Digital Commons Network^™

Development Of Collagen Mimetic Mini-Fibrils With Tunable Collagenase Susceptibility, Jui Chaugule

Dissertations, Theses, and Capstone Projects

Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid sequences, first form the rod-shaped collagen triple helix. These triple helices further self-assemble laterally in a specific manner to form fibrils having the characteristic 67 nm axially repeating structure known as the D-period. Enzymatic digestion of collagen fibrils by matrix metalloproteinases (MMPs) is critical for several physiological processes and is of particular consequence during wound healing. Many of the mechanisms of …

Play In The Undercommons: The Transformative Power Of Fugitive Practice In A Multiracial, International Teacher Inquiry Collective, Kushya Sugarman

Dissertations, Theses, and Capstone Projects

Though scholars have begun to position youth’s fugitivity, refusal, and disengagement as logical responses to hostile environments, and as part of a larger legacy of Black speculative planning and action, most teachers do not. Elementary teachers, especially in urban contexts, notoriously struggle with “classroom management” and teachers across contexts cite behavior challenges, such as “disruptive” behavior, as the number one challenge facing our schools. In fact, up to 50% of novice teachers leave the profession in the first five years due to students’ behaviors. This dissertation interrogates the common trope of the wayward student who must be controlled. I consider …

Dante’S Volgare And The Pastoral Presence: An Analysis Of The Concept Of Language In The Divina Commedia, Paola M. Rodriguez

Dissertations, Theses, and Capstone Projects

Dante’s conception of the Italian vernacular, the “volgare illustre”, is a central concern of his work and one which catalyses and nurtures, both overtly and covertly, his creation of the Commedia. Although Dante positions himself in his writings as the continual defender and most prolific poet of the vernacular, isolating a specific linguistic use and structure, a coherent definition of what vernacular Dante privileges or what appropriate usage he adheres to, is a difficult and often confusing task. The existence of two eclogues, the only works by Dante to have been written after the majority of the Commedia had been …

Newly Synthesized Pyroglutamate Amide And Its Neuroprotective Effect Against Neurotoxicity Induced Cell Death In Alzheimer's Disease, Nourelhouda Joutey Elamrani

Dissertations, Theses, and Capstone Projects

The neurodegenerative disorder is an umbrella term for a range of conditions that affects the neurons in the human brain causing neuronal cell death. The common pathway is the excitotoxicity, a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity leading to the cell death. One of the most common neurodegenerative disorders is Alzheimer’s disease (AD), which represents 60 – 70% of cases and it ranked fourth cause of mortality in the USA. In Alzheimer’s disease, glutamate released from astrocytes and activates extrasynaptic N-methyl-D-aspartate …

Assessing The Influence Of Llms On Online Review: Identifying And Addressing The Rise Of Convincing Fake Reviews, Zico Abhi Dey

Dissertations, Theses, and Capstone Projects

Large Language Models (LLMs) have made remarkable advancements, reaching a level where they can generate outputs that compete with human writing. LLM's sophisticated features, however, make it hard for us to spot the difference between human-written and AI-generated text. LLMs have several weaknesses since they are susceptible to hallucinations and outputting factually incorrect information. Additionally, they may be used maliciously to promote deception and instigate fraud, such as fake reviews generation, which rapidly appear on the internet while posing a challenge for consumers who want to place their faith in online reviews. To maintain trust in the online information system, …

Srebp2 Restricts Osteoclast Differentiation And Activity By Regulating Irf7 And Limits Inflammatory Bone Erosion, Haemin Kim, In Ah Choi, Akio Umemoto, Seyeon Bae, Kaichi Kaneko, Masataka Mizuno, Eugenia Giannopoulou, Tania Pannellini, Liang Deng, Kyung-Hyun Park-Min

Publications and Research

Osteoclasts are multinucleated bone-resorbing cells, and their formation is tightly regulated to prevent excessive bone loss. However, the mechanisms by which osteoclast formation is restricted remain incompletely determined. Here, we found that sterol regulatory element binding protein 2 (SREBP2) functions as a negative regulator of osteoclast formation and inflammatory bone loss. Cholesterols and SREBP2, a key transcription factor for cholesterol biosynthesis, increased in the late phase of osteoclastogenesis. The ablation of SREBP2 in myeloid cells resulted in increased in vivo and in vitro osteoclastogenesis, leading to low bone mass. Moreover, deletion of SREBP2 accelerated inflammatory bone destruction in murine inflammatory …

Thinking Blue / Writing Red: Marxism And The (Post)Human, Stephen C. Tumino

Publications and Research

Thinking Blue/Writing Red interrogates contemporary culture across a range of texts, from the pandemic (‘Covid’ and ‘Trump Speak’) to high theory (Melville's narratives) and popular culture (Beyoncé's ‘Formation’ and Super Bowl performance, Twin Peaks , metamodern ‘cli-fi’ films). Inspired by Derrida’s idea of the secret, Tumino examines the significance of social movements (Black Lives Matter, Occupy, alter-globalization) and naïve art (Darger, Ryden) to argue that these texts speak of the secrets that capitalism cannot speak. Contending that the cultural surfaces narrate only the ‘nonsecret,’ that to see the social logic of the culture one must dig into what Bruno Latour …

Spending The Peace Dividend: Nato And The Failures Of American Diplomacy, Caleb Batman

Theses and Dissertations

Recent years have seen a massive increase in available resources pertaining to US-Russian diplomacy in the years immediately following the collapse of the Soviet Union. Using these newly available resources including diplomatic cables, declassified transcripts, and personal correspondence between President Clinton of the United States and President Yeltsin of the Russian Federation the author attempts to illustrate how the White House missed a chance for reconciliation with Russia during the first Clinton term. Additionally, this paper illustrates how it was not merely bad diplomacy that led to a resumption of Cold War hostilities, but willful policy in Washington that sought …

Caring Until It Hurts: A Survey Of Compassion Fatigue And Moral Injury Among Wild Animal Caregivers And Its Implications For Animal Welfare In Zoos, Aquariums, Rehabilitation Centers, And Sanctuaries, Nadiya L. Delgado

Theses and Dissertations

Caregivers for captive wild animals are fundamental to the overall care, welfare, and conservation of animals in their charge, fulfilling diverse and critical roles. Caring for others, whether humans or animals, exposes caregivers to compassion fatigue – a state of emotional and physical exhaustion resulting from prolonged empathetic engagement with those they assist, and moral injury – psychological distress that arises from actions, or the lack of them, which violate one's moral or ethical code. This distress can manifest as intense feelings of guilt, shame, or a sense of betrayal by oneself or others. These phenomena are pertinent in environments …

The Effects Of People, Time Of Day, And Season On Affiliative And Stereotypic Behaviors In Captive Rhinoptera Bonasus And Other Rays Across Two Human-Interactive Enclosures, Wren C. A. Newman

Theses and Dissertations

Cownose rays (Rhinoptera bonasus) are among the most common species found in aquaria, yet the impact of touch enclosures on their welfare remains largely unknown. While research on animal-visitor interactions has produced mixed results for other species, the lack of studies focusing on fish welfare poses a risk of overlooking potential welfare concerns. Therefore, we aimed to establish a baseline for cownose rays regarding stereotypic behaviors, sociality, and activity in captivity, and to examine the influence of human interaction on these behaviors. We collected over 700 hours of footage from two enclosures at Adventure Aquarium in Camden, NJ …

Sex Differences In The Diets Of Forest-Dwelling Baboons (Papio Anubis), Kara Hartunian

Theses and Dissertations

The ability to eat and switch between many food sources is an adaptative feeding strategy utilized for meeting nutritional needs across different environments, seasons, and physiological conditions. Baboons (genus Papio) excel at both dietary flexibility and foraging selectively, and consequently have one of the most widespread geographic distributions in the Order. To further expand to our understanding of baboon feeding ecology, I analyzed foraging activity and the nutritional characteristics of the diets of the relatively understudied rainforest baboons (Papio anubis) living in Kibale National Park, Uganda. I also investigated if there are differences in food type choice …

Assessment Of Tripeptides Self-Assembly & Er Stress On Cell Viability And Exosome Secretion In Mda-Mb231, Azmat Parveen

Theses and Dissertations

This study delves into the effects of tripeptides KYpF and WYpK(NBD) on MDA-MB-231 cells, uncovering KYpF's ability to reduce cell proliferation and exosome secretion in peptide treated cells. Conversely, WYpK(NBD) demonstrated significant toxicity at 10 μM. These insights pave the way for optimizing peptide-based cellular treatments for exosome secretion purposes.

Maternal And Other Social Influences On Signature Whistle Structure Of A Captive Group Of Bottlenose Dolphins (Tursiops Truncatus), Riley Synan

Theses and Dissertations

Bottlenose dolphins (Tursiops truncatus) are social animals that use acoustics as a major method of communicating across a marine environment. They also live in fission-fusion groups and thus interact with many conspecifics over a lifetime. Individual dolphins have a signature whistle that functions as an identity call and serves to maintain group cohesion in murky waters or during reconciliation. Dolphins exhibit vocal learning and the signature whistle of a calf may be modeled after the whistle of their mother or another individual in the pod as they develop. Mother-calf pairs or other related animals sometimes have similar whistle types. Some …

Assessing Comprehension And Competence In Bottlenose Dolphins (Tursiops Truncatus) On The Concept: Do Something Different, Charlotte M. Mulligan

Theses and Dissertations

Many studies have been conducted using a training paradigm based on the research of Pryor et al. (1969) wherein the participants are trained on the abstract concept: do something different. This paradigm challenges working memory and requires the participants to respond with a behavior, either previously trained or novel, which has not yet been offered within the session. The work of Braslau-Schneck (1994) expanded this concept and demonstrated the ability of dolphins to successfully complete this task in synchronized pairs, though the method of accomplishing this task remained unclear. The present research was conducted as part of a broader …

Enhancing The Visual Environment Of Indoor Housed Laboratory Cynomolgus Macaques (Macaca Fascicularis) To Reduce Stress And Maladaptive Behavior, Jeannine C. Rodgers

Theses and Dissertations

Nonhuman primates housed in indoor laboratory environments are generally exposed to nondescript background visual stimuli. This environment is not ideal for species whose primary sensory modality is visual. To provide a more naturalistic visual environment that would potentially improve their welfare, this study assessed the efficacy of a passive natural visual stimulus in the reduction of stress and stereotypy and agonistic behaviors in a cohort of four (2 male, 2 female) Cynomolgus macaques (Macaca fascicularis) housed in an indoor laboratory facility in New York City. The macaques were exposed to four different videos depicting scenes of natural landscapes that were …

The Effect Of The Lunar Cycle On The Demographics Of Asian Elephants Observed In Open Areas In A Protected Wildlife Sanctuary And Surrounding Crop Fields, Serene K. Rivera

Theses and Dissertations

Due to human development and habitat fragmentation, Asian elephants increasingly use human landscapes and encounter people. These interactions have led to negative interactions between humans and elephants, such as crop-raiding. Despite efforts to mitigate these conflicts, farmers have not been able to consistently protect their crops from elephant foraging. Therefore, it is important to understand elephant behavior in these landscapes to help create long term mitigation plans. Specifically, research regarding demographic patterns in Asian elephants’ perceived predation risk can inform wild elephant management. This study used camera traps in Salakpra Wildlife Sanctuary in Kanchanaburi, Thailand to observe the wild Asian …

Envelope Of Ruin : Material And Spatial Responses Of New York City Homeless To The Covid-19 Pandemic, Kyle C. Maxey

Theses and Dissertations

This paper attempts to understand human material responses to catastrophic urban collapse. Using Henri Lefebvre's theories of spatial production and the history of a section of the Brooklyn-Queens Expressway (BQE) this paper develops a theoretical framework for understanding the dynamics present in the creation of an urban ruin. Through the observation of homeless material responses, particularly the construction of encampments under the BQE, during the COVID-19 pandemic "lock-down" in New York City, this thesis illustrates how populations respond to urban ruin and social collapse. Moving forward, this paper hopes to serve as a synthesis of urban theory and archeological observation …

Narcissus Goes Digital: The Impact Of Zoom’S Self-View Feature On Cognitive Load And Zoom Fatigue Among Those With High And Low Adhd Symptoms, Abigail Aris Weir

Theses and Dissertations

Individuals with ADHD may be more vulnerable to an increased cognitive load during video conferencing (e.g., Zoom) due to the distracting nature of their reflection being displayed by the self-view feature. This feature, however, may also provide stabilizing effects by offering consistent visual feedback for self-monitoring, thus reducing anxiety.

Fibersheds: Textiles As The Basis For A New World, Rebecca John

Theses and Dissertations

The Fibershed movement seeks to develop bioregional fiber systems to cultivate natural fibers through regenerative agriculture. Through this, it seeks to revive domestic textile production as an alternative to the global textile industry. This thesis investigates the Fibershed movement at national and regional scales, and assesses how they position themselves as an alternative economy.

Policing, Power, And Protests: Landscapes Of Surveillance In Private And Public Spaces In Lower Manhattan, Kelly Britt

Publications and Research

No abstract provided.

Experiment With The Scratch Application, Orit D. Gruber, Daniel Agman

Open Educational Resources

SCRATCH is a free and fun online application for exploring and creating animated programs, games, interactive stories, and projects.

Refer to the following link for an overview of Scratch: https://scratch.mit.edu/

You will be working with four(4) different starter programs; each starter program should be selected from a different category.

Spcl 3800: Introduction To Counseling Professions, Gerald Corbin

Open Educational Resources

This course introduces students to the practice of various counseling professions including school counseling, school psychology, clinical mental health counseling, clinical social work, substance abuse counseling, and clinical psychology. Foundations of these professions are explored including job descriptions, typical duties, education requirements, and licensure.  The role of these various professions and settings will be explored.

Interleukin 24 Induces Apoptosis Through Glycogen Synthase Kinase-3 Beta Inactivation In Prostate Cancer Cells, Sual J. Lopez, Moira Sauane

Theses and Dissertations

Interleukin 24 (IL-24) is a tumor-suppressing protein currently in clinical trials. IL-24 induces cancer-specific apoptosis by activating endoplasmic reticulum (ER) stress and mitochondria dysfunction. We have previously demonstrated that IL-24 leads to apoptosis in cancer cells by protein kinase A (PKA) activation in human breast cancer cells. To further understand the mechanism by which IL-24 induces apoptosis, I analyzed the role of glycogen synthase kinase-3 (GSK3), a highly conserved and normally active serine/threonine kinase in cancer cells and downstream target of PKA. The work reported here provides direct evidence that GSK3 was inhibited following IL-24 treatment in human prostate cancer …

Indo-Caribbean Youth And Suicidal Behavior: A Systematic Review, Raul Ruiz Camacho, Shiryn D. Sukhram

Publications and Research

The suicide rates in Guyana, Suriname and Trinidad and Tobago are among the highest in the Americas, containing significant Indo-Caribbean populations that are suggested to be most vulnerable to suicide. This systematic review analyzes the existing literature and identifies knowledge gaps in risk and protective factors against suicide in these countries. The literature search conducted followed PRISMA guidelines using the PubMed and APA PsycInfo databases. The PRISMA flow diagram illustrated that eight scholarly papers were eligible for inclusion. Included literature examined stratified data focused on the aforementioned countries, as well as their Indo-Caribbean adolescent populations. Excluded literature did not mention …

A One Health Approach To Enhancing Sars-Cov-2 Surveillance, Lauren C. Cybulska

Dissertations and Theses

Background

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes coronavirus disease-2019 (COVID-19) in humans, can also infect domestic dogs (Canis lupus familiaris) and cats (Felis catus). Susceptibility and viral transmissibility in these species are concerns for public health due to the spillover risk to humans or other animals. This dissertation uses a One Health framework to explore key issues on this topic. We aim to identify gaps in understanding of SARS-CoV-2 in companion animals and investigate novel surveillance methods through human, animal, and environmental health perspectives.

Methods

Paper 1 provides an in-depth exploration of …

A Randomized Double Blind Placebo Controlled Trial To Assess The Safety And Efficacy Of A Patented Fenugreek (Trigonella Foenum-Graecum) Seed Extract In Type 2 Diabetics, Rajinder Singh Gupta, Amarjit Singh Grover, Pawan Kumar, Apurva Goel, Samudra P. Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Partha Pal, Debasis Bagchi

Publications and Research

Background: Fenugreek plant (Trigonella foenum-graecum) constitutes a traditionally acclaimed herbal remedy for many human ailments including diabetes, obesity, neurodegenerative diseases, and reproductive disorders. It is also used as an effective anti-oxidative, anti-inflammatory, antibacterial, and anti-fungal agent. The seed of the plant is especially enriched in several bioactive molecules including polyphenols, saponins, alkaloids, and flavonoids and has demonstrated potential to act as an antidiabetic phytotherapeutic. A novel patented formulation (Fenfuro^®) was developed in our laboratory from the fenugreek seeds which contained >45% furostanolic saponins (HPLC).

Objective: A placebo-controlled clinical compliance study was designed to assess …

Advances In Bone And Orthopedics 2024 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

We are delighted to present the latest edition of ”Advances in Bone and Orthopedics,” a comprehensive compilation of pioneering research and innovative developments in the field. This volume brings together a selection of peer-reviewed abstracts from BONITOS 2024, the Fourth Season of the Bone and Orthopedics Interdisciplinary Symposium, held on May 31st, 2024, at the College of Staten Island in New York. This symposium, a hallmark event in the calendar of professionals dedicated to bone health and orthopedic excellence. The contributions within this volume reflect the breadth and depth of research presented at BONITOS 2024. These abstracts represent cutting-edge studies …

It’S Not A Few, It’S All: How Political Elites Create And Construct The Meaning Of Terrorism And Apply It To An Entire Group, Jamarne Mcgill

Publications and Research

In the aftermath of the September 11th terror attacks, we witnessed political elites make adequate use of coded language in order to justify the implementation of an aggressive and punitive foreign policy in the Middle East. Terror attacks are disruptive, catastrophic events that tend to produce feelings of racial resentment and a desire for collective punishment toward an entire group of people. Although the perpetrators of a terror attack do not represent or speak for the majority of a much larger group, the general population of the nation or state that was attacked may not feel this way. Therefore, an …

Past * An Introduction To The Problem, Zelimir Zilnik, Boris Buden, New Media Center Kuda.Org, Olivera Jokic

Publications and Research

Who can know what is in the past? Is it what historians can tell us? Should we also trust what we can remember? Past • An Introduction to the Problem proposes that the problem of the past now concerns everyone. Visions of a different, brighter future defeated in the Cold War and its heated afterlives, we are being offered the past as the only horizon of possibility. And what are we supposed to find in that past? Philosopher Boris Buden considers these questions in a series of essays and conversations with filmmaker Želimir Žilnik, one of the most prominent filmmakers …

Diaspora Documentation Of West Albay Bikol, Nhia Borja

Dissertations, Theses, and Capstone Projects

This paper presents a comprehensive linguistic analysis and cultural documentation of West Albay Bikol, a dialect spoken in Bikol, Philippines. Drawing upon narratives spoken by a native speaker, this study aims to expand the literature on Bikolano language and add the dialects of Balugo and Polangui to the conversation. The motivation for the project stems from a personal aspiration to learn West Albay Bikolano and provide authentic language examples.

The paper comprises six chapters. The first chapter briefly overviews Bikol dialects and Central Philippine languages and reviews existing literature on the overall Bikol language. The second chapter is an examination …