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Does Gamification Increase Engagement With Online Programs? A Systematic Review, Jemma Looyestyn, Jocelyn Kernot, Kobie Boshoff, Jillian Ryan, Sarah Edney, Carol Maher Jan 2017

Does Gamification Increase Engagement With Online Programs? A Systematic Review, Jemma Looyestyn, Jocelyn Kernot, Kobie Boshoff, Jillian Ryan, Sarah Edney, Carol Maher

Research outputs 2014 to 2021

Background Engagement in online programs is difficult to maintain. Gamification is the recent trend that offers to increase engagement through the inclusion of game-like features like points and badges, in non-game contexts. This review will answer the following question, ‘Are gamification strategies effective in increasing engagement in online programs?’ Method Eight databases (Web of Science, PsycINFO, Medline, INSPEC, ERIC, Cochrane Library, Business Source Complete and ACM Digital Library) were searched from 2010 to the 28th of October 2015 using a comprehensive search strategy. Eligibility criteria was based on the PICOS format, where “population” included adults, “intervention” involved an online program …


Users' Experiences Of Wearable Activity Trackers: A Cross-Sectional Study, Carol Maher, Jillian Ryan, Christina Ambrosi, Sarah Edney Jan 2017

Users' Experiences Of Wearable Activity Trackers: A Cross-Sectional Study, Carol Maher, Jillian Ryan, Christina Ambrosi, Sarah Edney

Research outputs 2014 to 2021

Background

Wearable activity trackers offer considerable promise for helping users to adopt healthier lifestyles. This study aimed to explore users’ experience of activity trackers, including usage patterns, sharing of data to social media, perceived behaviour change (physical activity, diet and sleep), and technical issues/barriers to use.

Methods

A cross-sectional online survey was developed and administered to Australian adults who were current or former activity tracker users. Results were analysed descriptively, with differences between current and former users and wearable brands explored using independent samples t-tests, Mann-Whitney, and chi square tests.

Results

Participants included 200 current and 37 former activity tracker …


Physical Activity And Survival Among Long-Term Cancer Survivor And Non-Cancer Cohorts, Anthony Gunnell, Sarah Joyce, Stephania Tomlin, Dennis Taaffe, Prue Cormie, Robert Newton, David Joseph, Nigel Spry, Kristjana Einarsdottir, Daniel A. Galvao Jan 2017

Physical Activity And Survival Among Long-Term Cancer Survivor And Non-Cancer Cohorts, Anthony Gunnell, Sarah Joyce, Stephania Tomlin, Dennis Taaffe, Prue Cormie, Robert Newton, David Joseph, Nigel Spry, Kristjana Einarsdottir, Daniel A. Galvao

Research outputs 2014 to 2021

Evidence suggests physical activity improves prognosis following cancer diagnosis; however, evidence regarding prognosis in long-term survivors of cancer is scarce. We assessed physical activity in 1,589 cancer survivors at an average 8.8 years following their initial diagnosis and calculated their future mortality risk following physical activity assessment. We also selected a cancer-free cohort of 3,145 age, sex, and survey year group-matched cancer-free individuals from the same source population for comparison purposes. Risks for cancer-specific mortality and all-cause mortality in relation to physical activity levels were estimated using Cox regression proportional hazard regression analyses within the cancer and non-cancer cohorts. Physical …


Caffeine Consumption With Relevance To Type 3 Diabetes And Accelerated Brain Aging, I. J. Martins Jan 2017

Caffeine Consumption With Relevance To Type 3 Diabetes And Accelerated Brain Aging, I. J. Martins

Research outputs 2014 to 2021

Major interests in caffeine consumption has increased with the alarming increase in the global NAFLD epidemic relevant to increased transport of caffeine to the brain with the induction of Type 3 diabetes. Specific nutritional diets are essential to maintain hepatic caffeine metabolism to facilitate rapid Aβ clearance in the periphery and to maintain the effects of drugs such as statins to reduce toxic Aβ formation not only in Type 3 diabetes but to various neurological diseases. Anti-aging gene Sirt 1 is responsible for brain Aβ and caffeine metabolism and inactivation of Sirt 1 by unhealthy diets is now relevant to …


Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert Newton, Michael Baker, Nigel Spry, Dennis Taaffe, Jeffery Thavaseelan, Daniel A. Galvao Jan 2017

Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert Newton, Michael Baker, Nigel Spry, Dennis Taaffe, Jeffery Thavaseelan, Daniel A. Galvao

Research outputs 2014 to 2021

Background:

Prostatectomy is associated with short- and long-term morbidity, which includes attenuation of muscle function and deterioration of lean body mass. Physical function is a known predictor of morbidity and mortality, with initial evidence indicating that presurgical exercise is associated with fewer postsurgical complications and shorter hospitalization. The aim was to determine the feasibility of a supervised presurgical exercise program for prostate cancer (PCa) patients scheduled for prostatectomy.

Methods:

Ten men (68+6.4 years old) with localized PCa undertook a 6-week resistance and aerobic exercise program prior surgery. Training was undertaken twice weekly and patients were assessed at baseline, presurgery, and …


“I Learned Quite A Lot Of The Maths Stuff Now That I Think Of It”: Māori Medium Students Reflecting On Their Initial Teacher Education, Ngārewa Hāwera, Merilyn Taylor Jan 2017

“I Learned Quite A Lot Of The Maths Stuff Now That I Think Of It”: Māori Medium Students Reflecting On Their Initial Teacher Education, Ngārewa Hāwera, Merilyn Taylor

Australian Journal of Teacher Education

Research involving preservice or initial teacher education (ITE) indicates that mathematics education is a vital component of study. Little is known however, of indigenous student views of their compulsory mathematics education courses for a teaching degree. This research contributes to that knowledge space as it explores Māori medium ITE students’ perceptions of mathematics education in Aotearoa New Zealand. A thematic and qualitative analysis of a focused group discussion provides insights into key factors that students reported as significant links between their university and practicum experiences (teaching practice in schools). Some suggestions for strengthening that programme were also expressed. Findings indicate …


Student-Athletes In My Classroom: Australian Teachers’ Perspectives Of The Problems Faced By Student-Athletes Balancing School And Sport, Maureen M. O'Neill, Angela A. Calder, Beverley Hinz Jan 2017

Student-Athletes In My Classroom: Australian Teachers’ Perspectives Of The Problems Faced By Student-Athletes Balancing School And Sport, Maureen M. O'Neill, Angela A. Calder, Beverley Hinz

Australian Journal of Teacher Education

This paper emerged from a larger project about Australian high performance school age athletes self-identified problems in balancing their academic and sporting lives. Teachers of student-athletes are ideally placed to observe stresses faced by these students, but little is published about teacher perspectives on this topic. A qualitative analysis of interview data from 10 teachers, across 10 Australian secondary schools, revealed critical information about the similarities and differences in their perspectives compared to those of student-athletes and parents. Teachers identified five main areas where student-athletes required dedicated support, and provided examples of solutions to address these. Their practical strategies complement …


School Leaders’ Perspectives On Educating Teachers To Work In Vulnerable Communities: New Insights From The Coal Face, Lynette Longaretti, Dianne Toe Jan 2017

School Leaders’ Perspectives On Educating Teachers To Work In Vulnerable Communities: New Insights From The Coal Face, Lynette Longaretti, Dianne Toe

Australian Journal of Teacher Education

Classroom teacher quality can significantly impact student learning outcomes. Increased access to skilled teachers in low socioeconomic status (SES) schools could substantially improve the learning outcomes and engagement levels of young people.

The National Exceptional Teaching for Disadvantaged Schools (NETDS) programme is a university based Teacher Education programme that has been implemented by Deakin University in the Geelong/Werribee area. It seeks to prepare high achieving pre-service teachers (PSTs) to teach in low SES school settings.

This project investigated the views of school leadership teams in low SES schools including their views of an exemplary teacher, and the understandings and skills …


Perceived Social-Ecological Barriers Of Generalist Pre-Service Teachers Towards Teaching Physical Education: Findings From The Get-Pe Study, Brendon P. Hyndman Jan 2017

Perceived Social-Ecological Barriers Of Generalist Pre-Service Teachers Towards Teaching Physical Education: Findings From The Get-Pe Study, Brendon P. Hyndman

Australian Journal of Teacher Education

Identifying and understanding the perceptions of pre-service teachers (PSTs) is vital to informing teaching practices. The purpose of the ‘Generalist Entry into Teaching Physical Education’ (GET-PE) study was to investigate Australian generalist PSTs' perceptions of the barriers to teaching physical education (PE) classes. A social-ecological model framework (SEM) was uniquely applied as the conceptual framework for the GET-PE study to analyse, explore and understand the multiple levels of barriers perceived by the generalist PSTs. A myriad of SEM level barriers were perceived by the generalist PSTs (n=71) at the intrapersonal level (knowledge gaps, physical abilities, reduced confidence), interpersonal level (community …


Revitalizing Ban Kaset Puttana Village Through Community-Based Tourism, Sairoong Dinkoksung, Mehran Nejati Jan 2017

Revitalizing Ban Kaset Puttana Village Through Community-Based Tourism, Sairoong Dinkoksung, Mehran Nejati

Research outputs 2014 to 2021

There has been a boom in health tourism. A growing number of tourists travel to other countries for preventive and rehabilitative care and seek detoxifying, destressing and healthy activities. Based on a community-based tourism project, this study aimed to explore the possibilities of developing health tourism in Ban Kaset Puttana, a village located in the suburban area of Ubon Ratchathani in Thailand. The one-year project based on participatory action research covered the entire process of forming thematic alternative health tourist products by employing the concept of natural-based health care. The project was then followed by 10 semistructured interviews with local …


Women In District Assemblies In Ghana: Gender Construction, Resistance And Empowerment, Janet Serwah Boateng Jan 2017

Women In District Assemblies In Ghana: Gender Construction, Resistance And Empowerment, Janet Serwah Boateng

Theses: Doctorates and Masters

Calls for more female participation in politics have featured strongly in developed and developing countries since 1975 when the UN made women’s issues a priority. Ghanaian society’s underlying patriarchal structure has made some progress towards gender equity in politics. Whilst there has been a significant improvement in levels of female participation and representation rates, targets have not been reached and the least amount of progress has taken place in local government. The thesis draws upon theories of gender and development (GAD) that emphasises on gender relations in development and proposed the empowerment of women as central to gender equality. Also, …


Investigating The Practice And Capacity Of Paediatric Occupational Therapists To Promote The Physical Activity Levels Of Children In Western Australia, Sally Coombs Jan 2017

Investigating The Practice And Capacity Of Paediatric Occupational Therapists To Promote The Physical Activity Levels Of Children In Western Australia, Sally Coombs

Theses: Doctorates and Masters

Reorientation of the Australian health care system to meet the increasing burden of disease requires health workers to develop a focus on disease prevention and health promotion. In Western Australia (WA) a priority area for the promotion of health involves increasing the physical activity levels (PAL) of children in accordance with Australia’s Physical Activity and Sedentary Behaviour Guidelines. There is substantial support in the literature for paediatric occupational therapists, who assist children to participate in a range of meaningful occupations, to incorporate the promotion of children’s PAL into their service. However, there is a dearth of research world-wide regarding occupational …


Activity Behavior And Physiological Profile Of Advanced-Stage Ovarian Cancer Survivors, Christelle Schofield Jan 2017

Activity Behavior And Physiological Profile Of Advanced-Stage Ovarian Cancer Survivors, Christelle Schofield

Theses: Doctorates and Masters

Background: Advanced-stage ovarian cancer survivors (OCS) often experience a multitude of disease symptoms and treatment-related side-effects. Additionally, most OCS are older, have comorbidities, are overweight or obese, and report being insufficiently physically active. Ovarian cancer survivors may benefit from exercise oncology interventions to reduce symptom-burden, manage comorbidities, minimize functional decline and maximize health-related quality of life (HRQoL). However, current knowledge gaps regarding the physiological characteristics of OCS throughout the entire survivorship spectrum challenge the development of tailored exercise interventions.

Purpose: The overall purpose of this thesis was to provide a more comprehensive physiological and activity behavior profile of post-treatment advanced-stage …


Food Insecurity And Fruit And Vegetable Consumption Among Regional And Remote Western Australian Children: Determinants, Prevalence And Predictors, Stephanie Louise Godrich Jan 2017

Food Insecurity And Fruit And Vegetable Consumption Among Regional And Remote Western Australian Children: Determinants, Prevalence And Predictors, Stephanie Louise Godrich

Theses: Doctorates and Masters

Living in a community with adequate availability of nutritious food, and the capacity to access and utilise it, are key food security determinants (FSD). However, inequities relating to these determinants exist between regional and remote Western Australian (WA) communities, particularly regarding fruit and vegetables (F&V). This negatively impacts vulnerable populations, especially children. In order to understand determinants, prevalence and predictors of F&V and food security (FS), three concepts were explored in this PhD; (1) F&V consumption among regional and remote WA children (including determinants of F&V consumption, quantities, types, varieties of F&V consumed); (2) FS among regional and remote WA …


A Nested Environmental Approach To Typhoid Epidemiology In Central Division, Fiji, Aaron Jenkins Jan 2017

A Nested Environmental Approach To Typhoid Epidemiology In Central Division, Fiji, Aaron Jenkins

Theses: Doctorates and Masters

Many current disease threats involve interactions within and between nested subsystems of biological organisation. Typhoid fever is a serious disease threat in the South Pacific region, with Fiji reporting the highest annual number of cases, yet risk factors in this setting have been poorly studied. While localised behaviours have dominated perspectives on typhoid transmission, interactions between distal ecological conditions, conditions of the residential environment and localised behaviour deserve greater attention for their potential to influence transmission. This thesis demonstrates a nested approach to typhoid epidemiology using a fivefold methodology to explore how regional, river basin, residential, socio-cultural and behavioural subsystems …


Integrating Diet And Exercise Into Care Of Prostate Cancer Patients On Androgen Deprivation Therapy, Mark A. Moyad, Robert Newton, Ulf W. Tunn, Damian Gruca Aug 2016

Integrating Diet And Exercise Into Care Of Prostate Cancer Patients On Androgen Deprivation Therapy, Mark A. Moyad, Robert Newton, Ulf W. Tunn, Damian Gruca

Research outputs 2014 to 2021

Improved diagnosis and treatment regimens have resulted in greater longevity for men with prostate cancer. This has led to an increase in both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and increased incidence of cardiovascular disease and type 2 diabetes. Given that the adverse effects of ADT are systemic, often debilitating, and difficult to treat, efforts continue in the development of new strategies for long-term management of prostate cancer. The PubMed database was searched to select trials, reviews, and meta-analyses …


The Role Of Clinical Proteomics, Lipidomics, And Genomics In The Diagnosis Of Alzheimer's Disease, Ian James Martins Mar 2016

The Role Of Clinical Proteomics, Lipidomics, And Genomics In The Diagnosis Of Alzheimer's Disease, Ian James Martins

Research outputs 2014 to 2021

The early diagnosis of Alzheimer’s disease (AD) has become important to the reversal and treatment of neurodegeneration, which may be relevant to premature brain aging that is associated with chronic disease progression. Clinical proteomics allows the detection of various proteins in fluids such as the urine, plasma, and cerebrospinal fluid for the diagnosis of AD. Interest in lipidomics has accelerated with plasma testing for various lipid biomarkers that may with clinical proteomics provide a more reproducible diagnosis for early brain aging that is connected to other chronic diseases. The combination of proteomics with lipidomics may decrease the biological variability between …


Cooperative Learning: Review Of Research And Practice, Robyn M. Gillies Jan 2016

Cooperative Learning: Review Of Research And Practice, Robyn M. Gillies

Australian Journal of Teacher Education

Cooperative learning is widely recognized as a pedagogical practice that promotes socialization and learning among students from pre-school through to tertiary level and across different subject domains. It involves students working together to achieve common goals or complete group tasks – goals and tasks that they would be unable to complete by themselves. The purpose of this paper is to review developments in research and practice on cooperative learning and to examine the factors that help to explain its success. In particular, the review focuses on the key elements that contribute to its success and the role teachers’ play in …


School-Based Youth Physical Activity Promotion: Thoughts And Beliefs Of Pre-Service Physical Education Teachers, Jerome N. Rachele, Thomas F. Cuddihy, Tracy L. Washington, Steven M. Mcphail Jan 2016

School-Based Youth Physical Activity Promotion: Thoughts And Beliefs Of Pre-Service Physical Education Teachers, Jerome N. Rachele, Thomas F. Cuddihy, Tracy L. Washington, Steven M. Mcphail

Australian Journal of Teacher Education

Physical education teachers are central to the facilitation of school-based physical activity promotion. However, teachers have self-reported a lack of knowledge, skills, understanding, and competence to successfully implement these strategies. The aim of this investigation was to explore the beliefs and perceptions of pre-service physical education teachers, concerning their potential roles in future school-based programs designed to promote student physical activity. Fifty-seven pre-service physical education teachers (21 males and 36 females) had complete data and were included in the analysis. Participants responded positively, and did not reveal concerns about their capacity to facilitate school-based physical activity promotion during practicum, and …


The Bridges And Barriers Model Of Support For High-Functioning Students With Asd In Mainstream Schools, Wendy Holcombe, Margaret Plunkett Jan 2016

The Bridges And Barriers Model Of Support For High-Functioning Students With Asd In Mainstream Schools, Wendy Holcombe, Margaret Plunkett

Australian Journal of Teacher Education

National statistics indicate the ongoing challenge of catering for the unique needs of students with Autism Spectrum Disorder (ASD) within the context of inclusive education. Higher rates of difficulty and poorer outcomes are experienced by this cohort when compared to both the general population and others within the disability sector. The perspectives of educators from a variety of roles were examined to identify factors impacting upon the educational experience of high-functioning students with ASD to determine how they could be supported more effectively. Findings indicate despite extensive educational experience and considerable knowledge of ASD, many educators lack an understanding of …


Hospital Utilisation In Indigenous And Non-Indigenous Infants Under 12 Months Of Age In Western Australia, Prospective Population Based Data Linkage Study, Kimberley Mcauley, Daniel Mcaullay, Natalie A. Strobel, Rhonda Marriott, David N. Atkinson, Julia V. Marley, Fiona J. Stanley, Karen M. Edmond Jan 2016

Hospital Utilisation In Indigenous And Non-Indigenous Infants Under 12 Months Of Age In Western Australia, Prospective Population Based Data Linkage Study, Kimberley Mcauley, Daniel Mcaullay, Natalie A. Strobel, Rhonda Marriott, David N. Atkinson, Julia V. Marley, Fiona J. Stanley, Karen M. Edmond

Research outputs 2014 to 2021

Background:

Indigenous infants (infants aged under 12 months) have the highest hospital admission and emergency department presentation risks in Australia. However, there have been no recent reports comparing hospital utilisation between Indigenous and non-Indigenous infants.

Methods:

Our primary objective was to use a large prospective population-based linked dataset to assess the risk of all-cause hospital admission and emergency department presentation in Indigenous compared to non-Indigenous infants inWestern Australia (WA). Secondary objectives were to assess the effect of socio-economic status (Index of Relative Socio-Economic Disadvantage [IRSD]) on hospital utilisation and to understand the causes of hospital utilisation.

Findings:

There were 3,382 …


Drug Therapy For Obesity With Anti-Aging Genes Modification, Ian J. Martins Jan 2016

Drug Therapy For Obesity With Anti-Aging Genes Modification, Ian J. Martins

Research outputs 2014 to 2021

Nutritional regulation and drug therapy has been the focus of the current obesity epidemic in various countries in the world. Epigenetics is the major mechanism for the development of insulin resistance and obesity with unhealthy diets, oxidative stress and environmental factors relevant to alterations in gene expression with effects on mitochondrial biogenesis, adipose tissue lipid metabolism and energy expenditure. Anti-aging genes are involved in the regulation of adipogenesis with increased sensitivity to anti-aging gene dysfunction associated with adipocyte-neuron interactions compared to other cells. Unhealthy diets downregulate adipocyte anti-aging genes associated with the development of Non Alcoholic Fatty Liver Disease (NAFLD) …


Accelerating Tropicalization And The Transformation Of Temperate Seagrass Meadows, Glenn A. Hyndes, Kenneth L. Heck, Jnr, Adriana Verges, Euan S. Harvey, Gary A. Kendrick, Paul Lavery, Kathryn Mcmahon, Robert J. Orth, Alan Pearce, Mathew Vanderklift, Thomas Wernberg, Scott Whiting, Shaun Wilson Jan 2016

Accelerating Tropicalization And The Transformation Of Temperate Seagrass Meadows, Glenn A. Hyndes, Kenneth L. Heck, Jnr, Adriana Verges, Euan S. Harvey, Gary A. Kendrick, Paul Lavery, Kathryn Mcmahon, Robert J. Orth, Alan Pearce, Mathew Vanderklift, Thomas Wernberg, Scott Whiting, Shaun Wilson

Research outputs 2014 to 2021

Climate-driven changes are altering production and functioning of biotic assemblages in terrestrial and aquatic environments. In temperate coastal waters, rising sea temperatures, warm water anomalies and poleward shifts in the distribution of tropical herbivores have had a detrimental effect on algal forests. We develop generalized scenarios of this form of tropicalization and its potential effects on the structure and functioning of globally significant and threatened seagrass ecosystems, through poleward shifts in tropical seagrasses and herbivores. Initially, we expect tropical herbivorous fishes to establish in temperate seagrass meadows, followed later by megafauna. Tropical seagrasses are likely to establish later, delayed by …


Periodization Strategies In Older Adults: Impact On Physical Function And Health, Jennifer Conlon, Greg Haff, James J. Tufano, Robert Newton Jan 2016

Periodization Strategies In Older Adults: Impact On Physical Function And Health, Jennifer Conlon, Greg Haff, James J. Tufano, Robert Newton

Research outputs 2014 to 2021

Purpose

This study compared the effect of periodized versus nonperiodized (NP) resistance training (RT) on physical function and health outcomes in older adults.

Methods

Forty-one apparently healthy untrained older adults (women = 21, men = 20; 70.9 ± 5.1 yr; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified to a NP, block periodized, or daily undulating periodized training group. Outcome measures were assessed at baseline and after a 22-wk × 3 d·wk−1 RT intervention, including; anthropometrics, body composition, blood pressure and biomarkers, maximal strength, functional capacity, balance confidence, and quality of life.

Results

Thirty-three …


Building Online Community On Snac: A Netnographic Study Of The Early Years Sector, Ruth Wallace, Leesa Costello, Amanda Devine Jan 2016

Building Online Community On Snac: A Netnographic Study Of The Early Years Sector, Ruth Wallace, Leesa Costello, Amanda Devine

Research outputs 2014 to 2021

‘‘Build it and they will come,’’ an adage critiqued as a common misconception of participatory engagement with online communities. Previous research indicated that a netnographic approach based upon researcher– participant engagement would provide the best opportunity to build and sustain a successful support community [...].


Regular Fat And Reduced Fat Dairy Products Show Similar Associations With Markers Of Adolescent Cardiometabolic Health, Theresa A. O'Sullivan, Alexandra P. Bremmer, Trevor A. Mori, Lawrence J. Beilin, Charlotte Wilson, Katherine Hafekost, Gina L. Ambrosini, Rae Chi Huang, Wendy H. Oddy Jan 2016

Regular Fat And Reduced Fat Dairy Products Show Similar Associations With Markers Of Adolescent Cardiometabolic Health, Theresa A. O'Sullivan, Alexandra P. Bremmer, Trevor A. Mori, Lawrence J. Beilin, Charlotte Wilson, Katherine Hafekost, Gina L. Ambrosini, Rae Chi Huang, Wendy H. Oddy

Research outputs 2014 to 2021

Reduced fat dairy products are generally recommended for adults and children over the age of two years. However, emerging evidence suggests that dairy fat may not have detrimental health effects. We aimed to investigate prospective associations between consumption of regular versus reduced fat dairy products and cardiometabolic risk factors from early to late adolescence. In the West Australian Raine Study, dairy intake was assessed using semi-quantitative food frequency questionnaires in 860 adolescents at 14 and 17-year follow-ups; 582 of these also had blood biochemistry at both points. Using generalized estimating equations, we examined associations with cardiometabolic risk factors. Models incorporated …


Metabolomics Enables Precision Medicine: “A White Paper, Community Perspective”, Richard D. Beger, Warwick B. Dunn, Michael A. Schmidt, Steven S. Cross, Jennifer A. Kirwan, Marta S. Cascante, Lorraine Brennan, David S. Wishart, Matej Orešič, Thomas Hankemeier, David Broadhurst, Andrew N. Lane, Karsten Suhre, Gabi Kastenmüller, Susan J. Sumner, Ines Thiele, Oliver E. Fiehn, Rima Kaddurah- Daouk Jan 2016

Metabolomics Enables Precision Medicine: “A White Paper, Community Perspective”, Richard D. Beger, Warwick B. Dunn, Michael A. Schmidt, Steven S. Cross, Jennifer A. Kirwan, Marta S. Cascante, Lorraine Brennan, David S. Wishart, Matej Orešič, Thomas Hankemeier, David Broadhurst, Andrew N. Lane, Karsten Suhre, Gabi Kastenmüller, Susan J. Sumner, Ines Thiele, Oliver E. Fiehn, Rima Kaddurah- Daouk

Research outputs 2014 to 2021

Introduction:Background to metabolomics:

Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or “-omics” level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person’s metabolic state provides a close representation of that individual’s overall health status. This metabolic state reflects what has been encoded by the genome, and modified by diet, environmental factors, and the gut microbiome. The metabolic profile provides …


Validation Of Type 2 Diabetes Risk Variants Identified By Genome-Wide Association Studies In Northern Han Chinese, Ping Rao, Yong Zhou, Siqi Ge, Anxin Wang, Xinwei Yu, Mohamed Ali Alzain, Andrea K. Veronica, Jing Qiu, Manshu Song, Jie Zhang, Hao Wang, Honghong Fang, Qing Gao, Youxin Wang, Wei Wang Jan 2016

Validation Of Type 2 Diabetes Risk Variants Identified By Genome-Wide Association Studies In Northern Han Chinese, Ping Rao, Yong Zhou, Siqi Ge, Anxin Wang, Xinwei Yu, Mohamed Ali Alzain, Andrea K. Veronica, Jing Qiu, Manshu Song, Jie Zhang, Hao Wang, Honghong Fang, Qing Gao, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Background:

More than 60 genetic susceptibility loci associated with type 2 diabetes mellitus (T2DM) have been established in populations of Asian and European ancestry. Given ethnic differences and environmental factors, validation of the effects of genetic risk variants with reported associations identified by Genome-Wide Association Studies (GWASs) is essential. The study aims at evaluating the associations of T2DM with 29 single nucleotide polymorphisms (SNPs) from 19 candidate genes derived from GWASs in a northern Han Chinese population.

Method:

In this case-control study, 461 T2DM-diagnosed patients and 434 controls were recruited at the Jidong oil field hospital (Hebei, China) from January …


Anti-Aging Genes Improve Appetite Regulation And Reverse Cell Senescence And Apoptosis In Global Populations, Ian James Martins Jan 2016

Anti-Aging Genes Improve Appetite Regulation And Reverse Cell Senescence And Apoptosis In Global Populations, Ian James Martins

Research outputs 2014 to 2021

Appetite regulation by nutritional intervention is required early in life that involves the anti-aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes involved in cell circadian rhythm, senescence and apoptosis. Interests in anti-aging therapy with appetite regulation improve an individual’s survival to metabolic disease induced by gene-environment interactions by maintenance of the anti-aging genes connected to the metabolism of bacterial lipopolysaccharides, drugs and xenobiotics. Interventions to the aging process involve early calorie restriction with appetite regulation connected to appropriate genetic mechanisms that involve mitochondrial biogenesis and DNA repair in neurons. In the aging process …


Diet And Nutrition Reverse Type 3 Diabetes And Accelerated Aging Linked To Global Chronic Diseases, Ian James Martins Jan 2016

Diet And Nutrition Reverse Type 3 Diabetes And Accelerated Aging Linked To Global Chronic Diseases, Ian James Martins

Research outputs 2014 to 2021

The acceleration in the rate of chronic diseases that involve insulin resistance has become of global concern. The rate of the most prevalent chronic disease such as cardiovascular disease is linked to the metabolic syndrome, non alcoholic fatty liver disease (NAFLD) and other chronic diseases that include obesity, diabetes and neurodegenerative diseases. The gene-environment interaction in Western countries indicates that with urbanization access to food and its content may lead to induction of epigenetic alterations and identify the gene Sirtuin 1 (Sirt 1) to be responsible for the increased risk for insulin resistance and NAFLD relevant to Type 1, Type …