Digital Commons Network^™

Essays On Communication, Shawn M. Simpson

Dissertations, Theses, and Capstone Projects

One of the central issues of contemporary philosophy and biology is the nature of communication. Early accounts of communication tended to focus on just one side of the communicative divide – the speaker side or the receiver side – and took as their starting point the case of human language. Animal communication, historically, was largely treated as a special case. Now things are different. Now it appears we might have a model that makes sense of sign use in both the human and animal realms and brings together both sides of the signaling divide. It’s still to be seen, however, …

The Role Of Tbx2 In Germ Layer Suppression And Dorsoventral Patterning During Early Vertebrate Development, Shoshana Reich

Dissertations, Theses, and Capstone Projects

The differentiation of the three primary germ layers is precisely regulated by inductive cues, the intracellular networks through which these signals are transduced, and a broad array of nuclear proteins, such as transcription factors and epigenetic modifiers. Precise regulation of these various factors is crucial to proper development. Members of the T-box family of DNA-binding proteins play a prominent role in the differentiation of the three primary germ layers. VegT, Brachyury, and Eomesodermin function as transcriptional activators, are expressed in the presumptive mesendoderm and, in addition to directly activating the transcription of endoderm- and mesoderm-specific genes, serve variously as regulators …

"Never Forget": Embodied Absence And Extended Relations Of Care After 9/11, Sophie L. Riemenschneider

Dissertations, Theses, and Capstone Projects

This dissertation is a reflection on how loss was articulated in the wake of 9/11. The terror attacks engendered a memorial style that sought to give shape to grief, acknowledging it without filling it in or erasing it. This new style, which I term embodied absence, exists across a range of mediums, from literature to architecture. It is such a potent memorial form because it also captures the traumatic process, which is prolonged, layered, and potentially open-ended. However, despite their ability to mirror the nature of trauma, instances of embodied absence never verbalize the attacks’ root trauma—the disconnect between our …

The Grid Elegies, Pamela A. Kallimanis

Dissertations, Theses, and Capstone Projects

Immigrants are a key component in New York City’s pandemic. Historically, New York is a city of immigrants and their children. In the latter part of the 20th Century, more immigrants arrived due to changes in migration policy. There was also an increased outmigration through second and third generations, which mirrors an economic trajectory seen in previous points in history, mainly in the 1970s. At that time, there was the lure of government policies – from federal mortgage agencies that graded white suburban areas as safer areas for banks to make loans than racially mixed urban areas, to road construction …

Perceiving The Body: On The Bodily Senses And The Nature Of Perception, Fiona C. Schick

Dissertations, Theses, and Capstone Projects

Visual perception dominates the philosophical study of perception. This dissertation shows that a complete understanding of the nature of perception as a general category requires a consideration of the nature of the bodily modalities such as interoception, proprioception, pain, touch, and thermoception. By understanding these modalities, we come closer to understanding the nature of perception (what it is, how it works, and what systems it encompasses). While non-visual modalities have been gaining more attention in philosophy, much of this work looks to philosophical issues particular to these modalities—not necessarily how they relate to questions about the nature of perception in …

Here Time Becomes Space: The Victorian Spatial Imaginary, Jonathan E. Rachmani

Dissertations, Theses, and Capstone Projects

My dissertation, “Here Time Becomes Space: The Spatiality of the Victorian Novel,” addresses the Victorian realist representation of space as the open zone of interaction where the circulation of affect among embodied subjects and the places and things in their environment challenges the individualist axis of Victorian plots. I envision this spatiality as a composite literary practice emerging from contact with eighteenth-century realism, the Gothic novel, and the radical revision of the social imagination under the Romantics. Through an analysis of major works by Charlotte Brontё, Charles Dickens, George Eliot, and Henry James, I trace the dialectical development of realist …

Effects Of Prenatal Cannabis Exposure On Offspring Emotional Development And Stress Response, Alexandra Pritchett

Dissertations, Theses, and Capstone Projects

While cannabis may be used by women during pregnancy, its effects on their offsprings’ developing stress response system are still largely unknown. The binding sites for the active chemicals in cannabis are operational at early time points in fetal development and are expressed in key limbic brain structures. The body’s natural endocannabinoid system serves as an important regulator of the stress response. Longitudinal studies have associated prenatal exposure with increased fearfulness and mood disturbances in offspring, but, despite the growing evidence of emotional dysfunction, there remains a critical gap in knowledge explaining how early prenatal exposure may lead to future …

Estrogen Modulation Of Vta Dopamine Neuron Physiology And Behavioral Responsivity To Variable Social Stressors, Mary R. Shanley

Dissertations, Theses, and Capstone Projects

The behavioral output of different animals, or even the same animal in different contexts, is remarkably variable in response to the same external stimulus. This behavioral diversity is due to the complex integration of external and internal stimuli, through both neuronal and hormonal signals that selects the best behavioral response. By their nature as long-distance signaling molecules, hormones play a critical role in communicating information about internal states across the organism. Many hormones produced in the periphery target the central nervous system to modulate animal behavior, selecting for behaviors that are appropriate over behaviors that are maladaptive in that specific …

Machine Learning And Solvation Theory For Drug Discovery, Lieyang Chen

Dissertations, Theses, and Capstone Projects

Drug discovery is a notoriously expensive and time-consuming process; hence, developing computational methods to facilitate the discovery process and lower the associated costs is a long-sought goal of computational chemists. Protein-ligand binding, which provides the physical and chemical basis for the mechanism of action of most drugs, occurs in an aqueous environment, and binding affinity is determined not only by atomic interactions between the protein and ligand but also by changes in their interactions with surrounding water molecules that occur upon binding. Thus, a quantitative understanding of the roles water molecules play in the protein-ligand binding process is an essential …

Spectral Urbanism: Modern Ghost Cities, Rare Earths, And Political Time At The Limits Of Materialism, Linsey Ly

Dissertations, Theses, and Capstone Projects

Contemporary urbanization in China is marked by speed, repetition, and similitude, key features of what I call spectral urbanism that also attends to the presence or absence, to recursivity and deferral. The mass development of empty, outmoded, and seemingly abandoned modern ghost cities in China’s borderlands come to be used as evidence of an interruption or lack in the veneer of Chinese modernity. The contours and quality of stalled development are measured, read in objects of the built environment that have yet to fulfill their anticipated function: vacant buildings, quiet roads that lead no one to empty parks, homes which …

Understanding The Influence Of Zinc On Grain Cadmium Accumulation And Bioaccessibility In Rice, Michael A. Tavarez

Dissertations, Theses, and Capstone Projects

The effect of cadmium and zinc on mineral concentrations in three cultivars of rice

Interactions between the essential mineral zinc (Zn) and the toxic heavy metal cadmium (Cd) play an important role in regulating transport of both minerals to rice grains. Understanding these interactions is crucial for limiting cadmium and increasing zinc transfer to the food chain. Previous studies on the matter have had conflicting results suggesting synergistic and antagonistic relationships between the minerals. The goal of this work was to identify the effect of external cadmium and zinc on the uptake and translocation of both minerals from roots to …

Apathy And Brain Atrophy During The First Year Of Moderate-Severe Traumatic Brain Injury: A Longitudinal Study, Gulnaz Kudoiarova

Dissertations, Theses, and Capstone Projects

Apathy, defined as disinterest and loss of motivation, is a common complication after moderate-severe traumatic brain injury (msTBI). The existing body of research in various neurological and neurodegenerative disorders suggests that apathetic symptoms may be associated with variation in the volume of the brain regions such as dorsal anterior cingulate cortex and ventral striatum. However, the longitudinal pattern of TBI-induced atrophy in these key regions and its relationship with apathy symptoms remain to be demonstrated. The current study aimed to describe the atrophy pattern in the anterior cingulate gyrus (ACG) and the nucleus accumbens (NAc; part of ventral striatum) after …

The Problem Of Leisure: A Modern History Of Work And Idleness, Lea S. Sanchez

Dissertations, Theses, and Capstone Projects

As our leisure time has increased in the twenty-first century, paradoxically, so too have social and cultural expectations about the nature and value of work. In this thesis, I argue that work in the modern world has taken on new shapes – the project of identity formation, image maintenance, and receptiveness to advertising – and how these new forms of work are fundamentally intertwined with leisure. I first aim to establish a timeline of Western attitudes to work, beginning with the works of Max Weber, Jon D. Wisman, and Matthew E. Davis. Then, through the lens of the 1970s punk …

Effectiveness And Safety Of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients With Active Cancer, Steve Deitelzweig, Allison V. Keshishian, Yan Zhang, Amiee Kang, Amol D. Dhamane, Xuemei Luo, Christian Klem, Mauricio Ferri, Jenny Jiang, Huseyin Yuce, Gregory Y.H. Lip

Publications and Research

BACKGROUND Patients with cancer are more likely to develop nonvalvular atrial fibrillation (NVAF). Currently there are no definitive clinical trials or treatment guidelines for NVAF patients with concurrent cancer.

OBJECTIVES This subgroup analysis of the ARISTOPHANES study compared the risk of stroke/systemic embolism (stroke/SE) and major bleeding (MB) among NVAF patients with active cancer who were prescribed non–vitamin K antagonist oral anticoagulants (NOACs) or warfarin.

METHODS A retrospective observational study was conducted in NVAF patients with active cancer who newly initiated apixaban, dabigatran, rivaroxaban, or warfarin from January 1, 2013, through September 30, 2015, with the use of Medicare and …

Reimagining Recovery: Debt, Mutual Aid, And Disaster Governance In Puerto Rico, Sarah Molinari

Dissertations, Theses, and Capstone Projects

This study analyzes the politics and lived experiences of debt and climate disaster recovery in Puerto Rico. It examines mutual aid and debt resistance in relation to governance techniques and overlapping crises marked by the U.S. territory’s bankruptcy, the aftermath of Hurricane Maria (2017), and culminating with popular mobilizations in the summer of 2019 that propelled the governor’s resignation. Tracing the ways that the post-hurricane social disaster and debt crisis are mutually constitutive, I investigate a case of women-led grassroots mutual aid organizing in the east-central municipality of Caguas, Puerto Rico and a political movement calling for a citizen audit …

Desire, Culture, And The Body, Zoey Lavallee

Dissertations, Theses, and Capstone Projects

What is the nature of desire? In this dissertation I develop a theory of desire according to which desires are essentially enculturated states that play the role of presenting favorable outcomes that act as inputs to intention formation, and thereby intentional action. This analysis of desire debunks a common assumption shared by prominent accounts of desire in philosophy of mind, what can be called the dualist assumption: that bodily desires such as urges and appetites differ in kind from conceptual desires that are typically described as higher cognitive attitudes. I argue that the desires traditionally understood as bodily or appetitive …

Investigation Of Notch Signaling In Cone Fate Specification In Vertebrate Retina, Xueqing Chen

Dissertations, Theses, and Capstone Projects

In the vertebrate retina, cone photoreceptors are crucial for high acuity color vision. Several retinal diseases lead to loss of cones and there is a need to identify the normal developmental genesis of these cells to inform the development of stem cell-based therapies. Cone genesis has previously been shown to be repressed by Notch signaling, however, the mechanism by which Notch signaling controls cone fate determination is still unclear. It has been identified that cone photoreceptors are formed from multipotent retinal progenitor cells (RPCs) that first generate genetically-defined, restricted RPCs with limited mitotic and fate potential to preferentially form cones …

Don't Sell Them Short, There's More To Bacterial Natural Products Than Antibiotics, Alison Clare Domzalski

Dissertations, Theses, and Capstone Projects

Recent genomic studies of microbiomes have revealed an overwhelming number of biosynthetic genes of unknown function. Most of these “cryptic” biosynthetic genes are not expressed in laboratory monocultures of individual microbes. Thus, there remains tremendous untapped potential for natural products discovery. Here we employ mixed microbial culture (MMC) as a simple yet powerful approach to awaken cryptic biosynthetic gene clusters. Our preliminary studies demonstrated that arrays of metabolites could be induced in MMCs upon environmental cues, such as surface adhesion. Using this system, we have screened, identified, and isolated bioactive bacterial metabolites, which were characterized structurally and biologically. Of the …

Digital Storytelling As Community Practices By Early Childhood Teacher Candidates, Ting Yuan

Open Educational Resources

This OER course unit is designed as part of an undergraduate literacy methods course. The unit will highlight teacher candidates’ digital storytelling practices and their development of teachable lesson plans and tutorials for local primary grade classrooms.

From Green Pastures To Scorched Earth: German Environmentalism And Ecology, C. 1800s-1945, Santiago G. Lozada

Student Theses

Nature Conservation in Germany from The Second German Empire until Nazi Germany

Decoding The Roles Of Astrocytes And Hedgehog Signaling In Medulloblastoma, Terence Teixeira Duarte, Silvia Aparecida Teixeira, Luis Gonzalez-Reyes, Rui Manuel Reis

Publications and Research

The molecular evolution of medulloblastoma is more complex than previously imagined, as emerging evidence suggests that multiple interactions between the tumor cells and components of the tumor microenvironment (TME) are important for tumor promotion and progression. The identification of several molecular networks within the TME, which interact with tumoral cells, has provided new clues to understand the tumorigenic roles of many TME components as well as potential therapeutic targets. In this review, we discuss the most recent studies regarding the roles of astrocytes in supporting sonic hedgehog (SHH) subgroup medulloblastoma (MB) and provide an overview of MB progression through SHH …

A New Function For Amyloid-Like Interactions: Cross-Beta Aggregates Of Adhesins Form Cell-To-Cell Bonds, Peter N. Lipke, Marion Mathelié-Guinlet, Albertus Viljoen, Yves F. Dufrêne

Publications and Research

Amyloid structures assemble through a repeating type of bonding called “cross-β”, in which identical sequences in many protein molecules form β-sheets that interdigitate through side chain interactions. We review the structural characteristics of such bonds. Single cell force microscopy (SCFM) shows that yeast expressing Als5 adhesin from Candida albicans demonstrate the empirical characteristics of cross-β interactions. These properties include affinity for amyloid-binding dyes, birefringence, critical concentration dependence, repeating structure, and inhibition by anti-amyloid agents. We present a model for how cross-β bonds form in trans between two adhering cells. These characteristics also apply to other fungal adhesins, so the mechanism …

Agency Rescues Competition For Credit Assignment Among Predictive Cues From Adverse Learning Conditions, Mihwa Kang, Ingrid Reverte, Stephen Volz, Keith Kaufman, Salvatore Fevola, Anna Matarazzo, Fahd H. Alhazmi, Inmaculada Marquez, Mihaela D. Iordanova, Guillem R. Esber

Publications and Research

A fundamental assumption of learning theories is that the credit assigned to predictive cues is not simply determined by their probability of reinforcement, but by their ability to compete with other cues present during learning. This assumption has guided behavioral and neural science research for decades, and tremendous empirical and theoretical advances have been made identifying the mechanisms of cue competition. However, when learning conditions are not optimal (e.g., when training is massed), cue competition is attenuated. This failure of the learning system exposes the individual’s vulnerability to form spurious associations in the real world. Here, we uncover that cue …

Interview, Elizabeth Naiden

Theses and Dissertations

An exploration of work by Liz Naiden in the form of a conversation discussing light and dark, attention and proprioception, and design and architectural theories of space in installation works. Addresses the role of voice, speech, and reading and speaking aloud, performing for oneself, and performing for others.

Mucinomics: A Bioinformatic Analysis Of Snail Mucins, And Their Function, Maxwell B. Mcdermott

Theses and Dissertations

This thesis outlines the current research on secreted snail mucus, highlighting the potential of this biopolymer, and also demonstrates a research strategy to fulfill the unmet need of examining the hierarchical structures that lead to the enormous biological and chemical diversity of snail mucus genes.

The Inconspicuous Lives Of Dr. Susan Smith Mckinney Steward And Dr. Elizabeth Blackwell, Alexandra W. Bogdanovich

Theses and Dissertations

This paper examines trailblazing American female doctors of the nineteenth century in New York. Through the lives of Dr. Susan Smith Mckinney Steward, who is black, and Dr. Elizabeth Blackwell, who is white, this analysis tries to understand what motivated these women and how they succeeded in spite of the confines of women’s prescriptive role in nineteenth-century America.

The Influence Of China/Asia On The West, Junli Diao

Publications and Research

This chapter provides a description of cultural communication between China and Europe before 20th century. It discusses the influence of Chinese materials to Western libraries, archives and museums.

Bullet Ricochet Of Polymer Coated Bullets, Stephen Daly

Student Theses

Polymer coated bullets were designed to limit a shooter’s exposure to lead. However, despite the advantages that these bullets give there are still difficulties which arise in a forensic firearms examination. Unlike in a typical metal coated bullet, individualizing striations will typically not be imparted to a polymer coated bullet making it unable to be linked to a specific firearm. Due to this difficulty any information that can be gained at the scene of the crime could be crucial. Some obtainable information includes the angle of ricochet and the angle of incidence of the discharged bullet as well as traces …

Anatomy And Physiology Preparatory Course Textbook (2nd Edition), Carlos Liachovitzky

Open Educational Resources

The goal of this preparatory textbook is to give students a chance to become familiar with some terms and some basic concepts they will find later on in the Anatomy and Physiology course, especially during the first few weeks of the course.

Organization and functioning of the human organism are generally presented starting from the simplest building blocks, and then moving into levels of increasing complexity. This textbook follows the same presentation. It begins introducing the concept of homeostasis, then covers the chemical level, and later on a basic introduction to cellular level, organ level, and organ system level. This …

Cmce 2351 Fluid Mechanics Lab, Course Outline, Rosemary Brybag

Open Educational Resources

This course studies the fundamentals of fluid mechanics including: properties of fluids, fluid statics, manometers, center of pressure, buoyancy, stability, principles of fluid flow, flow measurements, frictional head losses, conservation of momentum and energy, pump power and efficient, and open channel flow.