Digital Commons Network^™

Fun House, Stephanie Cobb

LSU Master's Theses

The expression “fun house” seems empathetic and joyful, but has potentially melancholy connotations. Fun houses are participatory. They allow guests to move freely through their colorful halls. At the same time, they do not organize guest’s experience. Usually, we are thoughtful of all possible contingencies that make the world so unpredictable. We prefer certainty to doubt and try to avoid risks. However, reason and order have limits. To feel alive, we must take risks. The connotation of the paintings in Fun House may imply either a sunny mood through tenderness between figures or a tense ambivalence that lingers in their …

Joseph Ducreux And The Physiognomical Millieu, Josiah Phelps

LSU Master's Theses

Joseph Ducreux was an eighteenth-century artist from Nancy, France, whose grimacing self-portraits made their way into to the Parisian Salons during the age of the French Revolution. His self-portraits showcased himself in a state of yawning, state of laughing, state of self-confidence, and state of fear. This series is believed to derive from his study of physiognomy and his knowledge of physiognomical studies by such Enlightenment scholars as Johann Kasper Lavater. It will contextualize Ducreux’s his oeuvre of self-portraits and his commercial portraits including those previously executed for the French court, with the influence of the pseudo-science of physiognomy. The …

Implementation Of Dietary Methionine Restriction Using Casein After Selective, Oxidative Deletion Of Methionine, Han Fang, Kirsten P. Stone, Laura A. Forney, Landon C. Sims, Gabriela C. Gutierrez, Sujoy Ghosh, Thomas W. Gettys

Division of Basic Science Faculty Publications

Dietary methionine restriction (MR) is normally implemented using diets formulated from elemental amino acids (AA) that reduce methionine content to ∼0.17%. However, translational implementation of MR with elemental AA-based diets is intractable due to poor palatability. To solve this problem and restrict methionine using intact proteins, casein was subjected to mild oxidation to selectively reduce methionine. Diets were then formulated using oxidized casein, adding back methionine to produce a final concentration of 0.17%. The biological efficacy of dietary MR using the oxidized casein (Ox Cas) diet was compared with the standard elemental MR diet in terms of the behavioral, metabolic, …

Mothering Across Borders: A Phenomenological Exploration Into The Work-Family Balance Experiences Of Jamaican Transnational Mothers In The United States, Phelecia Alecia Udoko

LSU Doctoral Dissertations

The U.S. is home to one of the largest Jamaican populations residing outside of Jamaica and comprises over 50% of the U.S.-Caribbean workforce. Despite this, the experiences of Jamaican mothers who balance domestic work and families abroad–a phenomenon known as transnational motherhood – is often overlooked in research on work-family balance. Currently, a need exists to further explore work-family balance (WFB) as the lack of it has been associated with negative organizational outcomes. The purpose of this dissertation is to understand the WFB experiences of Jamaican transnational mothers and to explore the role of institutional/national policies and culture on WFB …

Methodology Utilizing Triphosgene To Promote Cyclization Of Epoxy Ketones To Pyranoside Derivatives Via Proposed Epoxonium Ions, Isaac Camargo Dos Reis

LSU Master's Theses

The development of new methodologies in organic chemistry is of great importance. In fact, the discovery and creation of new reactions frequently uncovers new chemical reactivities and creates new areas of chemistry. The purpose of this thesis is to present the development of new synthetic reactions that were discovered through previous findings. Additionally, the main theme of this work relies on the intermediacy of a cationic reactive intermediate: epoxonium ions. Chapter 1 provides a brief review of bicyclic epoxonium ions and methods for their generation, as well as their utility in the synthesis of interesting heterocycles. Furthermore, Chapter 1 illustrates …

Incorporating Life Into Living Shorelines: Can Gulf Ribbed Mussels Reduce Shoreline Erosion And Enhance Restoration Practices?, Jordan Logarbo

LSU Master's Theses

The gulf ribbed mussel (Geukensia granosissima) exists throughout the Gulf of Mexico and influences biotic and abiotic environmental attributes as an ecosystem engineer. Ribbed mussels are an important component of marsh ecosystems providing services including filtering particulate matter, depositing and transforming nutrients in the system, increasing soil strength via byssal threads and providing structure via their shells.

The spatial distribution of mussels along the marsh edge of Sister Lake, LA was investigated via a broad survey of 150 sites, in relation to elevation, exposure and vegetation percent cover. This survey was followed by a second survey at a …

Evaluation Of Food Safety Practices At Louisiana Summer Feeding Sites And Food Safety Communication Via Social Media During Crises, Peyton E. Haynes

LSU Master's Theses

The United States Department of Agriculture’s Summer Food Service Program (SFSP) provided children under the age of 18 in low-income areas 145 million free meals in 2018 through summer feeding sites. Food safety issues arise for Louisiana feeding sites due to time-temperature controlled foods served, weather patterns in Louisiana, seasonal staff and short operation time, and lack of equipment. The purpose of this study was to assess food safety practices at Louisiana feeding sites through observational study with intention to compare food practices at institutional and noninstitutional sites. A rubric following USDA food safety guidelines based on categories: hot holding, …

Evolution Of Extreme Habitat Specialists In The Dark: Cavefishes And Anglerfishes, Pamela Hart

LSU Doctoral Dissertations

Extremophilic organisms are fascinating in that they thrive in physiologically demanding environments. Extreme habitats include subsurface caves and the deep sea, which share several qualities like low light and cold temperatures. Extremophiles have adapted bizarre characteristics that allow them to thrive in such harsh environments including eye and pigment loss (cavefishes) and development of a lure in anglerfishes. These traits are integral to the health and fitness of these organisms, yet the evolutionary history of these traits is unclear.

Cave adaptation has evolved repeatedly across the Tree of Life, famously leading to eye degeneration and loss, yet its macroevolutionary implications …

Quantifying Feature Overlaps In Deep Neural Networks And Their Applications In Unsupervised Learning And Generative Adversarial Networks, Edward Collier

LSU Doctoral Dissertations

Deep neural network learn a wide range of features from the input data. These features take many different forms from, structural to textural, and can be very scale invariant. The complexity of these features also differs from layer to layer. Much like the human brain, this behavior in deep neural networks can also be used to cluster and separate classes. Applicability in deep neural networks is the quantitative measurement of the networks ability to differentiate between clusters in feature space. Applicability can measure the differentiation between clusters of sets of classes, single classes, or even within the same class. In …

Semantics-Guided Human Motion Modeling In Virtual Reality Environment, Matthew Korban

LSU Doctoral Dissertations

Human Motion Modeling is essential in Computer Animation and Human-Computer Interaction. This dissertation studies how to enhance the speed and robustness of Human Motion Modeling in Virtual Reality (VR) environments. Specifically, we aim to design a pipeline to effectively capture and use semantic action information to guide the motion capturing from users in physical worlds and its transfer onto digital avatars in VR environments. To recognize the user's action, we first proposed a new Dynamic Directed Graph Convolutional Network (DDGCN) to model spatial and temporal features from users' skeletal representations. The DDGCN consists of several dynamic feature modeling modules to …

Mosquito Distribution And Stoichiometric Analysis Between Open And Closed Canopies In New Orleans Cemeteries, Rachel Rogers

LSU Master's Theses

Cemetery vases represent an important container habitat for mosquito larvae. Some species, like, Aedes albopictus and Aedes aegypti, prefer container habitats, whereas others, like Culex quinquefasciatus, will opportunistically use containers. In New Orleans, these three medically important vector species (Ae. albopictus Ae. aegypti, and Cx. quinquefasciatus) co-occur, despite a demonstrated competitive advantage of Ae. albopictus to the other two. Here we test the hypothesis that canopy cover from trees could be a mediating factor in driving mosquito assemblages in New Orleans, by influencing food sources, and the microclimate experienced by mosquito larvae. Samples from seven …

Mental Imagery In The Regulation Of Differential Fear Conditioning: A Multimodal Investigation Involving Self-Report, Psychophysiology, And Brain Imaging, Tyler Daniel Robinson

LSU Doctoral Dissertations

Mental imagery is a common component in a range of emotion regulation techniques. However, the effectiveness and neural mechanisms of regulation via mental imagery are underexplored due to a lack of studies targeting mental imagery specifically. This discrepancy results in uncertainty regarding the mechanism of regulation in existing paradigms. Biased competition for attentional resources presents a plausible model by which a mental imagery-based distracter can downregulate response to an emotional stimulus. If visualizing an imagined distracter effectively regulates emotional response, the inclusion of mental imagery components in other techniques represents a potential confound. To address this discrepancy, this dissertation investigates …

The Effect Of Phragmites Australis Dieback On Channel Sedimentation In The Mississippi River Delta: A Conceptual Modeling Study, Kelin Hu, Ehab Meselhe, J. Andrew Nyman

Faculty Publications

Phragmites australis is a globally distributed wetland plant. At the mouth of the Mississippi River, P. australis on natural levees of the network of distributary channels appears to increase the flow in the deep draft navigation channel, which, in turn, may reduce the sedimentation and benefit the navigation dredging. For several years, P. australis has been dying in the Mississippi River’s Bird’s Foot Delta, which appears to be shortening the distributary channels and increasing the lateral flow from the remaining portions. A conceptual model based on D-FLOW FM was applied to calculate channel sedimentation in a series of idealized deltaic …

Time Lags: Insights From The U.S. Long Term Ecological Research Network, Edward B. Rastetter, Mark D. Ohman, Katherine J. Elliott, J. S. Rehage, Victor H. Rivera-Monroy, R. E. Boucek, Edward Castañeda-Moya, Tess M. Danielson, Laura Gough, Peter M. Groffman, C. Rhett Jackson, Chelcy Ford Miniat, Gaius R. Shaver

Faculty Publications

Ecosystems across the United States are changing in complex ways that are difficult to predict. Coordinated long-term research and analysis are required to assess how these changes will affect a diverse array of ecosystem services. This paper is part of a series that is a product of a synthesis effort of the U.S. National Science Foundation’s Long Term Ecological Research (LTER) network. This effort revealed that each LTER site had at least one compelling scientific case study about “what their site would look like” in 50 or 100 yr. As the site results were prepared, themes emerged, and the case …

An Efficient Alternative To The Cdc Gravid Trap For Southern House Mosquito (Diptera: Culicidae) Surveillance, Timothy D. Mcnamara, Thomas A. O'Shea-Wheller, Nicholas Delisi, Emily Dugas, Kevin A. Caillouet, Randy Vaeth, Dennis Wallette, Kristen Healy

Faculty Publications

West Nile virus (WNV) is the most prevalent arbovirus found throughout the United States. Surveillance of surface breeding Culex vectors involved in WNV transmission is primarily conducted using CDC Gravid traps. However, anecdotal claims from mosquito abatement districts in Louisiana assert that other trap types may be more suited to WNV surveillance. To test the validity of these assertions, we conducted a series of trapping trials and WNV surveillance over 3 yr to compare the efficacy of multiple trap types. First, we compared the CDC Gravid trap, CO2-baited New Standard Miniature Blacklight traps, and CO2-baited CDC light traps with either …

Heavy Metal-Resistant Filamentous Fungi As Potential Mercury Bioremediators, Cristina L. Văcar, Eniko Covaci, Somsubhra Chakraborty, Bin Li, David Weindorf, Tiberiu Frentiu, Marcel Pârvu, Dorina Podar

Faculty Publications

No abstract provided.

A Hindbrain Dopaminergic Neural Circuit Prevents Weight Gain By Reinforcing Food Satiation, Yong Han, Guobin Xia, Yanlin He, Yang He, Monica Farias, Yong Xu, Qi Wu

Division of Basic Science Faculty Publications

The neural circuitry mechanism that underlies dopaminergic (DA) control of innate feeding behavior is largely uncharacterized. Here, we identified a subpopulation of DA neurons situated in the caudal ventral tegmental area (cVTA) directly innervating DRD1-expressing neurons within the lateral parabrachial nucleus (LPBN). This neural circuit potently suppresses food intake via enhanced satiation response. Notably, this cohort of DAcVTA neurons is activated immediately before the cessation of each feeding bout. Acute inhibition of these DA neurons before bout termination substantially suppresses satiety and prolongs the consummatory feeding. Activation of postsynaptic DRD1LPBN neurons inhibits feeding, whereas genetic deletion of Drd1 within the …

Conceptus Metabolomic Profiling Reveals Stage-Specific Phenotypes Leading Up To Pregnancy Recognition In Cattle†, Constantine A. Simintiras, José M. Sánchez, Michael Mcdonald, Elena O'Callaghan, Ahmed A. Aburima, Patrick Lonergan

Faculty Publications

Reproductive efficiency in livestock is a major driver of sustainable food production. The poorly understood process of ruminant conceptus elongation (a) prerequisites maternal pregnancy recognition, (b) is essential to successful pregnancy establishment, and (c) coincides with a period of significant conceptus mortality. Conceptuses at five key developmental stages between Days 8-16 were recovered and cultured in vitro for 6 h prior to conditioned media analysis by untargeted ultrahigh-performance liquid chromatography tandem mass spectroscopy. This global temporal biochemical interrogation of the ex situ bovine conceptus unearths two antithetical stage-specific metabolic phenotypes during tubular (metabolically retentive) vs. filamentous (secretory) development. Moreover, the …

Polycyclic Aromatic Hydrocarbon-Dna Adducts In Gulf Of Mexico Sperm Whale Skin Biopsies Collected In 2012, Miriam C. Poirier, Letizia Marsili, Maria Cristina Fossi, Céline A.J. Godard-Codding, Elena E. Hernandez-Ramon, Nancy Si, Kathyayini V. Divi, Rao L. Divi, Iain Kerr, John Pierce Wise, John Pierce Wise, Catherine F. Wise, Sandra S. Wise, Abou El Makarim Aboueissa, James T.F. Wise

Faculty Publications

The northern Gulf of Mexico has a long history of polycyclic aromatic hydrocarbon (PAH) contamination from anthropogenic activities, natural oil seepages, and the 2010 Deepwater Horizon explosion and oil spill. The continental shelf of the same area is a known breeding ground for sperm whales (Physeter macrocephalus). To evaluate PAH-DNA damage, a biomarker for potential cancer risk, we compared skin biopsies collected from Gulf of Mexico sperm whales in 2012 with skin biopsies collected from sperm whales in areas of the Pacific Ocean in 1999-2001. All samples were obtained by crossbow and comprised both epidermis and subcutaneous blubber. To evaluate …

Circadian Rhythms In Legumes: What Do We Know And What Else Should We Explore?, Hazel Marie Kugan, Nur Ardiyana Rejab, Nurul Amylia Sahruzaini, Jennifer Ann Harikrishna, Niranjan Baisakh, Acga Cheng

Faculty Publications

The natural timing devices of organisms, commonly known as biological clocks, are composed of specific complex folding molecules that interact to regulate the circadian rhythms. Circadian rhythms, the changes or processes that follow a 24‐h light–dark cycle, while endogenously programmed, are also influenced by environmental factors, especially in sessile organisms such as plants, which can impact ecosystems and crop productivity. Current knowledge of plant clocks emanates primarily from research on Arabidopsis, which identified the main components of the circadian gene regulation network. Nonetheless, there remain critical knowledge gaps related to the molecular components of circadian rhythms in important crop groups, …

Genome-Wide Association Study Reveals Genomic Regions Associated With Fusarium Wilt Resistance In Common Bean, Jean Fausto De Carvalho Paulino, Caléo Panhoca De Almeida, César Júnior Bueno, Qijian Song, Roberto Fritsche-Neto, Sérgio Augusto Morais Carbonell, Alisson Fernando Chiorato, Luciana Lasry Benchimol-Reis

Faculty Publications

Fusarium wilt (Fusarium oxysporum f. sp. phaseoli, Fop) is one of the main fungal soil diseases in common bean. The aim of the present study was to identify genomic regions associated with Fop resistance through genome-wide association studies (GWAS) in a Mesoamerican Diversity Panel (MDP) and to identify potential common bean sources of Fop’s resistance. The MDP was genotyped with BARCBean6K_3BeadChip and evaluated for Fop resistance with two different monosporic strains using the root-dip method. Disease severity rating (DSR) and the area under the disease progress curve (AUDPC), at 21 days after inoculation (DAI), were used for GWAS performed with …

Vr-Caps: A Virtual Environment For Capsule Endoscopy, Kağan İncetan, Ibrahim Omer Celik, Abdulhamid Obeid, Guliz Irem Gokceler, Kutsev Bengisu Ozyoruk, Yasin Almalioglu, Richard J. Chen, Faisal Mahmood, Hunter Gilbert, Nicholas J. Durr, Mehmet Turan

Faculty Publications

Current capsule endoscopes and next-generation robotic capsules for diagnosis and treatment of gastrointestinal diseases are complex cyber-physical platforms that must orchestrate complex software and hardware functions. The desired tasks for these systems include visual localization, depth estimation, 3D mapping, disease detection and segmentation, automated navigation, active control, path realization and optional therapeutic modules such as targeted drug delivery and biopsy sampling. Data-driven algorithms promise to enable many advanced functionalities for capsule endoscopes, but real-world data is challenging to obtain. Physically-realistic simulations providing synthetic data have emerged as a solution to the development of data-driven algorithms. In this work, we present …

Digital Art Application To Music Videos, Janna Kelly

Honors Capstones

No abstract provided.

Rev-Erb In Gabaergic Neurons Controls Diurnal Hepatic Insulin Sensitivity, Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher I. Amos, Yong Xu, Li Chen, Zheng Sun

Division of Basic Science Faculty Publications

Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking1,2. The molecular mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear receptors REV-ERB-α and REV-ERB-β (referred to here as ‘REV-ERB’) in the GABAergic (γ-aminobutyric acid-producing) neurons in the suprachiasmatic nucleus (SCN) (SCNGABA neurons) control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production in mice, without affecting diurnal eating or locomotor behaviours during regular light–dark cycles. REV-ERB regulates the rhythmic expression of genes that are involved in neurotransmission in the SCN, and modulates the oscillatory firing activity of SCNGABA neurons. Chemogenetic stimulation …

Α-Cgrp Disrupts Amylin Fibrillization And Regulates Insulin Secretion: Implications On Diabetes And Migraine, Amber L.H. Gray, Aleksandra Antevska, Benjamin A. Link, Bryan Bogin, Susan J. Burke, Samuel D. Dupuy, J. Jason Collier, Zachary A. Levine, Michael D. Karlstad, Thanh D. Do

Division of Basic Science Faculty Publications

Despite being relatively benign and not an indicative signature of toxicity, fibril formation and fibrillar structures continue to be key factors in assessing the structure-function relationship in protein aggregation diseases. The inability to capture molecular cross-talk among key players at the tissue level before fibril formation greatly accounts for the missing link toward the development of an efficacious therapeutic intervention for Type II diabetes mellitus (T2DM). We show that human α-calcitonin gene-related peptide (α-CGRP) remodeled amylin fibrillization. Furthermore, while CGRP and/or amylin monomers reduce the secretion of both mouse Ins1 and Ins2 proteins, CGRP oligomers have a reverse effect on …

Representations Of Female Agency In Medieval French Literature, Mathilde Pointiere

LSU Doctoral Dissertations

This dissertation examines the different ways authors portray female agency in medieval French literature. In focusing on three medieval writers, Chrétien de Troyes, Heldris de Cornouailles and Christine de Pizan, I contend that female agency arises as a result of trauma or crisis. I define my terms as follows: agency is the capacity and intention of performing actions on one’s own behalf. For a fictional character to have agency, therefore, she must be portrayed as having a sense of control and of being the owner of the action she executes. Additionally, I argue that as women characters assume their agency, …

Mental Imagery In Fear Extinction: A Multi-Component Examination Based On Behavioral, Physiological, And Neurological Measures, Xinrui Jiang

LSU Doctoral Dissertations

Imagery has long been utilized in clinical treatments of affective symptoms with the assumption that mental imagery can stand in for its perceptual counterpart and exert regulatory effects over emotional responses. While this assumption has its ground in theoretical framework of mental imagery supported by evidence of neurological overlaps between imagery and perception, and clinical applications of imagery interventions were found to be successful, very little has been done through means of experimental examinations.

This investigation began with a differential fear conditioning study (study 1) to simulate and assess imagery extinction. Results provided support for the efficacy of imagery exposure …

Green Alga Bicarbonate Transporter And Uses Thereof, James V. Moroney, Marylou C. Machingura, Joanna Bajsa-Hirschel

College of Science Patents

Provided herein are green alga Cia8 polypeptides and the polynucleotides that encode them. Also provided herein are transformed cells and transgenic plants that include one or more of the polynucleotides and/or polypeptides provided herein.

A Genetic Screen Identifies New Steps In Oocyte Maturation That Enhance Proteostasis In The Immortal Germ Lineage, M Samaddar, J Goudeau, M Sanchez, D H. Hall, M Samaddar, M Ingaramo, C Kenyon

Faculty Publications

Somatic cells age and die, but the germ-cell lineage is immortal. In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte maturation signals from sperm trigger the clearance of carbonylated proteins and protein aggregates. Here, we explore the cell biology of this proteostasis renewal in the context of a whole-genome RNAi screen. Oocyte maturation signals are known to trigger protein-aggregate removal via lysosome acidification. Our findings suggest that lysosomes are acidified as a consequence of changes in endoplasmic reticulum activity that permit assembly of the lysosomal V-ATPase, which in turn allows lysosomes to …

Capture And Metabolomic Analysis Of The Human Endometrial Epithelial Organoid Secretome, Constantine A. Simintiras, Pramod Dhakal, Chaman Ranjit, Harriet C. Fitzgerald, Ahmed Z. Balboula, Thomas E. Spencer

Faculty Publications

Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes to offspring susceptibility to chronic adult-onset disorders. However, our understanding of the biochemical composition and mechanisms underpinning UF formation and regulation remain elusive, particularly in humans. To address this challenge, we developed a high-throughput method for intraorganoid fluid (IOF) isolation from human endometrial epithelial organoids. The IOF is biochemically distinct to the extraorganoid fluid (EOF) and cell culture medium as evidenced by the exclusive presence of 17 metabolites in IOF. Similarly, 69 metabolites were unique to EOF, showing asymmetrical apical and basolateral secretion by the in vitro …