Digital Commons Network^™

Metabolic Profiling Of Genetically Modified Potato Periderm Tissues, Liqing Jin

Dissertations, Theses, and Capstone Projects

Potato tubers are protected from dehydration and pathogens by a covering peel (periderm) impregnated with suberin, a complex cross-linked biopolymer that contains both polyaliphatic and lignin-like aromatic domains. Current models describing the macromolecular structure of suberin assume that ferulic acid cross-links both domains as it may form carboxyl ester bonds with aliphatic monomers and non-ester radical-coupled bonds with phenolics. Ferulic acid also links by ester bonds to glycans and acts in cross-linking polysaccharides and lignin. Fatty alcohol/ω-hydroxyacid hydroxycinnamoyl transferase (FHT) is a BADH acyltransferase responsible for the synthesis of akyl-ferulates that is necessary for suberin biosynthesis. Periderm from FHT-RNAi …

Tuning Into Toxins And Channels: The Characterizations Of Tv1 And A Human Cardiac Sodium Channel Voltage-Sensor Domain, Mohammed H. Bhuiyan

Dissertations, Theses, and Capstone Projects

In nature, peptide toxins are an abundant resource, produced both by marine and terrestrial organisms. A major target of these peptide toxins is the group of the highly important voltage-gated ion channels. Due to their high specificity and affinity, peptide toxins have been used for over a decade in discovery and characterization of voltage-gated ion channels. Although peptide toxins have been extensively characterized structurally, the structural characterization of eukaryotic voltage-gated sodium channels has seen much less progress, due to their large size and high hydrophobicity. Voltage-gated sodium channels play crucial roles in many physiological processes, and when these processes are …

Lessons From The Past: Unfolding The Dynamics Among Climate, Balkan Landscapes, And Humans Over The Past Millennium, Charuta J. Kulkarni

Dissertations, Theses, and Capstone Projects

The primary objective of this doctoral dissertation is to reconstruct the environmental history of the Central Balkans (Serbia) over the past millennium utilizing biological proxies (pollen, spores, and charcoal), geochemical signals through X-ray fluorescence (XRF), statistical analyses, and atomic mass spectrometry (AMS) ¹⁴C chronology. This dissertation establishes the first chronological framework for vegetation-landscape changes in Serbia and discusses the role of humans and climate as underlying processes.

Chapter 1 discusses the background and the nature of the research problem followed by the extensive literature review on the topic of the Holocene climate and paleoecology. The state of Holocene paleoecology …

Consciousness, Perception, And Short-Term Memory, Henry F. Shevlin

Dissertations, Theses, and Capstone Projects

Dissertation Abstract: Consciousness, Perception, and Short-Term Memory

When we engage in almost any perceptual activity – recognizing a face, listening out for a phone-call, or simply taking in a sunset – information must be briefly stored and processed in some form of short-term memory. For philosophers attempting to develop an empirically grounded account of perception and conscious experience, it is therefore crucial to engage with scientific theories of the kinds of short-term memory mechanisms that underlie our moment-to-moment retention of information about the world. To that end, in this dissertation I review recent scientific evidence for a new form of …

The Emergence Of The Bird In Andean Paracas Art. C. 900 Bce - 200 Ce, Mary B. Brown

Dissertations, Theses, and Capstone Projects

In the first millennium BCE, an enigmatic cultural group now known as Paracas inhabited the remote desert coast of southern Peru. Following its disappearance, Paracas culture did not emerge in the historical record until 1927, when three burial centers were scientifically excavated on the arid Paracas peninsula that gave the culture its name. The burials contained over 400 mummy bundles that preserved the only physical remnants of this culture and its unique art forms. When unwrapped, mummy bundles of elite males revealed multiple layers of finely woven and elaborately embroidered textiles and painted ceramics, along with gold objects, feathers, and …

Therapeutic Targets For Alzheimer's Disease: Insights From In Vitro And In Vivo Models Of Inflammation, Magdalena J. Kiprowska

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive neuronal loss that over the years spreads from the hippocampus to the neural cortex and impairs memory and cognitive functions. At the cellular level AD is linked to the presence of β-amyloid plaques and neurofibrillary tangles but despite decades of research little is known about their contribution to neurodegeneration and whether they are a cause or rather a result of the disease. It is well established that proteasome activity is impaired in AD brains and some studies suggest that this could be one of the initial factors leading to development …

Virtue’S Web: The Virtue Of Empathic Attunement And The Need For A Relational Foundation, Georgina D. Campelia

Dissertations, Theses, and Capstone Projects

This dissertation focuses on two questions. First, is empathy a virtue? Second, if it is, then why is it neglected, even ostracized, in contemporary discourses on virtue? In response to the first question, this dissertation develops and defends a distinction between empathic practices and moral excellence in those practices, which is termed ‘empathic attunement’. This excellence is a virtue not because of its connection to standard altruistic behavior, but because it is a unique way of caring for, respecting, and understanding others’ emotional experiences in response to the need to be emotionally understood and the good of being emotionally understood. …

Evolving The Genre Of Empire: Gender And Place In Women's Natural Histories Of The Americas, 1688-1808, Diana Epelbaum

Dissertations, Theses, and Capstone Projects

In the eighteenth century, “natural history” was a capacious genre designation that alluded to conventions as diverse in their cultural and political resonances as they were in their applications within the New Science. My project is a genre study of seventeenth- and eighteenth-century natural history text and art produced by women scientists, explorers, colonists, and early Americans writing the New World; it destabilizes rigid notions of genre that exclude women, suggesting that genre is by nature fluid, inclusionary as well as exclusionary. To this end, I return into conversation understudied naturalists Maria Sybilla Merian, Jane Colden, and Eliza Pinckney, who …

Relative Clause Sentence Comprehension By Japanese-Speaking Children With Specific Language Impairment And Children With Typical Language Development, Miho Sasaki

Dissertations, Theses, and Capstone Projects

Comprehension of sentences with relative clauses was examined in Japanese-speaking children with SLI and children with TLD. The children with SLI showed comparable comprehension with the TLD peers, when the language and memory tests’ scores were controlled. The children with TLD consistently had difficulties in OR sentences than SR sentences, in spite of that Japanese relative clauses are different from English ones. The children with SLI showed the opposite pattern. Working memory rather than language knowledge predicted better the comprehension performance for all the children.

Mindfulness In Learning, Anna Malyukova

Dissertations, Theses, and Capstone Projects

In our everyday life, people feel busy, rushed, pressured to be productive and successful. There is little room for pausing, slowing down, having a moment of non-judgmental reflection on everyday activities, which include learning. One way to achieve balance and harmony in life is to become more mindful of oneself and one’s emotions. I argue that the speed and drive for productivity and achievement has disharmonized our lives, from the learning process inside and outside of the classroom to the way we interact with technology and attempt to find balance in life. Through my own personal journey of reflection on …

The Effects Of Alpha Oscillations On Touch Perception And Visuo-Tactile Integration, Lei Ai

Dissertations, Theses, and Capstone Projects

Previous studies have shown that touch perception and visuo-tactile integration have large inter-subject/intra-subject variations. For example, touch perception varies across trials and the temporal binding windows of visuo-tactile integration varies across subjects. I hypothesized that the variations might be due to the change of power, phase and peak frequency of brain alpha oscillations. In the first set of experiments, I examined whether the power and phase of alpha oscillations predict successful conscious touch perception. Near-threshold tactile stimuli were applied to the left hand while electroencephalographic (EEG) activity and fast signal optical imaging were recorded over the somatosensory cortex. Alpha power …

Series Of Intermittent Heroin Injections Enhances Acquisition Of Operant Responding For Cues Paired With Natural Rewards, Jennifer Morrison

Dissertations, Theses, and Capstone Projects

Repeated-intermittent heroin use has been implicated in altering learning processes. Ranaldi et al. (2009) and Morrison et al. (2011) demonstrated that repeated-intermittent heroin administration leads to an enhancement of conditioned reinforcement by a food-paired light stimulus; however, the mechanism governing this effect is still largely unknown. The aims of the present study were to examine modifications in Pavlovian and operant associations for cues paired with natural rewards after a series of intermittent heroin injections. The study consisted of three phases: (1) Pavlovian Conditioning Phase (4 days)- in which three groups of rats had a light stimulus paired with food, and …

Radical Interiorities, Aesthetic Selves: Charlotte Brontë, Henry James, Virginia Woolf, Miciah Hussey

Dissertations, Theses, and Capstone Projects

In her essay “On Being Ill” (1926), Virginia Woolf writes “We do not know our own souls, let alone the souls of others…There is a virgin forest in each; a snowfield where even the print of birds' feet is unknown.” My dissertation explores how the novel’s attempts to represent this inherently intimate and estranging “virgin forest” also test its formal limitations. From free indirect discourse to stream of consciousness, the development of the novel is marked by different modes of reproducing inner life that push beyond the boundaries of historical, social, and physiognomic indices. I argue that these narrative and …

Vocal Rhythm Coordination And Preterm Infants: Rhythms Of Dialogue In A High-Risk Nicu Sample, Adrianne E. Lange

Dissertations, Theses, and Capstone Projects

The contemporary bio-psycho-social view of mother-infant relationships holds that early interactions form the foundation of the growing infant’s sense of himself and the world. Prior to the development of linguistically-based communication, nonverbal communication patterns foster the infant’s socio-emotional growth, cognitive capacity and the development of optimal regulatory patterns. Preterm birth significantly alters the typical developmental trajectory on multiple levels and disrupts normal neurobiological and socio-emotional maturational processes, including those that build on early interpersonal experiences with caregivers. The current study of vocal rhythm coordination in preterm mother-infant dyads is the first of its kind. Aspects of infant prematurity (degree of …

Perception And Production Of /V/ And /W/ In Hindi Speakers, Vikas Grover

Dissertations, Theses, and Capstone Projects

This dissertation examines the ability of Hindi speakers to identify, discriminate and produce two English phonemes /v/ and /w/ which are difficult for Hindi speakers to distinguish. In Hindi, /v/ and /w/ are used interchangeably. This pattern of use has transferred to Indian English, resulting in English /v/ and /w/ words showing variable pronunciations (e.g., “whale” or “vale” for the word “whale”). Hindi speakers were asked to identify, discriminate and produce tokens of /v/ and /w/. This study also examined whether experience with American English, related to the length of residence (LOR) in the US affects Hindi listeners’ perception and …

Wet Data: The Ocean And Its Negative Archive, Kendra M. Sullivan

Dissertations, Theses, and Capstone Projects

This paper and the poetry cycle (Wet Data) it describes are in dialogue with a wide array of social and cultural histories of the sea; the production of the sea as a social, economic, and militarized space; maritime ethnographies; as well as artistic and literary projects stemming out of what are now being termed offshore art and forensic literature. The ocean is a contested territory that plays a profound and often under-examined role in defining geopolitics and nationalism under globalism. In eco-critical and creative art contexts, the sea is often represented as a metaphor for loss, the outside, …

The Role Of Individual Cognitive And Behavioral Ontogeny In Organization And Evolution Of Social Systems, Andrew G. Fulmer

Dissertations, Theses, and Capstone Projects

Exploration and explanation of the relationship between individual variation in behavior and the composition and adaptive success of social groups or populations are crucial problems in the fields of behavioral ecology, ethology, and comparative psychology. These questions have been the subject of a longstanding discussion at both the proximate and ultimate levels of inquiry. Adaptive mechanisms explaining social decision making, both in terms of affiliative and competitive partner choices, are at the center of such discussions. Inclusive fitness, kin-selection, handicap or prestige, risk seeking and risk avoiding strategies, pay-to-stay/reward principles, as well as other theories have been proposed and supported …

Computerized Classification Of Surface Spikes In Three-Dimensional Electron Microscopic Reconstructions Of Viruses, Younes Benkarroum

Dissertations, Theses, and Capstone Projects

The purpose of this research is to develop computer techniques for improved three-dimensional (3D) reconstruction of viruses from electron microscopic images of them and for the subsequent improved classification of the surface spikes in the resulting reconstruction. The broader impact of such work is the following.

Influenza is an infectious disease caused by rapidly-changing viruses that appear seasonally in the human population. New strains of influenza viruses appear every year, with the potential to cause a serious global pandemic. Two kinds of spikes – hemagglutinin (HA) and neuraminidase (NA) – decorate the surface of the virus particles and these proteins …

Schooling The Market: Venture Philanthropy, Field Building And The Newschools Venture Fund, Gregory E. Tewksbury

Dissertations, Theses, and Capstone Projects

Since the 1980s and the Reagan administration’s report “A Nation at Risk” and with the passage of No Child Left Behind during the George W. Bush Administration, the ground of public education has shifted. Reform efforts previously geared toward improving the system of public education have been superseded by the efforts of venture philanthropies and foundations like Gates, Walton and Broad to remake education into a private market. The power of these institutions politically, socially and economically to reshape the educational landscape inAmericaraises fundamental questions about the role of wealthy elites and their influence on democracy and education.

How is …

Death Priming In Investigations: The Effects On Worldview Threat, Out-Group Derogation, And Stereotyping, Laure Brimbal

Dissertations, Theses, and Capstone Projects

Terror Management Theory (TMT) hypothesizes that thinking about one’s own death creates a need to boost our worldview and our self-esteem in order to cope with this existential threat. Decades of research support the theory’s premises with findings in many different settings (Burke, Martens, & Faucher, 2010). The purpose of this dissertation is to extend the findings of TMT to research on decision making in investigations. In two studies, I evaluated how thinking about one’s death (Mortality Salience, MS) affected mock investigators’ reactions to the outcome of a case they investigated and their perceptions of a suspect, depending on their …

Seeking Holiness: The Contribution Of Nine Vernacular Narrative Texts From The Twelfth To The Fourteenth Centuries, Stephanie Grace Petinos

Dissertations, Theses, and Capstone Projects

Spirituality has been increasingly studied to determine the laity’s role within Church history in the Middle Ages. However, secular literature is often overlooked as a source of understanding lay spirituality, even though it is a crucial aspect of cultural and social history. I fill this gap by analyzing nine important vernacular texts to uncover several distinctive definitions of holiness, all of which blend the religious and the secular. Close reading of these texts reveals various paths to holiness, which undermine the Church’s attempts at sole control over spirituality. This study demonstrates that secular authors were concerned with exploring spiritual matters; …

Adult Neurogenesis In Avian Auditory Cortex, Caudomedial Nidopallium (Ncm): Lateralization And Effects Of Statins, Shuk C. Tsoi

Dissertations, Theses, and Capstone Projects

In the first part of this paper, we investigated the basic relationship between learning, memory and adult neurogenesis using zebra finches. We found that in the auditory cortex, the left hemisphere had more new neurons than the right hemisphere. This lateralization was correlated with song learning and memory. In the second part, we used juvenile zebra finches as a model organism to study the effects of Lipitor on learning, memory and neurogenesis. We found that Lipitor impaired song learning and memory storage. Lipitor treatments also changed the morphology of new neurons and size of old neurons, suggesting statins may affect …

Feeling Political: Affect, Emotion, And Ethics In Western Political Theory, John Mcmahon

Dissertations, Theses, and Capstone Projects

What conceptual and methodological resources would it take for political theory to be able to more deeply analyze the emotional and affective dimensions of political life? In this dissertation, I articulate interdisciplinary work on affect and emotion into political theory in order to realize four linked objectives: first, to develop a method of reading and interpreting political theory capable of tracing the theoretical work done by affect and emotion in works of political thought; second, to reassess the boundaries of the political theory canon in terms of the thinkers that ‘count’ as part of that canon as well as the …

Declining City, Born-Again Citadel: Faith-Based Organizations And The Reconstitution Of Inequality In Postindustrial America, Michael J. Boyle

Dissertations, Theses, and Capstone Projects

In the context of the hegemonic neoliberalism of recent decades, faith-based organizations (FBOs) have flourished as mechanisms for addressing poverty and other varieties of social need. For all of the contributions of contemporary anthropological research to the study of FBOs, however, most analyses have stressed the potency of FBOs and elided the agency of recipients. The present dissertation aims, through a multisited study of Evangelical FBOs in the postindustrial American city of Plainfield, to focus on the latter theme. Owing to the traditional behaviorism of American culture and also its Evangelical reproduction in FBO settings, the pursuit of charity thrusts …

Seeing And Perceptual Content, Ben S. Phillips

Dissertations, Theses, and Capstone Projects

There are two widely held assumptions about perception: ascriber-independence (the view that the facts regarding what a subject perceives, as well as what her perceptual states represent, are independent of the interests of those attributing the relevant states to her), and determinacy (the view that perceptual content is relatively determinate). I challenge both of these assumptions, and develop a new approach to perceptual content, with implications for theories of mental content more broadly. In chapter one, I address the question of whether, in addition to low-level features, vision represents ordinary objects. I argue that there is just no fact of …

Masculine Identities Among Asian American Men: Negotiating Varying Masculine Ideals For The Self And Others, Elisa J. Lee

Dissertations, Theses, and Capstone Projects

The study examined the implications of varying masculine identities for Asian American men of East Asian descent. The study tested the hypotheses that compared to White men, Asian American men would endorse lower levels of Western hegemonic masculine ideals, see themselves as less masculine in terms of those ideals, and report lower levels of believing others perceive them as masculine by Western hegemonic standards. It also examined if the type of masculinity Asian American men endorsed moderated the psychological functioning (gender role conflict, psychological distress, and substance use) related to any discrepancies and synchronicities between self-perception and others’ perception (e.g. …

Medication Management In Pediatric Chronic Illness: Should Patient Anxiety Be Considered?, Claire J. Hoogendoorn

Dissertations, Theses, and Capstone Projects

Introduction: There is growing support that psychological symptoms can impact various aspects of disease, well-being, and medical treatment for those with a chronic illness like Crohn’s disease (CD). Yet, almost no studies have examined whether psychological symptoms can influence management or efficacy of patient medication regimens. The aims of this project were to examine whether anxiety predicted pediatric patients’ level of medication management, medication prescription changes, and corticosteroid prescription and duration.

Method: A total of 105 pediatric patients ages 8-18 (M=14.5, SD=2.3) completed a validated anxiety questionnaire during a GI office visit (baseline). Prescribed IBD …

Screening Male Crisis: A Comparative Analysis Of The Alternative Coming-Of-Age Motion Picture, Matthew J. Tesoro

Dissertations, Theses, and Capstone Projects

This thesis will identify how the principle male character in select film narratives transforms from childhood through his adolescence in multiple locations and historical eras. The primary film narratives include Satyajit Ray’s Apu Trilogy: Pather Panchali (1955), Aparajito (1956), and Apur Sansar (1959), François Truffaut’s "Antoine Doinel" cycle: Les Quatre cents coups (1959), Antoine et Colette (1962), Baisers volés (1968), Domicile conjugal (1970), and L’Amour en fuite (1979), and Richard Linklater’s Boyhood (2014). These images of experience/maturation in motion are all intended to exemplify how the boy physically and psychologically changes over an extended period of time. The concept of …

Possible Underlying Mechanisms Of Hyperactivity In Children With Adhd, Nicole Feirsen

Dissertations, Theses, and Capstone Projects

Conceptualizations of Attention-Deficit/Hyperactivity Disorder (ADHD) have evolved significantly over the years. Historically, early conceptualizations of ADHD described hyperactivity as the core symptom of the disorder. However, when the third version of the Diagnostic and Statistical Manual of Mental Disorders (DSM) was published (1980), hyperactivity became a specific qualifier of the disorder and was no longer necessary for a diagnosis. Despite this shift in conceptualization of the disorder, there is an abundance of empirical evidence, both recent and historical, supporting the fact that hyperactivity is an enduring and clinically impairing symptom domain in ADHD. Despite having numerous validated instruments available to …

Perspectives On Iraq's Past, Present, And Future In The Works Of Muhammad Baqir Al-Sadr And Yusuf Salman Yusuf, Amnah Almukhtar

Dissertations, Theses, and Capstone Projects

Through a look at the writings of Muhammad Baqir al-Sadr and Yusuf Salman Yusuf, I argue that Iraq’s communists and Islamists during the middle of the twentieth century could not escape a common language, common circumstances and conditions which framed their conceptions of the relationship between their pasts, presents, and futures. Their political visions did not come from their disparate traditions, although couched in those terms, but from their common circumstances and struggles towards the establishment of a sovereign, independent Iraqi nation. Despite their disagreements or variously framed answers, they were guided by similar questions. Yusuf Salman Yusuf, also known …