Digital Commons Network^™

Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster

All Dissertations

This dissertation investigates the development and optimization of pathology-responsive polymersomes for simultaneous enhanced magnetic resonance imaging (MRI) and enzyme replacement therapy (ERT) in the treatment of GM1 gangliosidosis (GM1). While therapeutic strategies exist for similar, non-neuropathic lysosomal storage disorders, implementation towards GM1 faces significant challenges due to the blood-brain barrier.

Herein, we developed and characterized a range of low molecular weight hyaluronic acid-b-polylactic acid (HA-PLA) polymersomes (PSs) capable of encapsulating therapeutic enzymes in their hydrophilic core. These polymersomes exhibit pathophysiology-triggered responsiveness, degrading in the presence of acidic conditions, which is characteristic of lysosomes, and enzymes such as hexosaminidase A, which …

The Impact Of In Ovo Administration Of Probiotic Lactobacilli On The Gut Health And Immune Competence Of Broiler Chickens, Shreeya Sharma

All Theses

Due to the incomplete development of their immune system, newly hatched chicks are vulnerable to a wide range of pathogenic microorganisms, including enteric bacterial pathogens during the early stage of life. To boost their immune system during this critical period, numerous studies suggest early feeding, either in ovo or immediately post-hatch, of nutrients and immunomodulators such as prebiotics, probiotics, phytobiotics, Toll-like receptors (TLRs) ligands, vitamins and minerals. Probiotics, defined as live, non-pathogenic microorganisms that confer beneficial effects on the host, have been extensively studied for their effects on poultry health. Supplementation of probiotics to chickens has demonstrated a broad spectrum …

Field Prevalence Of Ring Nematodes In South Carolina And Its Potential To Predispose Peanut Pods To Aflatoxin Contamination, Sarala Giri

All Theses

Peanut ring nematode, Mesocriconema ornatum is a nematode pest of peanut which can cause necrotic lesions on pods, pegs, and roots. It has been reported to facilitate secondary infections in peanut and other crops resulting in more significant losses in yield and quality. Aspergillus flavus is a ubiquitous facultative saprophyte that produces aflatoxin, the most problematic mycotoxin for global health and economy. Experiments were conducted at the Edisto Research and Education Center of Clemson University to examine the relationship of ring nematode populations at pegging and harvest with aflatoxin concentration in peanut kernels due to infection by A. flavus …

Foster Care, Substance Use, And Social Determinants Of Health In South Carolina: A Geographic Approach, Patricia Carbajales-Dale

All Dissertations

Foster care is a critical intervention for vulnerable children, with approximately 400,000 children entering the system annually in the United States. Parental substance use, second only to neglect, is now a leading cause of foster care entry. While previous research has explored the relationship between socioeconomic factors and foster care, few studies have incorporated spatial approaches at the neighborhood level to understand how factors such as economic inequality, healthcare disparities, and substance use influence foster care entries. This study addresses that gap by integrating spatial analysis and machine learning techniques to examine the geographic and social dynamics underlying foster care …

Advancing Substance Use Disorder Treatment Using Genomics And Metabolomics, Lindsey Contella

All Dissertations

Advancing our understanding of genetic, metabolic, and environmental factors in substance use disorder (SUD) could lead to more effective therapies. In 2022, 16.5% of the U.S. population was diagnosed with SUD, yet current treatments lack efficacy for all patients, making a precision medicine approach crucial. This dissertation explores SUD's relationship with tryptophan (TRP) metabolism through the kynurenine pathway (KP) as a potential therapeutic target. Chapter I reviews current knowledge on SUD and KP. Chapter II identifies how SUD alters KP metabolite concentrations, identifying a reduced concentration of the neuroprotective metabolite, kynurenic acid (KA) and elevated concentrations of the neurotoxic metabolite, …

Parental Involvement In Early Warning System Use In A Mid To Low-Poverty School, Carrie Mccain

All Dissertations

This study examines the effectiveness of an Early Warning System (EWS) originally designed for high-poverty schools and its potential impact on improving outcomes for students living in poverty but attending a mid to low-poverty school. The focus is on reducing the graduation rate disparity between economically disadvantaged students and their more affluent peers through intentional parental involvement. The research explores how structured communication between parents, teachers, and students, combined with tailored interventions in the EWS, can enhance student engagement and academic performance. Quantitative data, including attendance, behavior, and course performance, were analyzed before and after the intervention, while qualitative data …

Space Operations Education Research: Studying Undergraduate Experiences As Predictors Of Early Career Performance For Military Space Operations Officers, Keith Balts

All Dissertations

Undergraduate students who go on to operate space systems, e.g., satellites, launch systems, and ground-based systems, come from a diverse set of demographics and undergraduate experiences. The United States Space Force (USSF), and United States Air Force (USAF) before them, like many professions, have a demonstrated interest in who enters their ranks, but have had limited research available to them to inform their recruiting, selection, training, and early career development policies and processes.

This Profession-Based Education Research study, a term introduced here in contrast to Discipline-Based Education Research, focused on the military space operations profession. This study analyzed newly commissioned …

Disability, Urban Influence, And Covid-19 Financial Hardships: Findings From A Predominantly Rural Sample, Mackenzie Brewer, Jodien Johnson, Kyra Davidson, Carson Mencken

Journal of Rural Social Sciences

This study examined the financial impacts of the early COVID-19 pandemic among households with children and compared outcomes based on disability status and urban influence. Survey data were collected in fall 2020 by the Urban Institute from mostly rural households participating in the Meals-to-You program, which delivered food to eligible households with children in the U.S. due to school closures. Relative risk contingency analysis and multivariate logistic regression were used to assess financial hardship from the pandemic. Sampled households reporting at least one member with a disability had greater odds of food insecurity, delaying purchases, depleting savings, and difficulty paying …

Fy2025 All Salaries $30-$50,000, Clemson University

Salary Reports

No abstract provided.

Fy2025 Salary Report - All Tabs, Clemson University

Salary Reports

No abstract provided.

Fy2025 Faculty Salaries Over $50,000, Clemson University

Salary Reports

No abstract provided.

2024 Annual Accountability Report, Clemson University

Accountability Reports

Clemson University's 2023-2024 Annual Accountability Report submitted to the South Carolina Budget and Control Board.

Long-Term Life-Skill Transfer From Sport-Based Positive Youth Development Programs, Travis R. Scheadler, Dawn Anderson Butcher, Samantha Bates

Journal of Youth Development

No abstract provided.

Assessing Staff-Youth Interaction Quality: Using The Class To Evaluate Afterschool Programs, Joel M. Hektner, Debarati Kole, Vimbayi Chinopfuktwa, Shawn L. Carlson

Journal of Youth Development

No abstract provided.

Clemson Commencement Program, August 2024, Clemson University

Clemson Commencement Programs

No abstract provided.

Survey Of Nematodes Associated With Strawberry In South Carolina And Evaluation Of Short-Term Heat Exposure On Nematode Reproduction Biology, Ivan A. Alarcon Mendoza

All Theses

Nematodes are a growing threat to the multi-billion-dollar strawberry industry in the US due to the lack of safe and effective management methods. Limited information on the distribution of nematodes in fumigated plasticulture strawberry fields further complicates their management. Additionally, climatic anomalies like rising soil temperatures and heat waves are occurring more often, and their impact on crop growth and nematode reproduction is not well understood. The current study was conducted with two main objectives: i) understand distribution and population densities of nematodes associated with plasticulture strawberry production in South Carolina, and ii) understand the impact of short-term high heat …

Disease Ecology Of The Caribbean Spiny Lobster Panulirus Argus: The Effect Of A Nemertean Egg Predator, Carcinonemertes Conanobrieni, On The Host's Reproductive Performance And Active Parental Care, Natalie C. Stephens

All Theses

Anthropogenic stressors and climate change are contributing to the rapid deterioration of marine ecosystems and the important ecological services they provide to coastal communities; concomitantly, this allows infectious agents that cause disease to proliferate in marine environments. At the forefront of marine disease ecology are the impacts of pathogens and parasites on commercially and recreationally exploited decapod crustaceans, including the Caribbean spiny lobster Panulirus argus. While there are few pathogens and parasites known to infect P. argus, emerging threats such as the nemertean micro-egg predator Carcinonemertes conanobrieni pose new, unexposed problems across its Greater Caribbean distribution. Beyond its …

Sustainability Across The Food System In The Southeastern United States: Mitigating Restaurant Plate Waste And Exploring Peach Orchard Viability Amidst Armillaria Root Rot, Samuel Francis

All Theses

In 2023, 5.6% ($1.5 trillion dollars) of the United States’ Gross Domestic Product was derived from agriculture, food, and related industries. Despite the sector being efficient, challenges still exists. For example, food waste is a problem in the hospitality industry and farmers face challenges related to disease. To ensure the security and efficiency of the food supply, it is in our best interest to make adjustments in these sectors by taking actions such as reducing waste and mitigating food loss associated with disease. I explore two areas of the food supply that can benefit from changes, seeking to mitigate food …

Effects Of Interrupting The Scotophase Period On Bone Health And Performance Of Laying Hens, Alexis J. Clark

All Theses

This thesis aimed to evaluate the effects of interrupting the daily scotophase period on bone health and production in laying hens. Modern commercial laying hens are prone to high rates of bone demineralization due to the constant mobilization of calcium to withstand daily eggshell calcification mechanisms. The industry light standard for laying hens is 16 hours of continuous light (photophase) and 8 hours of continuous darkness (scotophase) daily. During scotophase, physical activity is reduced due to instinctive perching behaviors, and thus, feeding behaviors are halted. However, physiological processes, including digestion, excretion, and reproduction, remain active during scotophase.

Most eggshell formation …

Elucidating The Roles Of Septin Proteins In Thermotolerance And Cell Wall Integrity In Cryptococcus Neoformans, Stephani S. Martinez Barrera

All Dissertations

Cryptococcus neoformans is a globally distributed fungal pathogen responsible for causing cryptococcal meningitis in immunocompromised individuals. This pathogenic yeast must adapt to changes in temperature upon entering the human host. Septin proteins are conserved filament-forming GTPases that assemble as higher-order complexes at the cell cortex to support cytokinesis and morphogenesis in fungal and animal cells. In C. neoformans, four septin homologs (Cdc3, Cdc10, Cdc11, and Cdc12) assemble at the mother-bud neck, contributing to cytokinesis through poorly understood mechanisms. C. neoformans strains lacking the septins Cdc3 or Cdc12 are viable at 25°C, but fail to proliferate at 37°C, and are …

Factors Influencing Adventitious Root Formation Of Floral Hemp In Propagation, Alexandra Carver

All Theses

Commercial propagators have reported relatively poor propagation success, e.g., <75% rooting, for many hemp (Cannabis sativa) cultivars. These rooting percentages have a significant economic impact due to the wasted labor, space and supplies. Also, the market demands 100% of the propagation cells in a tray to be fully rooted, thus repairing and replacing poorly rooted or unrooted cuttings requires significant labor cost. The goal of this thesis was to evaluate several factors that influence adventitious root formation of hemp stem cuttings.

Chapter 2 describes an experiment conducted to identify rooting hormone treatments that could improve propagation success. Sixteen combinations of indole-3-butyric acid (IBA; 0, …

Influence Of Row Pattern And Prohexadione Calcium On Peanut (Arachis Hypogaea L.) Maturity And Profitability, Samantha N. Mehl

All Theses

Many newer peanut cultivars offer yield benefits but have larger canopies and are taking 10 or more days longer to reach desired maturity levels. Prohexadione calcium (PC) and twin row planting pattern have been reported to increase the amount of orange, brown or black pods compared to their respective alternatives. Four cultivars were selected and studied based on frequency of use in South Carolina then paired into an earlier maturing group that reached optimal maturity at 135 to 140 days after planting, and a later maturing group that reached optimal maturity at 150 or more days after planting.

Twin row …

Interactions Between High-Pressure Processing And Natural Antimicrobials In Ground White-Meat Chicken: An Analysis Of Microbial, Textural Charactheristics And Physicochemical Changes, Amalia M. Diaz Alejandro

All Theses

High Pressure processing is an innovative technique for preserving a wide variety of foods, including meat, and this method is increasingly used to satisfy consumer demand for quality food products. High-pressure treatment can impact, negatively or positively, various aspects of meat quality, including color, texture, protein denaturation, and microbial stability, particularly when food products are processed at ambient or low temperatures. By minimizing thermal exposure, appropriate high-pressure ranges help to prevent quality and nutrition degradation, reduce microbial contamination, and enhance tenderness.

The first objective of this research was to examine the influence of high-pressure processing and addition of natural antimicrobials …

Exploring The Motivations And Determinants Of Farmer’S Market Consumers And Organic Specialty Crop Producers, Jane Arnold

All Theses

This two-chapter thesis evaluates the motivations and determinants of the central figures in farmers’ markets and organic markets. The first chapter explores the rise of farmers’ markets popularity through an in-person survey that was designed and distributed to 274 farmers' market consumers. Logit and ordered logit regressions were used to identify the motivations and characteristics that affect the likelihood of being a frequent farmers’ market customer (visiting 5 times or more per season) and spending over $50. The second chapter investigates the organic markets for cucumber and kale, which are dominant specialty crops on today’s grocery shelves. To identify the …

Don't Waste Our Time: Key Transformative Structures For Fast Track Learning, Carlita S. King

All Dissertations

Following a massive wave of school closures during the COVID-19 pandemic, educators found the need to be hyper-critical of how they spend their instructional time with students. Almost all students are expected to return nearly a full grade-level behind and would likely have to learn to navigate a completely new school environment. As a result, many educators were overwhelmed to cover unprecedented amounts of instructional content in less time. High-intensity tutoring programs have been known to have the potential to help struggling students advance their skills and gain up to three additional months of learning within a few sessions. The …

Effect Of Long-Term Use Of Antimicrobials On Commonly Used Surfaces In Foodservice Establishments, Anuradhi Bandaranayake

All Dissertations

none

Mental Health Of Healthcare Workers In Kosovo During The Covid-19 Pandemic, Latif Hoxha

All Dissertations

ABSTRACT

This study explored the mental health of healthcare practitioners in Kosovo during the COVID-19 pandemic, focusing on the prevalence of stress, depression, and anxiety, and the associated individual, family, and work-related factors. The research employed a cross-sectional design with a sample of 449 healthcare workers from two hospitals in Kosovo. The Depression, Anxiety, and Stress Scale (DASS-21) was used to assess mental health symptoms, while socio-demographic and work-related information was collected through a questionnaire.

Based on the descriptive statistics of DASS-21 scores, the prevalence of mental health issues among the participants included high levels of depression (18%), anxiety (25%), …

Ensuring The Privacy Compliance Of Voice Personal Assistant Applications, Song Liao

All Dissertations

Voice Personal Assistants (VPA) such as Amazon Alexa and Google Assistant are quickly and seamlessly integrating into people’s daily lives. Meanwhile, the increased reliance on VPA services raises privacy concerns, such as the leakage of private conversations and sensitive information. Privacy policies play an important role in addressing users’ privacy concerns and developers are required to provide privacy policies to disclose their apps’ data practices. In addition, voice apps targeting users in European countries are required to comply with the GDPR (General Data Protection Regulation). However, little is known about whether these privacy policies are informative and trustworthy on emerging …

Assessment Of American Tannin-Free Grain Sorghum As Feedstuff For Poultry: Nutrient Composition, Amino Acid Digestibility And Bird Performance, Santiago Sasia

All Dissertations

Given the rising cost of poultry diets, alternative ingredients like sorghum are crucial for maximizing returns without compromising product quality. Sorghum's drought tolerance and adaptability, along with its nutritional profile, make it a viable corn substitute. This dissertation examines the nutrient composition, amino acid digestibility, and performance of poultry fed with American tannin-free grain sorghum. Chapter II evaluates the impact of sorghum-based diets, with or without phytase superdosing, on broiler performance, including body weight, weight gain, feed intake, and feed conversion ratio. Results indicate that sorghum can replace corn without adverse effects on broiler performance. Chapter III explores the partial …

On Counter-Memes: A Rhetorical Study Of Allyship In Social Media Memetics From 2015-2024, Kaitlyn Samons

All Dissertations

This dissertation examines the importance of Online allyship through a newly coined term in Memetics and Mis- and Disinformation: “Counter-Memeship.” This work combines previous contributing works on “memes,” “counter-memes,” “counter-stories,” and “allyship” through the lens of feminist, white, and communication theories. Internet memes and studies are explored by looking at how Online participants in internet spaces interact with each other in modern-day protests in memetic ways. The researcher utilizes descriptive and exploratory methods to articulate better how internet memes work between 2015 and 2024. The primary purpose of this research is to see whether Online protests can be considered non-performative …