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Scs 6th Annual Meeting—Eevfa—11th International Congress Of Biochemistry And Physiology Of Exercise, Athens, Greece, 2023, Pedro E. Alcaraz, Elena Marín-Cascales, Anthony J. Blazevich, Tomás T. Freitas, Olyvia Donti, Konstantinos Spyrou, Gregory C. Bogdanis

Research outputs 2022 to 2026

On behalf of the Strength and Conditioning Society (SCS) and the Hellenic Society of Biochemistry and Exercise Physiology (EEVFA), we are pleased to present the abstracts of the SCS 6th Annual Meeting and EEVFA—11th International Congress of Biochemistry and Physiology of Exercise. The event was held at the Hellenic Olympic Committee headquarters in Athens, Greece, on 19–22 October 2023, and comprised several invited sessions from international and national speakers on a variety of topics related to biochemistry and exercise physiology, strength and conditioning practices and their application to health, injury prevention and sports performance. These included strength training in high-performance …

Validity Of Apple Watch, Garmin Forerunner® 935 And Geneactiv For Estimating Energy Expenditure During Close Quarter Battle Training In Special Forces Soldiers, Angela Uphill, Kristina L. Kendall, Alison Fogarty, Stuart Guppy, Hannah Brown, Travis Zomer, Simon Parker, G. Gregory Haff

Research outputs 2022 to 2026

The purpose of this study was to investigate the validity of three wrist-worn devices for estimating energy expenditure (EE) and heart rate (HR) during close “Close Quarter Battle” (CQB). Fifty male soldiers (mean ± SD: age 30.9 ± 4.6 years, height: 1.81 ± 0.64 m and body mass 87.3 ± 7.7 kg) wore three activity monitors (Apple Watch 5, Garmin Forerunner® 935 and GENEActiv accelerometer), a Metamax 3B metabolic cart and a Polar chest strap, whilst conducting a CQB training activity (duration: 26.6 ± 5.0 min). EE and HR data from each test device were compared against criterion measures using …

Young People's Alcohol Use In And Around Water: A Scoping Review Of The Literature, Renee N. Carey, Gemma Crawford, Jonine Jancey, Tina Lam, Lauren Nimmo, Gina Trapp, Christina Pollard, Paula Hooper, Justine E. Leavy

Research outputs 2022 to 2026

Issues: The surrounding social and commercial context, including alcohol advertising, heavily influences alcohol consumption. Alcohol use is a major risk factor for both fatal and non-fatal drowning, particularly for young people. Approach: We conducted a scoping review to explore the peer-reviewed literature on the use of alcohol by young people (aged 15–34 years) in the context of aquatic environments. Five electronic academic databases were searched for English-language studies conducted in high-income countries and published in the last 15 years (since 2008). The MetaQAT framework was used to assess methodological quality of included studies. Key Findings: The review included a total …

Vitamin K1 Intake Is Associated With Lower Risk For All-Cause And Cardiovascular Disease Mortality In Community-Dwelling Older Australian Women, Montana Dupuy, Simone Radavelli-Bagatini, Liezhou Zhong, Jack Dalla Via, Kun Zhu, Lauren C. Blekkenhorst, Nicola P. Bondonno, Allan Linneberg, Jaime W. Bellinge, Carl Schultz, William Courtney, Richard L. Prince, Jonathan M. Hodgson, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Background and aims: Assessing the relationship between vitamin K1 intakes, using region-specific food databases, with both all-cause, and cardiovascular disease (CVD) mortality warrants further investigation to inform future preventative strategies. Consequently, we examined the aforementioned associations in the Perth Longitudinal Study of Ageing Women (PLSAW). Methods and results: 1436 community-dwelling older Australian women (mean ± SD age 75.2 ± 2.7 years) completed a validated food frequency questionnaire at baseline (1998). Vitamin K1 intake was calculated based on an Australian vitamin K food database, supplemented with published data. All-cause and CVD mortality data was obtained from linked health records. Associations were …

Association Between Gamma Glutamyl Transpeptidase To Hdl-Cholesterol (Ggt/Hdl-C) Ratio And Metabolic Syndrome Resolution After Sleeve Gastrectomy, Melanni L. Lizarbe-Lezama, Jhoel E. Rodriguez-Macedo, Daniel Fernandez-Guzman, Ana L. Alcantara-Diaz, Gustavo Salinas-Sedo, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

OBJECTIVE: To evaluate the association between GGT/HDL-C ratio and resolution of MetS in adults after sleeve gastrectomy (SG). METHODS: We conducted a retrospective cohort study using secondary data from a Peruvian bariatric center. The study population consisted of adults aged 18 and above who underwent laparoscopic SG and were diagnosed with MetS prior to the surgery. The main outcome measured was MetS resolution 6 months post-surgery and the exposure variable was the GGT/HDL-C ratio. RESULTS: We analyzed 137 patients with a mean age of 38.9 ± 10.9 years; 64.2% were females. The median GGT/HDL-C ratio was 1.1 [0.7 - 1.5], …

The Role Of Pennation Angle And Architectural Gearing To Rate Of Force Development In Dynamic And Isometric Muscle Contractions, Bas Van Hooren, Per Aagaard, Andrea Monte, Anthony J. Blazevich

Research outputs 2022 to 2026

Background: Associations between muscle architecture and rate of force development (RFD) have been largely studied during fixed-end (isometric) contractions. Fixed-end contractions may, however, limit muscle shape changes and thus alter the relationship between muscle architecture an RFD. Aim: We compared the correlation between muscle architecture and architectural gearing and knee extensor RFD when assessed during dynamic versus fixed-end contractions. Methods: Twenty-two recreationally active male runners performed dynamic knee extensions at constant acceleration (2000°s−2) and isometric contractions at a fixed knee joint angle (fixed-end contractions). Torque, RFD, vastus lateralis muscle thickness, and fascicle dynamics were compared during 0–75 and 75–150 ms …

S-Methyl Cysteine Sulfoxide Does Not Ameliorate Weight Gain Or Hyperlipidemia In Mice Fed A High-Fat Diet, Caroline R. Hill, Armaghan Shafaei, Vance B. Matthews, Natalie C. Ward, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Lois Balmer, Lauren C. Blekkenhorst

Research outputs 2022 to 2026

Scope: Higher intake of cruciferous and allium vegetables is associated with lower cardiometabolic risk. Little research has investigated the cardiometabolic effects of S-methyl cysteine sulfoxide (SMCSO), found abundant in these vegetables. This study hypothesizes that SMCSO will blunt development of metabolic syndrome features in mice fed high-fat feed. Methods and results: Fifty C57BL/6 male mice are randomly assigned to standard-chow, high-fat, or high-fat supplemented with low-SMCSO (43 mg kg−1 body weight [BW] day−1), medium-SMCSO (153 mg kg−1 BW day−1), or high-SMCSO (256 mg kg−1 BW day−1) for 12-weeks. High-fat with SMCSO did not prevent diet-induced obesity, glucose intolerance, or hypercholesterolemia. …

Moderators Of Resistance Training Effects In Healthy Young Women: A Systematic Review And Meta-Analysis, Talita Molinari, Régis Radaelli, Anderson Rech, Clarissa M. Brusco, Anna M. Markarian, Pedro Lopez

Research outputs 2022 to 2026

Molinari, T, Radaelli, R, Rech, A, Brusco, CM, Markarian, AM, and Lopez, P. Moderators of resistance training effects in healthy young women: A systematic review and meta-analysis. J Strength Cond Res 38(4): 804-814, 2024 - To systematically review and analyze the effects of resistance-based exercise programs and potential moderators of change in body fat percentage, whole-body fat and lean mass, muscle hypertrophy, muscle strength, and muscle power/rapid force in healthy young women (between 18 and 35 years). A systematic search was undertaken in 7 databases from inception to May 2022. Eligible randomized controlled trials examined the effects of resistance-based exercise …

What Impact Have The Ioc Medical Consensus Statements Made On Athlete Health? A Survey Of Medical Commissions From National Olympic/ Paralympic Committees And International Sports Federations, Lauren V. Fortington, Marelise Badenhorst, Wayne Derman, Carolyn Emery, Kati Pasanen, Martin Schwellnus, Evert Verhagen, Caroline F. Finch

Research outputs 2022 to 2026

Background The International Olympic Committee (IOC) Medical and Scientific Commission has supported collating and sharing evidence globally by developing sports medicine consensus statements (‘Statements’'). Publishing the Statements requires substantial resources that must be balanced by use and impact on policy and practice. This study aimed to gain a better understanding of awareness and uptake of the Statements globally through a survey of the National Olympic Committees (NOC), National Paralympic Committees (NPC) and International Federations (IF). Method A cross-sectional survey of medical commission representatives from NOCs/NPCs/IFs. A structured questionnaire was distributed through the IOC head office, informed by prior research. Questions …

Decline In Muscle Strength And Physical Function After Fracture In Men - The Prospective Strambo Study, Paweł Szulc, Joshua R. Lewis, Roland Chapurlat

Research outputs 2022 to 2026

Studies on muscle strength and physical function after fracture are focused on short follow-ups and adjacent anatomical region. We compared loss of muscle strength and physical function in men after fracture with normal ageing-related decline. In 823 men aged 60-87, measurements of grip strength and clinical tests (chair stands, balance) were performed every 4 years for 12 years. In 155 men with incident fracture, we compared the status after vs. before the fracture. In men without fracture (controls), we compared the status on the first follow-up (4 years) vs. baseline. In men with fracture, grip strength decreased more than in …

Frailty Increases The Long-Term Risk For Fall And Fracture-Related Hospitalizations And All-Cause Mortality In Community-Dwelling Older Women, Elsa Dent, Jack Dalla Via, Trent Bozanich, Emiel O. Hoogendijk, Abadi K. Gebre, Cassandra Smith, Kun Zhu, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Frailty is associated with declines in physiological capacity across sensory, neurological, and musculoskeletal systems. An underlying assumption is that the frailer an individual, the more likely they are to experience falls and fractures. We examined whether grades of frailty can assess the long-term risk of hospitalized falls, fractures, and all-cause mortality in 1261 community-dwelling older women (mean age [SD] of 75.1 [2.7] yr) over 14.5 yr. Frailty was operationalized using a frailty index (FI) of cumulative deficits from 33 variables across multiple health domains (physical, mental, comorbidities) at baseline. The total score across these variables was summed and divided by …

Maternal Prebiotic Supplementation During Pregnancy And Lactation Modifies The Microbiome And Short Chain Fatty Acid Profile Of Both Mother And Infant, Jacquelyn M. Jones, Stacey N. Reinke, Mahsa Mousavi-Derazmahalleh, Johan Garssen, Maria C. Jenmalm, Ravisha Srinivasjois, Desiree Silva, Jeffrey Keelan, Susan L. Prescott, Debra J. Palmer, Claus T. Christophersen

Research outputs 2022 to 2026

Background & aims: Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from < 21 weeks' gestation to six months’ post-partum, in a double-blinded, randomised placebo-controlled trial. Methods: Stool samples were collected at multiple timepoints from 74 mother–infant pairs as part of a larger, double-blinded, randomised controlled allergy intervention trial. The participants were randomised to one of two groups; with one group receiving 14.2 g per day of prebiotic powder (galacto-oligosaccharides GOS and fructo-oligosaccharides FOS in ratio 9:1), and the other receiving a placebo powder consisting of 8.7 g per day of maltodextrin. The faecal microbiota of both mother and infants were assessed based on the analysis of bacterial 16S rRNA gene (V4 region) sequences, and short chain fatty acid (SCFA) concentrations in stool. Results: Significant differences in the maternal microbiota profiles between baseline and either 28-weeks’ or 36-weeks’ gestation were found in the prebiotic supplemented women. Infant microbial beta-diversity also significantly differed between prebiotic and placebo groups at 12-months of age. Supplementation was associated with increased abundance of commensal Bifidobacteria in the maternal microbiota, and a reduction in the abundance of Negativicutes in both maternal and infant microbiota. There were also changes in SCFA concentrations with maternal prebiotics supplementation, including significant differences in acetic acid concentration between intervention and control groups from 20 to 28-weeks’ gestation. Conclusion: Maternal prebiotic supplementation of 14.2 g per day GOS/FOS was found to favourably modify both the maternal and the developing infant gut microbiome. These results build on our understanding of the importance of maternal diet during pregnancy, and indicate that it is possible to intervene and modify the development of the infant microbiome by dietary modulation of the maternal gut microbiome.

Advancing The Decadal Plan For The Science Of Nutrition: Progressing A Framework For Implementation, Helen Truby, Margaret Allman-Farinelli, Eleanor J. Beck, Emma L. Beckett, Catherine Bondonno, Aimee L. Dordevic, Katherine M. Livingstone, Jane Willcox, Shelley A. Wilkinson

Research outputs 2022 to 2026

Aims: In 2019, the Australian Academy of Science in collaboration with the nutrition community published the decadal plan for the science of nutrition. This article aims to review progress towards each of its pillar goals (societal determinants, nutrition mechanisms, precision and personalised nutrition, and education and training) and two enabling platforms (a national data capability and a trusted voice for nutrition science), prioritise actions, and conceptualise program logic implementation models. This process also brought together public health nutrition researchers to reflect on societal determinants of health, and advise how the next 5 years of the decadal plan could reflect contemporary …

Unlocking The Therapeutic Potential Of Ellagic Acid For Non-Alcoholic Fatty Liver Disease And Non-Alcoholic Steatohepatitis, Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer

Research outputs 2022 to 2026

Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatitis (NASH), which can progress to severe fibrosis, through to hepatocellular carcinoma. There currently exists no treatment for the long-term management of NAFLD/NASH, however, dietary interventions have been investigated for the treatment of NASH, including several polyphenolic compounds. Ellagic acid is one such polyphenolic compound. Nutraceutical food abundant in ellagic acid undergoes initial hydrolysis to free ellagic acid within the stomach and small intestine. …

The Australian Multidomain Approach To Reduce Dementia Risk By Protecting Brain Health With Lifestyle Intervention Study (Au-Arrow): A Study Protocol For A Single-Blind, Multi-Site, Randomized Controlled Trial, Samantha L. Gardener, Stephanie J. Fuller, Sharon L. Naismith, Laura Baker, Miia Kivipelto, Victor L. Villemagne, Stuart M. Grieve, Paul Yates, Stephanie R. Rainey-Smith, Juliana Chen, Belinda Thompson, Nicola J. Armstrong, Malika G. Fernando, Carolina B. Castro, Silochna Meghwar, Rema Raman, Andrew Gleason, Catriona Ireland, Roger Clarnette, Kaarin J. Anstey, Kevin Taddei, Manohar Garg, Hamid R. Sohrabi, Ralph N. Martins

Research outputs 2022 to 2026

Introduction: The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World-Wide FINGERS (WW-FINGERS). As part of WW-FINGERS, the Australian AU-ARROW study mirrors aspects of FINGER, as well as US-POINTER.

Method: AU-ARROW is a randomized, single-blind, multisite, 2-year clinical trial (n = 600; aged 55–79). The multimodal lifestyle intervention group will engage in aerobic exercise, resistance training and stretching, dietary advice to encourage MIND diet adherence, BrainHQ cognitive training, and medical monitoring and health education. The Health Education and Coaching group will receive occasional health education sessions. The primary outcome measure is the change in a …

Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce

Research outputs 2022 to 2026

Sulfur containing compounds including glucosinolates (GLS), sulforaphane (SFN) and S-methyl-L-cysteine sulfoxide (SMCSO) have been proposed to be partly responsible for the beneficial health effects of cruciferous vegetables. As such, greater understanding of their measurements within foods is important to estimate intake in humans and to inform dietary intervention studies. Herein is described a simple and sensitive method for simultaneous analysis of 20 GLS, SFN and SMCSO by liquid chromatography mass spectrometry. Analytes were effectively retained and resolved on an Xbridge C18 column. Detection can be achieved using high resolution or unit resolution mass spectrometry; the latter making the method more …

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Affects Nitrate Metabolism, But Not Vascular Function Or Blood Pressure In Older Adults With Hypertension, Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M. Peake, Richard J. Woodman, Kevin D. Croft, Catherine P. Bondonno, Jonathan M. Hodgson, Michael Wolzt, Oliver Neubauer

Research outputs 2022 to 2026

The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via nitric oxide (NO) translate into improved vascular function and blood pressure-lowering in 15 men and women (age range: 56-71 years) with treated hypertension. We investigated the effects of a single ∼400 mg-dose at 3 hours post-ingestion (3H POST) and the daily consumption of 2 × ∼400 mg of nitrate through nitrate-rich compared with nitrate-depleted (placebo) beetroot juice over 4 weeks (4WK POST). Measurements …

Prostate Cancer Survivorship Essentials For Men With Prostate Cancer On Androgen Deprivation Therapy: Protocol For A Randomised Controlled Trial Of A Tele-Based Nurse-Led Survivorship Care Intervention (Pcessentials Hormone Therapy Study), Anna Green, Robert U. Newton, David P. Smith, Haitham Tuffaha, Daniel A. Galvão, Peter Heathcote, Manish I. Patel, David Christie, Sam Egger, Sally A. M. Sara, Nicole Heneka, Suzanne K. Chambers, Jeff Dunn

Research outputs 2022 to 2026

Introduction: Androgen deprivation therapy (ADT) is commonly used to treat men with locally advanced or metastatic prostate cancer. Men receiving ADT experience numerous side effects and frequently report unmet supportive care needs. An essential part of quality cancer care is survivorship care. To date, an optimal effective approach to survivorship care for men with prostate cancer on ADT has not been described. This protocol describes a randomised trial of tele-based nurse-led survivorship that addresses this knowledge gap: (1) determine the effectiveness of a nurse-led survivorship care intervention (PCEssentials), relative to usual care, for improving health-related quality of life (HR-QoL) in …

Use Of A Primary Care Dataset To Describe ‘The Real Picture’ Of Diabetes In Kimberley Aboriginal Communities, Caitlyn S. White, Kimberley Seear, Lorraine Anderson, Emma Griffiths

Journal of the Australian Indigenous HealthInfoNet

Objective
Aboriginal communities are impacted by high rates of diabetes, however these are currently underestimated by national data sources used by policy and decision makers to inform allocation of health resources. We aimed to estimate diabetes prevalence and screening coverage using primary care electronic medical record data.

Methods
A cross-sectional audit was conducted using primary care data from Aboriginal regular Aboriginal Community Controlled Health Service (ACCHS) clinic attendees aged 15 years and over (n=1763) in five remote communities in the Kimberley region. Main outcome measures were overall diabetes prevalence; age-specific diabetes prevalence; prevalence of pre-diabetes; and screening rates among patients …

Food Taste Experiences And Gastrophysics: Gender Matters?, Sangkyun Kim, Min Xu, Eerang Park

Research outputs 2022 to 2026

This chapter aims to compare factors determining food taste experiences of male and female food tourists in the context of food tourism destinations. Adopting a gastrophysics approach, this exploratory qualitative study researched domestic Chinese food tourists visiting the Hangzhou Cuisine Museum and its associated dining experience restaurants in China. The results demonstrated that gender differences in food taste experiences of food tourists manifested during three phases: food selection; expectation and imagined food taste; and food taste appraisal. At the phase of food selection, male food tourists were more obsessed with their personal food and taste preferences, whereas female tourists prioritised …

Lc-Ms/Ms Reveals Hordeins Are Enriched In Brewers’ Spent Grain, Mitchell G. Nye-Wood, Michelle L. Colgrave

Research outputs 2022 to 2026

Barley is commonly used in malting and brewing, and spent grain is repurposed for other foods. Barley contains gluten proteins called hordeins that cause intestinal damage and disease symptoms if eaten by people with celiac disease and related conditions. While the mashing process in brewing can partially hydrolyze immunogenic epitopes in hordeins, the immunogenic epitope load between the starting malt and spent grain has not been investigated. Herein, we quantified hordeins in commercially available spent grain and from matching malt. Liquid chromatography-mass spectrometry (LC-MS) and sandwich and competitive R5 ELISAs were used for quantification, revealing a higher abundance of gluten …

Characteristic Morphology And Biomass Production Of Napier Grass (Pennisetum Purpureum) Cultivar Gama Umami Under Teak Tree (Tectona Grandis) Shade In Blora, Central Java, Muhammad Zayyan Muafi, Nafiatul Umami, Bambang Suhartanto, Bambang Suwignyo, Miftahush Shirotul Haq, Nilo Suseno, Widiyatno Widiyatno, Leisa Armstrong, David Cook, Yogi Sidik Prasojo

Research outputs 2022 to 2026

This study aims to determine the characteristic morphology and biomass production of Napier grass (Pennisetum purpureum) cultivar Gama Umami under teak tree (Tectona grandis) shade in teak tree forest area of Blora, Central Java. The grass was planted using stem cuttings and maintained for four months using the randomized block design (RBD) method with six repetitions in each treatment. This study consisted of two treatments, namely shade under teak tree stands and non-shade or open area as a control. Maintenance was carried out for 14 weeks with the addition of fertilizers, such as NPK (nitrogen, phosphor, and potassium) and urea. …

Evaluation Of The Heal™Ing Mental Health Program: A Prospective Cohort Study Of Short-Term Changes From A Physical Activity And Lifestyle Education Program For People With Mental Health Disorders Living In Rural Australia, Annette J. Raynor, Sophia Nimphius, Daniel Kadlec, Sally Casson, Caitlin Fox-Harding, Lauren V. Fortington

Research outputs 2022 to 2026

This study aimed to evaluate short-term outcomes of the HEAL™ing Mental Health program, an 8-week intervention for change in functional, behavioural and physiological health and wellbeing designed for people living with mental health conditions in rural or regional areas of Australia. A prospective cohort study was completed, reporting on 19 items (pre-program) and 15 (post-participation change), organised across seven domains. Participants took part in an Accredited Exercise Physiologist/Nurse led supervised group exercise (60 minutes) and healthy lifestyle education program (60 minutes). Separate linear mixed models with restricted maximum likelihood were used to examine the primary research question considering the effect …

Communities Of Practice To Facilitate Change In Health Professions Education: A Realist Synthesis, Gemma Jenkins, Claire Palermo, Alexander M. Clark, Leesa Costello

Research outputs 2022 to 2026

Background: Communities of practice could contribute to transformations in health professions education to meet complex and emerging challenges. However, little is known about the underlying mechanisms of communities of practice in this setting, and how context influences outcomes. Objective: To understand when, why and how communities of practice with health professions education faculty work to facilitate higher education change. Design: A realist synthesis according to the RAMESES standards and steps described by Pawson and colleagues. Review methods: Early scoping of the literature informed the development of an initial program theory to describe underlying assumptions about how communities of practice in …

The Psychosocial Beliefs, Experiences And Expectations Of Children Living With Obesity, Lisa Newson, Nicola Sides, Amineh Rashidi

Research outputs 2022 to 2026

Background: Childhood obesity has been shown to impair psychological health. However, psychological factors are often overlooked in both research evaluations and treatment interventions, and children's perspectives on managing obesity are underexplored. Neglecting psychosocial factors might undermine interventions. This research explored the psychological beliefs, expectations and experiences of children living with obesity (range 7–13) and attending a weight management programme (WMP). Methods: Thirty-four participants (19 females, 15 males, average age 9.5 years) completed a semistructured interview. Recorded interviews were transcribed verbatim and analysed using thematic analysis. Results: Four overarching themes were developed: (1) defining health and self-recognition; (2) external influence; feedback, …

Dropout From Exercise Trials Among Cancer Survivors—An Individual Patient Data Meta-Analysis From The Polaris Study, Benedikte Western, Andreas Ivarsson, Ingvild Vistad, Ingrid Demmelmaier, Neil K. Aaronson, Gillian Radcliffe, Marc Van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Rachel Garrod, Martine M. Goedendorp, Kathleen A. Griffith, Wim H. Van Harten, Sandi C. Hayes, Fernando Herrero-Roman, Anouk E. Hiensch, Melinda L. Irwin, Erica James, Marlou-Floor Kenkhuis, Marie J. Kersten, Hans Knoop, Alejandro Lucia, Anne M. May, Alex Mcconnachie, Willem Van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Ron Plotnikoff, Martina E. Schmidt, Katie H. Schmitz, Karl-Heinz Schulz, Camille E. Short, Gabe S. Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Sveinung Berntsen, Laurien M. Buffart

Research outputs 2022 to 2026

Introduction: The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors. Methods: This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients …

The Role Of Diet And Gut Microbiota In Alzheimer’S Disease, D. M.Sithara Dissanayaka, Vijay Jayasena, Stephanie R. Rainey-Smith, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (A ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of A , the development of tau proteins, and the occurrence of neuroinflammation and oxidative stress are associated with AD. However, investigations into the gut–brain axis …

A Healthful Plant-Based Diet Is Associated With Lower Type 2 Diabetes Risk Via Improved Metabolic State And Organ Function: A Prospective Cohort Study, Alysha S. Thompson, Catharina J. Candussi, Anna Tresserra-Rimbau, Amy Jennings, Nicola P. Bondonno, Claire Hill, Solomon A. Sowah, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Background: Plant-based diets are becoming increasingly popular due to favourable environmental footprints and have been associated with lower risk of type 2 diabetes mellitus (T2DM). Here, we investigated the potential mechanisms to explain the lower T2DM risk observed among individuals following plant-based diets. Methods: Prospective data from the UK Biobank, a cohort study of participants aged 40 to 69 years at baseline, was evaluated. Associations between healthful and unhealthful plant-based indices (hPDI and uPDI) and T2DM risk were analysed by multivariable Cox regression models, followed by causal mediation analyses to investigate which cardiometabolic risk factors explained the observed associations. Results: …

Determining The Feasibility Of A Codesigned And Personalised Intervention (Veg4me) To Improve Vegetable Intake In Young Adults Living In Rural Australian Communities: Protocol For A Randomised Controlled Trial, Katherine M. Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Yuxin Zhang, Eric O, Stephanie L. Godrich, Sarah A. Mcnaughton, Gilly A. Hendrie, Kate Dullaghan, Gavin Abbott, Lauren C. Blekkenhorst, Ralph Maddison, Scott Barnett, John C. Mathers, Laura Alston

Research outputs 2022 to 2026

Introduction:

Diets low in vegetables are a main contributor to the health burden experienced by young adults in rural communities. Digital health interventions provide an accessible delivery model that can be personalised to meet the diverse preferences of young adults. A personalisable digital vegetable intake intervention (Veg4Me) was codesigned to meet the needs of young adults living in rural communities. This study will determine the feasibility of delivering a personalised Veg4Me programme and compare preliminary effects with a non-personalised Veg4Me (control).

Methods and Analysis:

A 12-week assessor-blinded, two-arm, parallel randomised controlled trial will be undertaken from August 2023 until April …

The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson

Theses: Doctorates and Masters

Background: Delirium is a prevalent acute brain dysfunction in patients within intensive care units. Delirium is marked by a fluctuating mental state, inattention, and altered consciousness. This condition affects a substantial proportion of patients in intensive care units, and which leads to increased mortality, severe physiological and psychological consequences, and a significant economic burden on healthcare systems. Despite the evidence that supports the use of non-pharmacological interventions to prevent or minimise the impact of delirium such as orientation, sensory stimulation, early mobilisation, and family involvement, their implementation in intensive care units remains inconsistent. The involvement of family members in the …