Digital Commons Network^™

Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins

Research outputs 2022 to 2026

Aims: This study aimed to determine the association of plasma neurofilament light (NfL), a marker of neurodegeneration, with diabetes status and glycaemic parameters in people with normal glycaemia (NG), pre-diabetes (PD) and type 2 diabetes (T2D). Methods: Clinical and descriptive data for the diagnostic groups, NG (n=30), PD (n=48) and T2D (n=29), aged between 40 and 75 years were included in this cross-sectional analysis. Plasma NfL levels were analyzed using the ultra-sensitive single-molecule array (Simoa) platform. Results: A positive correlation was evident between plasma NfL and fasting glucose (r = 0.2824; p = 0.0032). Plasma NfL levels were not correlated …

Effectiveness Of Nurse-Led Volunteer Support And Technology-Driven Pain Assessment In Improving The Outcomes Of Hospitalised Older Adults: Protocol For A Cluster Randomised Controlled Trial, Rosemary Saunders, Kate Crookes, Karla Seaman, Seng Giap Marcus Ang, Caroline Bulsara, Max K. Bulsara, Beverley Ewens, Olivia Gallagher, Renee M. Graham, Karen Gullick, Sue Haydon, Jeff Hughes, Mustafa Atee, Kim Huong Nguyen, Bev O'Connell, Debra Scaini, Christopher Etherton-Beer

Research outputs 2022 to 2026

Introduction:

Hospitalised older adults are prone to functional deterioration, which is more evident in frail older patients and can be further exacerbated by pain. Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.

Methods and Analysis:

This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. Prior to commencing …

She'll Be ‘Right… But Are They? An Australian Perspective On Women In High Performance Sport Coaching, Alexandra H. Roberts, Anthea Clarke, Caitlin Fox-Harding, Georgia Askew, Clare Macmahon, Sophia Nimphius

Research outputs 2022 to 2026

Participation and media coverage of women in high-performance sport has been steadily increasing in recent years throughout the world. While this increase in interest has led to many young women and girls becoming involved in grassroots sport, there has yet to be a significant change in the number of women in coaching roles, particularly at the high-performance level. This paper synthesizes and summarizes the current challenges facing women sport coaches in Australia, drawing from existing research, media and government reports to understand the barriers for women entering and progressing in these roles. We also present some of the more recent …

Weight Loss For Overweight And Obese Patients With Prostate Cancer: A Study Protocol Of A Randomised Trial Comparing Clinic-Based Versus Telehealth Delivered Exercise And Nutrition Intervention (The Telex Trial), Daniel A. Galvão, Dennis R. Taaffe, Dickon Hayne, Pedro Lopez, Philippa Lyons-Wall, Colin I. Tang, Suzanne K. Chambers, Amanda Devine, Nigel Spry, Emily Jeffery, Christine Kudiarasu, David Joseph, Robert U. Newton

Research outputs 2022 to 2026

Introduction Obese men with prostate cancer have an increased risk of biochemical recurrence, metastatic disease and mortality. For those undergoing androgen deprivation therapy (ADT), substantial increases in fat mass are observed in the first year of treatment. Recently, we showed that a targeted supervised clinic-based exercise and nutrition intervention can result in a substantial reduction in fat mass with muscle mass preserved in ADT-treated patients. However, the intervention needs to be accessible to all patients and not just those who can access a supervised clinic-based programme. The purpose of this study was to evaluate the efficacy of telehealth delivered compared …

The Mosaic Oat Genome Gives Insights Into A Uniquely Healthy Cereal Crop, Nadia Kamal, Nikos Tsardakas Renhuldt, Johan Bentzer, Heidrun Gundlach, Georg Haberer, Angéla Juhász, Thomas Lux, Utpal Bose, Jason A. Tye-Din, Daniel Lang, Nico Van Gessel, Ralf Reski, Yong Bi Fu, Peter Spégel, Alf Ceplitis, Axel Himmelbach, Amanda J. Waters, Wubishet A. Bekele, Michelle L. Colgrave, Mats Hansson, Nils Stein, Klaus F.X. Mayer, Eric N. Jellen, Peter J. Maughan, Nicholas A. Tinker, Martin Mascher, Olof Olsson, Manuel Spannagl, Nick Sirijovski

Research outputs 2022 to 2026

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid …

Effects Of Upper Body Eccentric Versus Concentric Strength Training And Detraining On Maximal Force, Muscle Activation, Hypertrophy And Serum Hormones In Women, Keijo Häkkinen, Robert U. Newton, Simon Walker, Arja Häkkinen, Sonja Krapi, Rebekka Rekola, Päivi Koponen, William J. Kraemer, G. Gregory Haff, Anthony Blazevich, Kazunori Nosaka, Juha Ahtiainen

Research outputs 2022 to 2026

Effects of eccentric (ECC) versus concentric (CON) strength training of the upper body performed twice a week for 10 weeks followed by detraining for five weeks on maximal force, muscle activation, muscle mass and serum hormone concentrations were investigated in young women (n = 11 and n = 12). One-repetition bench press (1RM), maximal isometric force and surface electromyography (EMG) of triceps brachii (TB), anterior deltoid (AD) and pectoralis major (PM), cross-sectional area (CSA) of TB (Long (LoH) and Lateral Head (LaH)) and thickness of PM, as well as serum concentrations of free testosterone, cortisol, follicle-stimulating hormone, estradiol and sex …

Dietary Nitrate Intake Is Associated With Decreased Incidence Of Open-Angle Glaucoma: The Rotterdam Study, Joëlle E. Vergroesen, Tosca O. E. De Crom, Lauren C. Blekkenhorst, Caroline C. W. Klaver, Trudy Voortman, Wishal D. Ramdas

Research outputs 2022 to 2026

Previous studies suggest that nitric oxide is involved in the regulation of the intraocular pressure (IOP) and in the pathophysiology of open-angle glaucoma (OAG). However, prospective studies investigating the association between dietary nitrate intake, a source of nitric oxide, and incident (i)OAG risk are limited. We aimed to determine the association between dietary nitrate intake and iOAG, and to evaluate the association between dietary nitrate intake and IOP. From 1991 onwards, participants were followed each five years for iOAG in the Rotterdam Study. A total of 173 participants developed iOAG during follow-up. Cases and controls were matched on age (mean …

Non-Pharmacological Self-Management Strategies For Chemotherapy-Induced Peripheral Neuropathy In People With Advanced Cancer: A Systematic Review And Meta-Analysis, Megan Crichton, Patsy M. Yates, Oluwaseyifunmi Andi Agbejule, Amy Spooner, Raymond J. Chan, Nicolas H. Hart

Research outputs 2022 to 2026

Non-pharmacological self-management interventions for chemotherapy-induced peripheral neurotherapy (CIPN) are of clinical interest; however, no systematic review has synthesized the evidence for their use in people with advanced cancer. Five databases were searched from inception to February 2022 for randomized controlled trials assessing the effect of non-pharmacological self-management interventions in people with advanced cancer on the incidence and severity of CIPN symptoms and related outcomes compared to any control condition. Data were pooled with metaanalysis. Quality of evidence was appraised using the Revised Cochrane Risk of Bias Tool for Randomized Trials (RoB2), with data synthesized narratively. Grading of Recommendations, Assessment, Development …

Telehealth Cancer-Related Fatigue Clinic Model For Cancer Survivors: A Pilot Randomised Controlled Trial Protocol (The T-Crf Trial), Rahul Ladwa, Elizabeth P. Pinkham, Laisa Teleni, Brigid Hanley, Gemma Lock, Jodie Nixon, Oluwaseyifunmi Andi Agbejule, Fiona Crawford-Williams, Lee Jones, Mark B. Pinkham, Jane Turner, Patsy Yates, Steven M. Mcphail, Joanne F. Aitken, Carmen P. Escalante, Nicolas H. Hart, Raymond J. Chan

Research outputs 2022 to 2026

INTRODUCTION: Cancer-related fatigue (CRF) is one of the most common and debilitating adverse effects of cancer and its treatment reported by cancer survivors. Physical activity, psychological interventions and management of concurrent symptoms have been shown to be effective in alleviating CRF. This pilot randomised controlled trial (RCT) will determine the feasibility of a telehealth CRF clinic intervention (T-CRF) to implement evidence-based strategies and assess the impact of the intervention on CRF and other clinical factors in comparison to usual care. METHODS AND ANALYSIS: A parallel-arm (intervention vs usual care) pilot RCT will be conducted at the Princess Alexandra Hospital in …

Evaluation Of The Major Seed Storage Proteins, The Conglutins, Across Genetically Diverse Narrow-Leafed Lupin Varieties, Arineh Tahmasian, Angéla Juhász, James A. Broadbent, Mitchell G. Nye-Wood, Thao T. Le, Michelle L. Colgrave

Research outputs 2022 to 2026

Lupin seeds have an excellent nutritional profile, including a high proportion of protein and dietary fiber. These qualities make lupin seeds an ideal candidate to help meet the growing global demand for complementary sources of protein. Of consequence to this application, there are nutritional and antinutritional properties assigned to the major lupin seed storage proteins—referred to as α-, β-, δ- and γ-conglutins The variation in the abundance of these protein families can impact the nutritional and bioactive properties of different lupin varieties. Hence, exploring the conglutin protein profiles across a diverse range of lupin varieties will yield knowledge that can …

Estropause, Sex Hormones And Metal Homeostasis In The Mouse Brain, Tianbing Liu, Richard L. Bowen, Andrea C. Wilson, Craig S. Atwood

Research outputs 2022 to 2026

Alterations in brain metal ion homeostasis have been reported with aging and are implicated in the pathogenesis of neurodegenerative diseases. To assess whether age-related changes in hypothalamic-pituitary-gonadal (HPG) hormones might be involved in modulating brain metal ion homeostasis, we treated 7.5-month intact, sham-ovariecomized and ovariectomized C57B6SJL mice with vehicle or leuprolide acetate (for 9-months) to differentiate between whether sex steroids or gonadotropins might modulate brain metal ion concentrations. Unlike other aging mammals, there was no increase in plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations following estropause in mice, suggesting there was sufficient residual production by the follicle depleted …

Plant Protein-Based Nanocomposite Films: A Review On The Used Nanomaterials, Characteristics, And Food Packaging Applications, Shima Jafarzadeh, Mehrdad Forough, Sajed Amjadi, Vahid J. Javan Kouzegaran, Hadi Almasi, Farhad Garavand, Masoumeh Zargar

Research outputs 2022 to 2026

Consumer demands to utilize environmentally friendly packaging have led researchers to develop packaging materials from naturally derived resources. In recent years, plant protein-based films as a replacement for synthetic plastics have attracted the attention of the global food packaging industry due to their biodegradability and unique properties. Biopolymer-based films need a filler to show improved packaging properties. One of the latest strategies introduced to food packaging technology is the production of nanocomposite films which are multiphase materials containing a filler with at least one dimension less than 100 nm. This review provides the recent findings on plant-based protein films as …

Shorter Constant Work Rate Cycling Tests As Proxies For Longer Tests In Highly Trained Cyclists, Chantelle Du Plessis, Mark Andrews, Lachlan J. G. Mitchell, Jodie Cochrane Wilkie, Trish King, Anthony J. Blazevich

Research outputs 2022 to 2026

Severe-intensity constant work rate (CWR) cycling tests simulate the high-intensity competition environment and are useful for monitoring training progression and adaptation, yet impose significant physiological and psychological strain, require substantial recovery, and may disrupt athlete training or competition preparation. A brief, minimally fatiguing test providing comparable information is desirable.

Purpose

To determine whether physiological variables measured during, and functional decline in maximal power output immediately after, a 2-min CWR test can act as a proxy for 4-min test outcomes.

Methods

Physiological stress (VO _2 kinetics, heart rate, blood lactate concentrations ([La-]b)) was monitored and performance fatigability was estimated (as pre-to-post-CWR …

Resistance Training Effectiveness On Body Composition And Body Weight Outcomes In Individuals With Overweight And Obesity Across The Lifespan: A Systematic Review And Meta-Analysis, Pedro Lopez, Dennis R. Taaffe, Daniel A. Galvão, Robert U. Newton, Elisa R. Nonemacher, Victória M. Wendt, Renata N. Bassanesi, Douglas J. P. Turella, Anderson Rech

Research outputs 2022 to 2026

To systematically review and analyze the effects of resistance-based exercise programs on body composition, regional adiposity, and body weight in individuals with overweight/obesity across the lifespan. Using PRISMA guidelines, randomized controlled trials were searched in nine electronic databases up to December 2020. Meta-analyses were performed using random-effects model. One-hundred sixteen articles describing 114 trials (n = 4184 participants) were included. Interventions involving resistance training and caloric restriction were the most effective for reducing body fat percentage (ES = −3.8%, 95% CI: −4.7 to −2.9%, p < 0.001) and whole-body fat mass (ES = −5.3 kg, 95% CI: −7.2 to −3.5 kg, p < 0.001) compared with groups without intervention. Significant results were also observed following combined resistance and aerobic exercise (ES = −2.3% and −1.4 kg, p < 0.001) and resistance training alone (ES = −1.6% and −1.0 kg, p < 0.001) compared with no training controls. Resistance training alone was the most effective for increasing lean mass compared with no training controls (ES = 0.8 kg, 95% CI: 0.6 to 1.0 kg, p < 0.001), whereas lean mass was maintained following interventions involving resistance training and caloric restriction (ES = ~ − 0.3 kg, p = 0.550–0.727). Results were consistently observed across age and sex groups (p = 0.001–0.011). Reductions in regional adiposity and body weight measures were also observed following combined resistance and aerobic exercise and programs including caloric restriction (p < 0.001). In conclusion, this study provides evidence that resistance-based exercise programs are effective and should be considered within any multicomponent therapy program when caloric restriction is utilized in individuals with overweight or obesity.

A Most Unusual Tail: Scoliosis In A Wild Australian Skink, And Reported Incidences And Suggested Causes Of Similar Malformations Amongst Squamates, Philip W. Bateman, Robyn Benken, Ryan Glowacki, Robert A. Davis

Research outputs 2022 to 2026

Malformations of vertebrae potentially occur across many taxa, particularly in Testudines, which are susceptible to kyphosis (dorsoventral curvature of the spine). Such malformations may stem from either genetic or environmental origins, and their prevalence and associated impacts on survival remain poorly understood. However, scoliosis (sideways curvature of the spine) is rarely reported and especially so in wild lizards. We report here on the first known case of scoliosis in a wild Australian lizard, the skink Ctenotus fallens, from Perth, Western Australia. This occurrence is the first of 805 individuals captured in a natural population monitored annually for the past 11 …

Bullied Because Of Their Teeth: Evidence From A Longitudinal Study On The Impact Of Oral Health On Bullying Victimization Among Australian Indigenous Children, Md Irteja Islam, Verity Chadwick, Tuguy Esgin, Alexandra Martiniuk

Research outputs 2022 to 2026

Making life better for Indigenous peoples is a global priority. Although bullying and oral health have always been a topic of concern, there is limited information regarding the impact of this problem on the general population, with no evidence in this regard among the Australian Indigenous population. Thus, we aimed to quantify the relationship between bullying victimization and oral health problems by remoteness among 766 Australian Indigenous children aged between 10–15-years using data from the LSIC study. Bivariate and multilevel mixed-effect logistic regression analyses were employed. Findings indicated children self-reported bullying more than parents reported their children were being bullied …

Characterization Of Retinal Drusen In Subjects At High Genetic Risk Of Developing Sporadic Alzheimer’S Disease: An Exploratory Analysis, Inés López-Cuenca, Elena Salobrar-García, Inés Gil-Salgado, Lidia Sánchez-Puebla, Lorena Elvira-Hurtado, José A. Fernández-Albarral, Federico Ramírez-Toraño, Ana Barabash, Jaisalmer De Frutos-Lucas, Juan J. Salazar, José M. Ramírez, Ana I. Ramírez, Rosa De Hoz

Research outputs 2022 to 2026

Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ε4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH-or FH+) and …

Dietary Iron And The Elite Dancer, Caitlin Attwell, Cory Dugan, Alannah K. A. Mckay, Joanna Nicholas, Luke Hopper, Peter Peeling

Research outputs 2022 to 2026

Dancers are an athlete population at high risk of developing iron deficiency (ID). The aesthetic nature of the discipline means dancers potentially utilise dietary restriction to meet physique goals. In combination with high training demands, this means dancers are susceptible to problems related to low energy availability (LEA), which impacts nutrient intake. In the presence of LEA, ID is common because of a reduced mineral content within the low energy diet. Left untreated, ID becomes an issue that results in fatigue, reduced aerobic work capacity, and ultimately, iron deficient anaemia (IDA). Such progression can be detrimental to a dancer’s capacity …

Social (In) Justice, Climate Change And Climate Policy In Western Australia, Naomi Joy Godden, Doreen Wijekoon, Kylie Wrigley

Research outputs 2022 to 2026

Climate change is a social justice issue, and people who experience disadvantage and marginalisation are most vulnerable to the impacts of climate change. In 2019–2020, the government of the state of Western Australia (WA) held the world’s first inquiry into climate change and health. The Inquiry report, submissions, and hearing transcripts make an important contribution to a small but growing body of evidence that climate change exacerbates and reinforces existing social inequalities in WA in areas such as health, economics, gender relations, and access and inclusion. However, in late-2020, the WA government released its 38-page Climate Policy, with very limited …

Parents' Experiences Of Children With A Rare Disease Attending A Mainstream School: Australia, Mandie Foster, Esther Adama, Diana Arabiat, Kevin Runions, Rena Vithiatharan, Maggie Zgambo, Ashleigh Lin

Research outputs 2022 to 2026

Purpose:

To explore the perceptions of parents who had a child or adolescent (6-18 years) diagnosed with a rare disease who attended a mainstream school in Western Australia.

Design and methods:

A cross-sectional online survey was conducted with 41 parents of children with a rare disease. Here we report the findings of 14 open-ended questions on their experience of illness-related factors and impact on school-related social activities, such as sports, school camps and leadership roles whilst their child with a rare disease attended a mainstream school in Australia. Responses were analysed using an inductive thematic content approach.

Results:

We identified …

Tuning The Physicochemical, Structural, And Antimicrobial Attributes Of Whey-Based Poly (L-Lactic Acid) (Plla) Films By Chitosan Nanoparticles, Farhad Garavand, Milad Rouhi, Shima Jafarzadeh, Diako Khodaei, Ilaria Cacciotti, Masoumeh Zargar, Seyed Hadi Razavi

Research outputs 2022 to 2026

Recently, the research and innovation to produce raw materials from microbial processes has gained much attention due to their economic and environmental impacts. Lactic acid is a very important microbial product due to its wide application in the food, pharmaceutical, cosmetic, and chemical industries. In the current study, poly (L-lactic acid) (PLLA) was produced by the ring opening polymerization (ROP) technique of L-lactic acid recovered from whey fermentation, and was used for the production of nanocomposites films reinforced with chitosan nanoparticles (CNPs) (average diameter ca. 100–200 nm). Three different CNPs concentrations, namely 1, 3, and 5% w/w, were tested, and …

Review Of Diabetes Among Aboriginal And Torres Strait Islander People, Katherine Ride, Samantha Burrow

Journal of the Australian Indigenous HealthInfoNet

Diabetes is the fastest growing chronic disease condition globally. Type 2 diabetes in particular, has reached epidemic proportions, with the greatest burden falling on socially disadvantaged groups and Indigenous peoples.

This review focuses primarily on type 2 diabetes among Aboriginal and Torres Strait Islander people, which is responsible for the majority of cases of diabetes in this population. It provides general information on the social and cultural context of diabetes, and the behavioural and biomedical factors that contribute to diabetes among Aboriginal and Torres Strait Islander people.

This review provides detailed information on:

• the extent of diabetes among Aboriginal and …

Physical Activity Estimated By Osteogenic Potential And Energy Expenditure Has Differing Associations With Bone Mass In Young Adults: The Raine Study, Carrie Anne Ng, David Scott, Marc Sim, Kun Zhu, Aris Siafarikas, Nicolas H. Hart, Jocelyn Tan, Paola Chivers

Research outputs 2022 to 2026

Summary: Ground impacts during physical activity may be important for peak bone mass. We found differences in how energy expenditure and impact scores estimated from a physical activity questionnaire related to bone health in young adults. Using both estimate types can improve our understanding of the skeletal benefits of physical activity. Purpose: It is unclear whether mechanical loading during physical activity, estimated from physical activity questionnaires which assess metabolic equivalents of task (METs), is associated with skeletal health. This longitudinal study investigated how physical activity loading scores, assessed at ages 17 and 20 years, (a) compares with physical activity measured …

Association Between Non-Tea Flavonoid Intake And Risk Of Type 2 Diabetes: The Australian Diabetes, Obesity And Lifestyle Study, Mary D. Adu, Catherine P. Bondonno, Benjamin H. Parmenter, Marc Sim, Raymond J. Davey, Kevin Murray, Simone Radavelli Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2022 to 2026

Studies examining the association between flavonoid intake and measures of insulin resistance and β-cell dysfunction, as markers of type 2 diabetes (T2DM) across the adult lifespan, may provide insights into how flavonoids influence T2DM risk. This study examined the cross-sectional associations between flavonoid intakes, from dietary sources other than tea, and biomarkers of glucose tolerance and insulin sensitivity in adults aged 25 years and older participating in the Australian diabetes, obesity and lifestyle (AusDiab) study. Additionally, longitudinal associations between non-tea flavonoid intakes and incident T2DM over 12 years were explored. Eligible participants (n = 7675) had no previous history of …

Comparison Of Flavonoid Intake Assessment Methods Using Usda And Phenol Explorer Databases: Subcohort Diet, Cancer And Health-Next Generations—Max Study, Fabian Lanuza, Nicola P. Bondonno, Raul Zamora-Ros, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Rikard Landberg, Jytte Halkjær, Cristina Andres-Lacueva

Research outputs 2022 to 2026

Flavonoids are bioactive plant compounds that are widely present in the human diet. Estimating flavonoid intake with a high degree of certainty is challenging due to the inherent limitations of dietary questionnaires and food composition databases. This study aimed to evaluate the degree of reliability among flavonoid intakes estimated using four different approaches based on the two most comprehensive flavonoid databases, namely, United States Department of Agriculture (USDA) and Phenol Explorer (PE). In 678 individuals from the MAX study, a subcohort of the Diet, Cancer and Health-Next Generations cohort, dietary data were collected using three 24-h diet recalls over 1 …

Why Aboriginal And Torres Strait Islander Australians Fall And Fracture: The Codesigned Study Of Indigenous Muscle And Bone Ageing (Simba) Protocol, Ayse Zengin, Cat Shore-Lorenti, Marc Sim, Louise Maple-Brown, Sharon Lee Brennan-Olsen, Joshua R. Lewis, Jennifer Ockwell, Troy Walker, David Scott, Peter Ebeling

Research outputs 2022 to 2026

OBJECTIVES: Aboriginal and Torres Strait Islander Australians have a substantially greater fracture risk, where men are 50% and women are 26% more likely to experience a hip fracture compared with non-Indigenous Australians. Fall-related injuries in this population have also increased by 10%/year compared with 4.3%/year in non-Indigenous Australians. This study aims to determine why falls and fracture risk are higher in Aboriginal and Torres Strait Islander Australians. SETTING: All clinical assessments will be performed at one centre in Melbourne, Australia. At baseline, participants will have clinical assessments, including questionnaires, anthropometry, bone structure, body composition and physical performance tests. These assessments …

Quantifying The Effect Of Monitor Wear Time And Monitor Type On The Estimate Of Sedentary Time In People With Copd: Systematic Review And Meta-Analysis, Fiona Coll, Vinicius Cavalheri, Daniel F. Gucciardi, Sheldon Wulff, Kylie Hill

Research outputs 2022 to 2026

In studies that have reported device-based measures of sedentary time (ST) in people with chronic obstructive pulmonary disease (COPD), we explored if the monitor type and monitor wear time moderated the estimate of this measure. Five electronic databases were searched in January 2021. Studies were included if >70% of participants had stable COPD, and measures of ST (min/day) were collected using wearable technology. Meta-regression was used to examine the influence of moderators on ST, monitor type, and wear time. The studies identified were a total of 1153, and 36 had usable data for meta-analyses. The overall pooled estimate of ST …

Application Of Red Cabbage Anthocyanins As Ph-Sensitive Pigments In Smart Food Packaging And Sensors, Reza Abedi-Firoozjah, Shima Yousefi, Mahshid Heydari, Faezeh Seyedfatehi, Shima Jafarzadeh, Reza Mohammadi, Milad Rouhi, Farhad Garavand

Research outputs 2022 to 2026

Anthocyanins are excellent antioxidant/antimicrobial agents as well as pH-sensitive indicators that provide new prospects to foster innovative smart packaging systems due to their ability to improve food shelf life and detect physicochemical and biological changes in packaged food. Compared with anthocyanins from other natural sources, red cabbage anthocyanins (RCAs) are of great interest in food packaging because they represent an acceptable color spectrum over a broad range of pH values. The current review addressed the recent advances in the application of RCAs in smart bio-based food packaging systems and sensors. This review was prepared based on the scientific reports found …

A Pilot Sequential Multiple Assignment Randomized Trial (Smart) Protocol For Developing An Adaptive Coaching Intervention Around A Mobile Application For Athletes To Improve Carbohydrate Periodization Behavior, Xiaoxi Yan, David M. Dunne, Samuel G. Impey, Brian Cunniffe, Carmen E. Lefevre, Rodrigo Mazorra, James P. Morton, David Tod, Graeme L. Close, Rebecca Murphy, Bibhas Chakraborty

Research outputs 2022 to 2026

Background: It has recently been identified that manipulating carbohydrate availability around exercise activity can enhance training-induced metabolic adaptations. Despite this approach being accepted in the athletic populations, athletes do not systematically follow the guidelines. Digital environments appear to allow nutritionists to deliver this intervention at scale, reducing expensive human coaching time. Yet, digitally delivered dietary behavior change interventions for athletes and the coaching strategy to support them are still novel concepts within sports nutrition. Methods/design: We aim to recruit 900 athletes across the UK. 500 athletes will be recruited to test the feasibility of a novel menu planner mobile application …

Causal Associations Between Covid-19 And Atrial Fibrillation: A Bidirectional Mendelian Randomization Study, Xiaoyu Zhang, Biyan Wang, Tao Geng, Di Liu, Qiuyue Tian, Xiaoni Meng, Qiaoyun Zhang, Mengyang Jiang, Yiqiang Zhang, Manshu Song, Wei Wang, Youxin Wang, Baoguo Wang

Research outputs 2022 to 2026

Background and aims: Observational studies showed that coronavirus disease (2019) (COVID-19) attacks universally and its most menacing progression uniquely endangers the elderly with cardiovascular disease (CVD). The causal association between COVID-19 infection or its severity and susceptibility of atrial fibrillation (AF) remains unknown. Methods and results: The bidirectional causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with not hospitalized COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and AF are determined by using two-sample Mendelian randomization (MR) analysis. Genetically predicted severe COVID-19 was not significantly associated with the risk of AF [odds ratio (OR), 1.037; 95% …