Digital Commons Network^™

Careful Compositions And Careless Constructions, Timothy Dalton

Dissertations, Theses, and Capstone Projects

This dissertation uses digital methods to analyze a digitized archive of life writing by disabled Civil War veterans through lenses of care ethics and rhetorical genre theory. Autobiographical letters by more than 370 disabled men respond to a contest prompt open to Union veterans injured in their right arms who had to relearn penmanship. This dissertation introduces the hybrid genre of “specimens of left-hand penmanship” through several critical lenses. It critiques the rhetoric of vocational rehabilitation and examines this archive as a site for early examples of concepts from contemporary disability studies. Finally, it turns explicitly to care ethics, and …

Autophagy And Meiotic Fidelity In C. Elegans, Kaitlin E. Kosinski

Dissertations, Theses, and Capstone Projects

Autophagy is an evolutionarily conserved multi-step recycling process in which cellular material is enclosed in the double membrane-bound autophagosome, which fuses with the lysosome to degrade its contents. Autophagy is essential for development and cellular adaptation to environmental or intracellular stress and is an important regulator of germline stem cell homeostasis in the model nematode C. elegans. We sought to determine if autophagy is important for genome stability during meiosis and found that the core adult C. elegans autophagy genes bec-1, atg-7, unc-51, and atg-18 were all required for proper meiotic development of oocytes. Loss of these …

Perceptual Expectation, Rebecca Keller

Dissertations, Theses, and Capstone Projects

You are currently seeing many things, and, hopefully, you are currently about to see many other things. Many of the things that you are about to see will not be surprising, because you expect to see them. Sometimes, though, when you expect to see one thing and are faced with another, that thing will look like the thing you expected it to be, and not like the thing it actually is. This dissertation is an attempt to get a handle on what is happening in the visual system in these instances. In particular, I am trying to figure out what …

Preschoolers’ Generation Of Quantity Implicatures, André Eliatamby

Dissertations, Theses, and Capstone Projects

This dissertation uses the developing child as a window into the mechanisms and representations that allow us to understand the meaning of utterances in their contexts. I present three studies investigating 4- and 5-year-olds’ ability to generate two types of “quantity implicatures,” classic scalar implicatures with some that imply not all, and free choice inferences that arise with sentences like “Larry is allowed to have cake or ice-cream.” Together, the studies suggest a close relationship between pragmatic development and word learning, something not appreciated in existing literature. In the first study investigating some, I show that preschoolers interpret …

Loneliness And The Urban American (Non-)Romantic, Sarah C. Cook

Dissertations, Theses, and Capstone Projects

Loneliness, also known as ‘perceived social isolation,’ is an increasingly common feeling among Americans. It can be critically unhealthy when chronic, and recent revelations about its health effects have garnered a significant amount of media attention. Although statistical evidence tells us that marriage is the strongest defense against loneliness, over a third of Millennials and Gen-Zers say marriage is outdated; and census data shows that living alone is both one of the fastest-growing demographics in America, as well as a relatively stable housing arrangement. After examining existing research and media reports on loneliness itself in some depth, including factors that …

Repurposing Bt-11 To Treat Alzheimer’S Disease: Exploring The Glutathione-S-Transferase Lancl2 As A Target, Emily Birnbaum

Dissertations, Theses, and Capstone Projects

Approximately 99.6% of potential Alzheimer’s drugs fail, thus developing successful drugs is a high priority. The failure at developing successful drugs relates to the complex nature of the disease itself. Many components act together to trigger a cascade that ultimately results in neurodegeneration and cognitive dysfunction associated with the disease. In building a multiplex model of Alzheimer’s it is important to understand its specific biological mechanisms. One of these key pathological mechanisms is neuroinflammation. Understanding the pathways involved in neuroinflammation in Alzheimer’s is an urgent need, as it poses a promising avenue for future effective therapeutics. Specifically, as many investigational …

Variability In Associations Among Seabirds And Marine Mammals: Causes And Consequences, Samantha A. Monier

Dissertations, Theses, and Capstone Projects

Marine predators today face multifaceted stressors from changing climate to changing prey availability, and these changes are occurring at unprecedented speeds. Any alteration to a species’ environment has the potential to disrupt social networks and thus, how animals obtain and transfer information. Interspecific social interactions in the form of local enhancement and facilitation are a critical, but not yet well-understood, component of seabird foraging; of immediate concern is that anthropogenic changes may be altering the quantity and quality of positive species interactions, with consequences for the species involved.

While we know these interactions are not immutable, less is known about …

Active Galactic Nuclei - The Arrhythmic Beat Of A Galactic Heart, Henry James Best V

Dissertations, Theses, and Capstone Projects

Active Galactic Nuclei (AGN) are generally believed to be supermassive black holes (SMBHs) at the center of galaxies which are actively accreting material from the host galaxy. Through this process, they emit radiation across the electromagnetic spectrum both as a smooth continuum and emission lines. However, there is a great variety of the signals we observe–some faint, some bright, some variable and others steady. The wide array of signals produced by AGN is believed to encode both the geometry and the physics surrounding these SMBHs, making them a valuable target for understanding the high gravity limit, their feedback mechanisms to …

Future Land, Futures Lost: Planning The Crisis On The Louisiana Coast, Sheehan Moore

Dissertations, Theses, and Capstone Projects

South Louisiana is rapidly losing coastal land to the combined forces of subsidence, sea-level rise, and worsening storms, accelerated by the effects of flood control engineering and extractive industrial development. With erosion threatening homes and industry alike, the state has marshaled a response on a massive economic and geographic scale: its Coastal Master Plan recommends $50 billion in river sediment diversions, barrier island restoration, and other projects over fifty years. This dissertation is about the emergence of Louisiana’s coast as a place from this knot of human and environmental relations, as an object for governance and a container for political …

The Epigenetic Impact Of Dietary Choline On Growth Outcomes Of Children Exposed To Gestational Diabetes Mellitus, Ismail Kadam

Dissertations, Theses, and Capstone Projects

Maternal insulin resistance and hyperglycemia lead to gestational diabetes mellitus (GDM) which can cause fetal hyperinsulinemia, ultimately leading to excessive fetal growth associated with macrosomia and increased adiposity at birth. Increased placental macronutrient transport and epigenetic changes in growth and metabolic genes affected by GDM contribute to fetal overgrowth and can result in complications such as overweight/obesity, insulin resistance/type 2 diabetes, cardiovascular disease risk factors, as well as cognitive impairment later in life. Choline, an essential nutrient, participates in lipid and energy metabolism by providing methyl groups for DNA methylation and thus may overcome the hypomethylation of growth and metabolic …

Cognitive Flexibility And Stability In Bilingual Older Adults, Lia Pazuelo

Dissertations, Theses, and Capstone Projects

Lifelong bilingual individuals develop expertise in language-switching, requiring a delicate balance between cognitive stability—safeguarding goals from interference—and cognitive flexibility—adapting goals to changing demands. While some studies demonstrate the transferability of these skills to non-linguistic tasks, signifying bilingualism's impact on cognitive processes, others find no direct correlation between non-linguistic task-switching and bilingualism. Our study investigated the cognitive processes underlying bilingual speakers' performance on a switching task, exploring whether varying degrees of bilingual experience in older adults result in different tendencies towards stability (e.g., lower mixing cost and response congruency effect) or flexibility (e.g., smaller switching costs). By treating the bilingual experience …

Establishing A Murine Model Of Malaria-Associated Acute Kidney Injury And Demonstrating The Contribution Of Extrinsic Apoptosis To Tubular Necrosis, Johanna Bensalel-Lyampe

Dissertations, Theses, and Capstone Projects

Malaria-associated acute kidney injury (MAKI) is a form of severe malaria (SM), which is usually caused by Plasmodium falciparum infection. Until recently, the impact of this particular complication of SM was severely underestimated and research in this area has been neglected. There is in fact a high prevalence (40-60%) of MAKI in SM patients and the associated risk of mortality and development of comorbidities is high. Furthermore, pediatric patients that recover often develop long-term complications such as chronic kidney disease or neurocognitive defects. The need for adjunctive therapies and early diagnostic biomarkers specific to this SM complication is critical but …

Living Color: Aesthetic Surfaces And Political Life In Brazil, Samuel E. Novacich

Dissertations, Theses, and Capstone Projects

This dissertation is about the manipulation of appearances – of both the human body and the built environment – in Rio de Janeiro, Brazil. Focused on Afro-aesthetic makeup and tanning practices as well as urban renewal projects, this ethnographic study reveals how the making over of both the skin and the urban landscape shape social inequalities and contribute to productions of race, gender, and national belonging. While some of the aesthetic technologies examined herein may be characterized as “bottom up” – or as the self-fashioning tactics of marginalized Afro-Brazilians – others constitute “top down” infrastructural interventions led by the state …

Competitive And Noncompetitive Credit Assignment To Reward Cues In The Lateral Orbitofrontal Cortex, Mihwa Kang

Dissertations, Theses, and Capstone Projects

This dissertation investigates the mechanisms underlying variations in credit assignment to reward cues, with a focus on the lateral orbitofrontal cortex (lOFC). The lOFC has long been implicated in signaling reward expectancies, with controversy as to whether it signals the economic value of future outcomes, their sensory features to guide behavior or both. However, whether the lOFC signals the relative (competition-dependent) or absolute (contiguity-dependent) credit of cues is unknown. To address this, I employed a combination of novel behavioral assays, in-vivo electrophysiological recordings and optogenetic stimulation in rats. In Chapter 2, I tested the suitability of a self-initiating variant of …

Meconium: A Potential Means To Predicting Later-Life Cognition, Leah Duran

Dissertations, Theses, and Capstone Projects

Maternal perinatal stress is a commonly experienced, yet chronically undiagnosed condition (CDC, 2010). Literature has suggested that perinatal stress exposure has long lasting implications of the developing child both physically and mentally (Behrman et al., 2007; Hobel et al., 2008; Bowman et al., 2004; Polanska et al., 2017; Van de Bergh et. al, 2020). The use of meconium in the clinical setting has become one that serves a purpose of detection in medical conditions like in utero drug exposure. Using meconium as a predictor for brain behavior, however, is still an emerging concept in the literature. It is quickly gaining …

The Truth And Other Fictions: The Nuance Of Truth In Medieval Literature, Mark-Allan Donaldson

Dissertations, Theses, and Capstone Projects

This dissertation, “The Truth and Other Fictions,” is an exploration of the functional relationship between fiction and truth. It discusses truth as a type of nuanced information which may exist in a variety of forms (i.e., objective truth, narrative truth, emotional truth, cultural truth, etc.) and explores how these truths may be created or communicated through the medium of literature. The dissertation also explores how fiction, either narrative or structural, assists in said creation and communication of truth and in some cases is the necessary component to these processes. The Middle Ages and its literature provide the ideal staging ground …

Brain Injury And Psychosocial Trauma: Outcomes Among Justice-Involved Individuals, Mahathi D. Kosuri

Dissertations, Theses, and Capstone Projects

Justice-involved individuals experience disproportionately high rates of both traumatic brain injuries (TBI) and psychosocial traumas. However, these traumas have yet to be conceptualized together, leaving a chasm of research on how they interact and influence this population. The current study was the first to measure the effects of TBIs as well as psychosocial trauma among justice-involved men, within the context of executive functioning, history of justice involvement, and recidivism. A sample of men (N=95) from a private correctional facility were given the Ohio State University Traumatic Brain Injury Questionnaire (OSU-TBI-ID), the Lifetime Stressor Checklist- Revised (LSC-R), along with …

Reviving Hysteria: The Nineteenth Century At The End Of The Twentieth, Christina Quintana

Dissertations, Theses, and Capstone Projects

This dissertation explores popular and medical representations of female madness in two time periods: the late nineteenth and late twentieth centuries. I argue that 1990s American culture produced an abundance of texts, images, and narratives that revitalized the iconography and medical discourses of late nineteenth-century hysteria. Analyzing popular texts, films, and cultural touchstones of the 1990s, I explore how Victorian ideas about women’s minds—such as the inherent feebleness of the female brain and nervous system; the fatalistic, life-altering effects of female puberty; the association between hysteria and deviant female sexuality; and the implicit racialization of hysteria and female madness more …

Black Horror Film And The Role Of Mood In Race Perception, Nicholas P. Whittaker

Dissertations, Theses, and Capstone Projects

Contemporary discussions of black or antiracist art are often haunted by an air of pessimism. This pessimism rests on the intuition that art cannot change the political realities of antiblackness and/or our relationships with blackness. In this dissertation, I resist this hegemonic view by arguing that black horror films generate a particular, politically-valuable aesthetic experience. Specifically, they allow us to experience blackness and black people as unintelligible. This, I argue, runs counter to everyday experience of blackness; when blackness appears unintelligible, we lose the sense of satisfied comprehension that characterizes our everyday experiences of it. I argue that these films …

Henry James And The Act Of Speech From Drama To Dictation, Mary Claire Brunelli

Dissertations, Theses, and Capstone Projects

This dissertation examines the idea of speech as an act in the writings of Henry James for the purpose of analyzing the author’s relationship to drama and how it influenced his practice of typewriter dictation. It traces the intersections of biography and bibliography within James’s notebooks, letters, and fiction produced during the years between his dismissal of playwriting after the public rejection of Guy Domville in January 1895 and his adoption of dictation due to writer’s cramp in the fall of 1896, as he worked on What Maisie Knew. In advancing an affective methodology to discover the embodied reality …

"White Slaves Of California": Race, Religion, And The Railroad In Maria Amparo Ruiz De Burton's The Squatter And The Don, Katie Buonanno

Dissertations, Theses, and Capstone Projects

In The Squatter and the Don (1885), Maria Amparo Ruiz de Burton depicts the decline of the Alamars, a patrician Californio family, in the years after California was annexed by the United States. This thesis explores the different rhetorical maneuvers Ruiz de Burton makes to place the Californios in a broad, enfranchising Anglo-American national paradigm. The novel negotiates the messy, competing histories of Spanish, Mexican, and American colonialism, ultimately making the case for the enduring presence of Spanish missionization in the region, as well as the cultural assimilability of the Californio population. While the novel has frequently been read as …

Ordinary Care: Affective Politics Of Migration And The Everyday Lives Of Syrian Refugees In Istanbul, Yasemin Ozer

Dissertations, Theses, and Capstone Projects

This dissertation makes two significant interventions into the literature on Syrian refugees in Turkey and the anthropology of migration and refugee studies more broadly. First, it focuses on the everyday lives of working-class urban refugees and argues that “ordinary care” is a crucial means by which they build sustainable and dignified lives while living in precarity in an often hostile environment in the aftermath of war and displacement. Ordinary care, as I theorize in this ethnography, includes sharing of resources, information, and advice as well as the formation of mutual relationships between kin, neighbors, and friends. Compared to the more …

The Crisis Of Market Society And The Fascist Solution In The Work Of Karl Polanyi, Nicholas E. Reynolds

Dissertations, Theses, and Capstone Projects

The revival of interest in the work of Karl Polanyi, which has generated valuable lines of inquiry across disciplines, has largely neglected Polanyi’s extensive writings on fascism. This dissertation argues that Karl Polanyi should be considered a theorist of fascism, one whose thinking revolves around the concept of a “fascist solution” arising as a consequence of a terminal deadlock of market society. This dissertation surveys two decades of Polanyi’s work to construct a full picture of his theory of fascism and its importance for his broader theorizing about the dynamics of capitalist societies. Polanyi makes at least three specific contributions …

Individual Differences In Wild Asian Elephant Behavior: Links Between Innovation And Responses To Novelty Across A Mosaic Landscape, Sarah L. Jacobson

Dissertations, Theses, and Capstone Projects

An animal’s responses to a novel or changing environment are influenced by a number of behavioral traits and cognitive abilities associated with flexible decision making. Animals also exhibit strong consistency in some behavioral responses, described as personality traits, which may influence their ability to adjust to environmental changes. It is important to investigate both flexibility and consistency in behavior, as well as how these two characteristics interact with each other, to understand the range of individual variation in behavior and decision making within a species. This knowledge can also help us understand how some species and individuals within a species …

Exploiting The Heavy Chain Glycans For The Improvement Of Radioimmunoconjugates, Cindy Rodriguez

Dissertations, Theses, and Capstone Projects

Radiolabeled antibodies have become indispensable tools in nuclear medicine. However, the natural roles of antibodies within the immune system mean that they have several intrinsic limitations as a platform for radiopharmaceuticals. A handful of recent preclinical studies suggest that binding by FcR and particularly FcyRI can affect the pharmacokinetic profiles of 89Zr-labeled radioimmunoconjugates. Fc receptors (FcR) are responsible for many of the interactions between immunoglobulins (IgG) and immune cells. In biomedicine, this interplay is critical to the activity of several types of immunotherapeutics; however, relatively little is known about how FcRs affect the in vivo performance of radiolabeled antibodies. Antibodies …

Pulsey: Stellar Pulsation Models In Python, Andrew Ayala

Dissertations, Theses, and Capstone Projects

The era of the Kepler/K2 and TESS space-telescope missions has inundated the astrophysics community with photometric data for millions of stars with continuous observation and very high cadence. This data confirms that nearly every observed stellar source exhibits an oscillating luminosity, with stellar pulsation being the driving mechanism behind a large fraction of the cause. The result has been an explosion in the field of asteroseismology, where the recorded luminosity variations, or "light curves", of pulsating stars to probe their interior structures. By modeling observed light curves, we can constrain values of the physical stellar parameters producing them. The brightness …

Constitutional Law Through Co-Curricular Civic Engagement, Jason M. Leggett

Open Educational Resources

No abstract provided.

The Influence Of Environmental Change On Genetic Diversity Across Spatial And Taxonomic Scales, Connor M. French

Dissertations, Theses, and Capstone Projects

The spatial distribution of genetic diversity is of interest to biodiversity scientists and conservationists and is a fundamental metric of biodiversity. Genetic diversity patterns across spatial and taxonomic scales contain information about population and assemblage dynamics that can convey their resilience to environmental change. Ectotherms are especially linked to their environments and may be especially sensitive to fluctuations in the environment over time. Herein, I investigate global and regional patterns of genetic diversity in two groups of ectotherms, insects and lizards, to understand the relationship between environmental change and genetic diversity, from populations to assemblages. Overall, my research aims to …

Incorporating Solvation Thermodynamic Mapping In Computer-Aided Drug Design, Yeonji Ji

Dissertations, Theses, and Capstone Projects

Advancements in computational techniques have revolutionized structure-based drug design, substantially improving the efficiency and effectiveness of the drug discovery process by reducing time, costs, and labor requirements. These advancements include various methods, such as investigating small molecule ligands binding to proteins, exploring alternative protein conformations, and solvation mapping on the protein surfaces. Among these methods, understanding the correlation between protein-ligand binding and the role of solvation is important.

A fundamental concept in protein-ligand binding is shape and electrostatic complementarity, which is complicated by the inherent flexibility of proteins. In the absence of small molecule ligands, proteins are complementary to surface …

Enhancing The Accuracy Of The Mild Cognitive Impairment Diagnosis In Community-Based, Racially/Ethnically Diverse Older Adults, Katherine H. Chang

Dissertations, Theses, and Capstone Projects

Mild cognitive impairment (MCI) is thought to represent an intermediate stage of cognitive impairment that is often, but not always, a transitional phase between normal aging and dementia. Diagnostic criteria for “MCI” and international consensus criteria have been developed and refined over decades beginning in the 1990s, but the definition is still debated. Moreover, the operationalization and measurement of one of the criteria for MCI (i.e., subjective cognitive concerns, SCC), which is included in most classification approaches, is highly variable and there is great inconsistency across the literature. Some research efforts even support the removal of this criterion on the …