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From Rationality To Relationality: Teacher-Student Relationship As Unknowing, Shaofei Han
From Rationality To Relationality: Teacher-Student Relationship As Unknowing, Shaofei Han
LSU Doctoral Dissertations
This dissertation reimagines the teacher-student relationship through a philosophical approach that draws on Laozi, Karen Barad, Deleuze & Guattari, and Emmanuel Levinas. The teacher-student relationship is normally considered a relationship of the knower (teacher) and the unknower (student) based on the modern western tradition of episteme. This dissertation interrogates the modern binary of the teacher/student, subject/object relationship by bringing ontology and ethics into educational discourse. The problematic practices of modern schooling include the reduction of teaching to knowledge transmission, and the rigid dichotomy of a subject/object relation between teacher and student. Following a Taoist Way of philosophical thinking, this work …
Mechanisms To Regulate Genes Encoding Clinically Relevant Multidrug Transporters At The Crossroads Of Antibiotic Resistance And Oxidative Stress Detection, Afsana Sabrin
LSU Doctoral Dissertations
Multiple Antibiotic Resistance Regulators (MarRs) are DNA binding proteins involved in bacterial survival and pathogenesis. My PhD dissertation focuses on a MarR homolog, OstR, which regulates genes encoding major multidrug transporters, a resistance-nodulation-division (RND) and an E. coli multidrug resistance B (EmrB) efflux pump homolog in Burkholderia thailandensis. The ostR gene is divergently oriented from genes encoding a hypothetical protein (Hyp) and an RND transporter and adjacent to a gene encoding an EmrB transporter. OstR binds to the promoters of each gene (Kd = 64.9 ± 8.0 nM, Kd = 126.1 ± 10.9 nM and K …
Epic Beginnings: A Symphonic Work And Aaron Copland (The American Stravinsky) Versus Igor Stravinsky, Terrell O. Jones
Epic Beginnings: A Symphonic Work And Aaron Copland (The American Stravinsky) Versus Igor Stravinsky, Terrell O. Jones
LSU Doctoral Dissertations
ABSTRACT
The first part of my dissertation is the original music written for this dissertation, which consists of tonal music that describes my life’s journey. I wanted to write something dark, melodic, and very energetic that described my struggles and shows the road I have taken. It exhibits everything that I have learned from my time here at the university. One of the many things that makes my passion so strong is the desire to express myself through music written for ensembles and used in films. The piece is entitled “Epic Beginnings.” Originally, it was named “The Last Dance,” a …
Can Assisted Reproductive Technologies Help Conserve 300 Million Years Of Evolution? A First Attempt At Developing These Technologies For Male Reptiles, Sean M. Perry
LSU Doctoral Dissertations
Biodiversity loss is the most critical environmental problem threatening ecosystem, animal, and human health today. Increases in extinction rates have been observed over the past 50 years, with reptile losses occurring twelve times faster than traditional extinction rates. This demonstrated biodiversity loss is secondary to climate change, habitat destruction, infectious disease, invasive species, poaching, and unsustainable trade. Approximately 20% of all reptiles are threatened with extinction and population declines are approaching rates similar to the current amphibian extinction crisis. Preventing the extinction of reptiles will require humans to acknowledge these losses and develop plans to preserve these evolutionary sentinel species. …
A Pedagogical And Performance Approach To A Selection Of Piano Solo Pieces Written By Chen Yi And Zhou Long, Weiying Tang
A Pedagogical And Performance Approach To A Selection Of Piano Solo Pieces Written By Chen Yi And Zhou Long, Weiying Tang
LSU Doctoral Dissertations
This dissertation will focus on the performance and pedagogical features of six piano solos composed by Chen Yi and Zhou Long. Both composers are Chinese-American who earned their Bachelor degrees in music from the Central Conservatory in Beijing, and came to United States in 1985-1986 to pursue doctoral studies in composition at Columbia University. Because of the composers’ personal experience, they were not only familiar with Chinese regional folk elements, but also trained in the Western classical music tradition. Their works tend to blend and expand both Chinese and Western cultural traditions, musical ideas and techniques.
The six piano solo …
Sonata For Violin And Piano By John Corigliano: A Performance Guide, Xinyu Yang
Sonata For Violin And Piano By John Corigliano: A Performance Guide, Xinyu Yang
LSU Doctoral Dissertations
John Corigliano is one of the most famous American composers of modern times having gained global recognition over the course of his career. The focus of this dissertation is on one of his earlier works, the Sonata for Violin and Piano. This sonata is the first of his compositions to have gained international attention. In the Sonata for Violin and Piano, Corigliano uses traditional music elements that are accessible to the audience. Although it is based on the traditional composition, Corigliano uses ambiguous tonality, polytonality, complicated rhythm, and polyrhythm throughout the piece. These factors cause several technical issues which occur …
Population Dynamics And Demographics Of Spotted Seatrout, Cynoscion Nebulosus, Through Spatial Analysis: Towards An Integrative Management Approach, Ashley Melancon Baer
Population Dynamics And Demographics Of Spotted Seatrout, Cynoscion Nebulosus, Through Spatial Analysis: Towards An Integrative Management Approach, Ashley Melancon Baer
LSU Doctoral Dissertations
Spotted seatrout (Cynoscion nebulosus) is one of the most highly prized sportfish along the Gulf of Mexico coast, particularly in Louisiana. Although spotted seatrout are considered to be well managed and sustainably fished according to the state’s most recent stock assessment, the spatial ecology of this species is largely understudied in Louisiana waters. Acoustic telemetry is an innovative technology that is commonly used to assess the movements and behavior of aquatic species, and can be used as a tool to address the paucity of information on the spatial dynamics of spotted seatrout. The focus of this study was …
Understanding The Social Relationships Of Youth With Callous-Unemotional Traits Using Peer Nominations, Tatiana M. Matlasz
Understanding The Social Relationships Of Youth With Callous-Unemotional Traits Using Peer Nominations, Tatiana M. Matlasz
LSU Master's Theses
The current study investigated the social correlates of conduct problems (CP) and callous-unemotional (CU) traits using peer nominations. Participants (n = 289), drawn from a sample of 3rd, 6th, and 8thgraders (Mage = 11.47 years; SD = 2.26), were asked to identify peers who they believed fit a number of different characteristics, in addition to individuals who they liked most and liked least. We also obtained self-, parent-, and teacher-reports of children’s behaviors. Analyses extracted three primary dimensions from peer nominations, including, indicators of being mean and cold (Mean/Cold), of being aloof and …
Determination Of Conversion Factors For Various Calibration Geometries Using Barium-133 In A Silver Zeolite Cartridge, Amin Hamideh
Determination Of Conversion Factors For Various Calibration Geometries Using Barium-133 In A Silver Zeolite Cartridge, Amin Hamideh
LSU Master's Theses
Iodine-131 (I-131) is a major fission product among other radionuclides released during a nuclear incident. This radioiodine has a half-life of 8.02 days and the primary organ of uptake through ingestion or inhalation is the thyroid gland. For these reasons, nuclear power plants must routinely monitor I-131 through air sampling. Currently, there are two adsorbing media to collect I-131: activated charcoal and silver zeolite cartridges. Silver zeolite cartridges are generally used during a post nuclear incident due to its affinity for iodine while not adsorbing noble gases such as krypton-85 and xenon-135. After an air sample is taken from a …
Modes Of Cartoon Corporeal Performance, Gregory Langner
Modes Of Cartoon Corporeal Performance, Gregory Langner
LSU Doctoral Dissertations
This dissertation project works to introduce and interrogate a phenomenon I am calling cartoon corporeality. The phenomenon refers to the varied ways in which cartoons “escape” their usual two-dimensionality through performance, appearing to manifest in physical environments in ways that should be understood as culturally impactful. Cartoon corporeality encompasses different modes of performance wherein the explicit visual presence of a cartoon subject informs an immediately observable physical impact through the body of the performer. I interrogate the phenomenon by focusing on four select modes of cartoon corporeal performance: videogame play, cosplay, theatrical adaptation, and the active weaving of cartoons …
Putting It All Together: Adding Value To The Global Ocean And Climate Observing Systems With Complete Self-Consistent Ocean State And Parameter Estimates, David Trossman
Faculty Publications
No abstract provided.
Portable X-Ray Fluorescence Spectroscopy For Rapid And Cost-Effective Determination Of Elemental Composition Of Ground Forage, Yadav Sapkota, Louis M. Mcdonald, Thomas C. Griggs, Thomas J. Basden, Brandon Lee Drake
Portable X-Ray Fluorescence Spectroscopy For Rapid And Cost-Effective Determination Of Elemental Composition Of Ground Forage, Yadav Sapkota, Louis M. Mcdonald, Thomas C. Griggs, Thomas J. Basden, Brandon Lee Drake
Faculty Publications
No abstract provided.
Cross-Shelf Habitat Shifts By Red Snapper (Lutjanus Campechanus) In The Gulf Of Mexico, Michael A. Dance, Jay R. Rooker
Cross-Shelf Habitat Shifts By Red Snapper (Lutjanus Campechanus) In The Gulf Of Mexico, Michael A. Dance, Jay R. Rooker
Faculty Publications
Habitat shifts that occur during the life cycles of marine fishes influence population connectivity and structure. A generalized additive modeling approach was used to characterize relationships between environmental variables and the relative abundance of red snapper Lutjanus campechanus over unconsolidated substrate on the continental shelf (< 150 m) of the U.S. Gulf of Mexico (GoM) at three different life stages: juvenile (age-0, < 125 mm FL), sub-adult (age-1-2, 125–300 mm FL), and adult (age-2+, >300 mm FL). Fisheries independent data (2008–2014) were used to develop separate models for both the eastern and western GoM, and final models were used to predict the relative availability of suitable habitat for each life stage across the two regions. Predictor variables included in final models varied by age class and region, with …
Marr Family Transcription Factors From Burkholderia Species: Hidden Clues To Control Of Virulence-Associated Genes, Ashish Gupta, Anuja Pande, Afsana Sabrin, Sudarshan S. Thapa, Brennan W. Gioe, Anne Grove
Marr Family Transcription Factors From Burkholderia Species: Hidden Clues To Control Of Virulence-Associated Genes, Ashish Gupta, Anuja Pande, Afsana Sabrin, Sudarshan S. Thapa, Brennan W. Gioe, Anne Grove
Faculty Publications
Copyright © 2019 American Society for Microbiology. All Rights Reserved. Species within the genus Burkholderia exhibit remarkable phenotypic diversity. Genomic plasticity, including genome reduction and horizontal gene transfer, has been correlated with virulence traits in several species. However, the conservation of virulence genes in species otherwise considered to have limited potential for infection suggests that phenotypic diversity may not be explained solely on the basis of genetic diversity. Instead, differential organization and control of gene regulatory networks may underlie many phenotypic differences. In this review, we evaluate how regulation of gene expression by members of the multiple antibiotic resistance regulator …
Bioassay-Guided Isolation And Structure Elucidation Of Fungicidal And Herbicidal Compounds From Ambrosia Salsola (Asteraceae), Frank R. Fronczek
Bioassay-Guided Isolation And Structure Elucidation Of Fungicidal And Herbicidal Compounds From Ambrosia Salsola (Asteraceae), Frank R. Fronczek
Faculty Publications
The discovery of potent natural and ecofriendly pesticides is one of the focuses of the agrochemical industry, and plant species are a source of many potentially active compounds. We describe the bioassay-guided isolation of antifungal and phytotoxic compounds from the ethyl acetate extract of Ambrosia salsola twigs and leaves. With this methodology, we isolated and identified twelve compounds (four chalcones, six flavonols and two pseudoguaianolide sesquiterpene lactones). Three new chalcones were elucidated as (S)-beta-Hydroxy-2,3,4,6'-tetrahydroxy-5-methoxydihydrochalcone (salsolol A), (S)-beta-Hydroxy-2',4,4',6'-tetrahydroxy-3-methoxydihydrochalcone (salsolol B), and (R)-alpha, (R)-beta-Dihydroxy-2,3,4,4,6'-pentahydroxydihydrochalcone (salsolol C) together with nine known compounds: balanochalcone, six quercetin derivatives, confertin, and neoambrosin. Chemical structures were determined …
Pyrethroid And Organophosphate Pesticide Resistance In Field Populations Of Horn Fly In Brazil, L. G. Brito, F. S. Barbieri, R. B. Rocha, A. P.L. Santos, R. R. Silva, E. S. Ribeiro, F. Guerrero, L. Foil, M. C.S. Oliveira
Pyrethroid And Organophosphate Pesticide Resistance In Field Populations Of Horn Fly In Brazil, L. G. Brito, F. S. Barbieri, R. B. Rocha, A. P.L. Santos, R. R. Silva, E. S. Ribeiro, F. Guerrero, L. Foil, M. C.S. Oliveira
Faculty Publications
© 2018 The Royal Entomological Society Pesticides are used worldwide to control arthropod parasites in cattle herds. The indiscriminate and/or inappropriate use of pesticides without veterinary guidance is a reality in several countries of South America. Improper pesticide use increases the chances of contamination of food and the environment with chemical pesticides and their metabolites. Reduction of these contamination events is an increasing challenge for those involved in livestock production. The horn fly, Haematobia irritans (Linnaeus) (Diptera: Muscidae), is one of the most economically important parasites affecting cattle herds around the world. As such, horn fly control efforts are often …
Duration Of Protection From Live Attenuated Vs. Sub Unit Hsv-2 Vaccines In The Guinea Pig Model Of Genital Herpes: Reassessing Efficacy Using Endpoints From Clinical Trials, David I. Bernstein, Rhonda D. Cardin, Derek A. Pullum, Fernando J. Bravo, Konstantin G. Kousoulas, David A. Dixon
Duration Of Protection From Live Attenuated Vs. Sub Unit Hsv-2 Vaccines In The Guinea Pig Model Of Genital Herpes: Reassessing Efficacy Using Endpoints From Clinical Trials, David I. Bernstein, Rhonda D. Cardin, Derek A. Pullum, Fernando J. Bravo, Konstantin G. Kousoulas, David A. Dixon
Faculty Publications
© 2019 Bernstein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. Methods A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the Guinea pig model of genital herpes. Three doses of intramuscular (IM) vaccine were provided followed by intravaginal challenge …
Deep-Ultraviolet Laser Ablation Electrospray Ionization Mass Spectrometry, Remilekun O. Lawal, Fabrizio Donnarumma, Kermit K. Murray
Deep-Ultraviolet Laser Ablation Electrospray Ionization Mass Spectrometry, Remilekun O. Lawal, Fabrizio Donnarumma, Kermit K. Murray
Faculty Publications
© 2019 John Wiley & Sons, Ltd. A 193-nm wavelength deep ultraviolet laser was used for ambient laser ablation electrospray ionization mass spectrometry of biological samples. A pulsed ArF excimer laser was used to ablate solid samples, and the resulting plume of the desorbed material merged with charged electrospray droplets to form ions that were detected with a quadrupole time-of-flight mass spectrometer. Solutions containing peptide and protein standards up to 66-kDa molecular weight were deposited on a metal target, dried, and analyzed. No fragmentation was observed from peptides and proteins as well as from the more easily fragmented vitamin B …
Past Amazon Basin Fluvial Systems, Insight Into The Cenozoic Sequences Using Seismic Geomorphology (Marañón Basin, Peru), Gérôme Calvès, Ysabel Calderon, Vincent Roso, Cédric Bonnel, Martin Roddaz, Stéphane Brusset, Patrice Baby, Peter D. Clift
Past Amazon Basin Fluvial Systems, Insight Into The Cenozoic Sequences Using Seismic Geomorphology (Marañón Basin, Peru), Gérôme Calvès, Ysabel Calderon, Vincent Roso, Cédric Bonnel, Martin Roddaz, Stéphane Brusset, Patrice Baby, Peter D. Clift
Faculty Publications
© 2018 Elsevier Ltd This study of the seismic geomorphology of riverine deposits describes and discusses the spatial resolution at which we can detect fluvial features and how the subsequently collected data can help with our understanding of ancient fluvial reservoirs. For this assessment we use three dimensional seismic reflection data, borehole data from ancient deposits in the Marañón foredeep basin of Peru, as well as digital elevation and satellite imagery data from the present day fluvial systems of the Amazonian Basin in the same area of Peru. Based on seismic stratigraphic principles on amplitude display we test parameters to …
Apoptosis Signal-Regulating Kinase-1 Promotes Inflammasome Priming In Macrophages, Camille N. Immanuel, Bin Teng, Brittany Dong, Elizabeth M. Gordon, Joseph A. Kennedy, Charlean Luellen, Andreas Schwingshackl, Stephania A. Cormier, Elizabeth A. Fitzpatrick, Christopher M. Waters
Apoptosis Signal-Regulating Kinase-1 Promotes Inflammasome Priming In Macrophages, Camille N. Immanuel, Bin Teng, Brittany Dong, Elizabeth M. Gordon, Joseph A. Kennedy, Charlean Luellen, Andreas Schwingshackl, Stephania A. Cormier, Elizabeth A. Fitzpatrick, Christopher M. Waters
Faculty Publications
© 2019 the American Physiological Society. previously showed that mice deficient in apo-ptosis signal-regulating kinase-1 (ASK1) were partially protected against ventilator-induced lung injury. Because ASK1 can promote both cell death and inflammation, we hypothesized that ASK1 activation regulates inflammasome-mediated inflammation. Mice deficient in ASK1 expression (ASK1 +/+ ) exhibited significantly less inflammation and lung injury (as measured by neutrophil infiltration, IL-6, and IL-1β) in response to treatment with inhaled lipopolysaccharide (LPS) compared with wild-type (WT) mice. To determine whether this proinflammatory response was mediated by ASK1, we investigated inflammasome-mediated responses to LPS in primary macrophages and bone marrow-derived macrophages (BMDMs) …
Milk And Kefir Maintain Aspects Of Health During Doxorubicin Treatment In Rats, L. K. Stewart, P. Smoak, D. S. Hydock, R. Hayward, K. O'Brien, J. K. Lisano, C. Boeneke, M. Christensen, A. Mathias
Milk And Kefir Maintain Aspects Of Health During Doxorubicin Treatment In Rats, L. K. Stewart, P. Smoak, D. S. Hydock, R. Hayward, K. O'Brien, J. K. Lisano, C. Boeneke, M. Christensen, A. Mathias
Faculty Publications
Doxorubicin (DOX), a powerful anthracycline antibiotic commonly used to treat a wide variety of cancers, is associated with the production of reactive oxygen species that cause oxidative damage, resulting in cardiac dysfunction. Components of dairy may have protective effects against DOX-induced cardiac damage. Kefir is a naturally fermented milk product containing antioxidants, probiotic bacteria, and yeast in addition to the protective components of dairy. We explored the effects of dietary milk and kefir on DOX-induced cardiotoxicity in rats. We used singly housed, 10-wk-old male Sprague Dawley rats assigned to 1 of 3 isocaloric diets, control (CON n = 24), milk …
Racial Discrimination In Jury Selection: James Batson, The Sixth Amendment Fair-Cross-Section Doctrine, And The Racially-Based Peremptory Challenge, Kristen Marie Vicknair
Racial Discrimination In Jury Selection: James Batson, The Sixth Amendment Fair-Cross-Section Doctrine, And The Racially-Based Peremptory Challenge, Kristen Marie Vicknair
Honors Capstones
No abstract provided.
Applications Of Unmanned Aerial Vehicles To Survey Mesocarnivores, Jacob D. Bushaw, Kevin M. Ringelman, Frank C. Rohwer
Applications Of Unmanned Aerial Vehicles To Survey Mesocarnivores, Jacob D. Bushaw, Kevin M. Ringelman, Frank C. Rohwer
Faculty Publications
With the widespread extirpation of top predators over the past two centuries, mesocarnivores play an increasingly important role in structuring terrestrial trophic webs. However, mesocarnivores are difficult to survey at a population level because their widely spaced territories and nocturnal behavior result in low detection probability. Existing field survey techniques such as track plates and motion-sensitive camera traps are time-consuming and expensive, and yet still yield data prone to systematic errors. Unmanned Aerial Vehicles (UAVs) have recently emerged as a new tool for conducting population surveys on a wide variety of wildlife, eclipsing the efficiency and even accuracy of traditional …
The Effect Of Invasive Aquatic Vegetation On Odonate Diversity In An Urban Area, Sarah Thomas
The Effect Of Invasive Aquatic Vegetation On Odonate Diversity In An Urban Area, Sarah Thomas
Honors Capstones
No abstract provided.
Assessing Knowledge Of Coastal Land Loss In Louisiana High School Graduates, Madelyn Smith
Assessing Knowledge Of Coastal Land Loss In Louisiana High School Graduates, Madelyn Smith
Honors Capstones
No abstract provided.
Evaluation Of Naturally Occurring Radioactive Material In Seafood From The Gulf Of Mexico, Charles Algeo Wilson Iv
Evaluation Of Naturally Occurring Radioactive Material In Seafood From The Gulf Of Mexico, Charles Algeo Wilson Iv
LSU Doctoral Dissertations
Radioactive disintegration of naturally occurring radioactive material was modeled with high precision and no assumptions to better understand serial decay in high order disequibrlia. This model helped develop a new method of quick analysis of NORM, where radioactivity can be measured with reasonable certainty before secular equilibrium is established. This approach was a significant improvement on previous similar approaches, halving time required for the same results and reduced wait time compared to classical approaches by 92%. Consequentially, NORM was measured in selected seafood samples from three areas in the Gulf of Mexico. Red Snapper, Red Drum, Northern Whiting, Spotted Trout …
Understanding Immune-Mediated Responses During The Pathogenesis Of Muco-Obstructive Airway Disease In Mice, Brandon Wayne Lewis
Understanding Immune-Mediated Responses During The Pathogenesis Of Muco-Obstructive Airway Disease In Mice, Brandon Wayne Lewis
LSU Doctoral Dissertations
The primary purpose of pulmonary ventilation is to supply oxygen for sustained aerobic respiration. However, a plethora of abiotic insults and airborne pathogens present in the environment are occasionally introduced into the airspaces during inhalation. Multiple layers of host defense, termed the mucociliary escalator, act in concert to eliminate unwanted constituents from the airspaces. Defects in the mucociliary escalator, as exhibited in cystic fibrosis (CF), compromise the mucociliary clearance (MCC) of inhaled pathogens, which favors microbial lung infection and progressive decreases in lung function. In CF, a mutation in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene results …
When Can Competition And Dispersal Lead To Checkerboard Distributions?, Tad Dallas, Brett A. Melbourne, Alan Hastings
When Can Competition And Dispersal Lead To Checkerboard Distributions?, Tad Dallas, Brett A. Melbourne, Alan Hastings
Faculty Publications
© 2018 The Authors. Journal of Animal Ecology © 2018 British Ecological Society Checkerboard distributions—mutually exclusive species co-occurrences—are a common observation in community ecology and biogeography. While the underlying causes of checkerboard distributions have remained elusive, a long-standing argument is that they are representative of strong competitive interactions and/or dispersal limitation. We explore this using a stochastic two-patch metacommunity model combined with an experimental two-patch system of competing Tribolium species, quantifying checkerboard distributions using the abundance-based index A st . We find that maintenance of checkerboard distributions is possible in a limited parameter space consisting of low dispersal rates, low …
Inward Rectifier Potassium (Kir) Channels Mediate Salivary Gland Function And Blood Feeding In The Lone Star Tick, Amblyomma Americanum, Zhilin Li, Kevin R. Macaluso, Lane D. Foil, Daniel R. Swale
Inward Rectifier Potassium (Kir) Channels Mediate Salivary Gland Function And Blood Feeding In The Lone Star Tick, Amblyomma Americanum, Zhilin Li, Kevin R. Macaluso, Lane D. Foil, Daniel R. Swale
Faculty Publications
© 2019 Li et al. Background Tick feeding causes extreme morbidity and mortality to humans through transmission of pathogens and causes severe economic losses to the agricultural industry by reducing livestock yield. Salivary gland secretions are essential for tick feeding and thus, reducing or preventing saliva secretions into the vertebrate host is likely to reduce feeding and hinder pathogen life cycles. Unfortunately, the membrane physiology of tick salivary glands is underexplored and this gap in knowledge limits the development of novel therapeutics for inducing cessation of tick feeding. Methodology We studied the influence of inward rectifier potassium (Kir) channel subtypes …
Factors Affecting Growth Kinetics And Spontaneous Metastasis In The B16f10 Syngeneic Murine Melanoma Model, Natalie Fowlkes, Kelli Clemons, Paul Jf Rider, Ramesh Subramanian, Nobuko Wakamatsu, Ingeborg Langohr, Konstantin G. Kousoulas
Factors Affecting Growth Kinetics And Spontaneous Metastasis In The B16f10 Syngeneic Murine Melanoma Model, Natalie Fowlkes, Kelli Clemons, Paul Jf Rider, Ramesh Subramanian, Nobuko Wakamatsu, Ingeborg Langohr, Konstantin G. Kousoulas
Faculty Publications
Melanoma is an immunogenic tumor that can metastasize quickly to proximal and distal sites, thus complicating the application of therapeutic modalities. Numerous mouse model systems have been used to gain understanding of the immunobiology and metastatic potential of melanoma. Here, we report the optimization of a syngeneic mouse melanoma model protocol using the mouse B16-derived melanoma cell line B16F10 that ensures the production of tumors on mice pinnae that are similar in size between animals and that enlarge in a time-dependent manner. In this model, B16F10 cells are first allowed to develop tumors after injection in the interscapular area or …