward J. Brooks, Zachary C. Zuckerman, Achim D. Herrmann, Daniel J. Madigan Jan 2019

Trophodynamics And Mercury Bioaccumulation In Reef And Open-Ocean Fishes From The Bahamas With A Focus On Two Teleost Predators, Oliver N. Shipley, Cheng Shiuan Lee, Nicholas S. Fisher, Georgiana Burruss, Michael G. Frisk, Edward J. Brooks, Zachary C. Zuckerman, Achim D. Herrmann, Daniel J. Madigan

Faculty Publications

© Inter-Research 2019. Identifying prey resource pools supporting fish biomass can elucidate trophic pathways of pollutant bioaccumulation. We used multiple chemical tracers (carbon [δ 13 C] and nitrogen [δ 15 N] stable isotopes and total mercury [THg]) to identify trophic pathways and measure contaminant loading in upper trophic level fishes residing at a reef and open-ocean interface near Eleuthera in the Exuma Sound, The Bahamas. We focused predominantly on the trophic pathways of mercury bioaccumulation in dolphinfish Coryphaena hippurus and wahoo Acanthocybium solandri, 2 commonly consumed pelagic sportfish in the region. Despite residing within close proximity to productive and extensive …

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Investigations Into Aspergillus Flavus Infection Of Corn And Regulation Of Aflatoxin Production By Volatiles And Biocontrol Strains, Rebecca R. Sweany Jan 2019

Investigations Into Aspergillus Flavus Infection Of Corn And Regulation Of Aflatoxin Production By Volatiles And Biocontrol Strains, Rebecca R. Sweany

LSU Doctoral Dissertations

Aspergillus flavus is an ascomycete fungus impacting agriculture, public and environmental health due to production of acutely-toxic, carcinogenic aflatoxins in oil seed crops, especially corn in Louisiana, and lung infections of immunocompromised patients resulting in a leading cause of AIDS patients’ deaths globally. The most effective aflatoxin mitigation strategy, biocontrol by atoxigenic A. flavus presents several concerns including: dissemination of a human pathogen, possible sexual reproduction and reliance on precise environmental conditions. Several aspects of A. flavus biology were investigated to potentially improve treatments. Studies investigated how genotypically diverse members within the A. flavus population interact with other population members …

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Design And Optimization Of An Ionizing-Radiation-Free Dental Imaging Scheme By Near Infrared Fluorescence, Thomas Hartzler Jan 2019

Design And Optimization Of An Ionizing-Radiation-Free Dental Imaging Scheme By Near Infrared Fluorescence, Thomas Hartzler

LSU Master's Theses

There is a global need for access to oral health care. Proper oral health care is necessary for physiological and psychological health, as well as social and economic issues. Major oral diseases that must be screened include caries, cracked teeth, and impacted molars. These diseases are screened and diagnosed using a variety of medical imaging methods, computed tomography (CT) X-ray being the most popular and efficient method. The challenges in screening with X-ray technology include financial and time cost as well as health risk, including radiation exposure induced cancer (REIC). This thesis summarizes research to explore the possibility of overcoming …

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Effects Of Shoal Margin Collapses On The Morphodynamics Of A Sandy Estuary, M. R. Hiatt Jan 2019

Effects Of Shoal Margin Collapses On The Morphodynamics Of A Sandy Estuary, M. R. Hiatt

Faculty Publications

Shoal margin collapses of several million cubic meters have occurred in the Western Scheldt estuary, the Netherlands, on average five times a year over the last decades. While these collapses involve significant volumes of material, their effect on the channel-shoal morphology is unknown. We hypothesize that collapses dynamicize the channel-shoal interactions, which could impact the ecological functioning, flood safety, and navigation in the estuary. The objective is to investigate how locations, probability, type, and volume of shoal margin collapse affect the channel-shoal dynamics. We implemented an empirically validated parameterization for shoal margin collapses and tested its effect on simulated estuary …

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Net Land Gain Or Loss For Two Mississippi River Diversions: Caernarvon And Davis Pond, R. Eugene Turner, M Layne, Y Mo, E M. Swenson Jan 2019

Net Land Gain Or Loss For Two Mississippi River Diversions: Caernarvon And Davis Pond, R. Eugene Turner, M Layne, Y Mo, E M. Swenson

Faculty Publications

Coastal wetland restoration can be complex and expensive, so knowing long-term consequences makes it important to inform decisions about if, when, and where to conduct restoration. We determined temporal changes in land gain and loss in receiving basins and adjacent reference areas for two diversions of the Mississippi River in south Louisiana (Davis Pond and Caernarvon initiated in 1991 and 2002, respectively). Water from both diversions went into receiving basins with vegetated areas as did the adjoining reference areas. The results from two different types of satellite imagery analyses demonstrate a net land loss after diversions began. The results were …

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Advocating For Science: Amici Curiae Brief Of Wetland And Water Scientists In Support Of The Clean Water Rule, R C. Gardner, E Okuno, S Tai, M S. Fennessy, R C. Gardner, M L. Otte, M Palmer, J E. Perry, C Simenstad, B R. Tanner, D Tufford, R. Eugene Turner, K Work, S C. Yaich, J B. Zedler Jan 2019

Advocating For Science: Amici Curiae Brief Of Wetland And Water Scientists In Support Of The Clean Water Rule, R C. Gardner, E Okuno, S Tai, M S. Fennessy, R C. Gardner, M L. Otte, M Palmer, J E. Perry, C Simenstad, B R. Tanner, D Tufford, R. Eugene Turner, K Work, S C. Yaich, J B. Zedler

Faculty Publications

The Trump administration has proposed replacing the Clean Water Rule, a 2015 regulation that defined the statutory term waters of the United States to clarify the geographic jurisdiction of the Clean Water Act. Since its promulgation, the Clean Water Rule has been subjected to numerous judicial challenges. We submitted an amici curiae brief to the United States Court of Appeals for the Sixth Circuit, explaining why the Clean Water Rule, and its definition of waters of the United States, is scientifically sound. The definition of waters of the United States is a legal determination informed by science. The best available …

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Feedback Of Coastal Marshes To Climate Change: Long-Term Phenological Shifts, Y Mo, M S. Kearney, R. Eugene Turner Jan 2019

Feedback Of Coastal Marshes To Climate Change: Long-Term Phenological Shifts, Y Mo, M S. Kearney, R. Eugene Turner

Faculty Publications

Coastal marshes are important carbon sinks facing serious threats from climatic stressors. Current research reveals that the growth of individual marsh plants is susceptible to a changing climate, but the responses of different marsh systems at a landscape scale are less clear. Here, we document the multi-decadal changes in the phenology and the area of the extensive coastal marshes in Louisiana, USA, a representative of coastal ecosystems around the world that currently experiencing sea-level rise, temperature warming, and atmospheric CO2 increase. The phenological records are constructed using the longest continuous satellite-based record of the Earth's ecosystems, the Landsat data, and …

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Effects Of Temperature And Salinity On Body Fluid Dynamics And Metabolism In The Estuarine Diamondback Terrapin (Malaclemys Terrapin), Amanda Southwood Williard, Leigh Anne Harden, T. Todd Jones, Stephen R. Midway Jan 2019

Effects Of Temperature And Salinity On Body Fluid Dynamics And Metabolism In The Estuarine Diamondback Terrapin (Malaclemys Terrapin), Amanda Southwood Williard, Leigh Anne Harden, T. Todd Jones, Stephen R. Midway

Faculty Publications

The diamondback terrapin is the only temperate turtle species that exclusively inhabits estuarine environments. Morphological, behavioral and physiological features contribute to the terrapin’s ability to regulate body fluid osmotic pressure in a euryhaline environment. Low integument permeability combined with aquatic–terrestrial shuttling behavior limits passive exchange of water and salts with the environment, and terrapins regulate active uptake of salts via alterations in drinking and feeding behavior. The lachrymal salt gland facilitates excretion of excess sodium (Na+) and chloride (Cl−) ions through active transport mechanisms. We investigated body fluid dynamics, oxygen consumption (V O2) and osmotic status …

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Naringenin Promotes Thermogenic Gene Expression In Human White Adipose Tissue, Candida J. Rebello, Frank L. Greenway, Frank H. Lau, Yuan Lin, Jacqueline M. Stephens, William D. Johnson, Ann A. Coulter Jan 2019

Naringenin Promotes Thermogenic Gene Expression In Human White Adipose Tissue, Candida J. Rebello, Frank L. Greenway, Frank H. Lau, Yuan Lin, Jacqueline M. Stephens, William D. Johnson, Ann A. Coulter

Faculty Publications

© 2018 The Obesity Society Objective: Naringenin, a citrus flavonoid, prevents diet-induced weight gain and improves glucose and lipid metabolism in rodents. There is evidence that naringenin activates brown fat and increases energy expenditure in mice, but little is known about its effects in humans. The goal of this study was to examine the effects of naringenin on energy expenditure in adipose tissue. Methods: Human white adipocyte cultures (hADSC) and abdominal subcutaneous adipose tissue (pWAT) were treated with naringenin for 7 to 14 days. Expression (quantitative real-time polymerase chain reaction, immunoblotting) of candidate genes involved in thermogenesis and glucose metabolism …

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Fabrication And Characterization Of Thiol-Triacrylate Polymer Via Michael Addition Reaction For Biomedical Applications, Anoosha Forghani, Leah Garber, Cong Chen, Fariborz Tavangarian, Timothy B. Tighe, Ram Devireddy, John A. Pojman, Daniel Hayes Jan 2019

Fabrication And Characterization Of Thiol-Triacrylate Polymer Via Michael Addition Reaction For Biomedical Applications, Anoosha Forghani, Leah Garber, Cong Chen, Fariborz Tavangarian, Timothy B. Tighe, Ram Devireddy, John A. Pojman, Daniel Hayes

Faculty Publications

© 2018 IOP Publishing Ltd. Thiol-acrylate polymers have therapeutic potential as biocompatible scaffolds for bone tissue regeneration. Synthesis of a novel cyto-compatible and biodegradable polymer composed of trimethylolpropane ethoxylate triacrylate-trimethylolpropane tris (3-mercaptopropionate) (TMPeTA-TMPTMP) using a simple amine-catalyzed Michael addition reaction is reported in this study. This study explores the impact of molecular weight and crosslink density on the cyto-compatibility of human adipose derived mesenchymal stem cells. Eight groups were prepared with two different average molecular weights of trimethylolpropane ethoxylate triacrylate (TMPeTA 692 and 912) and four different concentrations of diethylamine (DEA) as catalyst. The materials were physically characterized by mechanical …

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Dominin And Segon Form Multiprotein Particles In The Plasma Of Eastern Oysters (Crassostrea Virginica) And Are Likely Involved In Shell Formation, Qinggang Xue, Jean Philipe Beguel, Jerome La Peyre Jan 2019

Dominin And Segon Form Multiprotein Particles In The Plasma Of Eastern Oysters (Crassostrea Virginica) And Are Likely Involved In Shell Formation, Qinggang Xue, Jean Philipe Beguel, Jerome La Peyre

Faculty Publications

Copyright © 2019 Xue, Beguel and La Peyre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Dominin and segon are two proteins purified and characterized from the plasma of eastern oysters Crassostrea virginica, making up about 70% of the total plasma …

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Growth And Development Symposium: Stem And Progenitor Cells In Animal Growth: The Regulation Of Beef Quality By Resident Progenitor Cells, Xing Fu, Chaoyang Li, Qianglin Liu, Kenneth W. Mcmillin Jan 2019

Growth And Development Symposium: Stem And Progenitor Cells In Animal Growth: The Regulation Of Beef Quality By Resident Progenitor Cells, Xing Fu, Chaoyang Li, Qianglin Liu, Kenneth W. Mcmillin

Faculty Publications

© The Author(s) 2019. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. The intramuscular adipose tissue deposition in the skeletal muscle of beef cattle is a highly desired trait essential for high-quality beef. In contrast, the excessive accumulation of crosslinked collagen in intramuscular connective tissue contributes to beef toughness. Recent studies revealed that adipose tissue and connective tissue share an embryonic origin in mice and may be derived from a common immediate bipotent precursor in mice and humans. Having the same linkages in the development of adipose tissue and connective tissue …

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Erk1/2 Signaling Induces Skeletal Muscle Slow Fiber-Type Switching And Reduces Muscular Dystrophy Disease Severity, Justin G. Boyer, Vikram Prasad, Taejeong Song, Donghoon Lee, Xing Fu, Kelly M. Grimes, Michelle A. Sargent, Sakthivel Sadayappan, Jeffery D. Molkentin Jan 2019

Erk1/2 Signaling Induces Skeletal Muscle Slow Fiber-Type Switching And Reduces Muscular Dystrophy Disease Severity, Justin G. Boyer, Vikram Prasad, Taejeong Song, Donghoon Lee, Xing Fu, Kelly M. Grimes, Michelle A. Sargent, Sakthivel Sadayappan, Jeffery D. Molkentin

Faculty Publications

© 2019 American Society for Clinical Investigation. MAPK signaling consists of an array of successively acting kinases. ERK1 and -2 (ERK1/2) are major components of the greater MAPK cascade that transduce growth factor signaling at the cell membrane. Here, we investigated ERK1/2 signaling in skeletal muscle homeostasis and disease. Using mouse genetics, we observed that the muscle-specifc expression of a constitutively active MEK1 mutant promotes greater ERK1/2 signaling that mediates fber-type switching to a slow, oxidative phenotype with type I myosin heavy chain expression. Using a conditional and temporally regulated Cre strategy, as well as Mapk1 (ERK2) and Mapk3 (ERK1) …

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The Coming Of Democracy: Presidential Campaigning In The Age Of Jackson, Martin Hershock Jan 2019

The Coming Of Democracy: Presidential Campaigning In The Age Of Jackson, Martin Hershock

Civil War Book Review

Mark Cheathem’s The Coming of Democracy, which examines the beginnings of the nation’s turn toward cultural politics during the Jacksonian era, thus appears at an incredibly prescient moment and offers an interesting lens through which to examine both the nation’s current political setting as well as the robust and colorful political campaigns associated with the Age of Jackson. In this well written and accessible work, Cheatem offers readers a detailed account of the evolving usage of cultural politics in the elections that marked the birth of the second American party system.

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Synthesis And Investigation Of Phthalocyanine-Biotin Conjugates, M. Graca H. Vicente, Elizabeth A. Okoth, Zehua Zhou, Benson Ongarora Jan 2019

Synthesis And Investigation Of Phthalocyanine-Biotin Conjugates, M. Graca H. Vicente, Elizabeth A. Okoth, Zehua Zhou, Benson Ongarora

Faculty Publications

An isothiocyanato-functionalized phthalocyanine (Pc) was synthesized in good yield from the corresponding amine-substituted Pc. This Pc reacted with ethanolamine, biotin hydrazine, and biotin diethylamine under mild conditions (room temperature in DMF or DMSO in the presence of TEA) to produce the corresponding thiourea products in 60-75% yields. All Pcs showed intense Q absorptions in DMF around 677 nm, emissions centered at 683 nm, and fluorescence quantum yields in the range 0.18-0.27. The Pcs were phototoxic to human carcinoma HEp2 cells (IC50 similar to 7 at 1.5 J/cm(2)) and localized in multiple organelles, including the lysosomes, Golgi and ER. One biotin-Pc …

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Review Of The Herds Shot Round The World: Native Breeds And The British Empire, 1800—1900, By Rebecca Woods, Andrew Sluyter Jan 2019

Review Of The Herds Shot Round The World: Native Breeds And The British Empire, 1800—1900, By Rebecca Woods, Andrew Sluyter

Faculty Publications

No abstract provided.

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