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Multifunctional Polymeric Micelles For Drug Resistant Breast Cancer: Self-Assembling Poly(Lactide-Co-Glycolide)-Graft-Polyethylenimine, Graham Mackenzie Temples Dec 2017

Multifunctional Polymeric Micelles For Drug Resistant Breast Cancer: Self-Assembling Poly(Lactide-Co-Glycolide)-Graft-Polyethylenimine, Graham Mackenzie Temples

All Dissertations

Breast cancer is the most common malignancy and the leading cause of cancer death in women. Systemic breast cancer therapies include 1) hormone therapy, 2) immunotherapy, and 3) chemotherapy. Chemotherapy is commonly used in combination with immunotherapy, achieving synergistic activity by multiple mechanisms specific to the type of breast cancer. However, the efficacy of anticancer drugs has been limited by their toxic side effects in normal cells and drug resistance acquired by cancer cells. Therefore, the development of a novel treatment strategy for the selective delivery of therapeutic agents to breast cancer cells is crucial to improve the therapeutic index …

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Upland Cotton (Gossypium Hirsitum) Root Responses To Reniform Nematode (Rotylenchulus Reniformis) Infection, Wei Li Dec 2017

Upland Cotton (Gossypium Hirsitum) Root Responses To Reniform Nematode (Rotylenchulus Reniformis) Infection, Wei Li

All Dissertations

Reniform nematode (Rotylenchulus reniformis) is a semi-endoparasitic nematode that causes yield losses in numerous crops, including upland cotton (Gossypium hirsutum). Resistant cotton varieties are urgently needed, but the molecular basis of nematode-host plant interactions is poorly understood. To document plant responses to reniform nematode infection in upland cotton roots, we set up a split-root growth system to collect tissues from infected and uninfected portions of the same root system. A 12-day time course of histology and gene expression of infected roots were generated in Chapter 1. Results suggest reniform nematode infection induced protein synthesis and transport, …

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Characterization Of Volatile And Non-Volatile Compounds And Classification Of Different Cultivars Of Chinese Ziziphus Jujuba Mill. Fruits, Lina Wang Dec 2017

Characterization Of Volatile And Non-Volatile Compounds And Classification Of Different Cultivars Of Chinese Ziziphus Jujuba Mill. Fruits, Lina Wang

All Dissertations

Jujube (Ziziphus jujuba Mill.) is a desirable fruit that is widely grown in China. Also, it has been used as an herbal medicine and a functional food simultaneously for a very long time. In this study, 15 cultivars of jujube that were collected from a same farm in Shanxi Province, China, were analyzed in terms of their non-volatile components, including reducing sugars, organic acids, fatty acids, amino acids, minerals and antioxidants, and volatile compounds, in an effort to investigate their nutritional values, and the similarity between the cultivars so as to classify the cultivars based on their chemical composition. …

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Essays On Human Capital And Social Network Effects, Mahjuja M. Taznin Dec 2017

Essays On Human Capital And Social Network Effects, Mahjuja M. Taznin

All Dissertations

The first chapter of this dissertation looks at the relationship between parental investment in daughters' human capital and marital transfers in India. I evaluate the existence, nature, and magnitude of a causal relationship between a daughter's education level and the price her family pays for a groom in India using nationally representative data and a two stage least squares instrumental variable estimation methodology. I construct a policy instrument using an Indian national school-latrine-construction initiative to estimate the effect of an exogenous increase in a woman's years of education on the groom price that her parents pay. My OLS estimates show …

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A Comprehensive Model And Modulation Of Cellular Signaling Involved In Early Mammary Development And Aggressive Cancer Using A Novel Recombinant Protein Of The G3 Domain Of Laminin-5, Kathryn Adrian Elliott Dec 2017

A Comprehensive Model And Modulation Of Cellular Signaling Involved In Early Mammary Development And Aggressive Cancer Using A Novel Recombinant Protein Of The G3 Domain Of Laminin-5, Kathryn Adrian Elliott

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The mammary gland is a unique and specialized epidermal organ; mammary organogenesis begins in the embryo but is not fully complete until puberty. As such, formation of the mammary gland depends on temporally and spatially regulated developmental steps that require coordination of multiple biological and cell signaling processes; many of which have parallels with cancer development. Research describing the events that occur between birth and puberty is lacking and little is known about human breast development of youth. Since mammary gland development requires a coordinated balance between cell growth, proliferation, and apoptosis, it is critical to understand which signaling pathways …

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The Tiger Vol. 112 Issue 9 2017-11-13, Clemson University Nov 2017

The Tiger Vol. 112 Issue 9 2017-11-13, Clemson University

Tiger Newspapers 2017

No abstract provided.

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Recurrent Sublethal Warming Reduces Embryonic Survival, Inhibits Juvenile Growth, And Alters Species Distribution Projections Under Climate Change, Michael A. Carlo, Eric A. Riddell, Ofir Levy, Michael W. Sears Nov 2017

Recurrent Sublethal Warming Reduces Embryonic Survival, Inhibits Juvenile Growth, And Alters Species Distribution Projections Under Climate Change, Michael A. Carlo, Eric A. Riddell, Ofir Levy, Michael W. Sears

Publications

The capacity to tolerate climate change often varies across ontogeny in organisms with complex life cycles. Recently developed species distribution models incorporate traits across life stages; however, these life-cycle models primarily evaluate effects of lethal change. Here, we examine impacts of recurrent sublethal warming on development and survival in ecological projections of climate change. We reared lizard embryos in the laboratory under temperature cycles that simulated contemporary conditions and warming scenarios. We also artificially warmed natural nests to mimic laboratory treatments. In both cases, recurrent sublethal warming decreased embryonic survival and hatchling sizes. Incorporating survivorship results into a mechanistic species …

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Staff Senate Minutes, 2017 October 10, Clemson University Oct 2017

Staff Senate Minutes, 2017 October 10, Clemson University

Staff Senate Minutes

No abstract provided.

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The Tiger Vol. 112 Issue 6 2017-10-09, Clemson University Oct 2017

The Tiger Vol. 112 Issue 6 2017-10-09, Clemson University

Tiger Newspapers 2017

No abstract provided.

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Clemson Trustees Minutes, 2017 October 6, Clemson University Board Of Trustees Oct 2017

Clemson Trustees Minutes, 2017 October 6, Clemson University Board Of Trustees

Minutes

No abstract provided.

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2017 Annual Accountability Report, Clemson University Sep 2017

2017 Annual Accountability Report, Clemson University

Accountability Reports

Clemson University's 2016-2017 Annual Accountability Report submitted to the South Carolina Budget and Control Board.

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2017 Annual Accountability Report (Psa), Clemson University Sep 2017

2017 Annual Accountability Report (Psa), Clemson University

Accountability Reports

The 2016-2017 Annual Accountability Report for Clemson's PSA submitted to the South Carolina Budget and Control Board.

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Warming And Elevated Co2 Alter The Suberin Chemistry In Roots Of Photosynthetically Divergent Grass Species, Vidya Suseela, Nishanth Tharayil, Elise Pendall, Apparao M. Rao Sep 2017

Warming And Elevated Co2 Alter The Suberin Chemistry In Roots Of Photosynthetically Divergent Grass Species, Vidya Suseela, Nishanth Tharayil, Elise Pendall, Apparao M. Rao

Publications

A majority of soil carbon (C) is either directly or indirectly derived from fine roots, yet roots remain the least understood component of the terrestrial carbon cycle. The decomposability of fine roots and their potential to contribute to soil C is partly regulated by their tissue chemical composition. Roots rely heavily on heteropolymers such as suberins, lignins and tannins to adapt to various environmental pressures and to maximize their resource uptake functions. Since the chemical construction of roots is partly shaped by their immediate biotic/abiotic soil environments, global changes that perturb soil resource availability and plant growth could potentially alter …

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Staff Senate Minutes, 2017 August 8, Clemson University Aug 2017

Staff Senate Minutes, 2017 August 8, Clemson University

Staff Senate Minutes

No abstract provided.

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Correlation Of Trichome Density And Length And Polyphenol Fluorescence With Susceptibility Of Five Cucurbits To Didymella Bryoniae, Gabriel Rennberger, A. P. Keinath, M. Hess Aug 2017

Correlation Of Trichome Density And Length And Polyphenol Fluorescence With Susceptibility Of Five Cucurbits To Didymella Bryoniae, Gabriel Rennberger, A. P. Keinath, M. Hess

Publications

The fungal pathogen Didymella bryoniae causes gummy stem blight and black rot on a broad spectrum of cucurbits. However the substantial differences in susceptibility among Cucurbitaceae are not well studied. Susceptibility was characterized with muskmelon (Cucumis melo), watermelon (Citrullus lanatus), cucumber (Cucumis sativus), pumpkin (Cucurbita pepo), and zucchini (C. pepo). Lesion diameters on leaf disks inoculated with agar plugs were measured 7 days after inoculation, and the necrotized areas of leaf disks inoculated with conidial suspensions were measured 48 h after inoculation (hai). For each species, the number of trichomes …

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Predictive Models For Bariatric Surgery Risks With Imbalanced Medical Datasets, Talayeh Razzaghi, Ilya Safro, Joseph Ewing, Ehsan Sadrfaridpour, John D. Scott Aug 2017

Predictive Models For Bariatric Surgery Risks With Imbalanced Medical Datasets, Talayeh Razzaghi, Ilya Safro, Joseph Ewing, Ehsan Sadrfaridpour, John D. Scott

Publications

Bariatric surgery (BAR) has become a popular treatment for type 2 diabetes mellitus (T2DM) which is among the most critical obesity-related comorbidities. Patients who have bariatric surgery, are exposed to complications after surgery. Furthermore, the mid- to long-term complications after bariatric surgery can be deadly and increase the complexity of managing safety of these operations and healthcare costs. Current studies on BAR complications have mainly used risk scoring for identifying patients who are more likely to have complications after surgery. Though, these studies do not take into considera-tion the imbalanced nature of the data where the size of the class …

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Colleges And Universities: Prime Habitat For Hunter Recruitment And Retention, Brett Jonathon Stayton Aug 2017

Colleges And Universities: Prime Habitat For Hunter Recruitment And Retention, Brett Jonathon Stayton

All Theses

Hunting has played a prominent role throughout American history and continues to serve many important social, economic, and ecological functions in our society today. However, hunting participation in the United States is in a gradual state of decline. Today, less than 5% of the population hunts. In hopes of reversing these trends, many state fish and wildlife agencies, conservation organizations, and hunting and shooting sports industries have increasingly invested in new programs designed to enhance the recruitment, retention, and reactivation (R3) of new hunters from non-traditional hunting backgrounds. For example, many R3 initiatives have been designed to focus on women, …

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Quantitative Assessment Of Water Security Using A Hydrological Modeling Framework, Anoop Valiyaveettil Aug 2017

Quantitative Assessment Of Water Security Using A Hydrological Modeling Framework, Anoop Valiyaveettil

All Dissertations

Water scarcity and drought are major threats to water security. Quantifying and defining boundaries between these threats are necessary to properly assess water security of a region. A comprehensive assessment of water security in terms of water scarcity, water vulnerability and drought can address water policy issues related to hydrological conditions and their interactions with societal and ecosystem functioning. Therefore, study of water security can provide useful information to multiple stakeholders. The overarching goal of this thesis is to improve water security in river basins around the world. To demonstrate our proposed methods, we selected Savannah River Basin (SRB) as …

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Effects Of Embryonic Arsenic Exposure On Killifish (Fundulus Heteroclitus) Growth, Feeding Behavior, And Intestinal Morphology And Cell Types, Kaleigh Caroline Sims Aug 2017

Effects Of Embryonic Arsenic Exposure On Killifish (Fundulus Heteroclitus) Growth, Feeding Behavior, And Intestinal Morphology And Cell Types, Kaleigh Caroline Sims

All Theses

Arsenic is found as a contaminant of drinking water, rice, and other crops. Epidemiological studies have shown that embryonic exposure to arsenic can cause changes in behavior and reductions in growth, but the mechanisms for these effects are not well understood. So, we were interested in examining potential mechanisms by which arsenic could be affecting growth. Additionally, while many studies have looked at higher levels of arsenic exposure, we wanted to focus on environmentally-relevant levels to see if these concentrations could have lasting consequences on growth, even after the exposure had ended. Killifish (Fundulus heteroclitus) were used as the model …

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Investigation Of Uranium And Thorium Uptake In Pinus Taeda (Loblolly Pine) And Dichanthelium Commutatum (Variable Panicgrass) From A Naturally Occurring Source, Sam Santoso Aug 2017

Investigation Of Uranium And Thorium Uptake In Pinus Taeda (Loblolly Pine) And Dichanthelium Commutatum (Variable Panicgrass) From A Naturally Occurring Source, Sam Santoso

All Theses

Mobilization of radioactivity from natural sources could lead to concentrations of naturally occuring radioactive material (NORM) in groundwaters past the EPA maximum concentration limit (MCL) for drinking water (Hughes et al., 2005; Powell et al., 2007). The Piedmont and Blue Ridge aquifers are a continuous source of water for much of the Eastern U.S., however there are sources of natural contamination due to the area's geologic history. In the Tamassee and Salem Quadrangles (N 34° 56.152' W 83° 00.284) area of Upstate South Carolina off Highway 130 near Burgess Creek, an abandoned logging road dug through a sandy loam unit.This …

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Data Mining In Large-Scale Clinical Visit Data For Rett Syndrome Patients, Neela Saranya Avudaiappan Aug 2017

Data Mining In Large-Scale Clinical Visit Data For Rett Syndrome Patients, Neela Saranya Avudaiappan

All Theses

Rett syndrome (RTT) is a rare neurological disorder that predominantly affects girls. Research on RTT has mostly centered around gene mutations and possibility of cure using gene therapy. In this thesis we perform the first large scale systematic study of RTT patient records. The thesis has two major goals. One is to identify behavioral groups and the other is to study the association of medications and behavior or conditions. To achieve the first goal we apply standard clustering techniques like non-negative matrix factorization and k-means. We identify behavioral groups which could be used by clinicians for formulating better treatments. For …

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Selective Serotonin Re-Uptake Inhibitors Effects On Hybrid Striped Bass Predatory Behavior And Internal Chemistry, Lauren E. Stoczynski Aug 2017

Selective Serotonin Re-Uptake Inhibitors Effects On Hybrid Striped Bass Predatory Behavior And Internal Chemistry, Lauren E. Stoczynski

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Prescription drug use continues to increase across the United States. An important part of these medications are selective serotonin reuptake inhibitors (SSRIs) that function as anti-depressants and include drugs as citalopram (Celexa) and sertraline (Zoloft). SSRI's main mode of action is the inhibition of the serotonin reuptake transporter, causing a buildup of extracellular serotonin, one of the neurotransmitters in the central and peripheral nervous system. SSRIs can be considered persistent pollutants due to their continuous release from wastewater treatment effluent, drug manufacturing effluent, and agricultural runoff. Aquatic organisms can become non-target organisms when subjected to sub-lethal concentrations (low ppb to …

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Formulating A Composite Scaffold With Tissue Regeneration And Anti-Cancer Activity, Kendyl Marie Williams Aug 2017

Formulating A Composite Scaffold With Tissue Regeneration And Anti-Cancer Activity, Kendyl Marie Williams

All Theses

Breast cancer affects 1 in 8 women in the United States and is the second most commonly diagnosed cancer among women. Many treatment options, such as chemotherapy or surgery, are invasive, ineffective, or detrimental to the body. It has been previously demonstrated that tannic acid has anti-cancer properties and is effective in killing cancer cells while not adversely affecting healthy cells. Tannic acid crosslinks collagen type I. We have proposed using tannic acid crosslinked collagen type I beads to fill in the void left after surgery while simultaneously treating any remaining cancer cells after a breast cancer patient has a …

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Content Analysis Of Spanish-Language Materials Targeting Consumers With Information About Human Norovirus, Ana Romero Vega Aug 2017

Content Analysis Of Spanish-Language Materials Targeting Consumers With Information About Human Norovirus, Ana Romero Vega

All Theses

Background and Rationale: Worldwide, human norovirus is a significant public health problem. One way to reduce the burden of illness attributed to norovirus is to educate consumers about prevention and control strategies. A common vehicle to do so is the Internet. Unfortunately, the accuracy of information posted to the Internet is not well known as no universal review system is in place. Aim and Objectives: The aim of this study was to determine if web-based Spanish-language norovirus educational materials targeting consumers were clearly written and accurate (aligned with evidence-based prevention and control strategies). The objectives were: (1) determine if the …

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Clemson Commencement Program, August 2017, Clemson University Aug 2017

Clemson Commencement Program, August 2017, Clemson University

Clemson Commencement Programs

No abstract provided.

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Pilot Study: Evaluating The Risk Of Allergen Cross-Contact In Ice Cream Scoop Shop Dipper Wells, Lindsey Lake Aug 2017

Pilot Study: Evaluating The Risk Of Allergen Cross-Contact In Ice Cream Scoop Shop Dipper Wells, Lindsey Lake

All Theses

Food allergies are a serious and growing problem in developed countries. Allergen cross-contact at foodservice establishments is a common cause of food allergic reactions. Therefore, this study sought to determine if dipper wells used in ice cream scoop shops pose a relevant risk to food allergy sufferers. First, a matrix study was conducted to evaluate if peanut detection by real-time PCR was inhibited by the ice cream matrix, as fat and proteins are known PCR inhibitors. Frozen ice cream, liquid ice cream mix, and water matrices were tested. Second, a controlled time trial was conducted to evaluate the efficacy of …

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Processing And Cooking On Lentil Prebiotics To Reduce Obesity, Niroshan Siva Aug 2017

Processing And Cooking On Lentil Prebiotics To Reduce Obesity, Niroshan Siva

All Theses

Lentil is a rich source of proteins, range of prebiotic carbohydrates including sugar alcohols (SA), raffinose family oligosaccharides (RFO), fructooligosaccharides (FOS), and resistant starch (RS), minerals, and vitamins. Research indicated that foods rich in prebiotics reduce obesity via modulating gut microbiota. The objectives of this thesis were 1) to determine the effects of lentil processing (dehulling, splitting, and cooking) on SA, RFO, FOS, and RS in three lentil market classes (red, green, and pardina), and 2) to determine the effects of lentil diet on rat body weight, percent body fat, plasma triglycerides (TGs) concentration, and change of fecal bacteria. Lentil …

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Application Of Glycoconjugate-Functionalized Magnetic Nanoparticles As Potent Anti-Adhesion And Anti-Bacterial Agents, Yash S. Raval Aug 2017

Application Of Glycoconjugate-Functionalized Magnetic Nanoparticles As Potent Anti-Adhesion And Anti-Bacterial Agents, Yash S. Raval

All Dissertations

Magnetic nanoparticles (MNPs) are currently being extensively in multitude of biomedical applications on account of their exceptional biocompatibility. By attaching different targeting ligands/molecules, MNPs have been broadly used in magnetic hyperthermia, cancer therapy, targeted drug delivery, MRI imaging, pathogen detection, and biological cell-separation. In this dissertation, MNPs coated with polyethylene oxide (PEO) based polymer (PEO-MNPs) and functionalized with bacterial adhesin-specific glycoconjugate molecule Neu5Ac(α2-3)Gal(β1-4)-Glcβ-sp (GM3-MNPs), are investigated for their interactions with enterotoxigenic Escherichia coli (E. coli). It also describes the feasibility of using alternating magnetic fields (AMF) for targeted killing of E. coli K99 (EC K99) strain using MNPs. Lastly, the …

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Application Of Low-Cost Color Sensor Technology In Soil Data Collection And Soil Science Education, Roxanne Y. Stiglitz Aug 2017

Application Of Low-Cost Color Sensor Technology In Soil Data Collection And Soil Science Education, Roxanne Y. Stiglitz

All Dissertations

Sensor technologies provide opportunities to increase the quality and quantity of soils data while introducing new techniques and tools for classrooms. Linear regression models were developed for organic carbon prediction using color data gathered with the Nix Pro™ for dry (R2 = 0.7978, MSPE = 0.0819), and moist soils (R2 = 0.7254, MSPE = 0.1536). A mobile application, the Soil Scanner app, was created to allow for a more soil science dedicated interface that would allow users to create their own database consisting of GPS location and soil color data gathered using the Nix Pro™. The final application produced results …

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Adaptive Robust Methodology For Parameter Estimation And Variable Selection, Tao Yang Aug 2017

Adaptive Robust Methodology For Parameter Estimation And Variable Selection, Tao Yang

All Dissertations

The dissertation consists of three distinct but related projects. We consider regression model fitting, variable selection in regression, and autocorrelation estimation in time series. In each procedure we formulate the problem in terms of minimizing an objective function which adapts to the given data. First we propose a robust M-estimation procedure for regression. The main purpose of the proposed methodology is to develop a procedure that adapts to light/heavy tailed, symmetric/asymmetric distributions with/without outliers. We focus on studying the properties of the maximum likelihood estimator of the asymmetric exponential power distribution, a broad distribution class that holds both Normal and …

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