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Recent Advances In The Synthesis And Application Of Sf5-Containing Organic Compounds, Andrej V. Matsnev, Steven P. Belina, Si-Yan Qing, Kyle A. Berger, Anthony R. Scavuzzo, Piotr Dudzinski, Anna-Lena Dreier, Günter Haufe, Joseph S. Thrasher

Chemistry Annual Research Symposium

It is well known that fluorinated molecules play an important role in daily life. For example, organic molecules bearing either a fluorine atom itself or a short polyfluorinated substituent such as mono-, difluoro-, and trifluoromethyl groups, or pentafluoroethyl and perfluoropropyl groups are already widely used in medicinal and agricultural chemistry. In contrast, molecules with long perfluorinated chains have found vast application in materials science. Among the fluorine-containing moieties, the pentafluorosulfanyl (SF5) substituent occupies a special place.1 The pentafluorosulfanyl group brings unique properties to organic compounds and often improves their biological activities due to the group’s high chemical and metabolic stability, …

Development And Application Of Cu-Modified Carbon Electrodes From Pyrolyzed Paper Strips, Gema M. Durán, Tomás E. Benavidez, Jason Giuliani, Ángel Ríos, Carlos D. Garcia

Chemistry Annual Research Symposium

A one-step approach for the synthesis and integration of copper nanoparticles (CuNPs) onto paper-based carbon electrodes is herein reported. The method is based on the pyrolysis (1000 ºC under a mixture of 95% Ar / 5% H2 for 1 hour) of paper strips modified with a saturated solution of CuSO4 and yields to the formation of abundant CuNPs on the surface of carbonized cellulose fibers. The resulting substrates were characterized by a combination of scanning electron microscopy, EDX, Raman spectroscopy as well as electrical and electrochemical techniques. Their potential application, as working electrodes for non-enzymatic amperometric determination of glucose, was …

A Smart Polymer Hydrogel As A Chemical Sensor On Biomedical Implant, Md Arifuzzaman, Caleb Behrend, John Desjardins, Jeffrey N. Anker

Chemistry Annual Research Symposium

Orthopedic implants are manufactured to support on healing fractured bones. In United States, over 2 million fracture fixation devices, including intra-medullary nails, external fixation pins, plates, and screws, and over 600 thousands joint prostheses, are implanted in patients annually. While fairly common, these fixation surgeries (5%) sometimes lead to unavoidable infection, which only amplifies health care costs accumulated from the initial procedures. In most cases, bacterial biofilms acutely causes infection which is a major reason of medical device failure. In order to obtain proper infections detection around biomedical implants a non-invasive chemical sensor is required. In vivo detection of low …

Electrochemically-Preadsorbed Collagen Promotes Adult Human Mesenchymal Stem Cell Adhesion On Carbon Nanostructured Substrates, Tomás E. Benavidez, Marissa E. Wechsler, Madeleine M. Farrer, Rena Bizios, Carlos D. Garcia

Chemistry Annual Research Symposium

The effect of electric potential on the adsorption of collagen type I onto optically transparent carbon electrodes (OTCE) and its mediation on subsequent adhesion of adult, human, mesenchymal stem cells (hMSCs) is described. Adsorption was investigated as a function of the protein concentration and applied potential. The resulting substrate surfaces were characterized using spectroscopic ellipsometry (SE), atomic force microscopy (AFM), and cyclic voltammetry (CV). While the higher applied potential and protein concentration, the higher the adsorbed amount, the application of potential values higher than +800 mV resulted in the oxidation of the adsorbed protein. Subsequent adhesion of hMSCs on the …

Liquid Sampling-Atmospheric Pressure Glow Discharge Ion Source For Nonproliferation Of Nuclear Material, Edward Hoegg, R. Kenneth Marcus, Charles Barinaga, George Hager, David Koppenaal, Garret Hart

Chemistry Annual Research Symposium

An area of continuing intense interest has been the development of portable or fieldable (man-portable, luggable, or transportable) analytical instrumentation. One specific driver for portable or fieldable analytical instrumentation are the needs of the nuclear safeguards community for versatile, easy-to-use, in-field mass spectrometer systems for determining the 235U/238U isotope ratios in UF6 at enrichment facilities. In order to meet this demand the authors propose using a liquid sampling-atmospheric pressure glow discharge (LS-APGD) ion source, Fig 1.1-3 The LS-APGD was optimized for isotope ratio analysis to have a liquid flow rate of 30 uL min-1 a gas flow rate of 0.5 …

Investigation Of Ionic And Electronic Conductivities In Modified Carbon/Zirconia Composites, Jamie A. Shetzline, Jung-Min Oh, Stephen E. Creager

Chemistry Annual Research Symposium

Ionic and electronic conductivities were recently shown to be able to be independently probed utilizing a near-DC based method for free standing thin films containing mixtures of nafion and carbon black. Recently the mixed conductivity methodology was extended to packed powders in order to study ionic and electronic conductivities of carbon/zirconia nano composite materials for which molecular and polymer electrolytes were covalently grafted onto the carbon/zirconia particle surfaces. The method relies upon careful control of the nature of the contact between the sample and the current-carry-ing electrodes, as well as the geometry of the sample configuration.

Human Insulin Adsorption To Monolayer Graphene. A Molecular Dynamics Study., Richard Overstreet, Brian Dominy

Chemistry Annual Research Symposium

Molecular dynamics simulations were conducted using the CHARMM22 potential and TIP3P solvent to model human insulin adsorption to graphene. TIP3P explicit solvent was used to capture the hydrophobic effect, the mechanism responsible for the adsorption of proteins to hydrophobic surfaces. This water model was originally parameterized for the CHARMM22 potential and amino acid residues thus it was required to develop Lennard-Jones graphene carbon parameters to reproduce the empirical water graphite contact angle of 86 degrees. Adsorption was modeled with three different orientations about the graphene monolayer. Insulin shows varying degrees of adsorption surface area and correlated binding affinity due to …

Fast Production Of Microfluidic Devices By Co2 Laser Engraving Of Wax-Coated Glass Slides, Eric T. Da Costa, Mauro F.S. Santos, Hong Jiao, Claudimir L. Do Lago, Ivano G.R. Gutz, Carlos D. Garcia

Chemistry Annual Research Symposium

Glass is one of the most convenient materials for the development of microfluidic devices. However, most of the fabrication protocols, require long processing times and expensive facilities. Polymeric materials have been extensively used due to the fast and low-cost production methods. Ablation by CO2 laser has been used to prototype on polymeric materials, but is difficult to extend to glass devices, because the local heating causes surface cracking. We herein describe a simple procedure to produce microfluidic devices for capillary electrophoresis from microscope glass slides.

In Silico Model For Naatm1 Type Atp Binding Cassette Exporter Conformational Transitions, Yinling Liu, Brian N. Dominy

Chemistry Annual Research Symposium

No abstract provided.

Insights Into The Effect Of Metal Ions And Conformational Change On Binding Between Protective Antigen And Tumor Endothelial Marker 8, Zhe Jia, Christine Ackroyd, Kenneth Christensen, Brian Dominy

Chemistry Annual Research Symposium

No abstract provided.

Factors Associated With Anaplasma Spp. Seroprevalence Among Dogs In The United States, Christopher S. Mcmahan, Dongmei Wang, Melissa J. Beall, Dwight D. Bowman, Susan E. Little, Patrick O. Pithua, Julia L. Sharp, Roger W. Stich, Michael J. Yabsley, Robert B. Lund

Publications

Background

Dogs in the United States are hosts to a diverse range of ticks and tick-borne pathogens, including A. phagocytophilum, an important emerging canine and human pathogen. Previously, a Companion Animal Parasite Council (CAPC)-sponsored workshop proposed factors purported to be associated with the infection risk for tick-transmitted pathogens in dogs in the United States, including climate conditions, socioeconomic characteristics, local topography, and vector distribution.

Methods

Approximately four million test results from routine veterinary diagnostic tests from 2011–2013, which were collected on a county level across the contiguous United States, are statistically analyzed with the proposed factors via logistic regression …

Synchronization Of Pulse-Coupled Oscillators To A Global Pacemaker, Felipe Nunez, Yongqiang Wang, Andrew R. Teel, Francis J. Doyle Iii

Publications

Pulse-coupled oscillators (PCOs) are limit cycle oscillators coupled by exchanging pulses at discrete time instants. Their importance in biology and engineering has motivated numerous studies aiming to understand the basic synchronization properties of a network of PCOs. In this work, we study synchronization of PCOs subject to a global pacemaker (or global cue) and local interactions between slave oscillators. We characterize solutions and give synchronization conditions using the phase response curve (PRC) as the design element, which is restricted to be of the delay type in the first half of the cycle, interval (0,π)(0,π), and of the advance type in …

Performance Considerations Of Network Functions Virtualization Using Containers, Jason Anderson, Udit Agarwal, Hongda Li, Hongxin Hu, Craig Lowery, Amy W. Apon

Publications

The network performance of virtual machines plays a critical role in Network Functions Virtualization (NFV), and several technologies have been developed to address hardware-level virtualization shortcomings. Recent advances in operating system level virtualization and deployment platforms such as Docker have made containers an ideal candidate for high performance application encapsulation and deployment. However, Docker and other solutions typically use lower-performing networking mechanisms. In this paper, we explore the feasibility of using technologies designed to accelerate virtual machine networking with containers, in addition to quantifying the network performance of container-based VNFs compared to the state-of-the-art virtual machine solutions. Our results show …

Decision Support System For Optimally Managing Water Resources To Meet Multiple Objectives In The Savannah River Basin, Edwin A. Roehl, Jr., Paul A. Conrads

Journal of South Carolina Water Resources

Managers of large river basins face conflicting demands for water resources such as wildlife habitat, water supply, wastewater assimilative capacity, flood control, hydroelectricity, and recreation. The Savannah River Basin, for example, has experienced three major droughts since 2000 that resulted in record low water levels in its reservoirs, impacting dependent economies for years. The Savannah River estuary contains two municipal water intakes and the ecologically sensitive freshwater tidal marshes of the Savannah National Wildlife Refuge. The Port of Savannah is the fourth busiest in the United States, and modifications to the harbor to expand ship traffic since the 1970s have …

Use Of A Volunteer Monitoring Program To Assess Water Quality In A Tmdl Watershed Utilized For Recreational Use, Pickens County, South Carolina, Travis H. Nation, Leah A. Johnson

Journal of South Carolina Water Resources

Municipalities, regulatory agencies, and resource advocacy organizations are often tasked with the enormous responsibility of monitoring water quality and implementing management strategies for vast areas within their jurisdictions. A potential means for addressing the resulting sampling shortfall is the use of volunteer monitoring programs. The project reported herein demonstrates the use of QA/QC protocols developed by Georgia Adopt-a-Stream (AAS) to monitor water quality issues for Twelve Mile Creek located in Pickens County, SC. The Twelve Mile watershed has a storied past as a U.S. EPA Superfund site due to industrial PCB contamination. Recent mitigation efforts involving the removal of two …

Journal Of South Carolina Water Resources Volume 2, Issue 1

Journal of South Carolina Water Resources

In our day-to-day work, ‘managing messes’ seems like an apt description of how we react to what needs to be done. I started this note last July when South Carolina was in the midst of a mild yet potentially deepening drought. The early October storm turned things upside down, disrupting the state, leading to the deaths of a dozen people, and producing damage estimated to be in the billions of dollars. As of November 10, Charleston has recorded 71 inches of rain and should surpass the record yearly rainfall of 73 inches, set in 1964.

As we work on recovery …

Interstate Water Compacts: Partnerships For Transboundary Water Resource Management, Cindy G. Roper

Journal of South Carolina Water Resources

While there are both successes and challenges related to the use of interstate water compacts, in their most effective forms they allow states to take a comprehensive, holistic approach to water management. Successful compacts tend to encompass the natural hydrologic boundaries of the water basin. They are more likely to utilize a commission type governance structure with sufficient authority to carry out the mission and goals of the compacting agreement. Successful compacts are flexible and allow for future developments (including climate change) while being cognizant of the need to protect and enhance the environment. They are also sensitive to the …

Model Results And Software Comparisons In Myrtle Beach, Sc Using Virtual Beach And R Regression Toolboxes, Matthew J. Neet, R. Heath Kelsey, Dwayne E. Porter, Dan W. Ramage, Adrian B. Jones

Journal of South Carolina Water Resources

Utilizing R software and a variety of data sources, daily forecasts of bacteria levels were developed and automated for beach waters in Myrtle Beach, SC. Modeled results are then shown for beach locations via a website and mobile device app. While R provides a robust set of tools for use in forecast modeling, the software has an extensive learning curve and requires skilled statistical interpretation of results. The Environmental Protection Agency (EPA) created the “Virtual Beach” software package to address these concerns. To evaluate the utility of the more user-friendly Virtual Beach modeling toolbox, predictive models were developed and model …

Groundwater Recharge Rates In Isolated And Riverine Wetlands: Influencing Factors, Chenille Williams, Dan Tufford

Journal of South Carolina Water Resources

Isolated wetlands and riverine wetlands have been shown to have similar groundwater hydrology despite their difference in topography and surface water hydrology. The current study aimed to address the impact of topography and surface water hydrology on groundwater hydrologic behavior by comparing the groundwater recharge rates of several isolated and riverine wetlands in the Coastal Plain of South Carolina. Study sites contained an isolated wetland, a riverine wetland, and an upland that bisected the two wetland types. Shallow water tables and sandy soils, allowed a rapid response to precipitation to be clearly visible. Soil characteristics, water table fluctuations, and precipitation …

South Carolina's Climate Report Card: The Influence Of The El Niño Southern Oscillation Cold Warm Event Cycles On South Carolina's Seasonal Precipitation, Hope Mizzell, Jennifer Simmons

Journal of South Carolina Water Resources

This study was driven by the need to better understand variations in South Carolina’s seasonal precipitation. Numerous weather-sensitive sectors such as agriculture and water resource management are impacted by the seasonal variability and distribution of precipitation. Studies have shown that El Niño-Southern Oscillation (ENSO) has varying effects on seasonal temperature and precipitation across the United States.

The purpose of this study was to determine the relative influence of ENSO cold and warm event cycles on interannual variations of South Carolina’s seasonal precipitation (1950- 2015). The relationship between seasonal precipitation departures from normal and the average Multivariate ENSO Index was analyzed. …

Watershed-Based Planning For Murrells Inlet: Source Assessment Of Fecal Bacteria Using Volunteer And Shellfish Sanitation Program Data, Susan Libes, Heather Young, Daniel Newquist, Sue Sledz

Journal of South Carolina Water Resources

A watershed-based plan was recently developed for Murrells Inlet, a moderately tidal, euhaline estuary located on the northern coast of South Carolina. One of the goals of this planning effort was to collate and analyze existing data to refine assessments of the sources of fecal coliform detected by SC DHEC’s shellfish monitoring program. Coastal Carolina University’s Waccamaw Watershed Academy (WWA) was engaged to lead this data analysis effort. The most important sources identified were urbanized wildlife and canines. Results from the data analyses were used to prioritize subwatersheds for remediation. This has led to proposed strategies that focus on interception …

Analysis Of Climate Change And 24-Hour Design Storm Depths For A Range Of Return Periods Across South Carolina, Derek Hutton, Nigel B. Kaye, William D. Martin Iii

Journal of South Carolina Water Resources

A warming climate leads to a moister atmosphere and more rapid hydrologic cycle. As such, many parts of the country are predicted to experience more total rainfall per year and more frequent extreme rainfall events. Most regions of the country have stormwater systems designed to a standard that matches outflow rates to pre-development values for specified return period storms. Increases in these return period storm depths, as predicted by many global climate models, will stress existing stormwater infrastructure. This paper examines how rainfall patterns will change over the remainder of the century across the state of South Carolina.

Rainfall simulations …

Water Budget Of A Shallow Aquifer In The Lower Coastal Plain: Ace Basin, Sc, Rachael L.A. Kassabian, Timothy J. Callahan, Saundra Upchurch

Journal of South Carolina Water Resources

The expansive tidal salt marshes of South Carolina support a unique and sensitive ecosystem providing environmental and economic value to the coastal community. These tidal ecosystems are often altered by sea level rise through various processes, including the lesser-known stress of saltwater intrusion in groundwater systems. The goal of this research was to measure the baseline groundwater dynamics of an undeveloped tidal saltmarsh. Groundwater wells were installed along transects from the upland into the marsh and a culminating water budget of the watershed was developed. Analysis of water table dynamics showed that in the upland zone, evapotranspiration and precipitation were …

Watershed Plan Implementation Challenges For Sms4s In Murrells Inlet, Dave Fuss, Dan Newquist, Sue Sledz, Tracy Jones, Daniel R. Hitchcock

Journal of South Carolina Water Resources

This case study describes the plan development process, implementation strategies and initial and future challenges to implementation for the Murrells Inlet Watershed Plan (WRCOG, 2014). The Plan was crafted by a group of key stakeholders with community support and guidance to address fecal coliform bacteria loading in shellfish harvesting waters in the Murrells Inlet Estuary along the northeastern South Carolina coast. Stakeholders debated the interpretation of the data analysis and ultimately concluded that the primary pollutant sources were non-human, namely wildlife and domestic animals. Stakeholders also concluded that the loads from these sources were being delivered to the estuary via …

Hydraulic Geometry Curves In The Pee Dee Watershed, Z.T. Smoot, A.D. Jayakaran, D.R. Hitchcock

Journal of South Carolina Water Resources

Hydraulic bankfull geometry or regional curves are a useful metric for evaluating stream stability and planning stream restoration projects. Streams and tributaries within the Middle Pee Dee River Basin (MPDRB) in South Carolina drain an agrarian and forested landscape characterized by water conveyance structures, such as active and historical ditches which support forestry and agriculture. While streams in the region are generally stable, pockets of this landscape are beginning to face increasing pressure from development with signs of stream instability apparent in several locations as evidenced by streams in and around the urbanizing areas around Darlington and Florence, SC. In …

Comprehensive Annual Financial Report For The Year Ended June 30, 2015, Clemson University

Annual Comprehensive Financial Report

No abstract provided.

Upic Magazine, Issue 5, Center For Career And Professional Development

UPIC Magazine

Every semester, undergraduate students from every major and staff from every part of Clemson University join together through UPIC internships. These paid internships grant students real, on the job experience in professional fields and offer staff a chance to mentor some of Clemson’s most brilliant students.

To find out more about the UPIC Program, visit career.clemson.edu/internship_programs

UPIC is part of Clemson’s Center for Career and Professional Development

Common Data Set 2015-2016, Clemson University

Common Data Sets

No abstract provided.

Intentional Process For Intentional Space: Higher Education Classroom Spaces For Learning, Taimi Olsen, Stanley Guffey

Publications

This chapter addresses the confluence of theory and practice in developing and using “flexible” classrooms for student learning. A large classroom building renovation will be described, in terms of how collaboration and co-creation of value led to early success of the renovated space. Co-creation of value for staff and faculty can help overcome initial resistance to change, bridge understanding, and drive a successful change from lecture-based teaching to growing use of active learning pedagogies. At the University of Tennessee, Knoxville, co-creation was central to planning, conducting, and sustaining a renovation of space into flexible, technology-enhanced classrooms and changing classroom pedagogy.

Persistent Teaching Practices After Geospatial Technology Professional Development, Lori A. Rubino-Hare, Brooke A. Whitworth, Nena E. Bloom, Jennifer M. Claesgens, Kristi M. Fredrickson, James C. Sample

Publications

This case study described teachers with varying technology skills who were implementing the use of geospatial technology (GST) within project-based instruction (PBI) at varying grade levels and contexts 1 to 2 years following professional development. The sample consisted of 10 fifth- to ninth-grade teachers. Data sources included artifacts, observations, interviews, and a GST performance assessment and were analyzed using a constant comparative approach. Teachers’ teaching actions, beliefs, context, and technology skills were categorized. Results indicated that all of the teachers had high beliefs, but their context and level of technology skills strongly influenced their teaching actions. Two types of teachers …