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Development Of Nanomaterials: Complex Mesoporous Silicas And Highly Functional Multi-Responsive Hybrid Nanogels, Jinhui Yi

Dissertations, Theses, and Capstone Projects

The research work in this dissertation describes the study of the applications of polymers in several important areas. Two synthesis methods for bicontinuous cubic KIT6 silicas with block copolymer Pluronic P123 as templates were developed, expanding the range of available pore size and enchancing mesopore volume. In addition, two types of drug delivery systems were developed based on polymer nanoparticles.

In Chapter 2, it was shown that the addition of a suitable swelling agent at temperatures somewhat lower than those typically used in the syntheses of silicas with cubic Ia3d structure (19−25 °C vs 30−35 °C) allows one to induce …

Insights Into The Cyclooxygenase Pathway In A Progressive Rat Model Of Parkinson’S Disease Induced By Prostaglandin J2: Protection With Ibuprofen, Chuhyon Corwin

Dissertations, Theses, and Capstone Projects

Parkinson’s disease (PD) is a neurodegenerative disease with aging as a major risk factor. Its defining symptoms are motor deficits that are primarily associated with dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc) in the midbrain. Post-mortem PD brains exhibit abnormal intraneuronal inclusions of α-synuclein and ubiquitinated protein aggregates known as Lewy bodies, a hallmark of PD pathology.

Currently, there is no validated biomarker for PD. Especially the early stage of PD is difficult to detect as the pathology develops progressively. While symptom-managing treatments are available, there is no neuroprotective treatment as of yet, mainly due to the …

Social Influences On Songbird Behavior: From Song Learning To Motion Coordination, Iva Ljubičić

Dissertations, Theses, and Capstone Projects

Social animals learn during development how to integrate successfully into their group. How do social interactions combine to maintain group cohesion? We first review how social environments can influence the development of vocal learners, such as songbirds and humans (Chapter 1). To bypass the complexity of natural social interactions and gain experimental control, we developed Virtual Social Environments, surrounding the bird with videos of manipulated playbacks. This way we were able to design sensory and social scenarios and test how social zebra finches adjust their behavior (Chapters 2 & 3). A serious challenge is that the color output of a …

Mechanisms For Survival And Drug Resistance In Cancer Cells, Matthew B. Utter

Dissertations, Theses, and Capstone Projects

PART I

Prostate cells are hormonally driven to grow and divide. Typical treatments for prostate cancer involve blocking the hormone androgen from activating the androgen receptor (AR) and thus inhibit growth and proliferation of the cancer. Androgen deprivation therapy (ADT) can lead to the selection of cancer cells that grow and divide independently of androgen receptor activation. Prostate cancer cells that are insensitive to androgens commonly display metastatic phenotypes and reduced long-term survival of patients. In this study, we provide evidence that androgen-insensitive prostate cancer cells have elevated phospholipase D (PLD) activity relative to the androgen-sensitive prostate cancer cells. PLD …

"Betwixt The World Destroyed And World Restored": Subjectivity And Paradisal Recovery In John Milton's Late Poems, Chihping Ma

Dissertations, Theses, and Capstone Projects

This study focuses on the discovery of subjectivity through the recovery of lost paradise in Milton’s late poems, Paradise Lost, Paradise Regained, and Samson Agonistes. This theme revolves around the tension between the affective and the empirical, which also configure the spheres of the sacred and the profane. I explore how the irresistibly emancipatory impulse of recovering lost paradise compels Miltonic subjects to seek ways to return to their originary state or the divine ensemble. During this process, the subject is engaged with his own incapacity or privation while reaching into the sphere of unknown potentiality. In …

The Development Of Affect And Defense In Childhood And Adolescence, Kari Gray

Dissertations, Theses, and Capstone Projects

The purpose of this study is to further determine the nature of the relationship between how defense mechanisms affect and are affected by the ways in which feelings are modulated and regulated in children and adolescents. This study has been built upon an IRB-approved research project conducted under primary investigator Steven Tuber, Ph.D. at the Psychological Center and the City College of New York (From Child Assessment to Child Treatment; A Preliminary Investigation). The study data are pre-existing, collected from 5 – 16 year old children and adolescents presenting for treatment and/or assessment at the Psychological Center, a …

Dostoevsky As A Translator Of "Eugénie Grandet", Julia Titus

Dissertations, Theses, and Capstone Projects

The focus of this study in comparative criticism is a close analysis of Dostoevsky’s first literary publication - his 1844 translation of the first edition of Balzac’s Eugе́nie Grandet (1834) and the stylistic choices that he made as a young writer while working on Balzac’s novel. Through the prism of close reading this dissertation analyzes Dostoevsky’s literary debut in the context of his future mature aesthetic style and poetics. Comparing the original and the translation side by side, the dissertation focuses on the omissions, additions and substitutions that Dostoevsky brought into the text. It demonstrates how young Dostoevsky’s free translation …

Evidence Of The 1762 Arakan And Prior Earthquakes In The Northern Sunda Subduction, Dhiman Ranjan Mondal

Dissertations, Theses, and Capstone Projects

The objective of this dissertation is to understand the seismic hazard associated with Arakan segment of the northern Sunda subduction along SE Bangladesh. In order to do that, it is necessary to document geologic evidence for the 1762 Arakan earthquake and prior events, to help estimate the recurrence interval (repeat time) for that earthquake. Historical records described that the 1762 earthquake caused extensive damage along the Arakan segment of the Sunda subduction system. But the geologic evidence for the earthquake farther north is necessary to better understand its associated seismic hazard to the densely populated nation of Bangladesh. This dissertation …

Obesity, Type 2 Diabetes, And Dietary Acculturation Among Foreign-Born Blacks In New York City, Margrethe F. Horlyck-Romanovsky

Dissertations and Theses

Background: Black immigration to the US quadrupled between 1980 and 2000, and between 2000 and 2013 it further increased by 56%. The US Census estimates that by 2060, 16.5% of the US Black population will be foreign-born. Half of all foreign-born Blacks (FBBs) in the US, or more than 1.9 million people, are from the Caribbean, and of those, 682,000 were born in Jamaica alone. Besides the Caribbean, there are 1.36 million immigrants from sub-Saharan Africa. In New York City, non-Hispanic black Caribbean and West African immigrants constitute 19% and 4%, respectively, of the total foreign-born population. Research is limited …

Parp Pet Imaging Agents, Brandon Carney

Dissertations, Theses, and Capstone Projects

The poly (adenosine-diphosphate (ADP) ribose) polymerase (PARP) family of enzymes has been of interest to researchers and clinicians for over fifty years, especially the first member of the family, PARP1. This enzyme has become a target for cancer therapeutics due the reliance of highly proliferating cells on PARP1 for genomic maintenance. In the coming age of individualized medicine, however, highly specific therapeutic agents like PARP inhibitors are in need of similarly highly specific companion diagnostic agents. These kind of agents have been made possible with the quickly progressing field of molecular imaging. Specifically, positron emission tomography (PET) has enabled the …

Cynic And Epicurean Parrhesia In Horace's Epodes 5 & 6: Appropriating A Parallel Philosophical Debate For Poetic Purposes, Kent Klymenko

Dissertations, Theses, and Capstone Projects

Within Horace's fifth and sixth Epodes there is a juxtaposition of canine imagery. This imagery parallels two different interpretations of the philosophical concept of parrhesia or frank speech. Horace examines the parrhesia of Cynicism and contrasts it with the parrhesia of Epicureanism. After establishing Horace's philosophical influences, I engage in a close reading of the two poems through the lens of these competing philosophical interpretations of the same concept. I make the argument that Horace is using his knowledge of philosophy to make a larger poetic point. Although Horace's own stance on parrhesia favors Epicureanism, to the extent that one …

Footnotes To Footnotes: Whitehead's Plato, Nathan Oglesby

Dissertations, Theses, and Capstone Projects

This dissertation examines the presence of Plato in the philosophical expressions of Alfred North Whitehead (1861-1947). It was Whitehead who issued the well-known remark that “the safest general characterization of the European philosophical tradition is that it consists in a series of footnotes to Plato" -- the purpose of this project is to examine the manner in which Whitehead positioned himself as one such footnote, with respect to his thought itself, and its origins, presentation and reception.

This examination involves: first, an explication of Whitehead’s cosmology and metaphysics and their ostensibly Platonic elements (consisting chiefly in the Timaeus); second, investigation …

Militarization Of Conservation, Daniel Ryan Michel

Dissertations, Theses, and Capstone Projects

The world is facing biological diversity extinction of its wildlife solely caused by humans. One of the leading causes of the extinction crisis is attributed to poaching and the illegal trade of wildlife products. In search of finding suitable methods to curb the crisis, a dichotomy of overarching solutions has arisen: those who have advocated for community-based natural resource management and those who support militarized conservation. The focus of this paper is to delineate which method is, if any, the most appropriate when combatting poaching and the illegal wildlife trade. Concentrating on elephants (both African and Asian) and the rhinoceros, …

Aurality As Methexis And The Rise Of Castilian Literature: The Case Of The Siete Partidas, Maristela Verastegui

Dissertations, Theses, and Capstone Projects

Participation is the engine of cultural production. In the case of literature, the privileged modality that enables participation is auditory perception. In order to articulate a theory of literary cultural production based on auditory perception, participation needs to be analyzed in the context of Platonic methexis, understood as an embodied experience facilitated by brain mechanisms of sensory processing and cognition, which manifest in specific ways in written texts. The Siete Partidas, the first complete and systematic legal code of the Western World, provides the perfect case study to test a theory of literary cultural production based on methexis via …

Impact Of Neurodevelopmental Genes On The Trajectory Of Adhd Severity: A Pilot Study, Agnieszka Mlodnicka

Dissertations, Theses, and Capstone Projects

Attention-deficit/Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental disorder characterized by symptoms of inattention and hyperactivity, and is associated with delays in neural development. To assess the association of genes involved in neurodevelopment with symptoms and trajectory of ADHD, saliva was collected and genotyped from 145 participants from a longitudinal study of preschoolers who were followed annually for 7 years. We examined four single nucleotide polymorphisms (SNPs) in genes associated with neurodevelopment: neuregulin-1 (NRG-1; SNP rs3924999), neurotropin-3 (NT-3; SNP rs6489630), brain-derived neurotrophic factor (BDNF; rs6265), and regulator of G protein signaling 4 (RGS4; rs951439). Hierarchical linear modeling revealed that neuregulin-1 and …

Sites Of Historical Amusement: Tourism And The Recontextualization Of American History, Brendan Murphy

Dissertations, Theses, and Capstone Projects

Through the analysis of a theatrical event staged in Brooklyn, New York, entitled Black America (1895), this thesis interrogates cultural heritage tourism of the past and present and introduces a new classification of tourist site, “site of historical amusement.” In this current political moment, one during which regional pride and latent racism are bubbling to the surface, this study advocates for the continued interrogation of how the American story is bought and sold.

Sites of historical amusement are historically themed spaces that sell a recontextualized narrative that strips complexity from history, effectively flattening the past in order to create a …

Neural Hypervigilance In Trauma-Exposed Women, Seungyeon A. Yoon

Dissertations, Theses, and Capstone Projects

Trauma-exposed people often experience hypervigilance, which is a tonic condition of elevated alertness and excessive scanning for potential threat. A cardinal feature of hypervigilance is that no actual threat is needed to evoke or maintain the over-alertness and heightened affective response. However, most neuroimaging research in trauma to date has only focused on reactivity to an actual threat. Thus, the overarching aim of this dissertation was to investigate neural signatures and salivary markers of post-trauma hypervigilance in the absence of threat that can cause impairment in daily functioning and contribute to developing other trauma-related symptoms such as heightened threat reactivity. …

Moral Mode Switching: From Punishment To Public Health, Stephen Koppel

Dissertations, Theses, and Capstone Projects

A public health response to drug offenses has potential to improve both public safety and public health. However, the public’s desire for retribution represents a possible hindrance to reform. Relying on dual-process theory of moral decision-making, this dissertation examines agreement among laypeople about the relative blame deserved for various crime types, and probes several possible predictors of support—the need for cognition (“NFC”), intergroup bias, and free-will doubt—for retributive as well as consequentialist responses to crime. Findings from several web-based experiments show: (a) in comparison to core crimes (eg., murder) substantially less agreement about the relative blame deserved for noncore crimes …

Microrna 1207-3p In Prostate Cancer, Dibash Das

Dissertations, Theses, and Capstone Projects

Prostate cancer (PCa) is the most commonly diagnosed male cancer and the second leading cause of cancer-related death for men in the United States. Understanding the molecular mechanisms involved in progression from the asymptomatic androgen-dependent PCa to the lethal castration resistant prostate cancer (CRPC) is a major challenge. MicroRNAs (miRNAs), are known to be dysregulated in PCa. MicroRNA-1207-3p (miR-1207-3p) is encoded by the non-protein coding gene locus PVT1 on the 8q24 human chromosomal region, an established PCa susceptibility locus. However, the role of miR-1207-3p in PCa is unclear. We have discovered that miR-1207-3p is significantly underexpressed in PCa cell lines …

Embody: The Transformation Of Intimate Knowledges Through Generations In Liberal Societies, Lisa Kronberg

Dissertations, Theses, and Capstone Projects

This thesis project aims to examine how intimate knowledges[1] are transferred and communicated between generations in Western, liberal societies. By ‘Intimate knowledges’ I mean to encompass diverse knowledge of emotional intelligence, sexual identity, and gender.

Intimate knowledges evolve with human life circle everywhere and at all times, but in Western popular discourse of today, are treated with confusion and repression; they thus emerge as a “loud display of simultaneously silent sexual desire.” (Fine and McClelland, 2006) I explore this tension through a critical, feminist lens that sheds light on the ways in which political economy creates cultural norms that …

A Discourse Of True And False: An Analysis Of The Publications Of The Afl-Cio Between 1955-1965 As Archived In The Tamiment Library, John J. Gorham Jr.

Dissertations, Theses, and Capstone Projects

In 1955 the American Federation of Labor and Congress of Industrial Organizations healed their twenty-year schism. Provisions of the NIRA and the Wagner Act had given promising opportunities for union organization in the early 1930’s. Unions in coal and steel saw possibilities in organizing vertically entire industries, rather than according to traditional crafts. In 1935 some unions left the AFL to form more aggressive organizations under the banner of the newly formed CIO. The public perception of aggressive strikes led to anti-labor laws, most noticeably the Taft-Hartley Act of 1947. The increasingly hostile political climate, as states enacted the “right …

Neural Underpinnings Of Walking Under Cognitive And Sensory Load: A Mobile Brain/Body Imaging Approach, Brenda R. Malcolm

Dissertations, Theses, and Capstone Projects

Dual-task walking studies, in which individuals engage in an attentionally-demanding task while walking, have provided indirect evidence via behavioral and biomechanical measures, of the recruitment of higher-level cortical resources during gait. Additionally, recent EEG and imaging (PET, fNIRS) studies have revealed direct neurophysiological evidence of cortical contributions to steady-state walking. However, there remains a lack of knowledge regarding the underlying neural mechanisms involved in the allocation of cortical resources while walking under increased load. This dissertation presents three experiments designed to provide a greater understanding of the cortical dynamics implicated in processing load (top-down or bottom-up) during locomotion. Furthermore, we …

The Shari'a Courts Of Mogadishu: Beyond "African Islam" And "Islamic Law", Ahmed Ibrahim

Dissertations, Theses, and Capstone Projects

This dissertation, based on a year and eight months of fieldwork, is a historical ethnography of a Shari‘a-based movement which appeared in Mogadishu, Somalia within a year after the complete disintegration of the central government in 1991. The movement originated when religious authorities and “traditional” elders established centers in various neighborhoods in Mogadishu to deal with the vacuum of power after the fall of the state. Since Shari‘a structures of authority and discourse were integral to the formation and functioning of the centers, they became known as Shari‘a courts. My work on the Shari‘a courts intervenes in the literature on …

Bacterial Lps At The Immune Modulating Component In Juzen-Taiho-To, Diego Montenegro

Dissertations, Theses, and Capstone Projects

Juzen-taiho-to (JTT) is an immune-boosting herbal formulation with an ideal balance of safety and efficacy. For example, JTT is clinically used in Japan to stimulate the immunological functions of cancer patients undergoing chemotherapy and radiation. Although the clinical effects of JTT are recognized, the active compounds and mechanism of action are unknown. The studies conducted previously in our laboratory associated several phytosterols and plant glycolipids with the potent immunostimulatory activity of JTT: namely, β-sitosteryl β-D-glucoside (BSSG), glucocerebroside (GluCer), digalactosyldiacylglycerol (DGDG) and monogalactosyldiacylglycerol (MGDG). However, these compounds, when further purified, exhibited little or no immunostimulatory activity. This suggested that the immunostimulatory …

Conditions Of Personhood And Property, Zachary James Acree

Dissertations, Theses, and Capstone Projects

This paper seeks to demonstrate that a more robust understanding of personhood both reveals flaws in the underlying assumptions of modern property law, and orients that law to a more just application. To do this, the law needs not only a better definition of what persons are, but also a better understanding of how persons function in their society. First, in order to provide some context to the issues at stake, there is a brief historical introduction to some of the problems that personhood inquiries have faced. After the introduction, this paper is divided into four sections. Part I summarizes …

Musicking, Discourse, And Identity In Participatory Media Fandom, Aya Esther Hayashi

Dissertations, Theses, and Capstone Projects

In this dissertation, I study three forms of music-making within media fandom and their respective communities: filk, roughly, the folk music of the science fiction and fantasy fandom; wizard rock, a punk/DIY movement inspired by J.K. Rowling’s Harry Potter novels; and the YouTube musicals of Team StarKid and AVbyte. I consider their individual histories and the popular music movements and genres that influenced their respective developments. Even though the practices of these three communities are very different, their participants use similar, if identical, discourses when discussing what they do and why they do it, including but not limited to: openness, …

Rescinding Rancière: An Investigation Into The Conservative Tendencies Of A Leading Proponent Of Radical Democracy, And A Reconstruction Of The Participatory Democracy Of Ancient Athens, Tyler J. Olsen

Dissertations, Theses, and Capstone Projects

This thesis advances a critique of the political theory of Jacques Rancière, focusing on the problems that arise as a result of its rigid form combined with its narrow content. I argue that Rancière gets caught in a practice of immanent critique that merely presupposes bourgeois abstract right; and that his ontological and pragmatic commitments prohibit him from projecting a norm that would transcend the liberal order. I trace these ontological and pragmatic commitments in detail by examining the intellectual milieu from which Rancière’s project emerged, the post-foundational political philosophy of the 1980s, with particular attention given to Claude Lefort. …

Convergent Evolution Of Biochemical Innovations In Polychaetes: Characterizing The Molecular Basis Of Bioluminescence And Venom Production, Aida E. Verdes Gorín

Dissertations, Theses, and Capstone Projects

The convergent evolution of phenotypic traits is a widespread phenomenon across the tree of life and is explained as the outcome of different taxa facing similar selective forces or environmental conditions. A longstanding question in evolutionary biology is whether the evolution of convergent phenotypes in unrelated lineages is driven by similar or different molecular processes. The research presented here investigates this question by characterizing the molecular basis of two biochemical innovations, bioluminescence and venom production, that have evolved independently in different lineages of polychaetes worms (Annelida). We use an integrative approach, combining next-generation sequencing, phylogenetics and computational tools to evaluate …

Chronic Voluntary Oral Methamphetamine Induces Deficits In Spatial Learning And Hippocampal Protein Kinase Mzeta With Enhanced Astrogliosis And Cyclooxygenase-2 Levels, Jorge A. Avila, Roseanna M. Zanca, Denis Shor, Nicholas Paleologos, Amber A. Alliger, Maria E. Figueiredo-Pereira, Peter A. Serrano

Publications and Research

Methamphetamine (MA) is an addictive drug with neurotoxic effects on the brain producing cognitive impairment and increasing the risk for neurodegenerative disease. Research has focused largely on examining the neurochemical and behavioral deficits induced by injecting relatively high doses of MA [30 mg/kg of body weight (bw)] identifying the upper limits of MA-induced neurotoxicity. Accordingly, we have developed an appetitive mouse model of voluntary oral MA administration (VOMA) based on the consumption of a palatable sweetened oatmeal mash containing a known amount of MA. This VOMA model is useful for determining the lower limits necessary to produce neurotoxicity in the …

Disconnect Between Genes Associated With Ischemic Heart Disease And Targets Of Ischemic Heart Disease Treatments, C Mary Schooling, J. V. Huang, J. V. Zhao, M.K. Kwok, S. L. Au Yeung, S. L. Lin

Publications and Research

Background: Development of pharmacological treatments to mitigate ischemic heart disease (IHD) has encompassed disappointing results and expensive failures, which has discouraged investment in new approaches to prevention and control.Newtreatments aremost likely to be successful if they act on genetically validated targets. We assessed whether existing pharmacological treatments for IHD reduction are acting on genetically validated targets and whether all such targets for IHD are currently being exploited. Methods: Genes associatedwith IHDwere obtained fromthe loci of single nucleotide polymorphisms reported in either of two recent genome wide association studies supplemented by a gene-based analysis (accounting for linkage disequilibrium) of CARDIoGRAMplusC4D 1000 …