Digital Commons Network^™

Are Fireworms Venomous? Evidence For The Convergent Evolution Of Toxin Homologs In Three Species Of Fireworms (Annelida, Amphinomidae), Aida Verdes, Danny Simpson, Mandë Holford

Publications and Research

Amphinomids, more commonly known as fireworms, are a basal lineage of marine annelids characterized by the presence of defensive dorsal calcareous chaetae, which break off upon contact. It has long been hypothesized that amphinomids are venomous and use the chaetae to inject a toxic substance. However, studies investigating fireworm venom from a morphological or molecular perspective are scarce and no venom gland has been identified to date, nor any toxin characterized at the molecular level. To investigate this question, we analyzed the transcriptomes of three species of fireworms— Eurythoe complanata, Hermodice carunculata, andParamphinome jeffreysii—following a venomics approach to identify putative …

Midbrain Circuit Regulation Of Individual Alcohol Drinking Behaviors In Mice, Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edward, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, Ming-Hu Han

Publications and Research

Alcohol-use disorder (AUD) is the most prevalent substance-use disorder worldwide. There is substantial individual variability in alcohol drinking behaviors in the population, the neural circuit mechanisms of which remain elusive. Utilizing in vivo electrophysiological techniques, we find that low alcohol drinking (LAD) mice have dramatically higher ventral tegmental area (VTA) dopamine neuron firing and burst activity. Unexpectedly, VTA dopamine neuron activity in high alcohol drinking (HAD) mice does not differ from alcohol naive mice. Optogenetically enhancing VTA dopamine neuron burst activity in HAD mice decreases alcohol drinking behaviors. Circuit-specific recordings reveal that spontaneous activity of nucleus accumbens-projecting VTA (VTA-NAc) neurons …

Histomorphology Of Trauma In Charred And Decomposed Remains, Mariya Bezugly

Student Theses

Decomposition and burning of human remains are frequently encountered in forensic cases, and pose a challenge at determining an accurate cause of death. At autopsy, macroscopic techniques fail to reach beyond superficial layers of degraded tissue to identify wound morphology that characterizes blunt-force gunshot, and sharp-force trauma. The postmortem damage imparted on tissue with pre-existing injuries, obstructs the external features of trauma. Exploring beyond charred and decayed superficial tissue, histo-morphological patterns of injury are still identifiable as shown in this thesis. With detailed observation to the pattern of tissue disruption- an understanding of the type of trauma imposed can be …

Data Descriptor: An Open Resource For Transdiagnostic Research In Pediatric Mental Health And Learning Disorders, Lindsay M. Alexander, Jasmine Escalera, Lei Ai, Charissa Andreotti, Karina Febre, Alexandra Mangone, Natan Vega-Potler, Nicolas Langer, Alexis Alexander, Meagan Kovacs, Shannon Litke, Bridget O'Hagan, Jennifer Andersen, Batya Bronstein, Anastasia Bui, Marijayne Bushey, Henry Butler, Victoria Castagna, Nicolas Camacho, Elisha Chan, Danielle Citera, Jon Clucas, Samantha Cohen, Sarah Dufek, Megan Eaves, Brian Fradera, Judith Gardner, Natalie Grant-Villegas, Gabriella Green, Camille Gregory, Emily Hart, Shana Harris, Megan Horton, Danielle Kahn, Katherine Kabotyanski, Bernard Karmel, Simon P. Kelly, Kayla Kleinman, Bohwang Koo, Eliza Kramer, Elizabeth Lennon, Catherine Lord, Ginny Mantello, Amy Margolis, Kathleen R. Merikangas, Judith Milham, Giuseppe Minniti, Rebecca Neuhaus, Alexandra Levine, Yael Osman, Lucas C. Parra, Ken R. Pugh, Amy Racanello, Anita Restrepo, Tian Saltzman, Batya Septimus, Russell Tobe, Rachel Waltz, Anna Williams, Anna Yeo, Francesco X. Castellanos, Arno Klein, Tomas Paus, Bennett L. Leventhal, R. Cameron Craddock, Harold S. Koplewicz, Michael P. Milham

Publications and Research

Technological and methodological innovations are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, ambitions to achieve clinically useful tools to assist in the diagnosis and management of mental health and learning disorders are gaining momentum. To this end, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. The Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank of data from 10,000 New York area participants (ages 5–21). The HBN …

Objective Measures Of Electrophysiological Responses Of Children With Idiopathic Autism Spectrum Disorder And Phelan-Mcdermid Syndrome To A Contrast-Reversing Checkerboard, Chloe Brittenham

Theses and Dissertations

The heterogeneity of autism presents many challenges in understanding the disorder. The current study employs objective measures to examine visual evoked potential (VEP) responses of children with idiopathic autism (iASD) and Phelan-Mcdermid syndrome (PMS) to a contrast-reversing checkerboard in both long (60-second) and short (2-second) duration conditions.

Franz Roh And Visual Juxtaposition In Foto-Auge, Irini Zervas

Theses and Dissertations

This study of Foto-Auge (1929) is grounded on the approach of Franz Roh and aims to unlock the book’s meaning through an analysis of layout and visual sequence. This thesis also demonstrates how Foto-Auge proclaims photography’s ability not merely to record, but to disrupt any sense of reality in images.

The Twilight Zone: The Confluence Of Childhood Scenes And Future Anxiety, Jongwon Bae

Theses and Dissertations

Jongwon Bae’s paintings reflect his childhood memories as an archive that is to be repressed until it manifests itself in uncertain ways as it becomes confluent with the anxiety about the future.

Tattoo For Life And Afterlife, Kimberly Chin

Capstones

Man has searched for ways to live forever from time immemorial. But a curious group of tattoo enthusiasts developed a way to preserve one’s tattoo skin (at the least) post-mortem. Here’s a cultural exploration of a small albeit growing trend in which people’s perception of tattoos, burial rites and how to commemorate loved ones is examined and re-examined.

https://kimberlychin.atavist.com/tattoo-skin-preservation-capstone

Sanctuary, Sumeja Tulic

Capstones

The Sanctuary is a multimedia project documenting the stories of different members of the New Sanctuary Coalition in NYC -- an network of interfaith congregations, organizations, people fighting against the detention and deportation of undocumented immigrants.

The projects include a short documentary film, a book of recipes, and an audio documentary.

Unseen Science: Modern Discoveries Too Far Away Or Tiny For Human Eyes, Lucy Huang

Capstones

As science has progressed, scientists have realized that evidence goes beyond the realms of physical sight. Whether it is too small or difficult to find, scientists have developed different ways to get around this problem. We see this in cancer genomics and in extrasolar planetary research. Scientists use what they know and what they measure to validate their work.

https://lucy-huang-9tge.squarespace.com/

Of Rats And Men, Thomas S. Walsh

Capstones

This capstone is a data-driven investigation into New York City's rat problem. By using publicly available government data to map rat activity in NYC, I identified several socio-economic variables that correlate with rat populations at the community district, borough, and city-scale. I used these findings (mainly that rat problems are linked to lower incomes) as the basis of an investigation, which includes interviews with residents, experts, and city officials. Prof. Bobby Corrigan, urban rodentologist and formerly with the NYC Department of Health criticizes the city's efforts for the first time on the record.

https://thomasseiyawalsh.wixsite.com/ratstone

Intertidal, Alta Buden

Theses and Dissertations

Master of Fine Arts Thesis by Alta Buden. This paper details her process and research leading up to a body of work focused on our relationship to water, as she creates a series of sculptures about the waterways surrounding New York City beginning with the Superfund site Newtown Creek.

Inside The Aviary, Nikki Mehle

Theses and Dissertations

Modularity and movement of energy are two key concepts in the construction of Nikki Mehle's paintings. Painting is an act of both processing and creating reality – the duality of reflection and invention.

Healthy People Are Bad For Capitalism, Eri King

Theses and Dissertations

Healthy People are Bad For Capitalism is a four part installation that creates an alternative space for the chemicals, Red 40 and Monosodium Glutamate. Presented as a holistic center that offers healing services and remedies, Center for the Red 40 and MSG Healing explores the homeopathic doctrine of Like Cures Like (what make a human ill also cures them) through the relationship between Traditional Japanese Healing Practices, and Western Capitalism.

Healthy People are Bad For Capitalism presents Red 40 MSG Apothecary, Red 40 Zen MSG Healing Rock Garden, Theta Wave Eternal Flame Meditation and Red 40 MSG …

Southern Grotesque, Maggie Ellis

Theses and Dissertations

The scenes I paint are submerged in specific landscapes I have encountered in Georgia. Honoring my experiences from this vantage point, I depict the rough and tumble attitude of my upbringing that is at odds with a rarefied New York art world I currently live in.

Music From The Harpsichord House, Julie Zhu

Theses and Dissertations

Music from the Harpsichord House is an installation and series of concerts that exists in the binary of in and out of performance. During a concert, the harpsichordist is hidden inside the house and his face is live-projected outside. Fifteen new musical compositions were commissioned for the harpsichord house.

"Nothing Is Wrong With You", Carlos Rigau

Theses and Dissertations

Just as one object can give rise to multiple percepts, so an object may fail to give rise to any percept at all: if the percept has no grounding in a person's experience, the person may literally not perceive it.”

Perception literally guides human understanding as to what reality and truth is. My work intends to ruffle up commonly understood western percepts and their normality. I consistently choose media comprised of static images, moving images and sculpture. These forms are used to convey a singular and independent meaning, as well as a larger collective expression.

Four Legs Good, Two Legs Bad: How Slaughterhouse Safety Hasn’T Kept Up With The Times, Emily Ziemski

Capstones

From legal loopholes and outdated rules to undetectable infections and understaffing, the United States Department of Agriculture may not be doing all it can to make sure the American public’s health isn't at risk. As the people of the United States consume over 500 million pounds of beef a year, food safety policy and slaughterhouses are falling behind in proper procedural measurements in the beef industry.

emziemski.com/capstone

How The “Greatest Rapper Alive” Returned Hip Hop To Its Political Roots, Meeran Karim

Capstones

Rapper Kendrick Lamar’s powerful documentation of his own personal struggles and that of a country overcome with racial strife have revitalized the genre of hip hop music. More than just the “greatest rapper alive,” Lamar is also one of the most important storytellers in America today.

Capstone Link:

https://medium.com/@meeran.karim/kendrick-lamar-hiphop-political-roots-19e3f5e48385

Political Exiles Reckon With Rising China And A Lost Cause, Han Chen

Capstones

This capstone explores the overseas Chinese democracy movement in the United States. English-language coverage about the movement has been limited, and little systemic coverage exists. However, the exile movement is fundamental to understanding how China’s most prominent political opposition is faring as China became the second largest world economy. It will also detail human drama and infighting in this exile community. I interviewed more than a dozen U.S.-based political exiles, journalists and experts, in both Chinese and English.

Link to my capstone project: https://hanchen.atavist.com/chinese-exiles

Control Freak: How An Injured Esports Athlete Got Back Into The Game, Imad Khan

Capstones

This capstone profiles Aziz "Hax" Al-Yami, a professional Super Smash Bros. Melee player. Melee is a video game and Al-Yami is an esports competitor, i.e. a professional gamer. In this world, gamers compete as athletes, pushing their skills to their absolute limit to become the best in the world. Al-Yami, at 21, suffered from a wrist injury. This injury put him out of the game for over a year. His injury was so bad that doctor's told him that he could never compete again. But through his own research, Al-Yami surmised that if he were to get his FCU tendon …

Half A Mile To Hope, Ryan Kelley

Capstones

When you first see the football team from Frederick Douglass Academy in East Harlem, you can tell they have an edge. A certain swagger that says this team has something to prove. Their athleticism is scrappy, their personalities are animated, and their motivation is a dirt field, half a mile from the school.

That’s where they walk every day in the fall to practice. Instead of a football field, it’s a city park with a softball infield in each corner. The outfield grass in the middle is torn up from the team’s cleats. A cloud of dust is kicked up …

Inside The Grassroots Money Machine, Elizabeth Tung

Capstones

In the year since Donald Trump’s election, grassroots canvassing groups have generated millions of dollars for nonprofits like Planned Parenthood and the ACLU. These groups’ growing profile correlates with a post-election spike in liberal giving, and the rise of face-to-face fundraising in the US. But despite their progressive affiliations, several groups have come under fire for abusive labor practices and a lack of financial transparency. This piece looks at two of the biggest players in the canvassing industry, the Fund for the Public Interest and Grassroots Campaigns. Both groups are headed by the same person - a man named Doug …

Spotlight On Superfund: How Are New York’S Most Toxic Waste Sites Doing Under Trump’S E.P.A?, Sarah Stein Kerr

Capstones

No matter where you venture in New York City, you are never far from toxic pollution. And if you are in Brooklyn or Queens, you may be a stone’s throw from a federal Superfund, our nation’s most polluted sites.

For New York City’s Superfunds– Newtown Creek, the Gowanus Canal and the Wolff-Alport Chemical Company in Ridgewood, Queens – change is underfoot.

In February, President Donald J. Trump appointed former Oklahoma Attorney General Scott Pruitt to head the Environmental Protection Agency.

Pruitt, who made a career for himself suing and attacking the E.P.A, has already instituted sweeping changes as part of …

The Law Code Of Hammurabi: Transliterated And Literally Translated From Its Early Classical Arabic Language, Saad D. Abulhab

Publications and Research

This book, which includes new translations of the old Babylonian laws of Hammurabi, is the second book by the author examining, from a historical Arabic linguistic perspective, a major Akkadian document. The first book offered new translations of three tablets from a literary work, the Epic of Gilgamesh, written in a late Babylonian language. The pioneering methodology used by the author to decipher the ancient Mesopotamian texts in both documents involves the primary utilization of old etymological Arabic manuscripts written by hundreds of accomplished scholars more than a thousand years ago. Using this methodology does not only provide more accurate, …

Between The Alarm Clock And The Cell Phone, Sam Bornstein

Theses and Dissertations

The temporal-cultural matrix of fantasy refers to the relationship between the artist’s use of fantasy, and the sense of time and culture that is particular to their experience. It also refers to the way in which fantasy and the Fantastic can provide a space for critique, escape, relief, or commentary on those conditions.

Transcription Activator Like Effector Nucleases (Talens): A New, Important, And Versatile Gene Editing Technique With A Growing Literature, Philip Barnett

Publications and Research

Transcription activator like effector nucleases (TALENs) is a new and powerful technique in genetic engineering that can delete deleterious genes or add beneficial genes to organisms. It is being widely studied to improve crops and livestock, and is also being investigated clinically. Comparing the details of how both TALENs and its competitor, CRISPR-Cas9, function, reveals the potential advantages of TALENs. The growing literature, besides covering the scientific and technical aspects of TALENs, also includes pertinent information on regulatory aspects and the public’s perception and acceptance of TALENs.

Ocean Convergence And The Dispersion Of Flotsam, Eric A. D'Asaro, Andrey Y. Scherbina, Jody M. Klymak, Jeroen Molemaker, Guillaume Novelli, Cedric M. Guigand, Angelique C. Haza, Brian K. Haus, Edward H. Ryan, Gregg A. Jacobs, Helga S. Huntley, Nathan J. M. Laxague, Shuyi Chen, Falko Judt, James C. Mcwilliams, Roy Barkan, A. D. Kirwan Jr., Andrew C. Poje, Tamay M. Özgökmen

Publications and Research

Floating oil, plastics, and marine organisms are continually redistributed by ocean surface currents. Prediction of their resulting distribution on the surface is a fundamental, long-standing, and practically important problem. The dominant paradigm is dispersion within the dynamical context of a nondivergent flow: objects initially close together will on average spread apart but the area of surface patches of material does not change. Although this paradigm is likely valid at mesoscales, larger than 100 km in horizontal scale, recent theoretical studies of submesoscales (less than ∼10 km) predict strong surface convergences and downwelling associated with horizontal density fronts and cyclonic vortices. …

Identification And Quantification Of Cyanide And Its Metabolites In Lemur Urine, Jeremy Peralta

Student Theses

Cyanide is a chemical compound that contains the monovalent groups of carbon and nitrogen. This substance is considered a rapidly acting deadly chemical. However, some animals such as lemurs consume food products that are known to contain elevated levels of cyanide without major consequences. The mechanism by which the lemur can handle this high exposure to cyanide is unknown. In this study, we developed and validated two analytical methods for the determination of cyanide and two metabolites, thiocyanate and 2-aminothiazoline-4-carboxylic acid (ATCA) in lemur urine. The method was applied to 47 authentic lemur urine samples collected from 4 different species …

Insights Into The Molecular Roles Of Zika Virus In Human Reproductive Complications And Congenital Neuropathologies, Rajendra Ghardbaran, Latchman Somenarain

Publications and Research

The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor cells (NPCs) of the developing fetus, resulting in changes of brain structures, reminiscent of human microcephaly. In vitro and ex vivo studies using human cells and tissues showed that human NPCs and placental cells are targeted by ZIKV. Also of concern is the impact of ZIKV on human reproductive structures, with the potential …