Digital Commons Network^™

Creating And Using Open Educational Resources (Oer) In Reading And Writing Classes, Christine E. Hutchins

Publications and Research

Creating her own assignments using openly licensed course materials allows this professor and her students to be more creative and to take greater advantage of digital resources.

Childhood Memories Of Playful Antics And Punishable Acts Risking An Imperfect Future Of Teaching And Learning, Lisa Farley, Debbie Sonu, Julie Garlen, Sandra Chang-Kredl

Publications and Research

This paper takes up the question of risk by examining childhood memories of nuisance-making and punishment shared by 26 participants enrolled in teacher education and/or childhood studies programs. Our analysis surfaces a tension that, on the one hand, idealizes the child as innocent instigator of playful antics and, on the other, produces a child who is guilty of punishable acts. We read these memories as an invitation to theorize a middle ground of the teacher’s role as one of introducing children to a world of limits, while also limiting the force of this very effort.

Proteasome Mapping Reveals Sexual Dimorphism In Tissue-Specific Sensitivity To Protein Aggregations, Edmund Charles Jenkins, Nagma Shah, Maria Gomez, Gabriella Casalena, Dazhi Zhao, Timothy C. Kenny, Sara Rose Guariglia, Giovanni Manfredi, Doris Germain

Publications and Research

Defects in the proteasome can result in pathological proteinopathies. However, the pathogenic role of sex- and tissue-specific sensitivity to proteotoxic stress remains elusive. Here, we map the proteasome activity across nine tissues, in male and female mice, and demonstrate strong sexual dimorphism in proteasome activity, where females have significantly higher activity in several tissues. Further, we report drastic differences in proteasome activity among tissues, independently of proteasome concentration, which are exacerbated under stress conditions. Sexual dimorphism in proteasome activity is confirmed in a SOD1ALS mouse model, in which the spinal cord, a tissue with comparatively low proteasome activity, is severely …

Transposon Mutagenesis In Mycobacterium Kansasii Links A Small Rna Gene To Colony Morphology And Biofilm Formation And Identifies 9,885 Intragenic Insertions That Do Not Compromise Colony Outgrowth, William C. Budell, Gabrielle A. Germain, Niklas Janisch, Zaid Mckie-Krisberg, Anitha D. Jayaprakash, Andrew E. Resnick, Luis E. N. Quadri

Publications and Research

Mycobacterium kansasii (Mk) is a resilient opportunistic human pathogen that causes tuberculosis-like chronic pulmonary disease and mortality stemming from comorbidities and treatment failure. The standard treatment of Mk infections requires costly, long-term, multidrug courses with adverse side effects. The emergence of drug-resistant isolates further complicates the already challenging drug therapy regimens and threatens to compromise the future control of Mk infections. Despite the increasingly recognized global burden of Mk infections, the biology of this opportunistic pathogen remains essentially unexplored. In particular, studies reporting gene function or generation of defined mutants are scarce. Moreover, no transposon (Tn) mutagenesis tool has been …

Intrinsic Disorder Controls Two Functionally Distinct Dimers Of The Master Transcription Factor Pu.1, Suela Xhani, Sangchoon Lee, Hye Mi Kim, Siming Wang, Shingo Esaki, Van L. T. Ha, Mahtab Khanezarrin, Giselle L. Fernandez, Amanda V. Albrecht, James Aramini, Markus W. Germann, Gregory M. K. Poon

Advanced Science Research Center

Transcription factors comprise a major reservoir of conformational disorder in the eukaryotic proteome. The hematopoietic master regulator PU.1 presents a well-defined model of the most common configuration of intrinsically disordered regions (IDRs) in transcription factors. We report that the structured DNA binding domain (DBD) of PU.1 regulates gene expression via antagonistic dimeric states that are reciprocally controlled by cognate DNA on the one hand and by its proximal anionic IDR on the other. The two conformers are mediated by distinct regions of the DBD without structured contributions from the tethered IDRs. Unlike DNA-bound complexes, the unbound dimer is markedly destabilized. …

African Naked Mole-Rat Colony Behavior Based On Whole Colony Radio Frequency Identification (Colony Tt-2, April 2015), Dan Mccloskey, Michael E. Kress

Publications and Research

This file contains Radio Frequency Identification (RFID) data for routine activity of members of the TT-2 colony during a 26 day period in April 2015. The data are organized into a state matrix where the last known location for each of the 49 animals in the colony is listed in each row. A new row means that the raw data file updated the location of one animal. The leftmost column gives the date and time of the event, the headers for the other 49 columns give the RFID code for each of the animals in the colony. Animals demonstrated to …

Carbon Dioxide Attracts Nesting Behavior In Captive African Naked Mole-Rats, Dan Mccloskey

Publications and Research

This dataset contains raw Radio Frequency Identification data for a 185 hour gas infusion study conducted in the TT-2 colony at the College of Staten Island in May-June 2019. The purpose of this experiment was to determine whether colony members would be attracted to a chamber with elevated carbon dioxide levels matching the highest values recorded in the typical colony nest. The results show a significant attraction to the CO2-infused chamber during and after the period of CO2 in=fusion, with the relocation of the colony nest to this site for the first time in the history of this colony. These …

Proceedings Of The Cuny Games Conference 6.0, Robert O. Duncan, Joseph Bisz, Christina Boyle, Kathleen Offenholley, Maura A. Smale, Carolyn Stallard, Deborah Sturm

Publications and Research

The CUNY Games Network is an organization dedicated to encouraging research, scholarship and teaching in the developing field of games-based learning. We connect educators from every campus and discipline at CUNY and beyond who are interested in digital and non-digital games, simulations, and other forms of interactive teaching and inquiry-based learning. These proceedings summarize the CUNY Games Conference 6.0, where scholars shared research findings at a three-day event to promote and discuss game-based pedagogy in higher education. Presenters could share findings in oral presentations, posters, demos, or play testing sessions. The conference also included workshops on how to modify existing …

Daerim Dong As A Chinatown: Setbacks And Challenges, Wendy W. Tan

Publications and Research

While there is not a single Chinese paifang, or any establishment targeted for tourist attractions, Daerim Dong in Seoul, due to its high concentration of Chinese population and business activities, has been considered as an unofficial 2nd Korean Chinatown. However, at the same time, many indicators are also pointing to the discouraging fact that the path toward making this plan a reality is full of bumps. Why is this conflicting situation happening? To satisfy her own curiosity, the author did intensive literature research and also made a field trip to this district. This essay states some of her findings.

Raw Veganism: The Human Diet, Carlo Alvaro

Publications and Research

In this chapter, I present some compelling evidence that points to the conclusion that the human species has a specific diet, which is a raw vegan diet of fresh fruit, tender leafy greens, and a moderate amount of nuts and seeds. Out of the hundreds of thousands of species in the world, the only one—ours—cooks food. Not surprisingly, our species is the only one that suffers from numerous maladies. In other words, the argument is that the consumption of cooked food (especially animal-based) is unhealthful and undermines our nature. I present undeniable evidence, from evolutionary science to nutrition science, showing …

Open To What? A Critical Evaluation Of Oer Efficacy Studies, Ian Mcdermott

Publications and Research

This selective literature review evaluates open educational resources (OER) efficacy studies through the lens of critical pedagogy. OER have radical potential as transformative tools for critical pedagogy or they can serve as a cost-free version of the status quo, inclined toward propagating austerity. This review analyzes studies published since 2008 with regard to cost, access, pedagogy, commercialization, and labor. These criteria are used to make explicit subjects indirectly addressed, if not ignored completely, in the existing literature. Typically, ample attention is paid to a study’s design and methodology but the underlying institutional infrastructure and decision-making process is unexamined. What emerges …

Logical Pluralism And Vicious Regresses, Daniel Boyd

Dissertations, Theses, and Capstone Projects

This material in this dissertation will be divided into two parts. The first part is a preliminary discussion of vicious regress arguments in the philosophy of logic in the 20th century. The second part will focus on three different versions of logical pluralism, i.e., the view that there are many correct logics. In each case an argument will be developed to show that these versions of logical pluralism result in a vicious regress.

The material in part one will be divided into three chapters, and there are a few reasons for having a preliminary discussion of vicious regress arguments in …

The Remnants Of Harmonious Bildungs: The Classical Bildungsroman As An Ontological Dimension Of The Novel Of Counter-Development In England From Jane Austen To Ford Madox Ford (1813–1924), Anne E. Mcfadden

Dissertations, Theses, and Capstone Projects

This dissertation will examine the paradoxical tensions that exist in the English Bildungsroman, by studying the ways in which both the novel of emergence and autobiography at once strive towards a conformity with what is known as the Classical Bildungsroman form, while at the same time undermining that very generic formula. This dissertation pays attention to a wide range of British writers, some whose novels embody the archetypical Bildungsroman form, and then some whose work does not resemble the Classical Bildungsroman at all. For instance, this dissertation will focus on the work of Jane Austen, Thomas De Quincey, Henry James, …

Chinese Aesthetics And Performance Practice In Three Works For Piano By Chen Yi: Tunes From My Home, Northern Scenes, And Four Spirits, Cong Ji

Dissertations, Theses, and Capstone Projects

This dissertation provides both analyses and performance practice suggestions on the three selected works that include piano by Chinese-American composer Chen Yi (b. 1953): Tunes from My Home, Northern Scenes, and Four Spirits. The author takes a step beyond Chen Yi’s widely identified “fusion style” of Chinese and Western music, to explore her cultural roots and how she blends Chinese music, arts, aesthetics, philosophy, and mythology with her musical language and imagination on a deeper level.

As a performer and pedagogue, I believe that it is important not only to analyze Chen Yi’s music from the perspectives of …

The Leap And The Gap: Writing Suicide In Modernist Britain, Aaron Botwick

Dissertations, Theses, and Capstone Projects

Suicide is integral to the history of British literature, and yet the subject has yielded scant scholarly attention. This study attempts to partially rectify the absence by identifying a transformation in English suicide discourse between the nineteenth and twentieth centuries. I argue that, informed by both rationalism and cause-and-effect reasoning, Victorian literature—including poems, triple-decker novels, broadsheets, and sermons—largely conceived of suicide as a public phenomenon. The action, rather than the actor, is the object of study, and as a result what Andrew Bennett calls “the phenomenology, the lived experience … of suicide” is abandoned in favor of social …

The Synchronic And Diachronic Phonology Of Nauruan: Towards A Definitive Classification Of An Understudied Micronesian Language, Kevin Hughes

Dissertations, Theses, and Capstone Projects

Nauruan is a Micronesian language spoken in the Republic of Nauru, a small island nation in the central Pacific. Lack of data and difficulty in analysis has hindered progress in better understanding Nauruan for decades, particularly regarding its phonology and its classification within the Micronesian family. Because of these challenges, earlier researchers have presented their work on Nauruan as highly tentative. This dissertation establishes more confident analyses of Nauruan phonology, sound change and classification, which have been made possible through original fieldwork.

Approximately one hundred hours of digital recordings have been collected as part of this research, including wordlists, phrases, …

The Transcription Factor Atf5 Protects Cortical Neurons From Toxicity Induced By Prostaglandin J2, Fanny Cheung

Dissertations, Theses, and Capstone Projects

Mitochondrial dysfunction has been recognized to play a central role in the pathogenesis of neurodegenerative disorders, including Parkinson’s and Alzheimer’s disease. Transcription factor ATF5 has been shown to mediate an endogenous stress pathway known as the UPR^mt, a prosurvival mechanism amidst malfunctioning mitochondria. However, the ATF5/UPR^mt protective pathway associated with mitochondrial impairment in neurons remains to be elucidated. To decipher the regulatory mechanisms involved with mediating neuroprotection, the effect of ATF5 was examined on the mitochondrial dysfunction induced by the proinflammatory prostaglandin PGJ2 in rat cortical neurons. ATF5 overexpression protected the effects induced by PGJ2 by attenuating …

Hur Ubiquitination By Brca1/Bard1 And Its Role In Controlling Gene Expression During Dna Damage Response, Gamage M. Aruggoda

Dissertations, Theses, and Capstone Projects

Despite our understanding of the biochemistry of the BRCA1/BARD1 E3 ligase, we know very little of the mechanism by which its cellular substrates, how they are chosen, how its E3 Ub ligase activity is regulated, which are the cofactors involved in this regulation, and how the substrates are modified during DDR. In this dissertation, I further evaluate BRCA1/BARD1-mediated E3 ligase activity and how CstF-50 and p97 regulate this reaction working as cofactors. My data show that BRCA1/BARD1 is an E3 ligase that ubiquitinates the RNA binding protein Human antigen R(HuR).

HuR is abundant in the nucleus and is transported to …

The Phylogenetic Relationships Of Middle-Late Miocene Apes: Implications For Early Human Evolution, Kelsey D. Pugh

Dissertations, Theses, and Capstone Projects

The living great apes, humans, and their fossil relatives (family Hominidae) are among the most intensively studied mammalian groups, yet many aspects of their shared evolutionary history are not well understood. Phylogenetic relationships of fossil great apes are poorly resolved and the positions of many fossil taxa relative to crown ape clades are debated. Moreover, the relationships of Sahelanthropus, Orrorin, and Ardipithecus to hominins are disputed, with some authors suggesting that alternative positions within Hominidae are more likely. Analyzing the position of these taxa within the broader context of the Miocene ape fossil record is thus necessary to …

Mutational Analysis And Domain Characterization Of The Apolipoprotein L-1 Ion Channel, Charles M. Schaub

Dissertations, Theses, and Capstone Projects

The human innate immunity factor Apolipoprotein L-1 (APOL1) protects against Trypanosoma brucei brucei infection. Recent studies have shown recombinant APOL1 (rAPOL1) inserts into planar lipid bilayers at an acidic pH 5.6 and forms a cation-selective channel, which opens upon subsequent neutralization, pH 7.2. This corresponds with the pH changes APOL1 would encounter during endosome recycling, suggesting that APOL1 forms a pH-gated ion channel in the plasma membrane of the parasite, leading to uncontrolled ion flux and osmotic imbalance. However, structural and domain characteristics of the APOL1 channel are poorly understood, despite potential similarities to diphtheria and colicin toxins. Utilizing E. …

The Interplay Between Interference Control And L2 Proficiency In L2 Auditory Sentence Comprehension In The Presence Of Verbal And Non-Verbal Masking, Jungna Kim

Dissertations, Theses, and Capstone Projects

Speech perception and comprehension in the presence of interfering auditory stimuli is a challenge for bilingual listeners (e.g., Ezzatian, Avivi-Reich, & Schneider, 2010; Krizman, Bradlow, Lam, & Kraus, 2017). How efficiently and skillfully listeners manage auditory interference may also be closely related to their ability to pay attention to a target and suppress irrelevant information. Based on Friedman and Miyake’s (2004) framework of interference control, this dissertation investigated the underlying mechanisms of late Korean-English bilingual individuals’ auditory interference control in the presence of auditory verbal and nonverbal masking and evaluated the potential interaction between L2 proficiency and interference control.

Two …

Synthesis And Antitumor Activity Of Potentially Tumor Targeting Analogues Of The Tetrahydrofuran Containing Acetogenins, Patricia Gonzalez Periche

Dissertations, Theses, and Capstone Projects

The tetrahydrofuran containing acetogenins (THF-ACGs) are a naturally occurring class of compounds with potent toxicity against a broad range of tumors, including multidrug resistant (MDR) strains. However, the equally high toxicity to normal cells presents a hurdle for their clinical advancement. This study entails synthetic and tumor targeting strategies that are relevant to their therapeutic development.

Chapter 1 presents a review of the synthesis and biological activity of the THF-ACGs. Chapter 2 covers a modular approach for the synthesis of libraries of THF-ACGs. This strategy is illustrated in the synthesis of C-10 epimers of 4-deoxyannonomontacin (4-DAN), one of the more …

Missing Time: Remembrances Of History’S Return, Marissa Brostoff

Dissertations, Theses, and Capstone Projects

This dissertation chronicles a profound recent shift within the US political left from an essentially backward-looking orientation to one marked by an unfamiliar sense of timeliness. Presented chronologically, the essays included here approach the vertiginous American political landscape since 2016 through readings of cultural phenomena from Bernie Sanders’s short-lived career as an experimental writer to Caitlyn Jenner’s reality show. They make up a Trump-era diary haunted by the ghosts of twentieth-century social movements and an intellectual coming-of-age story about growing up at the end of the end of history.

Molecular Mechanisms Underlying Migratory And Immune-Evasion Properties Of Circulating Tumor Cells, Jeannette A. Huaman

Dissertations, Theses, and Capstone Projects

Metastasis is the leading cause of cancer deaths worldwide. However, there exist only limited treatment options and they are often ineffective. An important aspect of metastasis that requires study, but has previously been understudied is circulating tumor cells (CTCs). CTCs are a critical step in the metastatic cascade. They can be analyzed for the identification of key mechanisms in metastasis. To this end, we isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prostate cancer (CRPC). From these mouse models, primary tumor and CTC lines were established. Functional characterization of …

The Implementation Of Empathy In The Animated Television Show “Hey Arnold”, Starnise Johnson

Dissertations, Theses, and Capstone Projects

For children to learn better empathic skills we must provide more opportunities for children to explore empathetic learning. In Daniel Goleman’s “Emotional Intelligence” he states. . . “the root of altruism lies in empathy, the ability to read emotions in others; lacking a sense of another’s need or despair, there is no caring (xiii). What is empathy? According to the Merriam- Webster dictionary, empathy is the action of understanding, being aware of, being sensitive to, and vicariously experiencing the feelings, thoughts, and experience of another.

Other than in the academic setting and from parents or caregivers, children can learn empathy …

Experience-Dependent Changes In Nucleus Accumbens Activity Predict Cued Approach Learning: Contribution Of Nmda Receptors, Mercedes Vega Villar

Dissertations, Theses, and Capstone Projects

Animals learn associations between environmental cues and the natural rewards they predict (e.g., food, water, sex). As a result, reward-predictive cues come to trigger vigorous reward-seeking responses. Many neurons in the nucleus accumbens (NAc) become excited upon presentation of an already-learned reward-predictive cue. These NAc responses encode the motivational value of the cue and are necessary for the expression of the subsequent approach behavior. However, the precise temporal relationship between the emergence of cue-evoked excitations in the NAc and the acquisition of cued approach behavior remains unknown. In Experiment 1, NAc activity was recorded as rats learned to approach a …

Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave

Dissertations, Theses, and Capstone Projects

Many types of neurons act as multimodal signaling centers. Yet, we have only limited insight into the regulation and functional consequences of neuronal co-transmission. For example, dopamine (DA) neurons, whose degeneration causes motor deficits characteristic of Parkinson’s Diseases (PD), communicate with all their targets by DA but only a selective subset of their targets using GABA, Glutamate, and the secreted cell signaling protein Sonic Hedgehog (Shh). It is unknown whether Levo-dopamine (L-Dopa) induced dyskinesia (LIDs), a severely debilitating side effect of DA supplementation in PD, might appear because DA neuron targets are exposed to high DA- but low Shh- signaling …

Parp1-Targeted Radiotherapies, Stephen Jannetti

Dissertations, Theses, and Capstone Projects

Poly-ADP-ribosylation reactions were first reported by Chambon in 1963 as enzymatic activity that increases incorporation of ATP in the presence of nicotinamide mononucleotide. In the decades since that publication, Poly(ADP-ribose)polymerase 1 (PARP1) and the PARP family enzymes have been widely studied. PARP enzymes are currently known to play various roles in mammals, including anti-aging processes, interactions with Breast Cancer Suppressor Protein-1 (BRCA1), and DNA damage repair. A significant focus of PARP1 research has been elucidating its role in DNA damage repair. PARP1 is recruited to repair single strand DNA (ssDNA) breaks, which can become double stranded DNA (dsDNA) breaks if …

Failures Of Grace: Limits Of Tragedy In The Late Nineteenth-Century Novel, Anick S. Rolland

Dissertations, Theses, and Capstone Projects

Failures of Grace argues that nineteenth-century novelists challenge the hegemonies of literary form and the value of personal suffering through what I call the trans-genre tragic novel. This new form is emblematic of a period in which values hang in the balance and places traditional values at odds with themselves by combining the low form of the novel with the highest mimetic mode in the Western tradition: tragedy. It simultaneously proposes the most vulnerable members of society as tragic heroes in contrast to the noble figures who previously were presumed to define the genre.

Through close readings of works by …

The Cortico-Motoneuronal System In The Plexina1 Knock-Out Mouse: Sculpting The Motor Response And Activity-Dependent Plasticity, John Kalambogias

Dissertations, Theses, and Capstone Projects

Higher primates, apes, and humans have cortico-motoneuronal (CM) connections between the motor cortical areas and spinal motoneurons. The CM system is thought to confer individuated finger movements and other aspects of skilled movement control; in part, by the selective CM cell they recruit, leading to fractionated patterns of muscle activity. Although CM connections have been examined using several approaches in monkeys, the presence and properties of the CM connection was elucidated in all the species using the technique of stimulus-triggered averaging (StTA). The electrophysiological signature for the CM response is short-latency EMG facilitation (post-stimulus facilitation; PStF) in individual muscles, followed …