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Slow Dissociation Of A Charged Ligand: Analysis Of The Primary Quinone Qa Site Of Photosynthetic Bacterial Reaction Centers, Jennifer Madeo, Maja Mihajlovic, Themis Lazaridis, M. R. Gunner

Publications and Research

Reaction centers (RCs) are integral membrane proteins that undergo a series of electron transfer reactions during the process of photosynthesis. In the QA site of RCs from Rhodobacter sphaeroides, ubiquinone-10 is reduced, by a single electron transfer, to its semiquinone. The neutral quinone and anionic semiquinone have similar affinities, which is required for correct in situ reaction thermodynamics. A previous study showed that despite similar affinities, anionic quinones associate and dissociate from the QA site at rates ≈104 times slower than neutral quinones indicating that anionic quinones encounter larger binding barriers (Madeo, J.; Gunner, M. R. Modeling binding kinetics at …

The Accuracy Of The Electrocardiogram During Exercise Stress Test Based On Heart Size, Jason C. Siegler, Shafiq Rehman, Geetha P. Bhumireddy, Raushan Abdula, Igor Klem, Sorin J. Brener, Leonard Lee, Christopher C. Dunbar, Barry Saul, Terrence J. Sacchi, John F. Heitner

Publications and Research

Background Multiple studies have shown that the exercise electrocardiogram (ECG) is less accurate for predicting ischemia, especially in women, and there is additional evidence to suggest that heart size may affect its diagnostic accuracy. Hypothesis The purpose of this investigation was to assess the diagnostic accuracy of the exercise ECG based on heart size. Methods We evaluated 1,011 consecutive patients who were referred for an exercise nuclear stress test. Patients were divided into two groups: small heart size defined as left ventricular end diastolic volume (LVEDV) <65 mL (Group A) and normal heart size defined as LVEDV ≥65 mL (Group B) and associations between ECG outcome (false positive vs. no false positive) and heart size (small vs. normal) were analyzed using the Chi square test for independence, with a Yates continuity correction. LVEDV calculations were performed via a computer-processing algorithm. SPECT myocardial perfusion imaging was used as the gold standard for the presence of coronary artery disease (CAD). Results Small heart size was found in 142 patients, 123 female and 19 male patients. There was a significant association between ECG outcome and heart size (χ2 = 4.7, p = 0.03), where smaller hearts were associated with a significantly greater number of false positives. Conclusions This study suggests a possible explanation for the poor diagnostic accuracy of exercise stress testing, especially in women, as the overwhelming majority of patients with small heart size were women.

Comparative Genomics Of The Pathogenic Ciliate Ichthyophthirius Multifiliis, Its Free-Living Relatives And A Host Species Provide Insights Into Adoption Of A Parasitic Lifestyle And Prospects For Disease Control, Robert S. Coyne, Linda Hannick, Dhanasekaran Shanmugam, Jessica B. Hostetler, Daniel Brami, Vinita S. Joardar, Justin Johnson, Diana Radune, Irtisha Singh, Jonathan H. Badger, Ujjwal Kumar, Milton Saier, Yufeng Wang, Hong Cai, Jianying Gu, Michael W. Mather, Akhil B. Vaidya, David E. Wilkes, Vidyalakshmi Rajagopalan, David J. Asai, Chad G. Pearson, Robert C. Findly, Harry W. Dickerson, Martin Wu, Cindy Martens, Yves Van De Peer, David S. Roos, Donna M. Cassidy-Hanley, Theodore G. Clark

Publications and Research

Background

Ichthyophthirius multifiliis, commonly known as Ich, is a highly pathogenic ciliate responsible for 'white spot', a disease causing significant economic losses to the global aquaculture industry. Options for disease control are extremely limited, and Ich's obligate parasitic lifestyle makes experimental studies challenging. Unlike most well-studied protozoan parasites, Ich belongs to a phylum composed primarily of free-living members. Indeed, it is closely related to the model organism Tetrahymena thermophila. Genomic studies represent a promising strategy to reduce the impact of this disease and to understand the evolutionary transition to parasitism.

Results

We report the sequencing, assembly and annotation …

Group 11 Metal Compounds With Tripodal Bis(Imidazole) Thioether Ligands. Applications As Catalysts In The Oxidation Of Alkenes And As Antimicrobial Agents, Fangwei Liu, Reema Anis, Eunmi Hwang, Rafael Ovalle, Armando Varela-Ramírez, Renato J. Aguilera, María Contel

Publications and Research

New group 11 metal complexes have been prepared using the previously described tripodal bis(imidazole) thioether ligand (N-methyl-4,5-diphenyl-2- imidazolyl)2C(OMe)C(CH3)2S(tert-Bu) ({BITOMe,StBu}, 2). The pincer ligand offers a N2S donor atom set that can be used to coordinate the group 11 metals in different oxidation states [AuI , AuIII, AgI , CuI and CuII]. Thus the new compounds [Au{BITOMe,StBu}Cl][AuCl4]2 (3), [Au{BITOMe,StBu}Cl] (4), [Ag{BITOMe,StBu}X] (X = OSO2CF3 - 5, PF6 - 6) and [Cu{BITOMe,StBu}Cl2] (7) have been synthesized from reaction of 2 with the appropriate metal precursors, and characterized in solution. While attempting characterization in the solid state of 3, single crystals of the …

Bone Morphogenetic Protein Inhibition Promotes Neurological Recovery After Intraventricular Hemorrhage, Krishna Dummula, Govindaiah Vinukonda, Philip Chu, Yiping Xing, Furong Hu, Sabrina Mailk, Anna Csiszar, Caroline Chua, Peter Mouton, Robert J. Kayton, Joshua C. Brumberg, Rashmi Bansal, Praveen Ballabh

Publications and Research

Intraventricular hemorrhage (IVH) results in neural cell death and white matter injury in premature infants. No therapeutic strategy is currently available against this disorder. Bone morphogenetic protein (BMP) signaling suppresses oligodendrocyte development through basic-helix-loop-helix (bHLH) transcription factors and promotes astrocytosis. Therefore, we hypothesized that IVH in premature newborns initiates degeneration and maturation arrest of oligodendrocyte lineage and that BMP inhibition alleviates hypomyelination, gliosis, and motor impairment in the survivors of IVH. To test the hypotheses, a rabbit model of IVH was used in which premature rabbit pups (E29) are treated with intraperitoneal glycerol at 2 hours of age to induce …

Stream Recession Curves And Storage Variability In Small Watersheds, Nir Y. Krakauer, Marouane Temimi

Publications and Research

The pattern of streamflow recession after rain events offers clues about the relationship between watershed runoff (observable as river discharge) and water storage (not directly observable) and can help in water resource assessment and prediction. However, there have been few systematic assessments of how streamflow recession varies across flow rates and how it relates to independent assessments of terrestrial water storage. We characterized the streamflow recession pattern in 61 relatively undisturbed small watersheds (1–100 km2 ) across the coterminous United States with multiyear records of hourly streamflow from automated gauges. We used the North American Regional Reanalysis to help identify …

Computational Insight With Monte Carlo Simulations, Boyan Kostadinov

Publications and Research

We introduce Monte Carlo simulations for estimating areas by playing a game of "darts". We also introduce simulations of random walks. We use compact, vectorized programming, based on the R language, for all computer simulations and visualizations, aimed at high school students. This presentation is based on the Invited, prime time lecture given at the summer camp for gifted high school students at City College of New York, July 13, 2011.

The Role Of Information Technology In Fulfilling The Promise Of Corporate Social Responsibility, David Salb, Hershey H. Friedman, Linda Weiser Friedman

Publications and Research

Young people today want to work at a meaningful job and make a difference in the world. Information technology (IT) is an effective enabler for all sorts of business strategies, so it comes as no surprise that IT is useful for implementing a firm's corporate social responsibility (CSR) initiative as well. The computer professional of the twenty-first century has the tools, training, and talent to be involved in strategic decision making that will have a lasting impact on society. Computer technology can be used to increase profits; but it can also be used to enhance the workplace, create adaptations for …

The Criminalization Of Peacemaking, Corporate Free Speech, And The Violence Of Interpretation: New Challenges To Cause Lawyering, Avi Brisman

City University of New York Law Review

No abstract provided.

Fathers' Time Investments In Children: Do Sons Get More?, Kristin Mammen

Publications and Research

Evidence suggests that, from birth, fathers treat sons differently than daughters in the U.S., as well as in developing countries. Fathers' time investments in children are one channel through which differential treatment by gender may affect children's outcomes. This paper uses data from the 2003 American Time Use Survey to explore three questions about paternal time in married two-parent families: Does the gender composition of his children affect the amount of time a father spends with them? If so, does the gender of the individual child have an additional effect? And is a girl advantaged or disadvantaged by the presence …

Redesigned With Them In Mind: Evaluating An Online Library Information Literacy Tutorial, Rebeca Befus, Katrina Byrne

Urban Library Journal

This study investigates Wayne State University Library System’s redesigned information literacy tutorial: re:Seach. Seventy-two students participating in the 2010 Wayne State Federal TRIO Student Support Service Summer Residential Program participated in the questionnaire. The questionnaire measured student learning via a multiple choice knowledge based test. Confidence and satisfaction were also measured using a five point Likert scale. Students received an overall average score of 71% on the knowledge portion and student responses varied on the confidence and satisfaction portions of the questionnaire. Results clearly indicated the necessity for future revisions. The discussion will address the specific revisions being undertaken and …

Conformational-Dependent And Independent Rna Binding To The Fragile X Mental Retardation Protein, Xin Yan, Robert B. Denman

Publications and Research

The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts produced by in vitro transcription contain a population of conformers, which can be modulated by preannealing. Accordingly, FMRP differentially binds to the annealed and unannealed conformer populations. Using partial RNase digestion, we demonstrate that annealed BC1 RNA contains a unique conformer that FMRP likely binds. We further demonstrate that this interaction is 100-fold weaker than that the binding of eEF-1A …

Fluid Shear Stress Regulates The Invasive Potential Of Glioma Cells Via Modulation Of Migratory Activity And Matrix Metalloproteinase Expression, Henry Qazi, Zhong-Dong Shi, John M. Tarbell

Publications and Research

Background Glioma cells are exposed to elevated interstitial fluid flow during the onset of angiogenesis, at the tumor periphery while invading normal parenchyma, within white matter tracts, and during vascular normalization therapy. Glioma cell lines that have been exposed to fluid flow forces in vivo have much lower invasive potentials than in vitro cell motility assays without flow would indicate. Methodology/Principal Findings A 3D Modified Boyden chamber (Darcy flow through collagen/cell suspension) model was designed to mimic the fluid dynamic microenvironment to study the effects of fluid shear stress on the migratory activity of glioma cells. Novel methods for gel …

The Fight For Public Higher Education In Staten Island: The Saga Of The College Of Staten Island, Mark Rivera

Publications and Research

The College of Staten Island has a unique history as part of the City University of New York (CUNY). The formation of the College of Staten Island coincides in many ways with the development of the borough of Staten Island and its struggle for acknowledge in the greater New York City. The article discusses how the institution was an outcome of compromise, conflict, politics, and desperation. The story begins with the development of the Richmond County/the Borough of Staten Island, the fight for New York City's first public community college, the establishment of New York City's first Upper Division Undergraduate …

Noncomputable Functions In The Blub-Shub-Smale Model, Wesley Calvert, Ken Kramer, Russell Miller

Publications and Research

Working in the Blum-Shub-Smale model of computation on the real numbers, we answer several questions of Meer and Ziegler. First, we show that, for each natural number d, an oracle for the set of algebraic real numbers of degree at most d is insufficient to allow an oracle BSS-machine to decide membership in the set of algebraic numbers of degree d + 1. We add a number of further results on relative computability of these sets and their unions. Then we show that the halting problem for BSS-computation is not decidable below any countable oracle set, and give a more …

Electrode Positioning And Montage In Transcranial Direct Current Stimulation, Alexandre F. Dasilva, Magdalena Sarah Volz, Marom Bikson, Felipe Fregni

Publications and Research

Transcranial direct current stimulation (tDCS) is a technique that has been intensively investigated in the past decade as this method offers a non-invasive and safe alternative to change cortical excitability2. The effects of one session of tDCS can last for several minutes, and its effects depend on polarity of stimulation, such as that cathodal stimulation induces a decrease in cortical excitability, and anodal stimulation induces an increase in cortical excitability that may last beyond the duration of stimulation6. These effects have been explored in cognitive neuroscience and also clinically in a variety of neuropsychiatric disorders – especially when applied over …

A Transcriptional Analysis Of Carotenoid, Chlorophyll And Plastidial Isoprenoid Biosynthesis Genes During Development And Osmotic Stress Responses In Arabidopsis Thaliana, Stuart Meier, Oren Tzfadia, Ratnakar Vallabhaneni, Chris Gehring, Eleanore T. Wurtzel

Publications and Research

Background The carotenoids are pure isoprenoids that are essential components of the photosynthetic apparatus and are coordinately synthesized with chlorophylls in chloroplasts. However, little is known about the mechanisms that regulate carotenoid biosynthesis or the mechanisms that coordinate this synthesis with that of chlorophylls and other plastidial synthesized isoprenoid-derived compounds, including quinones, gibberellic acid and abscisic acid. Here, a comprehensive transcriptional analysis of individual carotenoid and isoprenoid-related biosynthesis pathway genes was performed in order to elucidate the role of transcriptional regulation in the coordinated synthesis of these compounds and to identify regulatory components that may mediate this process in Arabidopsis …

A Statistical Method To Correct Radiometric Data Measured By Avhrr Onboard The National Oceanic And Atmospheric Administration (Noaa) Polar Orbiting Environmental Satellites (Poes), Md Zahidur Rahman, Leonid Roytman, Abdelhamid Kadik

Publications and Research

This paper apply an statistical technique to correct radiometric data measured by Advanced Very High Resolution Radiometers(AVHRR) onboard the National Oceanic and Atmospheric Administration (NOAA) Polar Orbiting Environmental Satellites(POES). This paper study Normalized Difference Vegetation Index (NDVI) stability in the NOAA/NESDIS Global Vegetation Index (GVI) data for the period 1982-2003. AVHRR weekly data for the five NOAA afternoon satellites NOAA-7, NOAA-9, NOAA-11, NOAA-14, and NOAA-16 are used for the China dataset, for it includes a wide variety or different ecosystems represented globally. GVI has found wide use for studying and monitoring land surface, atmosphere, and recently for analyzing climate and …

Lacuny Executive Council Meeting Minutes, May 2011, Lacuny

Meeting Minutes

No abstract provided.

Historical Legacies, Information And Contemporary Water Science And Management, Daniel J. Bain, Jennifer A. S. Arrigo, Mark B. Green, Brian A. Pellerin, Charles J. Vörösmarty

Advanced Science Research Center

Hydrologic science has largely built its understanding of the hydrologic cycle using contemporary data sources (i.e., last 100 years). However, as we try to meet water demand over the next 100 years at scales from local to global, we need to expand our scope and embrace other data that address human activities and the alteration of hydrologic systems. For example, the accumulation of human impacts on water systems requires exploration of incompletely documented eras. When examining these historical periods, basic questions relevant to modern systems arise: (1) How is better information incorporated into water management strategies? (2) Does any point …

Changes In The Regulatory Environment And There Effects On Audits And Auditors, Margaret Ann Wood

Publications and Research

No abstract provided.

Administrative Censoring In Ecological Analyses Of Autism And A Bayesian Solution, Scott M. Bartell, Thomas A. Lewandowski

Publications and Research

Widely cited ecological analyses of autism have reported associations with mercury emissions, with precipitation, and race at the level of counties or school districts. However, state educational agencies often suppress any low numerical autism counts before releasing data—a phenomenon known as “administrative censoring.” Previous analyses did not describe appropriate methods for censored data analysis; common substitution or exclusion methods are known to introduce bias and produce artificially narrow confidence intervals. We apply a Bayesian censored random effects Poisson model to reanalyze associations between 2001 Toxic Release Inventory reported mercury emissions and 2000-2001 autism counts in Texas. Relative risk estimates for …

Melting Trends Over The Greenland Ice Sheet (1958-2009) From Spaceborne Microwave Data And Regional Climate Models, X. Fettweis, Marco Tedesco, M. Van Den Broeke, J. Ettema

Publications and Research

To study near-surface melt changes over the Greenland ice sheet (GrIS) since 1979, melt extent estimates from two regional climate models were compared with those obtained from spaceborne microwave brightness temperatures using two different remote sensing algorithms. The results from the two models were consistent with those obtained with the remote sensing algorithms at both daily and yearly time scales, encouraging the use of the models for analyzing melting trends before the satellite era (1958–1979), when forcing data is available. Differences between satellite-derived and model-simulated results still occur and are used here to identify (i) biases in the snow models …

Roots Of Conflict: A Multi-Level Analysis Of The South Atlantic War Of 1982, David E. Firester

Publications and Research

On 2 April 1982, the Argentinian military had invaded and occupied a series of islands known as the Islas Malvinas, or Falkland Islands.* Subsequently, The United Kingdom had responded with a counter-invasion and occupation in an effort to deny the Argentinian claim of sovereignty over the archipelago. After nearly two months and combat casualties in excess of a thousand soldiers the British military was able to negate the Argentinian success and assert its ownsovereignty over the disputed territories. While the outcome of the dispute is clear, the impetus for its initiation is somewhat murky. This paper will attempt …

Infrapatellar Straps Decrease Patellar Tendon Strain At The Site Of The Jumper’S Knee Lesion, Michael Lavagnino, Steven P. Arnoczky, Julie Dodds, Niell Elvin

Publications and Research

Background: The impetus for the use of patellar straps in the treatment of patellar tendinopathy has largely been based on empirical evidence and not on any mechanistic rationale. A computational model suggests that patellar tendinopathy may be a result of high localized tendon strains that occur at smaller patella–patellar tendon angles (PPTAs). Hypothesis: Infrapatellar straps will decrease the mean localized computational strain in the area of the patellar tendon commonly involved in jumper’s knee by increasing the PPTA. Study Design: Controlled laboratory study. Methods: Twenty adult males had lateral weightbearing and nonweightbearing radiographs of their knees taken with and without …

Metrical Theory And Verdi's Midcentury Operas, William Rothstein

Publications and Research

Both historical and recent theories of meter have tended to assume that meter is a single phenomenon, definable in a single (though perhaps complex) way. Most U.S. theories of meter have been based on a limited repertoire: instrumental music by German composers. Examination of Verdi's mid-century operas, from Macbeth through La traviata (1846–53), suggests that different theoretical approaches may be appropriate for different repertoires. National traditions of composition, depending often on national poetic traditions, may require different ways of hearing and counting, and thus different ways of modeling meter. The metrical theories of Fred Lerdahl and Ray Jackendoff, David Temperley, …

Transplantation Of Adult Mouse Ips Cell-Derived Photoreceptor Precursors Restores Retinal Structure And Function In Degenerative Mice, Budd A. Tucker, In-Hyun Park, Sara D. Qi, Henry J. Klassen, Caihui Jiang, Jing Yao, Stephen Redenti, George Q. Daley, Michael J. Young

Publications and Research

This study was designed to determine whether adult mouse induced pluripotent stem cells (iPSCs), could be used to produce retinal precursors and subsequently photoreceptor cells for retinal transplantation to restore retinal function in degenerative hosts. iPSCs were generated using adult dsRed mouse dermal fibroblasts via retroviral induction of the transcription factors Oct4, Sox2, KLF4 and c-Myc. As with normal mouse ES cells, adult dsRed iPSCs expressed the pluripotency genes SSEA1, Oct4, Sox2, KLF4, c-Myc and Nanog. Following transplantation into the eye of immunecompromised retinal degenerative mice these cells proceeded to form teratomas containing tissue comprising all three germ layers. At …

Reflections On Juvenile Justice Reform In New York. Keynote Address Delivered At The Diane Abbey Law Center For Children And Families Conference In New York, Ny Law School., Jeremy Travis

Publications and Research

No abstract provided.

Dual Testing Algorithm Of Bed-Ceia And Axsym Avidity Index Assays Performs Best In Identifying Recent Hiv Infection In A Sample Of Rwandan Sex Workers, Sarah L. Braunstein, Denis Nash, Andrea A. Kim, Ken Ford, Lambert Mwambarangwe, Chantal M. Ingabire, Joseph Vyankandondera, Janneke H. H. M. Van De Wijgert

Publications and Research

Background

To assess the performance of BED-CEIA (BED) and AxSYM Avidity Index (Ax-AI) assays in estimating HIV incidence among female sex workers (FSW) in Kigali, Rwanda.

Methodology and Findings

Eight hundred FSW of unknown HIV status were HIV tested; HIV-positive women had BED and Ax-AI testing at baseline and ≥12 months later to estimate assay false-recent rates (FRR). STARHS-based HIV incidence was estimated using the McWalter/Welte formula, and adjusted with locally derived FRR and CD4 results. HIV incidence and local assay window periods were estimated from a prospective cohort of FSW. At baseline, 190 HIV-positive women were BED and Ax-AI …

College Senate Minutes April 7, 2011, Bronx Community College Senate

BCC Governance Archives

Minutes for the meeting of the College Senate on April 7, 2011.