Digital Commons Network^™

High-Affinity Naloxone Binding To Filamin A Prevents Mu Opioid Receptor–Gs Coupling Underlying Opioid Tolerance And Dependence, Hoau-Yan Wang, Maya Frankfurt, Lindsay H. Burns

Publications and Research

Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown. Here we show that with approximately 200-fold higher affinity than for the mu opioid receptor, naloxone binds a pentapeptide segment of the scaffolding protein filamin A, known to interact with the mu opioid receptor, to disrupt its chronic opioid-induced Gs coupling. Naloxone binding to filamin A is demonstrated by the absence of [3H]-and FITC-naloxone binding in the melanoma M2 cell …

Depression In Parkinson's Disease: Health Risks, Etiology, And Treatment Options, Pasquale G. Frisina, Joan C. Borod, Nancy S. Foldi, Harriet R. Tenenbaum

Publications and Research

Depression is found in about 30%-40% of all patients with Parkinson's disease (PD), but only a small percentage (about 20%) receive treatment. As a consequence, many PD patients suffer with reduced health-related quality of life. To address quality of life in depressed PD patients, we reviewed the literature on the health correlates of depression in PD (eg, cognitive function), etiology of depression in PD, and treatment options (ie, antidepressants, electroconvulsive therapy, and psychotherapy). The current review is unique in its focus on psychosocial aspects, as well as neuropathological factors, of depression in PD. Overall, we conclude that neurochemical (eg, serotonin) …

Concourse Dreams: A Bronx Neighborhood And Its Future, William A. Casari

Publications and Research

This master's thesis focuses on the West Bronx recent past and illustrates what upward mobility meant for the Grand Concourse neighborhood populated with second generation immigrant groups at the beginning of the 20th century, including Jewish, Italian and Irish people. Later, most of the same area became a slum at the hands of city planners, New York City administration, and negative media portrayals. Race and ethnicity became even more talked about when non-white immigrants and migrants began moving to the Grand Concourse in huge numbers after World War Two.Through a celebrated Bronx past before 1950 and eventually the sensational media …

The Ticker, January 28, 2008

The Ticker

The Ticker is the student newspaper of Baruch College. It has been published continuously since 1932, when the Baruch College campus was the School of Business and Civic Administration of the City College of New York.

Does Economic Development Contribute To Sex Differences In Ischaemic Heart Disease Mortality? Hong Kong As A Natural Experiment Using A Case-Control Study, Mary Schooling, Tai Hing Lam, Sai Yin Ho, Kwok Hang Mak, Gabriel M. Leung

Publications and Research

Background
The male excess risk of premature ischemic heart disease (IHD) mortality may be partially due to an unknown macro-environmental influence associated with economic development. We examined whether excess male risk of IHD mortality was higher with birth in an economically developed environment.

Methods
We used multivariable logistic regression in a population-based case-control study of all adult deaths in Hong Kong Chinese in 1998 to compare sex differences in IHD mortality (1,189 deaths in men, 1,035 deaths in women and 20,842 controls) between Hong Kong residents born in economically developed Hong Kong or in contemporaneously undeveloped Guangdong province in China. …

Diverse Antidepressants Increase Cdp-Diacylglycerol Production And Phosphatidylinositide Resynthesis In Depression-Relevant Regions Of The Rat Brain, Kimberly R. Tyeryar, Ashiwel S. Undieh, Habiba Ou Vongtau

Publications and Research

Background: Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain regions associated with the disease. Monoamine transmitters activate multiple signaling cascades some of which have been investigated as potential mediators of depression or antidepressant drug action. However, the diacylglycerol arm of phosphoinositide signaling cascades has not been systematically investigated, even though downstream targets of this cascade have been implicated in depression. With the ultimate goal of uncovering the primary postsynaptic actions that may initiate cellular antidepressive signaling, we …

A Technique For Characterizing The Development Of Rhythms In Bird Song, Sigal Saar, Partha P. Mitra

Publications and Research

The developmental trajectory of nervous system dynamics shows hierarchical structure on time scales spanning ten orders of magnitude from milliseconds to years. Analyzing and characterizing this structure poses significant signal processing challenges. In the context of birdsong development, we have previously proposed that an effective way to do this is to use the dynamic spectrum or spectrogram, a classical signal processing tool, computed at multiple time scales in a nested fashion. Temporal structure on the millisecond timescale is normally captured using a short time Fourier analysis, and structure on the second timescale using song spectrograms. Here we use the dynamic …

The Osu1/Qua2/Tsd2-Encoded Putative Methyltransferase Is A Critical Modulator Of Carbon And Nitrogen Nutrient Balance Response In Arabidopsis, Peng Gao, Zeyu Xin, Zhi-Liang Zheng

Publications and Research

The balance between carbon (C) and nitrogen (N) nutrients must be tightly coordinated so that cells can optimize their opportunity for metabolism, growth and development. However, the C and N nutrient balance perception and signaling mechanism remains poorly understood. Here, we report the isolation and characterization of two allelic oversensitive to sugar1 mutants (osu1-1, osu1-2) in Arabidopsis thaliana. Using the cotyledon anthocyanin accumulation and root growth inhibition assays, we show that the osu1 mutants are more sensitive than wild-type to both of the imbalanced C/N conditions, high C/low N and low C/high N. However, under the balanced C/N conditions (low …

Course Catalog 2008-2009, Laguardia Community College

Course Catalogs

No abstract provided.

Angels And Demons: Christina Rossetti’S Goblin Market As A Social Critique Of The Victorian Ideal Of The “Angel In The House” And The Pre-Raphaelites’ Response To That Ideal, Melissa Adams

Theses and Dissertations

Christina Rossetti’s poem Goblin Market presents a subversive critique on the socially constructed dichotomy of Angel versus Demon as depicted in Pre-Raphaelite artwork, Dante Gabriele Rossetti’s poetry, and Coventry Patmore’s poem Angel in the House. An analysis of Goblin Market in relation to Patmore’s poem and the Pre-Raphaelite paintings The Annunciation, Ophelia, Lady Lilith, Circe Offering the Cup to Ulysses, and Sibylla Palmifera and Dante Gabriele Rossetti’s poems “Soul’s Beauty” and “Body’s Beauty” illustrate the ways in which Rossetti presents a counter-image that breaks down this socially constructed dichotomy. This is additionally supported by an exploration …

Gender Violence And Work: Reckoning With The Boundaries Of Sex Discrimination Law, Julie Goldscheid

Publications and Research

No abstract provided.

Servant Of One's Own: The Continuing Class Struggle In Feminist Legal Theories And Practices, Ruthann Robson

Publications and Research

No abstract provided.

Our Existential Death Penalty: Judges, Jurors, And Terror Management, Jeffrey Kirchmeier

Publications and Research

No abstract provided.

The Lgbtq Short Story, Matt Brim

Publications and Research

“The LGBTQ Short Story” is a lengthy entry in the three-volume encyclopedia LGBTQ America Today, edited by queer scholar John Hawley. The entry explores the characteristics of the genre and synthesizes the work of the top 25 living queer short story writers.

Measuring Knowledge Of Natural Selection: A Comparison Of The C.I.N.S., An Open-Response Instrument, And An Oral Interview, Ross Nehm, Irvin Sam Schonfeld

Publications and Research

Growing recognition of the central importance of fostering an in-depth understanding of natural selection has, surprisingly, failed to stimulate work on the development and rigorous evaluation of instruments that measure knowledge of it. We used three different methodological tools, the Conceptual Inventory of Natural Selection (CINS), a modified version of Bishop and Anderson's (Bishop and Anderson [1990] Journal of Research in Science Teaching 27: 415-427) open-response test that we call the Open Response Instrument (ORI), and an oral interview derived from both instruments, to measure biology majors' understanding of and alternative conceptions about natural selection. We explored how these instruments …

Tintoretto And James: Exposing The Shattered Subject, Phyllis E. Vanslyck

Publications and Research

Though “influence” may be too strong a word, the compositional affinities between James and Tintoretto are pervasive and worthy of comparative analysis, especially because both artists capture the moment when wonder gives way to the lonely and final uncertainty of our knowledge—of self, of others, of secular or spiritual truth.

Separated by three centuries, these two artists both stage a forceful assault on the conventions of their medium and engender in the viewer or reader (as well as internal “perceivers”) a kind of vertigo—a visual and psychological dislocation that is the basis of a new kind of insight. In Tintoretto, …

Dominican Women Across Three Generations: Educational Dreams, Goals And Hopes, Rosie M. Soy, Stefan Bosworth

Publications and Research

This study explores the struggle of Dominican women to access formal education and the impact of such access in their lives and on their own perceptions of their experiences. The essay captures the voices of female members of three generations of Dominican immigrant families in New York City.

‘Never Forget Syphilis’: Public Health, Modernity And Gender In The Discourse Of Previsión Social During The Trujillato, Melissa Madera

Publications and Research

This is an introduction to the study of public health during the dictatorship of Rafael Leonidas Trujillo Molina (1930-1961). The essay shows how the dictatorship sought to advance the regime's agenda of patriarchal modernity making women responsible for the health of the nation. The essay extensively cites issues of the periodical publication Previsión Social.

Advertisements: Interpreting Images Used To Sell To Young Adults, Alyssa Dana Adomaitis, Kim P. Johnson

Publications and Research

Purpose – The purpose of this study is to identify images used in advertising directed toward young adults, investigate what young adults thought of these images, and explore how young adults used these images.

Design/methodology/approach – A content analysis of 674 apparel and cosmetic advertisements located in four fashion magazines (Elle Girl, Seventeen, YM, and TeenVogue) resulted in eight categories. Participants (n ¼ 32) viewed advertisements representative of the categories and answered questions related to their thoughts about the model depicted in the advertisement and their use of the images.

Findings – Participants’ used the models as a point of …

A Transnational Conversation On French Colonialism, Immigration, Violence And Sovereignty, Miriam Ticktin, Ruth Marshall, Paolo Bacchetta

Publications and Research

This conversation was transcribed from a panel discussion that took place at The Scholar & Feminist Conference XXXII, “Fashioning Citizenship: Gender and Immigration,” held on March 24, 2007 at Barnard College.

Retinal Tissue Engineering Using Mouse Retinal Progenitor Cells And A Novel Biodegradable, Thin-Film Poly(E-Caprolactone) Nanowire Scaffold, Stephen Redenti, Sarah Tao, Jing Yang, Ping Gu, Henry Klassen, Sunita Saigal, Tejal Desai, Michael J. Young

Publications and Research

Retinal progenitor cells (RPCs) can be combined with nanostructured polymer scaffolds to generate compos- ite grafts in culture. One strategy for repair of diseased retinal tissue involves implantation of composite grafts of this type in the subretinal space. In the present study, mouse retinal progenitor cells (RPCs) were cultured on laminin- coated novel nanowire poly(e-caprolactone)(PCL) scaf- folds, and the survival, differentiation, and migration of these cells into the retina of C57bl/6 and rhodospsin −/−mouse retinal explants and transplant recipients were analyzed. RPCs were cultured on smooth PCL and both short (2.5μm) and long (27μ m) nanowire PCL scaffolds. Scaffolds with …

Hiding Out: Creative Resistance Among Anonymous Workbloggers, Abigail Schoneboom

Dissertations, Theses, and Capstone Projects

Anonymous workbloggers—employees who write online diaries about their work—are often simultaneously productive workers and savage critics of the corporate cultures in which they toil. Writing under an assumed identity, these workers create satirical portraits of their supervisors and colleagues, rail against management gurus and corporate buzzwords, celebrate time-wasting capers, and daydream about quitting. Their irreverent and fictionalized accounts of work, which are shielded from the gaze of co-workers and supervisors, reveal how office workers critically negotiate a labor process that, increasingly, demands their hearts and minds.

This study, which comprises an overview of media and organizational responses to the phenomenon, …

The Im Cometh: The Future Of Chat Reference, Stephen Francoeur

Publications and Research

No abstract provided.

Legal Lore, Marissa Moran

Publications and Research

No abstract provided.

Science Fiction And Postmemory Han In Contemporary Korean American Literature, Seo-Young J. Chu

Publications and Research

In this essay, Seo-Young Chu explores representations of a specifically Korean American type of postmemory that she calls "postmemory han."

Forgetting The Subject, Christa Davis Acampora

Publications and Research

No abstract provided.

Composition And Seasonality Of Diet In Wild Hamadryas Baboons: Preliminary Findings From Filoha, Larissa Swedell, Getenet Hailemeskel, Amy Schreier

Publications and Research

Here we report the first year-round quantitative data on dietary composition and seasonality in wild hamadryas baboons. Study subjects were adult male members of Band 3 at the Filoha field site in central lowland Ethiopia. Data collection consisted of 10-minute focal samples during all-day follows 4-6 days per month over the course of one year. The two largest contributors to the diet were Hyphaene thebaica and Acacia senegal, and these were the only plant species found in the diet during every month of the year. Other relatively major contributors to the diet, such as Cyperus grandibulbosus, Seddera bagshawei, …

Ferry Parking And Landside Access Study: Implementing Public Outreach And Impact Assessment, Jochen Albrecht, Stephanie Camay, Laxmi Ramasubramanian, Brandon Derman, Eric Bohn, William Milczarski, Maria Boile, Sotiris Theofanis

Publications and Research

Through federal regulations, metropolitan planning organizations (MPOs) are mandated to perform public outreach and impact assessment. Although there are some established parameters, the quality and effectiveness of public outreach efforts vary widely, and in many instances information dissemination becomes the central focus of public outreach efforts. However, information dissemination, although essential, is not as effective as a two-way process of public involvement in which members of the public may provide feedback to shape agency initiatives. Research conducted for the Ferry Parking and Landside Access Study is used to describe best practices in public outreach, focusing on socio-economic and community impact …

Ferry Parking And Landside Access Study: Implementing Public Outreach And Impact Assessment, Stephanie Camay, Laxmi Ramasubramanian, Brandon Derman, Eric Bohn, Jochen Albrecht, William Milczarski, Maria Boile, Sotiris Theofanis

Publications and Research

Through federal regulations, metropolitan planning organizations (MPOs) are mandated to perform public outreach and impact assessment. Although there are some established parameters, the quality and effectiveness of public outreach efforts vary widely, and in many instances information dissemination becomes the central focus of public outreach efforts. However, information dissemination, although essential, is not as effective as a two-way process of public involvement in which members of the public may provide feedback to shape agency initiatives. Research conducted for the Ferry Parking and Landside Access Study is used to describe best practices in public outreach, focusing on socioeconomic and community impact …

Race, Civil Rights, And Hate Speech In The Digital Era, Jessie Daniels

Publications and Research

The emergence of the digital era has had unintended consequences for race, civil rights, and hate speech.This chapter looks at the prevalence of both overtly racist sites, such as Stormfront, and at "cloaked" sites, that purport to advocate civil rights but disguise a racist agenda.