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Forecasting Trends In Educational Measurement And Assessment Topics In The Ai Era : Text Mining Analysis With Bayesian Multilevel Piecewise Regression Model, Siwachoat Srisuttiyakorn, Kanit Sriklaub, Yotsawee Saifah
Forecasting Trends In Educational Measurement And Assessment Topics In The Ai Era : Text Mining Analysis With Bayesian Multilevel Piecewise Regression Model, Siwachoat Srisuttiyakorn, Kanit Sriklaub, Yotsawee Saifah
Journal of Education Studies
This study aimed to 1) identify latent research topics in educational measurement and evaluation from academic databases covering the years 2008–2025 using Structural Topic Modeling (STM), 2) analyze topic prevalence trends and forecast their growth trajectories for 2027 using Bayesian Multilevel Piecewise Regression (BMPR), and 3) synthesize strategic research themes from the topic classification and forecasting results. The dataset consisted of 1,695 research articles from the proceedings of three international conferences. The data were processed to extract 10,858 standardized keywords and key phrases, which were then analyzed using STM to identify latent research topics. Topic labeling and interpretation were conducted …
Editorial Vol. 54 Issue 2, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Editorial Vol. 54 Issue 2, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Journal of Education Studies
No abstract provided.
Cover Vol. 54 Issue 2, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Cover Vol. 54 Issue 2, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Journal of Education Studies
No abstract provided.
Holding The Line: Teacher Resilience And Engagement In Myanmar’S Conflict-Affected, Non-State Schools, Lugyi No, Hilary Lustick
Holding The Line: Teacher Resilience And Engagement In Myanmar’S Conflict-Affected, Non-State Schools, Lugyi No, Hilary Lustick
Journal of Education Studies
This qualitative study explores teacher resilience, professional engagement, and informal leadership in community-led schools located in conflict-affected areas of Myanmar. The study draws on two online focus group discussions with 14 high school teachers selected through purposive sampling. The research instrument was a semi-structured focus group discussion protocol. The discussions were conducted in the Myanmar language, and the data were analyzed using inductive thematic analysis. The findings indicate that teachers sustain resilience through moral purpose, professional commitment, and strong relational ties with students, peers, and local communities. In the absence of formal governance structures, teachers assume informal leadership roles by …
Eco-Literacy As The Foundation Of Transformative Education: Integrating Theory, Practice, And Sustainable Development, Siriping Deedoo, Omsin Jatuporn
Eco-Literacy As The Foundation Of Transformative Education: Integrating Theory, Practice, And Sustainable Development, Siriping Deedoo, Omsin Jatuporn
Journal of Education Studies
Eco-literacy has been widely recognized as a crucial body of knowledge and a key competency for citizens in the 21st century, as it forms the foundation for understanding the complex interrelationships among humans, nature, and society. This article has three main objectives, namely: 1) describe the theoretical foundations of Eco-literacy, 2) examine its development from past to present and 3) discuss the educational roles of integrating this concept into curricula and teaching practices. The review of literature shows that the development of the concept revealed that eco-literacy has evolved from an early emphasis on providing environmental science data to a …
Ikigai: From A Philosophical Concept To An Enrichment Of Learning Management, Jiradach Nukunrot, Chommanad Kijkhun
Ikigai: From A Philosophical Concept To An Enrichment Of Learning Management, Jiradach Nukunrot, Chommanad Kijkhun
Journal of Education Studies
In recent years, some dance education practitioners have confronted significant challenges and obstacles regarding traditional pedagogical frameworks, which have been critiqued for being overly teacher-centric, with a lack of flexibility. Students are encouraged to discover value, skills, and benefits of the limited skill development. The integration of pedagogical concepts with the Japanese philosophy of Ikigai is an approcah with an aim to facilitate a paradigm shift toward truly learner-centered education. The philosophy of Ikigai provides a philosophy of life based on Japanese culture that encourages individuals to explore and discover what they love, what they are good at, what benefits …
Bmi-Perception Discordance And School Health Communication Profiles Among Us High School Students: Evidence From The 2023 Youth Risk Behavior Survey, Hoang Thanh Thu, Nguyen Khac Toan
Bmi-Perception Discordance And School Health Communication Profiles Among Us High School Students: Evidence From The 2023 Youth Risk Behavior Survey, Hoang Thanh Thu, Nguyen Khac Toan
Journal of Health Research
Background: Body mass index (BMI) screening is commonly used in schools to identify students at risk of overweight or obesity, but BMI alone may not adequately guide counselling when students’ perceived weight differs from BMI-based status.
Method: This cross-sectional secondary analysis used 2023 US Youth Risk Behavior Survey data from 17,814 students in grades 9–12. Survey-weighted estimates and logistic regression examined overweight or obesity, underestimation among students with overweight or obesity, and excessive concern among students without overweight or obesity.
Results: Overall, 30.63% of students had overweight or obesity. Among students reporting perceived weight, 53.04% were concordant, …
An Mhealth Application For The Rehabilitation Of Community-Dwelling Individuals With Chronic Mental Health Conditions: A Randomized Controlled Trial, Pornpat Hengudomsub, Pornpun Sudjai, Pornprasert Kaewkham, Kiattisak Raihinthaung
An Mhealth Application For The Rehabilitation Of Community-Dwelling Individuals With Chronic Mental Health Conditions: A Randomized Controlled Trial, Pornpat Hengudomsub, Pornpun Sudjai, Pornprasert Kaewkham, Kiattisak Raihinthaung
Journal of Health Research
Background: Developing a nursing service system to promote rehabilitation among individuals with chronic mental health conditions is essential for maintaining self-care and social functioning. This study examined the effectiveness of the BUU True Friends mobile application (mHealth) in enhancing rehabilitation and reducing relapse risk.
Methods: A two-arm, pretest–posttest randomized controlled trial (RCT) was conducted with 80 participants (aged 20–59) recruited from an outpatient service in Eastern Thailand. Participants were randomly assigned to an intervention group (n=40) receiving standard care plus the mHealth app, or a control group (n=40). Outcomes were assessed at baseline and after an eight-week intervention. Data were …
Preliminary Clinical Evaluation Of Inhalation Aromatherapy With Blended Essential Oils On Sleep Quality In Adults With Sleep Disturbance, Punyanut Amorndoljai, Laddawan Choothong, Surachai Techaoei, Em-On Chaiprateep
Preliminary Clinical Evaluation Of Inhalation Aromatherapy With Blended Essential Oils On Sleep Quality In Adults With Sleep Disturbance, Punyanut Amorndoljai, Laddawan Choothong, Surachai Techaoei, Em-On Chaiprateep
Journal of Health Research
Background: Sleep disturbances impact cognition and physiology. While individual essential oils are documented, a gap remains in how multi-component blends can target multiple pathways. This study evaluated a blended essential oil (BEO) systematically guided by Thai Traditional medicine (TTM) principles to balance the "Wind" element (Tard Lom) alongside modern neurobiological validation.
Methods: A one-group pretest–posttest quasi-experimental study was conducted in adults (aged ≥ 20 years, n = 38) with sleep disturbances (PSQI > 5). The BEO formulation consisting of orange (2.5% w/w), lavender (1.0% w/w), ylang-ylang (1.5% w/w), geranium (0.5% w/w), cedarwood (2.0% w/w), and rosewood (2.0% w/w) in 95% ethanol …
Latent Profile Analysis Of Physical And Cognitive Leisure Activity Level Among Chinese Middle-Aged And Older Adults: A Cross-Sectional Study, Zhenying Liang, Pankaew Tantirattanakulchai, Nuchanad Hounnaklang
Latent Profile Analysis Of Physical And Cognitive Leisure Activity Level Among Chinese Middle-Aged And Older Adults: A Cross-Sectional Study, Zhenying Liang, Pankaew Tantirattanakulchai, Nuchanad Hounnaklang
Journal of Health Research
Background: The global aging trend has accelerated. This study tried to identify the factors related to different patterns of physical and cognitive leisure activities among Chinese middle-aged and older adults.
Method: Latent Profile Analysis was conducted to classify 12,480 participants aged 45 and above, followed by logistic regression to understand associations between activity profiles and related factors.
Results: Physical activity (n = 2,269) and cognitive leisure activity groups (n = 10,211) were identified according to their different levels of physical activity and cognitive leisure activity engagement. Middle-aged individuals (aOR = 1.42, 95% CI: 1.29–1.56), rural residents (aOR = 1.38, 95% …
Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian
Efficacy Of A Mouthwash Containing Standardized Centella Asiatica Extract (Eca 233) In Patients With Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial, Alisa Awapark, Wanchai Chongcharoen, Mayuree H. Tantisira, Nattapon Rotpenpian
The Thai Journal of Pharmaceutical Sciences
Background: Gingivitis is the earliest and most reversible stage of periodontal disease, characterized by inflammation of the gingiva caused by the accumulation of plaque. In addition to removing plaque, mouthwash containing antiseptic or anti-inflammatory could be used as an adjunct therapy.
Objectives: The objective of this study is to evaluate the efficacy of a 0.10% standardized Centella asiatica extract (ECa 233) mouthwash compared to 0.12% chlorhexidine and placebo mouthwashes in individuals with gingivitis.
Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 75 patients assigned equally to ECa 233, chlorhexidine, or placebo groups. Participants used the assigned …
Cost Analysis Of Integrated Genderaffirming And Sexual Health Services For Transgender Women In Thailand: Evidence From The Tangerine Clinic, Braprut Sawatwipachai, Kunncadah Anuwong, Nittaya Phanuphak, Rena Janamnuaysook, Kritima Samitpol, Sujin Nitadpakorn
Cost Analysis Of Integrated Genderaffirming And Sexual Health Services For Transgender Women In Thailand: Evidence From The Tangerine Clinic, Braprut Sawatwipachai, Kunncadah Anuwong, Nittaya Phanuphak, Rena Janamnuaysook, Kritima Samitpol, Sujin Nitadpakorn
The Thai Journal of Pharmaceutical Sciences
Background: Transgender women experience a disproportionate burden of human immunodeficiency virus (HIV) globally and in Thailand. Integrating gender-affirming care into sexual health services may improve uptake of HIV and sexually transmitted infections (STIs) testing, treatment, and prevention. Cost data are essential to inform program planning and policy decisions regarding inclusion of such services within Thailand’s Universal Health Coverage (UHC) system.
Objectives: To estimate the full and unit costs of trans-led, integrated gender-affirming and sexual health services along the HIV care cascade.
Methods: Costs of Tangerine Clinic services in 2021 were assessed from the provider perspective, using standard and activity-based costing …
Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee
Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee
The Thai Journal of Pharmaceutical Sciences
Background: Patients with congenital heart disease who have previously undergone right ventricular outflow tract (RVOT) surgery frequently require repeat valve replacement later in life. While transcatheter pulmonary valve replacement (TPVR) offers less invasive reintervention compared with surgery, its high device cost raises concerns about affordability under Indonesia’s National Health Insurance Program (Jaminan Kesehatan Nasional).
Objectives: To compare the cost-effectiveness of surgical pulmonary valve replacement (SPVR) versus TPVR in post-RVOT surgery patients, and to estimate the TPVR price threshold for cost-effectiveness from a societal perspective.
Methods: A Markov model simulated a hypothetical cohort of 15-year-old patients with prior RVOT surgery over …
Anti-Diabetic Activity Of Combination Of Aloe Vera, Allium Sativum, Selenium, And Chromium Picolinate In Alloxaninduced Diabetic Rats, Satyajit Mangate, Syed Ayaz Ali, Zainab Shabbir Shaikh, Mohd Mukhtar Khan, Subur Wadood Khan
Anti-Diabetic Activity Of Combination Of Aloe Vera, Allium Sativum, Selenium, And Chromium Picolinate In Alloxaninduced Diabetic Rats, Satyajit Mangate, Syed Ayaz Ali, Zainab Shabbir Shaikh, Mohd Mukhtar Khan, Subur Wadood Khan
The Thai Journal of Pharmaceutical Sciences
Background: Diabetes mellitus (DM) is a metabolic disorder characterized by deleterious effects on multiple organs. Existing remedial strategies highlight the advancement of herbal and mineral agents to target multiple mechanisms controlling the pathology of DM.
Objectives: This study aims to investigate the hypoglycemic and organ-protective effects of poly-herbal poly-mineral combinations for DM treatment.
Materials and Methods: Five groups of Wistar rats comprising 6 rats in each group were treated with vehicle (sterile water) to control group, alloxan (150 mg/kg, i.p.) to all the groups except the vehicle control group, sitagliptin (40 mg/kg, p.o.) as standard drug treatment, polyherbal polymineral combination …
Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara
Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara
The Thai Journal of Pharmaceutical Sciences
Background: Diphtheria remains endemic in parts of Thailand and continues to threaten unvaccinated populations. To strengthen vaccine self-sufficiency, the Government Pharmaceutical Organization has developed in-house diphtheria–tetanus–pertussis (DTP) and diphtheria– tetanus (dT) vaccines. Potency testing of diphtheria toxoid is traditionally performed in guinea pigs; however, limitations in animal availability, cost, and logistics have prompted evaluation of alternative models.
Objectives: To compare diphtheria toxoid potency estimates of in-houseproduced DTP and dT vaccines using guinea pigs and mice, followed by a Vero cell-based toxin neutralization assay, and to assess the suitability of mice as an alternative model for potency testing.
Materials and Methods: …
Development Of Micellar Sprays Containing Rhinacanthus Nasutus Extract For Dandruff Management, Suwipa Ungphaiboon Associate Professor, Sutasinee Ardhanwanich, Ketsuda Wongsuwan, Salwa Yanya, Nattanit Aekwattanaphol
Development Of Micellar Sprays Containing Rhinacanthus Nasutus Extract For Dandruff Management, Suwipa Ungphaiboon Associate Professor, Sutasinee Ardhanwanich, Ketsuda Wongsuwan, Salwa Yanya, Nattanit Aekwattanaphol
The Thai Journal of Pharmaceutical Sciences
Background: Dandruff is a common scalp disorder associated with altered sebum secretion and microbial imbalance, particularly between Cutibacterium and Staphylococcus, which correlates with disease severity.
Objectives: This study aimed to develop and optimize a multifunctional leave-on hair and scalp spray with anti-dandruff, nourishing, and protective properties.
Materials and Methods: Micelles containing Rhinacanthus nasutus extract were prepared using eco-friendly methods, including film hydration and direct solubilization. The formulations were optimized and evaluated for physicochemical properties, drug release, and antibacterial activity.
Results: The optimized micellar spray (BP), prepared through direct solubilization in citrate buffer, exhibited a mean particle size of 192.45 …
Modified Etoposide Loaded Graphene Oxide Nanoparticles: In-Depth Physical And Biological Evaluation For Lung Cancer Treatment, Umesh Kumar Atneriya, Jitendra Sainy
Modified Etoposide Loaded Graphene Oxide Nanoparticles: In-Depth Physical And Biological Evaluation For Lung Cancer Treatment, Umesh Kumar Atneriya, Jitendra Sainy
The Thai Journal of Pharmaceutical Sciences
Background: Lung cancer is approximately 25% of all death cases in any cancer and the death beats the number of deaths reported by colorectal cancer, breast cancer, and prostate cancer combined.
Objectives: This present study was carried out with an objective to investigate the possibility of graphitic carbon toward making a multifunctional anti-lung cancer nano-platform targeting etoposide (ETS) as a model drug.
Materials and Methods: First, the synthesis of graphene oxide (GO) was made by the Hummer method based on graphite flakes and further modified with folic acid (FA) and polyethylene glycol to make FA/GO/ETS. The formation of FA/GO/ETS was …
Prevalence And Characteristics Of Feline Pleural Effusion In Khon Kaen, Thailand: A 2024–2025 Study, Karn Yongvanit, Naruepon Kampa
Prevalence And Characteristics Of Feline Pleural Effusion In Khon Kaen, Thailand: A 2024–2025 Study, Karn Yongvanit, Naruepon Kampa
The Thai Journal of Veterinary Medicine
Pleural effusion (PE) is a life-threatening condition in cats that can cause severe respiratory compromise. Identification of the underlying etiology is essential for prognosis and treatment planning. This study investigated the prevalence and characteristics of diseases associated with feline pleural effusion in northeastern Thailand. Medical records of cats diagnosed with pleural effusion at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Khon Kaen University, Thailand, between January 2024 and January 2025 were retrospectively reviewed. Cases lacking a complete diagnostic workup were excluded. Diagnoses were confirmed using cytology or histopathology for neoplasia, echocardiography for heart disease, polymerase chain reaction (PCR) for …
From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan
From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan
Journal of Health Research
Background: Organizational readiness is essential for AI-enabled digital transformation as healthcare organizations increasingly integrate artificial intelligence (AI). However, empirical evidence regarding the relationship between AI readiness and organizational change, the mediating role of digital maturity, remains limited in healthcare settings. This study investigated the mediating role of digital maturity in the relationship between AI readiness and organizational change.
Methods: This cross-sectional study involved 300 healthcare professionals from two Indonesian hospitals: Persahabatan Hospital (n = 165) and St. Carolus Hospital (n = 135). Data were collected using a questionnaire and analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess …
Identifying Pyle's Metaphyseal Dysplasia – An Incidental Finding Of Skeletal Pathology On A Dental Checkup, Shruthi Parthasarathy, Amudhan Azhagan, Arthisri Anandhi Sekar, Poongodi V, Ram Shankar
Identifying Pyle's Metaphyseal Dysplasia – An Incidental Finding Of Skeletal Pathology On A Dental Checkup, Shruthi Parthasarathy, Amudhan Azhagan, Arthisri Anandhi Sekar, Poongodi V, Ram Shankar
Chulalongkorn Medical Journal
Introduction:
Pyle's disease, also known as familial metaphyseal dysplasia, is a rare autosomal recessive genetic disorder that primarily affects the skeletal system, particularly in children and adolescents. Characterized by distinctive radiographic features such as Erlenmeyer flask deformity and metaphyseal widening, Pyle's disease often goes underdiagnosed due to its mild clinical manifestations.
Case report:
This case report details a 15-year-old female patient presenting with retained milk teeth and unerupted permanent teeth, alongside notable skeletal abnormalities including genu valgum and kyphosis. Clinical and radiographic evaluations revealed significant dental anomalies, including multiple impacted permanent teeth and mild dysmorphic facial features. Although genetic testing …
Beyond Lipid-Lowering: Pleiotropic Effects Of Statins In Inflammation, Coagulation, And Cell Proliferation – Mechanisms And Clinical Implications, Kasidid Lawongsa, Yutthana Pansuwan, Supanut Kumjan
Beyond Lipid-Lowering: Pleiotropic Effects Of Statins In Inflammation, Coagulation, And Cell Proliferation – Mechanisms And Clinical Implications, Kasidid Lawongsa, Yutthana Pansuwan, Supanut Kumjan
Chulalongkorn Medical Journal
Statins are widely used lipid-lowering agents that significantly reduce cardiovascular morbidity and mortality through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Beyond their cholesterol-lowering properties, increasing evidence demonstrates that statins exert several pleiotropic effects independent of lipid reduction. These effects include anti-inflammatory, anti-thrombotic, and anti-proliferative actions mediated primarily through inhibition of the mevalonate pathway and downstream signaling molecules such as Rho, Rac, and Ras. Experimental and clinical studies have suggested potential benefits of statins in various non-cardiovascular conditions, including autoimmune diseases, venous thromboembolism, sepsis-associated coagulopathy, and certain malignancies. In addition, pharmacoepidemiologic studies have provided insights into the real-world effects and …
Evaluation Of Mdm2 Mrna Expression According To Clinicopathological Characteristics In Oral Squamous Cell Carcinoma (Oscc) Patients, Tirta Wardana
Evaluation Of Mdm2 Mrna Expression According To Clinicopathological Characteristics In Oral Squamous Cell Carcinoma (Oscc) Patients, Tirta Wardana
Chulalongkorn Medical Journal
Background: The murine double minute 2 (MDM2) gene encodes an E3 ubiquitin ligase that targets p53 for degradation, thereby influencing the pathogenesis of oral squamous cell carcinoma (OSCC).
Objective. The present study investigates MDM2 mRNA expression and its association with clinical and pathological characteristics in OSCC patients.
Methods: We conducted an observational-analytical study using a cross-sectional design. The study involved 39 OSCC patients. RNA extraction, cDNA synthesis, and quantitative PCR (qPCR) were performed. We quantified relative MDM2 mRNA expression using the Livak method (2-ΔΔCT) and GenEX MultiD software version 6.0. Statistical significance was assessed using independent t-tests.
Results: Although no …
Factors Associated With Colorectal Cancer Screening Decision-Making Among Older Adults At The Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chalisa Thanapura, Nawasiri Siriprasert, Thacha Pithayapibulpong, Bhorn-Ake Manasvanich, Vichai Viriyautsahakul
Factors Associated With Colorectal Cancer Screening Decision-Making Among Older Adults At The Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chalisa Thanapura, Nawasiri Siriprasert, Thacha Pithayapibulpong, Bhorn-Ake Manasvanich, Vichai Viriyautsahakul
Chulalongkorn Medical Journal
Abstract
Background: The incidence of colorectal cancer (CRC) in Thailand is constantly increasing, and is highest in individuals aged 60-75 years. However, the number of older individuals undergoing CRC screening remains suboptimal.
Objective: This study aimed to identify factors associated with CRC screening decision-making among Thai older adults attending the Comprehensive Geriatric Clinic at King Chulalongkorn Memorial Hospital. The secondary objective was to identify factors associated with the choice of screening method—colonoscopy versus fecal occult blood testing (FOBT)
Methods: A cross-sectional study was conducted using a data record form at the Comprehensive Geriatrics Clinic, King Chulalongkorn Memorial Hospital in Bangkok, …
Integrative Analysis Of Bioinformatics Databases To Identify Thyroid Cancer Drug Target Candidates, Desti Rahmawati, Putri Permata Suka Admanegara, Rista Yulianti, Siska Widiastuti, Wirawan Adikusuma, Brilliant Citra Wirashada, Rahmat Dani Satria, Darmawi Darmawi, Baik Heni Rispawati, Rockie Chong, Ilker Ates, Lalu Muhammad Irham, Petrina Theda Philothra
Integrative Analysis Of Bioinformatics Databases To Identify Thyroid Cancer Drug Target Candidates, Desti Rahmawati, Putri Permata Suka Admanegara, Rista Yulianti, Siska Widiastuti, Wirawan Adikusuma, Brilliant Citra Wirashada, Rahmat Dani Satria, Darmawi Darmawi, Baik Heni Rispawati, Rockie Chong, Ilker Ates, Lalu Muhammad Irham, Petrina Theda Philothra
Chulalongkorn Medical Journal
Background: Thyroid cancer is an endocrine malignancy whose incidence continues to rise globally. Although thyroid cancer generally has a favourable prognosis, aggressive subtypes such as anaplastic thyroid cancer remain a therapeutic challenge. Drug repurposing strategies offer the opportunity to accelerate the development of therapies by utilising drugs already available and with an established safety profile.
Objective: This study aims to identify candidate thyroid cancer risk genes by analyzing data extracted from GWAS and PheWAS databases, and to evaluate their potential therapeutic relevance through drug repositioning
Methods: Significant gene variants were obtained from GWAS and PheWAS databases and functionally annotated …
The Mathematical Model Predicts Peripheral Blood Cd34+ Cell Yield And Blood Volume Processing For Peripheral Blood Stem Cell Apheresis., Rattaporn Vichitratchaneekorn, Kanokpol Siriphanthong, Kanokwan Chinbordee, Phandee Watanaboonyongcharoen, Ponlapat Ronjnuckarin
The Mathematical Model Predicts Peripheral Blood Cd34+ Cell Yield And Blood Volume Processing For Peripheral Blood Stem Cell Apheresis., Rattaporn Vichitratchaneekorn, Kanokpol Siriphanthong, Kanokwan Chinbordee, Phandee Watanaboonyongcharoen, Ponlapat Ronjnuckarin
Chulalongkorn Medical Journal
Introduction: The accurate prediction of stem cell yields is important for planning peripheral blood stem cell (PBSC) collection. This study aimed to develop a formula forecasting required blood volume processing to ensure adequate CD34+ cell products.
Methods: Data from donors and patients who underwent PBSC apheresis conducted at a tertiary care hospital were reviewed. BD FACSCanto™ II and Navios EX flow cytometry machines were used to determine the pre-collection CD34+ cell counts (preCD34).
Results: Of 50 donors and 85 patients, 145 leukapheresis procedures were performed. Linear regression models accurately predicted absolute CD34+ cell yields from pre-apheresis values, supporting optimal procedural …
Ameliorative Effect Of Ethanolic Extract Of Nardostachys Jatamansi Against High Fat Diet Induced Dyslipidemia In Rats, Umanath Preethi, Govindaraj Sumathy, Nathiya Shanmugam
Ameliorative Effect Of Ethanolic Extract Of Nardostachys Jatamansi Against High Fat Diet Induced Dyslipidemia In Rats, Umanath Preethi, Govindaraj Sumathy, Nathiya Shanmugam
Chulalongkorn Medical Journal
ABSTRACT:
Background and objective: The present study aimed to evaluate the antioxidant and hypolipidemic effects of ethanol extract of Nardostachys Jatamansi (N.J) in a high-fat diet-induced obesity model in male Wistar albino rats.Materials and methods:36 male Wistar albino rats were randomly divided into six groups, each comprising six animals: Group I received a normal diet for 9 weeks, while Group II was fed a high-fat diet (HFD) for the same period. Groups III–VI were also given HFD throughout. From week 5, Group III received rosuvastatin (10 mg/kg), and Groups IV–VI were treated with Nardostachys Jatamansi. extract at 100, 200, and …
Machine Learning-Based Gene Signature Detection Highlights Cxcl12 As A Key Marker For Aml Prediction, Selahattin Alperen Uysal, Burçin Kaymaz
Machine Learning-Based Gene Signature Detection Highlights Cxcl12 As A Key Marker For Aml Prediction, Selahattin Alperen Uysal, Burçin Kaymaz
Chulalongkorn Medical Journal
Background: Acute myeloid leukemia (AML) is a severe hematologic malignancy marked by uncontrolled proliferation and impaired differentiation of myeloid cells, disrupting normal hematopoiesis and resulting in poor clinical outcomes. Conventional diagnostic approaches often lack the precision to accurately classify AML subtypes, necessitating the integration of advanced computational methods to improve diagnostic and therapeutic strategies.
Objectives: This study aimed to apply machine learning (ML) techniques to transcriptomic data in order to identify a concise and informative gene signature capable of distinguishing AML cases from normal samples. Additionally, the study sought to evaluate the performance of predictive models in supporting AML prediction …
Assessing The Reliability Of Machine Learning Models In Classifying Depression Severity Using Facebook Text, Keito Yoneyama
Assessing The Reliability Of Machine Learning Models In Classifying Depression Severity Using Facebook Text, Keito Yoneyama
Chulalongkorn Medical Journal
Depression is a growing global issue that requires urgent attention, particularly in Thailand. Without timely intervention, it can lead to serious consequences such as health complications, reduced social participation, and even suicide. Consequently, there has been increased research focused on developing algorithms to identify and classify social media data according to depression severity. This study aimed to evaluate the extent to which such algorithms are a suitable tool for the preliminary classification of Thai Facebook text into different levels of depression severity. The methodology involved data collection through surveys and Facebook scraping, followed by data preprocessing, feature engineering, and model …
Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl
Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl
The Thai Journal of Veterinary Medicine
Urinary calculi are commonly encountered in veterinary practice; however, information regarding their distribution of stone that underwent analysis and associated clinical findings remains limited. This study investigated the distribution of urolithiasis and the associations between stone types and clinical and laboratory findings in dogs and cats presented to the Chulalongkorn Small Animal Teaching Hospital between 2020 and 2024. The three most common stone types in both species were calcium oxalate (CaOx), struvite, and urate, with relatively stable trends over the 5-year period. Small-breed dogs had a higher risk of developing CaOx urolithiasis than medium-breed dogs (OR = 10.4, 95% CI …
Mobile Health (Mhealth) Interventions To Promote Exclusive Breastfeeding In Low-Income Communities: A Scoping Review, Winarsih Winarsih, Dayat Subekti, Herdini Widyaningpertiwi, Tri Sunarsih, Endah Puji Astuti, Elvika Fit Ari Shanti
Mobile Health (Mhealth) Interventions To Promote Exclusive Breastfeeding In Low-Income Communities: A Scoping Review, Winarsih Winarsih, Dayat Subekti, Herdini Widyaningpertiwi, Tri Sunarsih, Endah Puji Astuti, Elvika Fit Ari Shanti
Journal of Health Research
Background: Exclusive breastfeeding (EBF) is a critical determinant of infant health and survival, yet its prevalence remains suboptimal in low-income communities globally. Barriers such as limited access to lactation support and misinformation continue to challenge EBF promotion efforts in these settings. This review maps and evaluates mHealth interventions that promote exclusive breastfeeding in low-income populations.
Methods: This scoping review was conducted following the JBI methodology and reported in accordance with the PRISMA-ScR guidelines. A systematic search of PubMed, Scopus, and Web of Science was conducted for articles published up to July 2025. Eligible studies involved any mHealth-based breastfeeding intervention …