Digital Commons Network^™

The Georgian Of Heritage Speaker Children, Cass Lowry

Dissertations, Theses, and Capstone Projects

This dissertation presents three research articles united in the goal of describing the Georgian language as it is spoken by heritage speakers in the Brooklyn diaspora. The Georgian heritage speaker subjects recruited for these studies were children due to immigration patterns at the time when experimental data was collected. Their production of morphosyntactic inflection and pronouns is compared to adult and child homeland speakers.

Heritage speakers of Georgian demonstrate the following divergences from homeland and standard language comparisons. Nominal case inflection is most affected in heritage production, as heritage speakers use a default case or collapse Georgian's split-ergative and inverse …

Potential Role Of A Ruthenium-Based Compound Ru-Im In The Treatment Of Triple Negative Breast Cancer, Rachele Rameau

Dissertations, Theses, and Capstone Projects

Triple negative breast cancer (TNBC) is an aggressive and heterogeneous molecular subtype of breast cancer that has limited available treatments. The organometallic cationic ruthenium derivative Ru-IM was found to be highly water soluble, was differentially toxic for breast cancer cells and tumors, and was involved in the pI3K/AKT/mTOR pathway. However, a full understanding of genetic and epigenetic factors that can be part of regulatory mechanisms of Ru-IM is yet to be determined. Epigenetic assays including DNA methylation, histone acetylation and histone deacetylation were performed with the half inhibitory concentration (IC50) values of Ru-IM. Bisulfite sequencing of untreated and treated MDA-MB-231 …

Love Amid The Rage: Feminist Affect In Women's Life-Writing, Genesis Siverio

Dissertations, Theses, and Capstone Projects

The aim of this thesis is to show the ways women’s emotions or affect, particularly rage and love, are described by women writers in their most intimate stories. I discuss the way emotion has been demeaned, and how feminist scholars have instead viewed the body as a place of insight, reclaiming a knowledge from the senses. In the midst of white supremacy and heteropatriarchy, women give voice to their affectual experiences and cultivate the feelings they have so often been denied. Focusing on the particular ways women’s anger manifests in their lives and in their bodies, I zoom in on …

Imagined Empires: Roman And Chinese Constructions Of One Another In Antiquity, Elizabeth S. Tsang

Dissertations, Theses, and Capstone Projects

This thesis examines how the Roman and Han Chinese empires conceptualized one another during the first centuries CE, despite never establishing sustained direct contact. It argues that mutual perceptions were shaped less by firsthand experience than by mediated reports, commodities, and the political interests of intermediaries. The study proceeds in four parts. The first explores how Roman authors employed the ethnonym Seres to frame China as a land of wonder, wealth, and alterity. The second analyzes the Chinese designation Da Qin, showing how it projected Han imperial ideals outward by casting Rome as a mirror-image polity. The third turns to …

Dónde Están: Searching For Desaparecidos Of The Argentine Dirty War, Paula Fleischer

Dissertations, Theses, and Capstone Projects

This project is a data physicalization textile representing the 30,000 'desaparecidos' from the Argentine Dirty War of late 1970s. The large quilt visualizes the official count of 9,000 missing persons in the shape of a headscarf worn by their mothers and grandmothers, while the overall dimensions of the quilt acknowledges 30,000 missing persons. The quilt and accompanying missing persons posters encourage the viewer to interact with the data, however the observed reluctance to engage influenced the direction of this discussion about the hegemonic disinclination to get involved when authority figures 'disappear' fellow residents of our communities.

Giving Voice To The Frames Of War: A Digital Humanities Framework For Evaluating War Crimes Databases, Leila Markosian

Dissertations, Theses, and Capstone Projects

Developments in digital technologies have complicated existing debates around the ethics of cataloging war crimes and human rights violations. Digital humanities methods of evaluating digital scholarship can help to construct a framework for evaluating war crimes databases, a process which requires a fine-tuned critical analysis aimed towards understanding the purpose of compiling the database, the platform or media template through which the database is presented, and the communicative potentials of the database. The following paper presents a survey of the existing literature on war crime databases and the politics of memory; a model of how war crimes database analyses may …

Ai-Powered Multi-Omics Integration For Predictive Modeling Of Genotype-Environment-Phenotype Relationships, You Wu

Dissertations, Theses, and Capstone Projects

This dissertation presents a series of machine learning frameworks for modeling genotype–environment–phenotype relationships through integrative predictive modeling of multi-omics data. The work addresses three major axes of biological complexity: modeling biological information transmission cross-levels from genes to proteins to phenotypes, predicting molecular features cross-scale from cells to tissues to organisms, and translating phenotypes cross-species from model systems to humans. Each proposed method also tackles key machine learning (ML) challenges in the biomedical domain, including data scarcity, domain shift, out-of-distribution (OOD) generalization, and hierarchical modeling. Specifically, this dissertation introduces five novel deep learning algorithms: MultiDCP predicts drug-induced transcriptomic and viability responses …

Origin And Maintenance Of The Andean Bird Fauna, Elkin A. Tenorio

Dissertations, Theses, and Capstone Projects

The origin and maintenance of the tropical montane diversity have been evaluated over multiple decades using various techniques and perspectives. Despite major progress in understanding phylogenetic relationships, diversification patterns, distributional data, and general ecology in the Andean biota, large gaps in our understanding remain, particularly in the synthesis across scales. To fill these gaps, I aimed to explore patterns and processes that underlie species diversification in birds of the tropical Andes of South America by combining different approaches using phenotypic, phylogenetic, and genomic data in multiple temporal and spatial scales.

In the first chapter, I examined the macroevolutionary patterns of …

Alerted And Anxious? The Effects Of Mobile Crime Alerts On Perceptions Of Personal And Public Safety, Amanda C. Benjamin

Dissertations, Theses, and Capstone Projects

Mobile crime alert platforms promise to enhance personal and public safety by delivering frequent notifications about nearby dangers—claims that, until now, have not been experimentally tested. For-profit applications like Citizen deliver real-time, geo-targeted push notifications about nearby crime incidents to over 9 million users, often operating outside the bounds of institutional oversight. Although marketed as tools to enhance awareness and protection, these platforms may simultaneously empower users through information while also potentially amplifying anxiety, heightening threat perceptions, and eroding trust in community. Despite their increasing prominence and integration into public safety communications, the psychological and behavioral impacts of mobile crime …

The Question Of Money: State, Protest, And Informal Currencies In The Wake Of Greece’S Economic Crisis, Helen Panagiotopoulos

Dissertations, Theses, and Capstone Projects

Monetary unions are designed to foster political, social, and economic integration among member states by enabling the free movement of people, goods, services, and capital. Yet when a member nation faces economic crisis, citizens may respond by creating monetary systems of their own. This research asks whether such practices are simply demonstrations of human resiliency and adaptability, or whether they also challenge the very idea of a shared market and currency that do not align with national identity. Greece offers a crucial case for this inquiry. Following the 2008 debt crisis, austerity measures led to economic depression, mass unemployment, and …

Choreographies Of Care: Disability And Relationality In Performance, Kiera Bono

Dissertations, Theses, and Capstone Projects

My dissertation explores enactments of what I am calling “choreographies of care” in interdisciplinary performance practices in the 21^st century. Working across disability studies, race and ethnicity studies, queer theory, and performance studies, I investigate the ways in which chronically ill and disabled artists have generated multisensorial movement, sound, and performance works that resist normative understandings of time, space, bodies, and interactions between bodies. Focusing mostly on performances and events that I have attended in New York City or virtually over the past decade, my project engages directly with disability arts communities in which I have been deeply embedded …

The Sonic Hedgehog Effector Smoothened Modulates Cholinergic Interneuron Activity, Physiology, And Striatum-Dependent Behaviors, Santiago Uribe-Cano

Dissertations, Theses, and Capstone Projects

The striatum is a central node in action selection and associative learning, integrating cortical, thalamic, and neuromodulatory input. Among its principal modulators, dopamine (DA) and acetylcholine (ACh) are known for their temporally coordinated yet mechanistically distinct influences on striatal output. However, the upstream signals that regulate their dynamic interplay, particularly within cholinergic interneurons (CINs)—the primary source of striatal ACh—remain incompletely characterized. This dissertation investigates the role of Smoothened (Smo), a G protein-coupled receptor (GPCR) effector of Sonic Hedgehog (Shh) signaling, in modulating ACh signaling dynamics in the striatum.

Building on evidence that midbrain DA neurons co-release Shh and that CINs …

Leveraging Stellar Chemistry For A Global View Into The Atmospheres Of Brown Dwarfs And Giant Exoplanets, Emily Calamari

Dissertations, Theses, and Capstone Projects

In the era of the James Webb Space Telescope (JWST), it is now possible to examine substellar mass atmospheres in unparalleled detail and precision. However, unraveling the complicated thermodynamics and chemistry in these atmospheres remains a challenge. Atmospheric retrievals are a leading data-driven technique capable of recovering an object’s fundamental parameters such as mass, radius, effective temperature, gravity, cloud structure and composition and chemical abundances. However, in directly imaged or isolated worlds, constraining and/or interpreting these fundamental parameters can be difficult, particularly as retrieval models try to parameterize the overall impact of clouds.

For my dissertation, I turned to main …

The Effect Of Tbi On Working Memory And Anxiety In Rats, Mariola Sobolewska

Dissertations, Theses, and Capstone Projects

Traumatic Brain Injury (TBI) is a significant public health concern, often leading to cognitive and emotional impairments. This study examined the effects of TBI on working memory and anxiety-like behavior in young male Sprague-Dawley rats using the Radial Arm Maze (RAM) and Elevated Plus Maze (EPM), which are behavioral assessments. The RAM tests spatial working memory by evaluating the animal’s ability to remember and efficiently navigate multiple arms to retrieve rewards. The EPM assesses anxiety-like behavior based on the animal’s preference for open versus closed arms. The study utilized young male Sprague-Dawley rats, a well-established rodent model known for its …

The Architecture Of Exclusion: Disability, Race, And The History Of New York City’S 600 Schools, Francine Almash

Dissertations, Theses, and Capstone Projects

This dissertation investigates the largely erased history of New York City’s 600 schools—segregated public schools created to house students labeled as emotionally disturbed or socially maladjusted. These institutions, operating throughout the mid-20th century, disproportionately served Black and Puerto Rican youth, many of whom were placed in these schools under vague behavioral criteria and with little to no pathway for return to general education settings.

Combining archival research, longitudinal policy analysis, historical media review, and critical race and disability studies frameworks—including DisCrit (Disability Critical Race Theory)—this project situates the 600 schools at the intersection of institutional racism and ableism. It argues …

Bmp Signaling Co-Regulation Of Immune Response And Lipid Metabolism, Katerina K. Yamamoto

Dissertations, Theses, and Capstone Projects

The Bone Morphogenetic Proteins (BMPs) are secreted peptide ligands of the Transforming Growth Factor beta (TGF-β) family, initially identified for their roles in development and differentiation across animal species. They are now increasingly recognized for their roles in physiology and infectious disease. In the nematode Caenorhabditis elegans, the BMP ligand DBL-1 controls fat metabolism and immune response, in addition to its roles in body size regulation and development. DBL-1 regulates classical aspects of innate immunity, including the induction of anti-microbial peptides. We theorized that BMP-dependent regulation of fat metabolism could also promote resilience against microbial pathogens. We found that …

Detecting Sonic Hedgehog Expression In The Adult Mouse Brain Using A Gene Expression Tracer, Kendra Stephens-Jones

Dissertations, Theses, and Capstone Projects

Sonic Hedgehog (Shh) is best known for its role in development, yet evidence supports Shh signaling plays a functional role in the adult brain. Previous work demonstrated that Shh is expressed by dopamine (DA) neurons in the ventral midbrain and that loss of Shh from these neurons leads to late-onset motor and structural abnormalities resembling Parkinson’s disease. However, the extent of Shh expression and its connectivity to the striatum in the adult mouse brain remain unclear due to the lack of reliable antibodies for Shh detection. To address this gap, the present study employed Shh ^L/L and DAT-Cre^+/- mice …

Mechanisms Of Sleep Regulation In Drosophila Melanogaster, Anfal A. Abuhilal

Dissertations, Theses, and Capstone Projects

Sleep is a fundamental biological need, and sufficient sleep is required for physical and mental well-being. Sleep is regulated by two biological mechanisms: sleep-wake homeostasis and circadian rhythm. Circadian rhythms are near 24-h rhythms in behavior and physiology that are generated by endogenous mechanisms. In mammals, the suprachiasmatic nucleus (SCN) is the central circadian pacemaker, which is known to receive a significant amount of serotonergic input that likely modulates sleep rhythms. In addition to circadian modulation, sleep is subject to homeostatic regulation. Several neuromodulators have been proposed as mediators of sleep homeostasis. Serotonin has been implicated in sleep drive and …

Crisis Narratives And The Vicissitudes Of Haitian Foodways: A Critical Comparison Of Three Food Items, Marc S. Gabriel

Dissertations, Theses, and Capstone Projects

Polities and media external to Haiti direct a lot of narrative focus on the country being the source of its own protracted crises. This represents a powerful narrative hegemony that casts the post-colonial nation as a zone of perpetual disasters or crisis. To maintain that narrative domination over Haiti, opportunistic observers of Haiti’s media spectacles of crisis only need to atomize the country’s newest crisis or natural disaster from the history that situates it. The elision of the Haitian memory – a memory of structural adjustment programs, systematic displacement, foreign-sponsored paramilitary violence, erosion of peasant foodways and agriculture – from …

The Role Of Water In Peptide Behavior And Peptide-Based Water-Responsive Crystals, Janel Jannette Rivera Cancel

Dissertations, Theses, and Capstone Projects

Water plays a crucial role in shaping the behavior and function of biomolecules across the liquid, supercooled, and glassy states. This thesis presents a dual approach combining computational simulations and experimental investigations to explore the influence of water on biomolecular systems, particularly peptide-based materials. We employ molecular dynamics simulations to study the hydration-dependent structural dynamics of homopolymer peptides. Simulations were carried out across a range of temperatures and pressures to analyze changes in hydration and structural stability, shedding light on the behavior of peptides under supercooled and glassy conditions. These studies are especially relevant for understanding biomolecular stability in cryopreservation. …

Structural Characterization Of A Tarantula Toxin And Its Interactions With Lipid Bilayers And Voltage-Gated Sodium Channels, Krishnakoli Adhikary

Dissertations, Theses, and Capstone Projects

Voltage-gated ion channels are membrane protein complexes. They allow the selective flow of their respective ions down an electrochemical gradient through a central ion conduction pore surrounded by four voltage-sensing domains (VSDs). Various neurological and cardiovascular diseases are caused by mutations in voltage-gated ion channels (VGICs). One of the biggest challenges today is addiction to opioid medication. Coming up with non-opioid drug leads can be a real blessing for society. This is where voltage-gated sodium channel research comes in. Na_v1.7, Na_v1.8, and Na_v1.9 are responsible for pain sensations. Loss or gain of function in …

Tradition, Individuality, And Innovation In Western Classical Music Performance: A Quantitative Analysis Of Bach’S Fourth Cello Suite Prelude, Clare Monfredo

Dissertations, Theses, and Capstone Projects

Why do we seek out new performances of a commonly performed piece of music? An essential tradition of Western classical music (WCM) is the performance of canonical works by composers, an activity that requires the interpretation and execution of written scores by individual performers. In this practice, performers are not only expected to determine the composer’s “intentions,” but also somehow (paradoxically) share these in a “unique” performance interpretation. In musical education, performers are trained by teachers to create these “unique” interpretations by learning how to intuit composers’ intentions in a system that passes down interpretative traditions through master-apprentice one-on-one lessons. …

Mechanistic Insights Into The Neuroprotective Effects Of The Antidepressant Agomelatine In Alzheimer's Disease, Grace Terry

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease (AD) is a complex neurodegenerative disease that has limited treatment options and no cure. AD is characterized by robust pathology including extracellular amyloid beta plaques, intracellular neurofibrillary tangles, neuronal and synaptic loss, neuroinflammation, and brain atrophy. AD presents with cognitive decline and memory loss but only years after neuropathology has started to accumulate. This robust pathology has made AD difficult to treat and highlights the need for therapeutics that modulate multiple pathways. Agomelatine (AGO) was selected by a high-throughput machine learning drug repurposing algorithm by our collaborator Dr. Lie Xie (Hunter College Dept. of Comp. Sci.) as having …

Investigating The Role Of Early Growth Response 1 (Egr1) Gene In Riluzole-Induced Apoptosis In Osteosarcoma, Syeda Maryam Azeem

Dissertations, Theses, and Capstone Projects

Osteosarcoma is a rare but aggressive bone malignancy most commonly affecting adolescents and young adults (AYA). With 5-year survival rate stagnating over the last four decades despite the advancements in multi-modal therapy, drug repurposing offers a rapid path to new osteosarcoma treatments. Recent studies suggest that Riluzole, a drug approved for amyotrophic lateral sclerosis (ALS), may be repurposed for osteosarcoma treatment due to its ability to slow tumor progression and induce apoptosis. Previously, we have shown that Riluzole increases reactive oxygen species (ROS), activating c-Abl, which phosphorylates YAP in the nucleus. YAP then forms a complex with p73 to enhance …

Behavioral Biomarkers Of Vulnerability In The Aba Model, Nora Ozer

Dissertations, Theses, and Capstone Projects

Anorexia nervosa (AN) is a severe psychiatric disorder with the highest mortality rate among mental health conditions, yet effective biological treatments remain limited. The activity-based anorexia (ABA) paradigm, which combines food restriction with wheel access to model the hyperactivity and self-starvation cycle characteristic of AN, shows considerable individual variability in vulnerability. Understanding what predisposes certain individuals to develop the full ABA phenotype while others remain resilient could inform early intervention strategies for human AN. This study employed continuous behavioral monitoring technology to identify early predictors of vulnerability to activity-based anorexia in mice, with the goal of discovering behavioral biomarkers that …

Interspecies Responsivity In Early Modern Drama And Animal Performances, Taylor C. Culbert

Dissertations, Theses, and Capstone Projects

This dissertation proposes an expansive, interspecies definition of performance that uses behavior rather than cognition as the decisive feature and illustrates how such a definition can reshape our approach to theatre and performance history. Using the concept of responsivity, which refers to the embodied and affective ways that humans and non-human animals acknowledge and react to one another, I trace human–animal interactions across a variety of sixteenth- and seventeenth-century performance genres, from the aristocratic stag hunt and entertainments involving trained animals to the plays of Molière and Shakespeare. Drawing on my experience training animals, I offer a new perspective on …

The Crisis Of Safety, Well-Being, And Belonging Facing Lgbtq Children: Mad/Crip Of Color Critique Towards A Curriculum Of Radical Care, Jameson Goetz

Dissertations, Theses, and Capstone Projects

In this thesis, I turn toward the study of educational experience, defined broadly to include lived experiences both within and outside of formal schooling institutions. I approach curriculum as an ongoing project of self-understanding in which one becomes mobilized for engaged pedagogical action alongside others in the pursuit social justice. I am guided by the following question, foundational to the field of curriculum studies: for those of us who work alongside LGBTQ children, what knowledge is of most worth? Critically reflecting on ways of working alongside LGBTQ children in the pursuit of social justice, I formulate a mad/crip of color …

Investigation Of Motor Neuronal And Circuit Level Mechanistic Determinants Of Spinal Excitability Following Cst Injury, Thelma Bethea

Dissertations, Theses, and Capstone Projects

The corticospinal tract (CST) is the primary descending motor pathway in mammals, essential for precise, dexterous movements, especially in humans and nonhuman primates. Damage to the CST, such as from spinal cord injury (SCI), impairs skilled motor function and triggers maladaptive changes including aberrant proprioceptive afferent sprouting and increased spinal excitability. These changes are closely linked to both muscle weakness and the development of hyperreflexia, compounding the functional deficits. Animal models of SCI are valuable for investigating mechanisms of injury and recovery, though traditional models often limit the ability to isolate circuit-specific contributions. To address this, I employed selective unilateral …

The Evolution And Reproduction Of Andean Miconia (Melastomataceae), Juan Angulo

Dissertations, Theses, and Capstone Projects

Understanding the factors that shape diversification and distribution in tropical plant lineages is central to explaining the origins of Neotropical biodiversity. Assessing evolutionary history with trait evolution and climatic niche dynamics provides key insights into the drivers of diversification and biogeography, while natural history data remains critical for these evolutionary studies. The Tropical Andes, with its exceptional biodiversity and environmental heterogeneity, offers an ideal setting to explore these processes. In this dissertation, I investigate how reproductive systems, climatic niche dynamics, and pollination strategies influence the evolution and biogeography of Miconia III, a large and ecologically diverse clade in the …

Low-Resource Ecoacoustic Audio Classification, Enis Berk Coban

Dissertations, Theses, and Capstone Projects

Ecoacoustic monitoring via machine learning enables scalable analysis but is often constrained by labeled data scarcity, particularly in remote regions like the Arctic. This thesis confronts low-resource ecoacoustic audio classification by developing and evaluating complementary machine learning methodologies. We introduce EDANSA, the first publicly available, expert- labeled Arctic dataset of its kind, curated via novel active learning, alongside a baseline CNN. We systematically evaluate transfer learning, showing general audio embeddings effectively bootstrap classifiers for challenging Arctic sounds, significantly outperforming direct label mapping. Optimizing label utility, we investigate standard data augmentation and introduce novel audio data valuation via Shapley values, revealing …