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Etsu Health Annual Report - 2019, 2019

ETSU Health Annual Reports

No abstract provided.

2019-Notes From The Field- Emily Perez Does Appe Rotation In Infection Diseases At Jcmc, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

Meet Emily Perez, who did a May 2019 APPE Rotation in Infectious Diseases with Dr. Paul Lewis at Johnson City Medical Center.

Looking back, what made you decide to pursue the rotation?

EP: Honestly, I love everything infectious disease related! I see myself working as an ID clinical pharmacist in the future, so I wanted to give myself every opportunity to learn from a specialist in a clinical setting. 

What was your favorite part of the rotation?

EP: My favorite part of the rotation was seeing all of the different activities that an ID clinical pharmacist is involved in and …

Binding Of Elementary Bodies By The Opportunistic Fungal Pathogen Candida Albicansor Soluble Β-Glucan, Laminarin, Inhibits Chlamydia Trachomatisinfectivity, Michael D. Kruppa, Jeremy Jacobs, Kelsey King-Hook, Keleigh Galloway, Amy Berry, Jennifer Kintner, Judy D. Whittimore, Rolf Fritz, Robert V. Schoborg, Jennifer V. Hall

ETSU Faculty Works

Microbial interactions represent an understudied facet of human health and disease. In this study, the interactions that occur between Chlamydia trachomatis and the opportunistic fungal pathogen, Candida albicans were investigated. Candida albicans is a common component of the oral and vaginal microbiota responsible for thrush and vaginal yeast infections. Normally, Candida exist in the body as yeast. However, disruptions to the microbiota create conditions that allow expanded growth of Candida, conversion to the hyphal form, and tissue invasion. Previous studies have shown that a myriad of outcomes can occur when Candida albicans interacts with pathogenic bacteria. To determine if C. …

Playing To Live: Outcome Evaluation Of A Community-Based Psychosocial Expressive Arts Program For Children During The Liberian Ebola Epidemic, Caroline A. Decosimo, J. Hanson, Megan Quinn, P. Badu, E. G. Smith

ETSU Faculty Works

Background. This paper reviews the efficacy of a community psychosocial arts program focused on building mental health capacity within post-Ebola Liberia. The aim of this paper was to evaluate the outcome effects of two groups using pre- and post-treatment data. We hypothesized that there would be a difference in symptoms pre- and post-treatment, and the longer program would yield more significant results.

Methods. There was a total of 870 child participants. Of 40 sites, 24 were selected for a 5-month treatment (TG1) while the remaining 16 sites received 3 months of treatment (TG2). Paired t tests and a mixed-model analysis …

State Of The University Annual Report - 2018-2019, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University

Office of the President State of the University Annual Report

No abstract provided.

2018-December-01-Asking What If, University Marketing And Communications, East Tennessee State University

ETSU News

JOHNSON CITY – During the past year, faculty members in the Department of Biomedical Sciences at East Tennessee State University’s Quillen College of Medicine were awarded $6.7 million in new extramural funding.

The grant proposals were funded by agencies such as the National Institutes of Health, American Heart Association, American Foundation for Suicide Prevention, and the Swiss National Science Foundation and will support research studies in the areas of heart disease, neurological and psychiatric diseases, infectious diseases and cancer.

“This is an era in which earning extramural support for research projects has become increasingly competitive, and the success our department …

The Role Of Non-Neuronal Acetylcholine In Urogenital Chlamydial Infection, Jessica R. Lockhart

Electronic Theses and Dissertations

Chlamydia trachomatiscauses a bacterial sexually transmitted infection, Chlamydia, that is often chronic and casues reproductive complications in women. We hypothesized that Chlamydia infection increases local acetylcholine (ACh) production, which regulates the host’s inflammatory response to the infection. Female mice infected with C. muridarumwere sacrificed at days 3, 9, 15, and 21 post-infection, genital tract tissues harvested, and immunohistochemistry performed to enumerate ACh-producing cells. Infection increased the number of ACh-producing cells in cervical tissue at days 3,15, and 21 post-infection (pi), uterine tissue at day 3 and 9 pi, and ovarian tissue day 3, 15, and 21 pi. These …

Candida Albicans Β-Glucan Differentiates Human Monocytes Into A Specific Subset Of Macrophages, Julia Leonhardt, Silke Große, Christian Marx, Fatina Siwczak, Sven Stengel, Tony Bruns, Reinhard Bauer, Michael Kiehntopf, David L. Williams, Zhao Qi Wang, Alexander S. Mosig, Sebastian Weis, Michael Bauer, Regine Heller

ETSU Faculty Works

β-Glucan derived from cell walls of Candida albicans is a potent immune modulator. It has been shown to induce trained immunity in monocytes via epigenetic and metabolic reprogramming and to protect from lethal sepsis if applied prior to infection. Since β-glucan-trained monocytes have not been classified within the system of mononuclear phagocytes we analyzed these cells metabolically, phenotypically and functionally with a focus on monocyte-to-macrophage differentiation and compared them with naïve monocytes and other types of monocyte-derived cells such as classically (M1) or alternatively (M2) activated macrophages and monocyte-derived dendritic cells (moDCs). We show that β-glucan inhibits spontaneous apoptosis of …

2018-November-15-New Employees, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Distinct Migratory Properties Of M1, M2, And Resident Macrophages Are Regulated By ΑDΒ2And ΑMΒ2Integrin-Mediated Adhesion, Kui Cui, Christopher L. Ardell, Nataly P. Podolnikova, Valentin P. Yakubenko

ETSU Faculty Works

Chronic inflammation is essential mechanism during the development of cardiovascular and metabolic diseases. The outcome of diseases depends on the balance between the migration/accumulation of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in damaged tissue. The mechanism of macrophage migration and subsequent accumulation is still not fully understood. Currently, the amoeboid adhesion-independent motility is considered essential for leukocyte migration in the three-dimensional environment. We challenge this hypothesis by studying the contribution of leukocyte adhesive receptors, integrins αMβ2, and αDβ2, to three-dimensional migration of M1-polarized, M2-polarized, and resident macrophages. Both integrins have a moderate expression on M2 macrophages, while αDβ2 is upregulated …

2018-November-7-Community Of Scholars, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (Nov. 7, 2018) – A new forum has been created at East Tennessee State University to disseminate information from the research community to interested faculty and the Tri-Cities community. The first “Community of Scholars” presentation will be held on Friday, Nov. 16.

Dr. Jonathan Moorman, professor of medicine and section chief for Infectious Diseases at the Quillen Veterans Affairs Medical Center, will discuss “Translational Research in HIV/AIDS” from 9-9:45 a.m. in The James and Nellie Brinkley Center, followed by a question-and-answer session. Then, seed grant recipients from ETSU’s Center of Excellence in Inflammation, Infectious Diseases and Immunity will …

The Sex Specific Effect Of Alcohol Consumption On Circulating Levels Of Ctrp3, Ashley R. Degroat, Christina K. Fleming, Samantha M. Dunlay, Kendra L. Hagood, Jonathan P. Moorman, Jonathan M. Peterson

ETSU Faculty Works

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The goal of this project was to establish the effect of alcohol consumption on the circulating levels of the adipose tissue derived protein C1q TNF Related Protein 3 (CTRP3). Adipose tissue secretes several adipokines, such as adiponectin and leptin, which exert a multitude of biological effects important for human health. However, adipose tissue is extremely sensitive to alcohol consumption, leading not only to disrupted fat storage, …

The Type I Interferon Receptor Is Not Required For Protection In The Chlamydia Muridarum And Hsv-2 Murine Super-Infection Model, Jessica A. Slade, Jennifer V. Hall, Jennifer Kintner, Robert V. Schoborg

ETSU Faculty Works

Chlamydia trachomatis/HSV-2 vaginal co-infections are seen clinically, suggesting that these sexually transmitted pathogens may interact. We previously established an intravaginal Chlamydia muridarum/HSV-2 super-infection model and observed that chlamydial pre-infection protects mice from a subsequent lethal HSV-2 challenge. However, the mechanism of protection remains unknown. The type I interferon, IFN-β, binds to the type I interferon receptor (IFNR), elicits a host cellular antiviral response and inhibits HSV replication in vitro and in vivo. Previous studies have demonstrated that C. muridarum infection stimulates genital tract (GT) IFN-β production; therefore, we hypothesized that chlamydial pre-infection protects mice from HSV-2 challenge via the IFN-β/IFNR-induced …

2018 October 22 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Etsu Today - Fall 2018, University Marketing And Communication, East Tennessee State University

ETSU Today [magazine]

Since the founding of East Tennessee State University in 1911, the stories of our students, faculty, staff, and alumni have built upon each other to tell an even bigger story, of an institution focused on improving the quality of life for the people of the region. Today, nearly 95,000 ETSU alumni live and work in 50 states and 68 countries. Each of you represents a part of our story as a university—from the chapters you helped write as students conducting important service, research, and educational missions to the chapters yet to be written, with compelling stories of our alumni making …

Screening Tools In Adolescent Health Care, David L. Wood

ETSU Faculty Works

Learning Objectives: (1) Identify three primary care friendly screening tools useful for identifying behavioral health concerns in adolescents. (2) Describe how a "champion" (quality improvement) team can help facilitate implementation of a screener in a primary care.

Speech-Language-Hearing Clinic Handbook - August 2018, Department Of Audiology And Speech-Language Pathology, East Tennessee State University

Speech-Language Pathology Handbooks

No abstract provided.

Role Of Ataxia-Telangiectasia Mutated Kinase In Cardiac Autophagy And Glucose Metabolism Under Ischemic Conditions, Patsy Thrasher

Electronic Theses and Dissertations

Ataxia-telangiectasia mutated kinase (ATM), a serine/threonine kinase primarily located in the nucleus, is typically activated in response to DNA damage. Individuals with mutations in ATM gene develop a disease called Ataxia telangiectasia (AT). These individuals are more susceptible to ischemic heart disease and metabolic disorder. Our lab has previously shown that ATM plays a critical role in β-adrenergic receptor (β-AR) - and myocardial infarction (MI)-stimulated myocyte apoptosis and cardiac remodeling. This study tested the hypothesis that ATM plays a critical role in cardiac autophagy and glucose metabolism following MI and ischemia, respectively. Early during MI (4 hours after its onset) …

2018-July-18-Liver Disease Research, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-July-15-Dr. Aaron Polichnowski, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Incorporating A Structural Approach To Reducing The Burden Of Non-Communicable Diseases, Joshua S. Yang, Hadii M. Mamudu, Rijo John

ETSU Faculty Works

Background: Non-communicable diseases (NCDs) account for over two-thirds of deaths worldwide, and global efforts to address NCDs have accelerated. Current prevention and control efforts rely primarily on individual behavior/lifestyle approaches that place the onus of responsibility for health on the individual. These approaches, however, have not stopped the increasing trend of NCDs worldwide. Thus, there is urgent need for exploring alternative approaches in order to attain the aim of reducing global premature NCDs mortality by 25% by 2025, and meeting the NCD reduction objective in the Sustainable Development Goals. Discussion: We suggest the need for a structural approach to addressing …

Quillen Magazine - Summer 2018, Quillen College Of Medicine, East Tennessee State University

Quillen Magazine

No abstract provided.

2018-June-12-Research Award, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-June-05-Lymphoma Research, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-June-04-Dr. Tammy Ozment, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-June-04-Dr. Shunbin, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-May-21-Nih Funding, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-May-16-Syringe Exchange Program, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Changes In Risk Perceptions During The 2014 Ebola Virus Disease Epidemic: Results Of Two Consecutive Surveys Among The General Population In Lower Saxony, Germany, Julie Obenauer, Nicole Rübsamen, Ekaterine Garsevanidze, André Karch, Rafael T. Mikolajczyk

ETSU Faculty Works

Background: The Ebola virus disease (EVD) outbreak 2014 received extensive news media coverage, which faded out before the outbreak ended. News media coverage impacts risk perception; it is, however, unclear if the components of risk perception (affective and cognitive responses) change differently over time. Methods: In an online panel, we asked participants (n = 1376) about EVD risk perceptions at the epidemic's peak (November 2014) and after news media coverage faded out (August 2015). We investigated worry (affective response), perceived likelihood of infection, perceived personal impact, and coping efficacy (dimensions of cognitive response), and knowledge about transmission. Differences between the …

Can Alcaligenes Be A New Treatment For Staphylococcus Species?, Devin Narwani

Undergraduate Honors Theses

Members of the Staphylococcus genus are known to cause serious human infections in the clinical environment. Many species of this genus are typically found among the normal flora of the skin, nasal cavities, and the linings of the throat; however, the bacterium becomes an opportunistic infection when there is a break in the physical barriers or when a contaminated medical device is implanted in the human body. As more resistant strains are beginning to appear it is becoming drastically harder to treat patients infected with this bacterium. One such strain is Methicillin Resistant Staphylococcus aureus (MRSA). MRSA is a major …