Digital Commons Network^™

Development Of An Online General Biology Open Educational Resource (Oer) Laboratory Manual, Dmitry Y. Brogun, Azure N. Faucette, Kristin Polizzotto, Farshad Tamari

Publications and Research

Currently, many academic institutions are using one or more variations of online modalities due to the COVID-19 pandemic, and science educators face a unique challenge with distance-learning laboratories. Many resources to engage students in virtual, interactive laboratory activities exist, but we found that high costs and/or overlooked content left gaps for several topics typically taught in a general, introductory biology course for undergraduate biology majors (e.g., organismal biology). Additionally, resources for an online lab must be identified and curated from multiple sources, requiring intense demands on the instructors’ time. To meet this need and to overcome the financial burden of …

Effects Of Feeding Enrichment On The Behavior Of Ex-Pet Ring-Tailed Lemurs (Lemur Catta), Amanda Rodriguez

Theses and Dissertations

Environmental enrichment is a prevailing tool used to enhance the welfare of captive species. Benefits of enrichment commonly range from promoting activity levels to reducing stereotypic/abnormal behavior. This study investigated the impact of two forms of feeding enrichment on the behavior of ring-tailed lemurs confiscated from the illegal pet trade.

Griffithsin And Carrageenan Combination Results In Antiviral Synergy Against Sars-Cov-1 And 2 In A Pseudoviral Model, Sahar Alsaidi, Nadjet Cornejal, Oneil Mahoney, Claudia Melo, Neeharika Verma, Thierry Bonnaire, Theresa Chang, Barry R. O'Keefe, James Sailer, Thomas M. Zydowsky, Natalia Teleshova, José A. Fernández Romero

Publications and Research

Over 182 million confirmed cases of COVID-19 and more than 4 million deaths have been reported to date around the world. It is essential to identify broad-spectrum antiviral agents that may prevent or treat infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but also by other coronaviruses that may jump the species barrier in the future. We evaluated the antiviral selectivity of griffithsin and sulfated and non-sulfated polysaccharides against SARS-CoV-1 and SARS-CoV-2 using a cytotoxicity assay and a cell-based pseudoviral model. The half-maximal cytotoxic concentration (CC50) and half-maximal effective concentration (EC50) were determined for each compound, using a dose-response-inhibition …

Increasing Obesity Odds Among Foreignborn New Yorkers Are Not Explained By Eating Out, Age At Arrival, Or Duration Of Residence: Results From Nyc Hanes 2004 And 2013/2014, Margrethe F. Horlyck-Romanovsky, Sean J. Haley

Publications and Research

Background: Among the foreign-born in the United States (US) dietary acculturation and eating out may increase obesity risk. Using the 2004 (N = 1952) and 2013/14 (N = 1481) New York City (NYC) Health and Nutrition Examination Surveys, we compared for the foreign-born and US-born by survey year: 1) odds of obesity; 2) association between eating out and obesity and 3) effect of age at arrival and duration of residence among the foreign-born. Weighted logistic regression estimated odds of obesity.

Results: Compared to the US-born, the foreign-born had lower odds of obesity in 2004, (aOR = 0.51 (95%CI 0.37– 0.70), …

A Systematic Review And Meta-Analysis On The Efficacy Of Stem Cell Therapy On Bone Brittleness In Mouse Models Of Osteogenesis Imperfecta, Lauren Battle, Shoshana Yakar, Alessandra Carriero

Publications and Research

There is no cure for osteogenesis imperfecta (OI), and current treatments can only partially correct the bone phenotype. Stem cell therapy holds potential to improve bone quality and quantity in OI. Here, we conduct a systematic review and meta-analysis of published studies to investigate the efficacy of stem cell therapy to rescue bone brittleness in mouse models of OI. Identified studies included bone marrow, mesenchymal stem cells, and human fetal stem cells. Effect size of fracture incidence, maximum load, stiffness, cortical thickness, bone volume fraction, and raw engraftment rates were pooled in a random-effects meta-analysis. Cell type, cell number, injection …

Notch Signaling Represses Cone Photoreceptor Formation Through The Regulation Of Retinal Progenitor Cell States, Xueqing Chen, Mark M. Emerson

Publications and Research

Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells. However, the mechanism by which Notch signaling controls these processes is unknown. Recently, restricted retinal progenitor cells with limited proliferation capacity and that preferentially generate cone photoreceptors have been identified. Thus, there are several potential steps during cone genesis that Notch signaling could act. Here we use cell type specific cis-regulatory elements to localize the primary role of Notch signaling in cone genesis to the formation of restricted retinal progenitor cells from multipotent retinal progenitor cells. Localized …

The Effects Of Climate And Demographic History In Shaping Genomic Variation Across Populations Of The Desert Horned Lizard (Phrynosoma Platyrhinos), Keaka Farleigh, Sarah A. Vladimirova, Christopher Blair, Jason T. Bracken, Nazila Koochekian, Drew R. Schield, Daren C. Card, Nicholas Finger, Jonathan Henault, Adam D. Leaché, Todd A. Castoe, Tereza Jezkova

Publications and Research

Species often experience spatial environmental heterogeneity across their range, and populations may exhibit signatures of adaptation to local environmental characteristics. Other population genetic processes, such as migration and genetic drift, can impede the effects of local adaptation. Genetic drift in particular can have a pronounced effect on population genetic structure during large-scale geographic expansions, where a series of founder effects leads to decreases in genetic variation in the direction of the expansion. Here, we explore the genetic diversity of a desert lizard that occupies a wide range of environmental conditions and that has experienced post-glacial expansion northwards along two colonization …

Holding Space For Uncertainty And Vulnerability: Reclaiming Humanity In Teacher Education Through Contemplative | Equity Pedagogy, Malgorzata Powietrzynska, Linda Noble, Sharda O’Loughlin‑Boncamper, Aundrey Azeez

Publications and Research

In this manuscript we describe our journey as two White coteachers conducting interpretive research with Black and Brown students in a remote-learning teacher preparation course in New York City. In the context of uncertainty, during the twin epidemics of COVID-19 and racial injustice, we explore how we reframed our contemplative pedagogy by embracing an equity-oriented framework. We share stories about moments of awakening drawn from spaces between us and our exceptional cohort of special education teachers – reflections about sensations, emotions, biases, and lived experiences as we embrace the identity of interbeing. Specifically, we explore transformations in our approach to …

Learning Of Food Preferences: Mechanisms And Implications For Obesity & Metabolic Diseases, Hans-Rudolf Berthoud, Christopher D. Morrison, Karen Ackroff, Anthony Sclafani

Publications and Research

Omnivores, including rodents and humans, compose their diets from a wide variety of potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to sweet and avoidance of bitter, they have limited innate dietary knowledge and must learn to prefer foods based on their flavors and postoral effects. This review focuses on postoral nutrient sensing and signaling as an essential part of the reward system that shapes preferences for the associated flavors of foods. We discuss the extensive array of sensors in the gastrointestinal system and the vagal pathways conveying information about ingested nutrients to the …

Biol 4010w/7190g/Cisc2810w: Macromolecular Structure And Bioinformatics, Shaneen Singh

Open Educational Resources

No abstract provided.

Oral Manifestations Of Tuberculosis, Diana V. Macri, Sandra Castellanos, Elvir Dincer

Publications and Research

This article will update the reader on tuberculosis and its oral manifestations.

After decades of decreasing incidence, tuberculosis resurgence is being seen in some global regions due to factors that include the human immunodeficiency virus (HIV) epidemic, increased immigration from countries with endemic tuberculosis, transmission of tuberculosis in crowded or unsanitary environments, and poor healthcare infrastructure. Additionally, this review is especially prescient considering the increasing prevalence of drug-resistant tuberculosis.

Minerva Cuevas: Disidencia, Alaina Claire Feldman, Clayton Press, Solange Farkas, Gabriel Bogossian

Publications and Research

Bilingual catalogue for the exhibition "Minerva Cuevas: Disidencia" presented at Baruch College's Mishkin Gallery.

Telomeric And Sub-Telomeric Structure And Implications In Fungal Opportunistic Pathogens, Raffaella Diotti, Michelle Esposito, Chang Hui Shen

Publications and Research

Telomeres are long non-coding regions found at the ends of eukaryotic linear chromosomes. Although they have traditionally been associated with the protection of linear DNA ends to avoid gene losses during each round of DNA replication, recent studies have demonstrated that the role of these sequences and their adjacent regions go beyond just protecting chromosomal ends. Regions nearby to telomeric sequences have now been identified as having increased variability in the form of duplications and rearrangements that result in new functional abilities and biodiversity. Furthermore, unique fungal telomeric and chromatin structures have now extended clinical capabilities and understanding of pathogenicity …

Weather And Crime: New York State, Yuna Kim

Student Theses

The present study assesses the degree to which temperature affects the crime rates in all 62 counties in the State of New York. Five different crimes (i.e., robbery, aggravated assault, burglary; larceny, and motor vehicle theft) for the year 2019 were selected from the Division of Criminal Justice Services of New York to be examined. The current study examined whether the rate of these crimes was associated with the changes in weather, with the assumption that higher weathers would lead to higher property and violent crimes, when controlling for the effect of various control variables. The findings suggest that the …

The Effect Of Fluid Flow Shear Stress And Substrate Stiffness On Yes-Associated Protein (Yap) Activity And Osteogenesis In Murine Osteosarcoma Cells, Thomas R. Coughlin, Ali Sana, Kevin Voss, Abhilash Gadi, Upal Basu-Roy, Caroline M. Curtin, Alka Mansukhani, Oran D. Kennedy

Publications and Research

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%; OS is an aggressive disease for which new treatments are needed. All bone cells are sensitive to their mechanical/ physical surroundings and changes in these surroundings can affect their behavior. However, it is not well understood how OS cells specifically respond to fluid movement, or substrate stiffness—two stimuli of relevance in the tumor microenvironment. We used cells from spontaneous OS tumors in a mouse engineered to have a bone-specific knockout of pRb-1 and p53 in …

Area Characteristics And Consumer Nutrition Environments In Restaurants: An Examination Of Hispanic Caribbean Restaurants In New York City, Melissa Fuster, Hanish Kodali, Krishnendu Ray, Brian Elbel, Margaret A. Handley, Terry T. Huang, Glen Johnson

Publications and Research

Hispanics in the USA, particularly those of Caribbean descent, experience high levels of diet-related diseases and dietary risk factors. Restaurants are an increasingly important yet understudied source of food and may present opportunities to positively influence urban food environments. We sought to explore food environments further, by examining the association between neighborhood characteristics and restaurant consumer nutrition environments within New York City’s Hispanic Caribbean (HC) restaurant environments. We applied an adapted version of the Nutrition Environment Measurements Survey for Restaurants (NEMS-R) to evaluate a random sample of HC restaurants (n=89). NEMS-HCR scores (continuous and categorized as low, medium, and high …

Quantifying The Speed Of Chromatophore Activity At The Single-Organ Level In Response To A Visual Startle Stimulus In Living, Intact Squid, Stavros P. Hadjisolomou, Rita W. El-Haddad, Kamil Kloskowski, Alla Chavarga, Israel Abramov

Publications and Research

The speed of adaptive body patterning in coleoid cephalopods is unmatched in the natural world. While the literature frequently reports their remarkable ability to change coloration significantly faster than other species, there is limited research on the temporal dynamics of rapid chromatophore coordination underlying body patterning in living, intact animals. In this exploratory pilot study, we aimed to measure chromatophore activity in response to a light flash stimulus in seven squid, Doryteuthis pealeii. We video-recorded the head/arms, mantle, and fin when squid were presented with a light flash startle stimulus. Individual chromatophores were detected and tracked over time using image …

Homesick, Or Sacred Heterosexual Spaces, Ryan A. Drake

Theses and Dissertations

A dark satire about a young queer man who comes home under mysterious circumstances to find that he's been replaced by someone who looks just like him. He starts having dreams that his family is trying to kill him...but are they dreams?

Native App Ux With A Social Design Emphasis, Katya Rozanova

Open Educational Resources

This course is designed to teach students how to design user experiences (UX) for native applications for mobile devices while considering what types of digital products can and should be put out into the world as tools for the day-to-day, as speculative art projects, or as forms of resistance to existing systems in place. The course focuses on usability heuristics, research (human-centered design methodologies) and competitive analysis, information architecture, rapid prototyping and usability testing. Students will familiarize themselves with native UI elements in Apple and Android platforms and design for one of the platforms of their choice. They will learn …

Sacred Music In Colonial Era Hispaniola: The Evangelization Of The Taino People, Tito J. Gutierrez

Student Theses

During the 15th-18th centuries, the major European religious orders; the Franciscans, Dominicans, Jesuits, and Jeronymites, journeyed to the newly colonized American territories in an attempt to convert the multitudes of natives peoples living there. Along with prayer books, crucifixes, and religious images, these missionaries brought sacred European music to American shores in an attempt to attract the native people to the Catholic faith.The use of music as a tool for conversion of native people in places such as Mexico, South America, California, and the South West United States, have been well researched and documented. However, the research of the spiritual …

Defining The Basis Of Cyanine Phototruncation Enables A New Approach To Single-Molecule Localization Microscopy, Siddharth S. Matikonda, Dominic A. Helmerich, Mara Meub, Gerti Beliu, Philip Kollmannsberger, Alexander Greer, Markus Sauer, Martin J. Schnermann

Publications and Research

The light-promoted conversion of extensively used cyanine dyes to blue-shifted emissive products has been observed in various contexts. However, both the underlying mechanism and the species involved in this photoconversion reaction have remained elusive. Here we report that irradiation of heptamethine cyanines provides pentamethine cyanines, which, in turn, are photoconverted to trimethine cyanines. We detail an examination of the mechanism and substrate scope of this remarkable twocarbon phototruncation reaction. Supported by computational analysis, we propose that this reaction involves a singlet oxygeninitiated multistep sequence involving a key hydroperoxycyclobutanol intermediate. Building on this mechanistic framework, we identify conditions to improve the …

Detection Methods And Clinical Applications Of Circulating Tumor Cells In Breast Cancer, Hongyi Zhang, Xiaoyan Lin, Yuan Huang, Minghong Wang, Chunmei Cen, Shasha Tang, Marcia R. Dique, Lu Cai, Manuel A. Luis, Jillian Smollar, Yuan Wan, Fengfeng Cai

Publications and Research

Circulating Tumor Cells (CTCs) are cancer cells that split away from the primary tumor and appear in the circulatory system as singular units or clusters, which was first reported by Dr. Thomas Ashworth in 1869. CTCs migrate and implantation occurs at a new site, in a process commonly known as tumor metastasis. In the case of breast cancer, the tumor cells often migrate into locations such as the lungs, brain, and bones, even during the early stages, and this is a notable characteristic of breast cancer. Survival rates have increased significantly over the past few decades because of progress made …

Transit Mobility And Premature Birth In New York City: A Population-Based Study, Ross B. Maddux

Theses and Dissertations

Transit mobility has been recognized as an essential element to economic attainment, environmental sustainability, and as a vital part of public health⁠. Social and economic disparities paired with elusive and inefficient public transit present real barriers for the ability of efficient planning and use of time⁠. Lengthier commutes and generally less efficient travel contribute to stress during a pregnancy and limit the ability to access work and prenatal care. In survey studies of women utilizing clinics as their prenatal care provider, nearly 25% listed transportation as a barrier to accessing care.

Prior research has not linked directly premature birth and …

Design, Synthesis And Evaluation Of Molecules With Selective And Poly-Pharmacological Actions At D1r, D3r And Sigma Receptors, Pierpaolo Cordone

Dissertations, Theses, and Capstone Projects

The dopamine D3 receptor (D3R) is one of the most studied receptors involved in drug addiction. One of the most common strategies to treat substance use disorders is via D3R antagonism. The majority of the D3R antagonists synthesized so far have poor pharmacokinetic properties and/or lack selectivity toward D3R. In this thesis, the design, synthesis and biological evaluation of novel molecules that target the dopamine D1 receptor (D1R), D3R and the serendipitous discovery of molecules that target s receptors will be described.

Chapter 1 presents a survey of the fundamental pharmacology of D1R, D3R and s receptors and the therapeutic …

Monumentality, Fortification, And Movement: Preclassic Maya Developments As Seen At Muralla De León, Petén, Guatemala, Justin D. Bracken

Dissertations, Theses, and Capstone Projects

Analysis of settlement patterning in relation to natural and constructed defensive elements expands understanding of the impact of warfare well beyond the relatively brief period of active battle. Advance preparation in advance of conflict, including reshaping the landscape for defensibility and conscription of labor toward that end, alters patterns of movement, social interaction, and physical settlement, effects that can extend for generations beyond the cessation of hostilities. This project investigates the role played by warfare in shaping the physical and social landscape of the Maya of the central Petén during the Late Preclassic period (400 B.C. – A.D. 150), as …

The Emotional Illusion Of Music: Contemporary Western Musical Aesthetics In Dialogue With Ancient Eastern Philosophy, Yin Zhang

Dissertations, Theses, and Capstone Projects

This project aims to examine whether music has an emotional nature. I use the ancient Chinese text Music Has No Grief or Joy to construct three arguments for the illusion view, according to which music has no emotional nature and the emotional appearances of music are illusory. These arguments highlight representational inconstancy, expressive incapability, and evocative underdetermination as three ways to problematize the idea that music has an emotional nature. I draw on the Confucian tradition to formulate three responses to the illusion view from representational reliability, expressive sincerity, and evocative appropriateness. These responses are shown to be inadequate. To …

Alcohol And Its Long-Term Effects On Hearing Loss: A Systematic Review, Talia Sowalsky

Dissertations, Theses, and Capstone Projects

Objective: To review the literature on potential permanent effects of long-term alcohol consumption on hearing status in adults 40 years of age and older.

Study Design: Systematic review of prospective and retrospective studies; meta-analysis of case-controlled studies.

Methods: One researcher independently reviewed MEDLINE (January 1, 2000-May 1, 2019), CINAHL (January 1, 2000-May 1, 2019), PubMed (January 1, 2000-May 1, 2019), and Web of Science (January 1, 2000-May 1, 2019). A manual reference search was additionally conducted. Randomized controlled trials, prospective cohort studies, consecutive/non-consecutive case series, and retrospective reviews in which a clear definition of hearing loss was stated were included …

Understanding And Predicting The Distribution Of Biodiversity In The Atlantic Forest, Andrea Paz Velez

Dissertations, Theses, and Capstone Projects

Understanding how biodiversity is distributed in geography is essential for conservation. This requires an understanding of the multiple dimensions of biodiversity: species, their ecological functions, and their evolutionary history. For my Ph.D. dissertation, I devised a study to explore the environmental drivers of biodiversity patterns in Neotropical species. I first investigated broad macroecological patterns in the Brazilian Atlantic Forest, combining occurrence data and phylogenetic information from multiple clades of animals and plants (Chapter 1). I discovered that one can accurately predict the accumulation of species richness and phylogenetic diversity based on current climatic descriptors – particularly precipitation – but not …

Negotiated Access: Haccessibility, Autonomy, And Infrastructure In The Age Of The Abstraction, Patrick Smyth

Dissertations, Theses, and Capstone Projects

Negotiated Access asks how we can exercise our values from within systems and structures over which we have little control. The project, fundamentally, is about autonomy, a specific form of resistance to control, or the ability to act on values or goals despite influence from outside or above. Negotiation, here, is the ongoing encounter with enclosing or encircling systems, entities, or spaces. It is the gap, the small room for maneuver, between ourselves and the physical or social environment.

The project begins with local and concrete challenges and radiates outward to analyze and critique broader structures, forces, and institutions that …

Nation(S) And Narrative(S) In Forms Of Chinese Culture, Angela Chun Ling Wei

Dissertations, Theses, and Capstone Projects

This dissertation aims to explore the difference in "forms" between literary works and their adapted films, and then examine the relationships between the narrative and subject matter both in written and motion-picture form. In the process, the artistic relationship to life narratives and changes in national culture and government will be explored, employing the backdrop of four important national crises in history: the cultural revolution in mainland China, post-civil war Taiwan, Japanese hegemony in Shanghai, and the 1997 return of Hong Kong. The works covered are novels from Modern Chinese literature and their adapted films, King of Children, A …