Digital Commons Network^™

Gastrointestinal Microenvironment And The Gut-Lung Axis In The Immune Responses Of Severe Covid-19, Yun Yang, Weishan Huang, Yubo Fan, Guo-Qiang Chen

Faculty Publications

The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented threat to the human health. A close association of the digestive tract is implied by the high frequency of gastrointestinal syndromes among COVID-19 patients. A better understanding of the role of intestinal microenvironment in COVID-19 immunopathology will be helpful to improve the control of COVID-19 associated morbidity and mortality. This review summarizes the immune responses associated with the severity of COVID-19, the current evidence of SARS-CoV-2 intestinal tropism, and the potential involvement of gut microenvironment in COVID-19 severity. Additionally, we …

Structure-Activity Relationship Analysis Of Psychedelics In A Rat Model Of Asthma Reveals The Anti-Inflammatory Pharmacophore, Thomas W. Flanagan, Gerald B. Billac, Alexus N. Landry, Melaine N. Sebastian, Stephania A. Cormier, Charles D. Nichols

Division of Basic Science Faculty Publications

Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms. We hypothesized that the distinct structural features of psychedelics underlie functionally selective mechanisms at the target 5-HT2A receptor to elicit maximal anti-inflammatory effects. In order to test this hypothesis, we developed a new rat-based screening platform for allergic asthma. Next, we investigated 21 agonists at the 5-HT2A receptor from the three primary chemotypes (phenylalkylamine, ergoline, and tryptamine) for their ability to prevent airways hyperresponsiveness as a measure of pulmonary inflammation. Furthermore, we assessed each drug for in vitro …

Anesthetic Combination Of Alfaxalone, Dexmedetomidine And Hydromorphone For Comparison Of Endoscopy-Guided Intubation And Blind Orotracheal Intubation In Domestic Rabbits (Oryctolagus Cuniculus), Stephanie Reabel

LSU Master's Theses

Domestic rabbits have a high risk of anesthesia-related mortality compared to other companion animals. Factors that may contribute to increased mortality include drug-induced cardiopulmonary effects (Grint & Murison 2008; Navarrete-Calvo et al. 2013), difficulty performing intubation (Aeschbacher 1995; Flecknell 2016; Wenger et al. 2017) or damage to laryngeal and tracheal tissues following orotracheal intubation (Grint et al. 2006; Phaneuf et al. 2006; Engbers et al. 2017).

Alfaxalone is a neuroactive steroid that produces induction of anesthesia and cardiorespiratory depression in a dose-dependent manner when injected intravenously. The ability to induce anesthesia via an intramuscular (IM) route has several advantages in …

Implementing Four Modeling Improvement Strategies To Measure The Economic Contribution Of The Alligator Farming Industry In Louisiana, Ilich Fernan Rosales Chiessa

LSU Master's Theses

The alligator industry in Louisiana has not had a study in thirty years that has measured its economic contribution. The industry has changed structurally over that period, and it produces more alligator skins but is concentrated in a smaller number of producers. With current threats to the industry through potential bans on alligator sales in states like California, the importance of these studies for the industry are more important now than ever. This study measures the economic contribution of American alligator across the supply chain of the state of Louisiana through four different modeling improvement strategies. These consist of using …

Dynamic Energy Budget Modelling To Predict Eastern Oyster Growth, Reproduction, And Mortality Under River Management And Climate Change Scenarios, Romain Lavaud, Megan K. La Peyre, Dubravko Justic, Jerome F. La Peyre

Faculty Publications

Eastern oysters growing in deltaic Louisiana estuaries in the northern Gulf of Mexico must tolerate considerable salinity variation from natural climate variability (e.g., rainfall and stream run-off pushing isohalines offshore; tropical storms pushing isohalines inshore) and man-made diversions and siphons releasing freshwater from the Mississippi River. These salinity variations are predicted to increase with future climate change because of the increased frequency of stronger storms and also in response to proposed large-scale river diversions. Increased Mississippi River flow into coastal estuaries from river diversions, along with potential changes in rainfall and stream run-off from climate change will alter spatial and …

Louisiana Agriculture Spring, 2021, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Central- Spring 2021, Lsu Agcenter

Horticulture Hints

No abstract provided.

An Early Global Role For Axin Is Required For Correct Patterning Of The Anterior-Posterior Axis In The Sea Urchin Embryo, Hongyan Sun, Chieh Fu Jeff Peng, Lingyu Wang, Honglin Feng, Athula H. Wikramanayake

Faculty Publications

Activation of Wnt/β-catenin (cWnt) signaling at the future posterior end of early bilaterian embryos is a highly conserved mechanism for establishing the anterior-posterior (AP) axis. Moreover, inhibition of cWnt at the anterior end is required for development of anterior structures in many deuterostome taxa. This phenomenon, which occurs around the time of gastrulation, has been fairly well characterized, but the significance of intracellular inhibition of cWnt signaling in cleavage-stage deuterostome embryos for normal AP patterning is less well understood. To investigate this process in an invertebrate deuterostome, we defined Axin function in early sea urchin embryos. Axin is ubiquitously expressed …

Parasite Prevalence In Marsh Rice Rats (Oryzomys Palustris) On Sites Affected By The 2010 Deepwater Horizon Oil Spill, Layni Leblanc

Honors Capstones

No abstract provided.

Spring 2021 Catalog, Lsu Press

LSU Press Seasonal Catalogs

No abstract provided.

Effects Of Cryopreservation, Immunophenotype And Sex On Multipotentiality, Cell Proliferation And Gene Expression In Feline Adipose-Derived Stromal Cells, Maia Williams

Honors Capstones

No abstract provided.

Restoration Agriculture In Louisiana: On The Prospects And Ethics Of Creating A Permanent, Dynamic Agricultural System Suited For Louisiana's Environment, Noah Willsea

Honors Capstones

No abstract provided.

Baculovirus Translocation Through Maize: Examining A Novel Route For Insect Herbivore Infection, Peter Pierre Issa

Honors Capstones

No abstract provided.

Rainwater Catchment Systems: How Designers Can Utilize Architectural Strategies To Improve Water Access, Madeleine Juneau

Honors Capstones

No abstract provided.

The Synchrony Of Pathogen Events, Tivon Eugene

Honors Capstones

No abstract provided.

Stakeholder’S Risk Perceptions Ofwild Pigs: Is There A Gender Difference?, Maria Bampasidou, Michael D. Kaller, Shaun M. Tanger

Faculty Publications

Substantial literature indicates that genders differ in terms of risk perception and values regarding wildlife management. Lack of equal stakeholder representation is also documented, which can also impact the effectiveness of human-wildlife conflict resolution interventions and education and outreach efforts. This paper investigates gender differences in perceptions about risks and potential adverse impacts on production, health, environment, safety, and population management posed by wild pigs. A survey was used to collect data from a random sample of adult residents (N = 1221) in Louisiana. We analyzed responses from 226 female and 832 male producers. We observed differences in how these …

Physiology Of Energy Intake In The Weight-Reduced State, Hans Rudolf Berthoud, Randy J. Seeley, Susan B. Roberts

Division of Basic Science Faculty Publications

Physiological adaptations to intentional weight loss can facilitate weight regain. This review summarizes emerging findings on hypothalamic and brainstem circuitry in the regulation of body weight and identifies promising areas for research to improve therapeutic interventions for sustainable weight loss. There is good evidence that body weight is actively regulated in a homeostatic fashion similar to other physiological parameters. However, the defended level of body weight is not fixed but rather depends on environmental conditions and genetic background in an allostatic fashion. In an environment with plenty of easily available energy-dense food and low levels of physical activity, prone individuals …

Evaluation Of Changes In Drug Susceptibility And Population Genetic Structure In Haemonchus Contortus Following Worm Replacement As A Means To Reverse The Impact Of Multiple-Anthelmintic Resistance On A Sheep Farm, Melissa M. George, Adriano F. Vatta, Sue B. Howell, Bob E. Storey, Ciaran J. Mccoy, Adrian J. Wolstenholme, Elizabeth M. Redman, John S. Gilleard, Ray M. Kaplan

Faculty Publications

A population of Haemonchus contortus that was highly resistant to benzimidazoles and avermectin/milbemycins with a subpopulation that was resistant to levamisole, was replaced with a susceptible laboratory isolate of H. contortus in a flock of sheep. The anthelmintic susceptibility and population genetics of the newly established population were evaluated for 3.5 years using in vivo, in vitro, and molecular methods. Successful replacement of the resistant population with a susceptible population was confirmed using phenotypic and genotypic measurements; larval development assay indicated full anthelmintic susceptibility; albendazole treatment yielded 98.7% fecal egg count reduction; pyrosequence genotyping of single nucleotide polymorphisms in positions …

Evaluation Of Eight Kinds Of Flavor Enhancer Of Umami Taste By An Electronic Tongue, Kai Wang, Haining Zhuang, Fangling Bing, Da Chen, Tao Feng, Zhimin Xu

Faculty Publications

The umami intensity of single flavor enhancer was detected by an electronic tongue and human sensory. The linear fit was performed to unravel the concentration–response values correlations of eight flavor enhancers. The electronic tongue response data were then analyzed using principal component analysis (PCA) and discriminant factor analysis (DFA) method. It was found that the umami response value of the electronic tongue and the flavor enhancer concentration showed a semi-logarithmic function. Moreover, the PCA and DFA could successfully distinguish the variety and concentration of flavor enhancer. The umami intensities were also assessed by human sensory and showed consistency with those …

Determination Of Ligustrazine In Rat Serum By Polymer Monolithic Micro-Extraction Combined With Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry, Danling Sun, Xitian Peng, Maomin Peng, Xian Zhang, Hong Xia, Zhimin Xu, Xizhou Hu

Faculty Publications

This study focused on developing an effective and environmentally friendly method to measure ligustrazine in rat serum by using polymer monolith micro-extraction (PMME) technique. A poly (methacrylic acid-ethylene glycol dimethacrylate) material was used to extract ligustrazine through hydrophobic and ion-exchange interaction. Qualitative and quantitative analysis was performed by a liquid chromatography and tandem mass spectrometry. After optimization of several PMME conditions, the developed method exhibited excellent extraction performance to the ligustrazine. Good linearity was acquired ranging from 10 to 2,000 ng mL-1, and the limit of detection of the proposed method was 0.14 ng mL-1. The recoveries measured by spiking …

Envrtype: A Software To Interplay Enviromics And Quantitative Genomics In Agriculture, Germano Costa-Neto, Giovanni Galli, Humberto Fanelli Carvalho, Jose Crossa, Roberto Fritsche-Neto

Faculty Publications

Envirotyping is an essential technique used to unfold the nongenetic drivers associated with the phenotypic adaptation of living organisms. Here, we introduce the EnvRtype R package, a novel toolkit developed to interplay large-scale envirotyping data (enviromics) into quantitative genomics. To start a user-friendly envirotyping pipeline, this package offers: (1) remote sensing tools for collecting (get_weather and extract_GIS functions) and processing ecophysiological variables (processWTH function) from raw environmental data at single locations or worldwide; (2) environmental characterization by typing environments and profiling descriptors of environmental quality (env_typing function), in addition to gathering environmental covariables as quantitative descriptors for predictive purposes (W_matrix …

Hybrid Modeling And Prediction Of Oyster Norovirus Outbreaks, Shima Shamkhali Chenar, Zhiqiang Deng

Faculty Publications

This paper presents a hybrid model for predicting oyster norovirus outbreaks by combining the Artificial Neural Networks (ANNs) and Principal Component Analysis (PCA) methods and using the Moderate Resolution Imaging Spectroradiometer (MODIS) satellite remote-sensing data. Specifically, 10 years (2007-2016) of cloud-free MODIS Aqua data for water leaving reflectance and environmental data were extracted from the center of each oyster harvest area. Then, the PCA was utilized to compress the size of the MODIS Aqua data. An ANN model was trained using the first 4 years of the data from 2007 to 2010 and validated using the additional 6 years of …

Oxytocin Receptor Expressing Cells In The Mouse Retina, Jackson Green

Honors Capstones

No abstract provided.

Effect Of Kisspeptin-10 On Glucose-Induced Insulin Secretion In Equines, Amy Taylor

Honors Capstones

No abstract provided.

Expression And Purification Of Mitochondrial Group 3 Lea Protein, Afrlea3m_29, From Diapause Embryos Of Artemia Franciscana, Ivan Dinh Nguyen

Honors Capstones

No abstract provided.

Oleoyl Coa Inhibition Of Complex Ii-Dependent Respiration In Embryos Of Artemia Franciscana: Possible Contributor To Metabolic Arrest During Diapause, Alexander P. Landry

Honors Capstones

No abstract provided.

The Physiological Effect Of Dietary Exposure To Microplastics In Fish Species: A Literature Review And Novel Polylactic Acid Project Proposal, Elise Hernandez

Honors Capstones

No abstract provided.

The Investigation Of Young, Lineage Specific Alu Elements In The Owl Monkey (Aotus), Lydia Rewerts

Honors Capstones

No abstract provided.

The Ldoe’S Innovative Assessment Pilot: Bridging Or Widening The Gap?, Eric Forbes

Honors Capstones

No abstract provided.

Understanding The Story Behind The Story: A Comparative Textual Analysis Of Newspaper Coverage Following Mob Violence In 1921 Tulsa, Oklahoma And 2020 Minneapolis, Minnesota, Justin Franklin

Honors Capstones

No abstract provided.