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Antioxidant And Chemotherapeutic Synergy: Triphala Enhances Doxorubicin Cytotoxicity In Breast Cancer Cells And Reduces Toxicity In Non-Tumorigenic Cells, Supamas Charucharana, Poonlarp Cheepsunthorn Ph.D., Chalisa Louicharoen Cheepsunthorn Ph.D. Mar 2025

Antioxidant And Chemotherapeutic Synergy: Triphala Enhances Doxorubicin Cytotoxicity In Breast Cancer Cells And Reduces Toxicity In Non-Tumorigenic Cells, Supamas Charucharana, Poonlarp Cheepsunthorn Ph.D., Chalisa Louicharoen Cheepsunthorn Ph.D.

Chulalongkorn Medical Journal

Background: The combining of antioxidants with chemotherapy is increasingly explored to minimize toxicity in non-cancerous cells during breast cancer treatment. Triphala (TPL), a Thai herbal compound rich in antioxidants, shows potential as a complementary candidate for breast cancer chemotherapy.

Objective: This study investigated the combined effects of TPL and low-dose doxorubicin (DOX) on human breast cancer and non-tumorigenic mammary epithelial cells.

Methods: TPL’s bioactive compounds were analyzed via high-performance liquid chromatography (HPLC). Cell viability and reactive oxygen species (ROS) levels were assessed in breast cancer (MDA-MB-231, MCF-7) and epithelial (MCF-10A) cells using thiazolyl blue tetrazolium bromide (MTT) and chloromethyl 2′,7′-dichlorodihydrofluorescein …


Blood Tnf-Α And Gabra-1 Levels In Individuals With Poor Ovarian Response Underwent In Vitro Fertilization Program, Gadsara Ruangprachum, Paweena Thuwanut, Wisan Sereepapong, Vorasuk Shotelersuk, Siraprapa Tongkobpetch, Porntip Sirayapiwat Mar 2025

Blood Tnf-Α And Gabra-1 Levels In Individuals With Poor Ovarian Response Underwent In Vitro Fertilization Program, Gadsara Ruangprachum, Paweena Thuwanut, Wisan Sereepapong, Vorasuk Shotelersuk, Siraprapa Tongkobpetch, Porntip Sirayapiwat

Chulalongkorn Medical Journal

Background: Poor ovarian response (POR) to ovarian stimulation during in vitro fertilization (IVF) program remains a critical issue contributing to decreased ovarian reserve and cancellation of IVF cycles. Nevertheless, the complete etiology of PRO condition remains inadequately understood.

Objectives: This research primarily aimed to compare levels of blood pro-inflammatory cytokine (TNF-α) and apoptotic marker (GABRA-1) between those exhibiting normal ovarian response (NOR) and those with poor ovarian response during IVF program.

Methods: A cross-sectional study involving whole blood collection from 25 participants was conducted (15 individuals in NOR group and 10 in POR group). Relative gene expression levels of blood …


Reliability And Validity Of Thai Version Genital Appearance Satisfaction (Gas) Questionnaire, Suvit Bunyavejchevin, Thanawat Sangnucktham, Purim Ruanphoo Mar 2025

Reliability And Validity Of Thai Version Genital Appearance Satisfaction (Gas) Questionnaire, Suvit Bunyavejchevin, Thanawat Sangnucktham, Purim Ruanphoo

Chulalongkorn Medical Journal

Background: GAS questionnaire is constructed to measure feelings towards women’ own genitals in a broader spectrum. Thai language GAS questionnaire will be useful for clinical and research purpose.

Objectives: The aim of this study was study the reliability and validate the Thai version GAS questionnaire.

Materials and methods: Ninety Thai women attending the gynecologic outpatient clinic at King Chulalongkorn Memorial hospital were recruited between July 2017 to June 2018 in this study. Ten participants dropped out because they did not answer the second questionnaire. The original English-version of GAS questionnaire was translated into Thai version and backward translated …


Quality Control Of Clinical Protocols Of Ct Using The Accreditation Phantom, Walaiporn Suksancharoen, Apawadee Chakrapong, Sakultala Ruenjit, Anchali Krisanachinda Mar 2025

Quality Control Of Clinical Protocols Of Ct Using The Accreditation Phantom, Walaiporn Suksancharoen, Apawadee Chakrapong, Sakultala Ruenjit, Anchali Krisanachinda

Chulalongkorn Medical Journal

Background: The daily quality control of the Computed Tomography system consists of the measurement of the accuracy of CT Number and the artifact evaluation. The annual quality control includes the clinical protocol review. The CT radiologist is responsible for ensuring that all Quality Assurance (QA) requirements are met. The clinical team reviews and manages the CT protocol to deliver the appropriate radiation dose to the patient for each examination.

Objectives: To verify CT Number Accuracy, to review clinical protocols and to verify that the low-contrast performance of clinical protocols is adequate for diagnosis.

Methods: American College of Radiology (ACR) CT …


Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr. Mar 2025

Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr.

Chulalongkorn Medical Journal

Abstract:

Background: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by inflammation and joint damage.

Objective: This study aimed to evaluate the antiarthritic activity of Trigonella foenum-graecum (TFG) Transferosomal gel in a Freund’s adjuvant-induced arthritic rat model and compare it with Diclofenac gel, a standard anti-inflammatory drug.

Methods: Arthritis was induced in rats by injecting a 0.1 mL (1mg/ml) CFA suspension into the left hind foot in the subplantar region, allowing them to develop arthritis for 21 days.

Results: Arthritis induction led to a significant increase in paw volume, indicative of inflammation. Treatment with both TFG-transferosomal gel and Diclofenac …


Dengue Cases In Hanoi, Vietnam: Unseasonal Surge Foreshadows Increased Incidence That Demands Organized Preventive Action, Andrew W. Taylor-Robinson Mar 2025

Dengue Cases In Hanoi, Vietnam: Unseasonal Surge Foreshadows Increased Incidence That Demands Organized Preventive Action, Andrew W. Taylor-Robinson

Chulalongkorn Medical Journal

Letter to the Editor - Abstract not required.


Regional Government Preparedness In Response To The Covid-19 Pandemic In Indonesia, Eme Stepani Sitepu, Dumilah Ayuningtyas, Purnawan Junadi, Satibi Satibi Mar 2025

Regional Government Preparedness In Response To The Covid-19 Pandemic In Indonesia, Eme Stepani Sitepu, Dumilah Ayuningtyas, Purnawan Junadi, Satibi Satibi

Journal of Health Research

Background: The high number of COVID-19 cases in Indonesia, with 6,811,201 people affected and 161,844 deaths up to June 2023, was influenced by regional governments' varying approaches to disease control. This study aimed to analyze regional government preparedness in response to the COVID-19 pandemic and the factors that influenced their preparedness.

Methods: We conducted a qualitative research study using purposive sampling. We collected data from September 2023 to April 2024 via semi-structured interviews with staff at health and disaster agencies in Bali and West Java. The interview guide was developed using the Six Building Blocks of World Health Organization (WHO)’s …


Knowledge And Attitude Towards Genetics And Genetic Testing Among Late Adolescents And Adults In Indonesia, Asyirah Mujahidah Fillah, Muh Akram, Clarissa Evangelina Hartono, Annette D'Arqom, Zakiyatul Faizah, Danti Nur Indiastuti, Nurina Hasanatuludhhiyah, Mhd Zamal Nasution, Junaidah Yusof Mar 2025

Knowledge And Attitude Towards Genetics And Genetic Testing Among Late Adolescents And Adults In Indonesia, Asyirah Mujahidah Fillah, Muh Akram, Clarissa Evangelina Hartono, Annette D'Arqom, Zakiyatul Faizah, Danti Nur Indiastuti, Nurina Hasanatuludhhiyah, Mhd Zamal Nasution, Junaidah Yusof

Journal of Health Research

Background: Despite the potential benefits, genetic testing has a negative stigma in Indonesia, leading to relatively low utilization. Without adequate knowledge, the incidence of genetic disorders could rise. Thus, a clear understanding of knowledge and attitudes towards genetics and testing among late adolescents and adults is crucial.

Method: A web-based questionnaire was administered between May and October 2022. Respondents (n= 467), composed of late adolescents (n= 332) and adults (n= 135), were recruited through social media and email. General genetic knowledge, perceptions about personal knowledge of genetic testing applications and its social implications, and the attitude toward genetic …


Factors Associated With Delayed Onset To Services Among Patients With Acute Coronary Syndrome In Yala Province, Southern Thailand, Suwaibah Arboo, Bhunyabhadh Chaimay, Somkiattiyos Woradet Mar 2025

Factors Associated With Delayed Onset To Services Among Patients With Acute Coronary Syndrome In Yala Province, Southern Thailand, Suwaibah Arboo, Bhunyabhadh Chaimay, Somkiattiyos Woradet

Journal of Health Research

Background: Delayed access to services for acute coronary syndrome (ACS) can worsen outcomes. This hospital-based, cross-sectional study aimed to identify factors associated with delayed access to ACS care in Yala Province, Southern Thailand.

Methods: The study analyzed ACS patients from community hospitals in Yala Province, enrolled between October 1, 2018, and September 30, 2021, using data from the Yala ACS Registry and HosXp Database. Among 668 patients, 289 experienced delayed access to services, while 379 did not. Descriptive statistics and multiple logistic regression were applied for analysis.

Results: The incidence of delayed access to services was 43.26 % (95 …


Factors Associated With Access To Water, Sanitation, And Hygiene (Wash) Services In Communities Along Siem Reap River, Cambodia, Cindy Is Lee, Yee Chu Kwa, Aminiril Aa Hamid, Norlilawati Suboh, Massimo Maio, Michaela L Goodson, Claire L Walsh Mar 2025

Factors Associated With Access To Water, Sanitation, And Hygiene (Wash) Services In Communities Along Siem Reap River, Cambodia, Cindy Is Lee, Yee Chu Kwa, Aminiril Aa Hamid, Norlilawati Suboh, Massimo Maio, Michaela L Goodson, Claire L Walsh

Journal of Health Research

Background: Access to clean water, sanitation, and hygiene (WASH) are essential rights that impact individual and community health. The Siem Reap River is a vital water source in Cambodia for domestic, agricultural, and industrial use. However, limited local data and resources in the region exacerbate the challenge of providing adequate WASH services. This study aimed to evaluate WASH provision for communities living near the Siem Reap River and identify associated factors.

Method: A cross-sectional study in April 2023 across four Siem Reap River villages used purposive sampling to select 120 respondents from diverse backgrounds. Data were gathered through face-to-face …


Prevalence And Perioperative Complications Of Super-Obese Parturients Undergoing Cesarean Delivery, Patchareya Nivatpumin, Tripop Lertbunnaphong, Kotchapun Taibowornpitak Mar 2025

Prevalence And Perioperative Complications Of Super-Obese Parturients Undergoing Cesarean Delivery, Patchareya Nivatpumin, Tripop Lertbunnaphong, Kotchapun Taibowornpitak

Journal of Health Research

Background: Perioperative anesthetic and obstetric complications in morbidly obese patients have been extensively researched, revealing a greater incidence of complications compared to both obese and non-obese patients. This study aimed to determine the prevalence and perioperative complications specifically among super-obese parturients undergoing cesarean delivery.

Method: This retrospective study used data from Thailand's largest university hospital from January 1, 2014, to January 31, 2023, including cesarean patients with a BMI > 50 kg/m² on the day of surgery. Patients with a gestational age < 24 weeks or incomplete anesthetic records were excluded.

Results: Of 30,383 cesarean deliveries at our institute, 42 patients with a BMI > 50 kg/m² were analyzed, with …


Factors Associated With Delayed Thrombolytic Medication Among Patients With St-Segment Elevation Myocardial Infarction In Southern Thailand, Mamaphoasee Suemae, Bhunyabhadh Chaimay, Somkiattiyos Woradet Mar 2025

Factors Associated With Delayed Thrombolytic Medication Among Patients With St-Segment Elevation Myocardial Infarction In Southern Thailand, Mamaphoasee Suemae, Bhunyabhadh Chaimay, Somkiattiyos Woradet

Journal of Health Research

Background: ST-Segment Elevation Myocardial Infarction (STEMI) is among the most prevalent heart diseases worldwide and a leading cause of death. Delayed thrombolytic treatment significantly increases mortality risk in affected patients. This study aimed to identify factors associated with delayed administration of thrombolytic medication in STEMI patients.

Methods: A cross-sectional analytical study was conducted in Narathiwat Province, involving 1,074 STEMI patients documented in the Acute Coronary Syndrome Registry between January 1, 2016, and December 31, 2021. Of these, 781 eligible patients were categorized into two groups: 464 with delayed thrombolytic medication and 317 without. Descriptive statistics and multiple logistic regression used …


Ya-Hok-Sing: Bioactive Substance Components, In Vitro Toxicity, And A Case Series, Khareeyoh Asae, Oratai Neamsuvan, Nantiya Joycharat Mar 2025

Ya-Hok-Sing: Bioactive Substance Components, In Vitro Toxicity, And A Case Series, Khareeyoh Asae, Oratai Neamsuvan, Nantiya Joycharat

Journal of Health Research

Background: Ya-Hok-Sing is a traditional Thai polyherbal medicine used by Singhanakhon healers, Thailand. This study aimed to provide scientific evidence supporting the traditional use of Ya-Hok-Sing as an anti-fever remedy.

Methods: The chemical fingerprinting and in vitro toxicity of Ya-Hok-Sing were investigated using the Liquid Chromatography-Quadrupole time-of-flight-Mass spectrometry (LC-QTOF-MS) method and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The clinical efficacy of Ya-Hok-Sing for fever relief was examined using a case series of five patients following treatment from a traditional Thai healer.

Results: The mass-spectrometry-total ion chromatogram (MS‑TIC) for Ya-Hok-Sing revealed the presence of thirty-six compounds, including twenty-one phenolics and fifteen organic acids. …


Experiences Of Caregivers Of Children With Covid-19 In Isolation Rooms: A Qualitative Study Conducted At Queen Sirikit National Institute Of Child Health In Bangkok, Thailand, Kidjapan Pinchai, Surasak Treenai, Chollada Jongsomjitt Mar 2025

Experiences Of Caregivers Of Children With Covid-19 In Isolation Rooms: A Qualitative Study Conducted At Queen Sirikit National Institute Of Child Health In Bangkok, Thailand, Kidjapan Pinchai, Surasak Treenai, Chollada Jongsomjitt

Journal of Health Research

Background: Children were significantly impacted during COVID-19 surges, especially with highly transmissible variants like Delta. This study explored caregivers' experiences of children with COVID-19 in hospital isolation rooms, focusing on psychological and practical challenges.

Methods: Qualitative methods were used to describe the experiences of caregivers of children with COVID-19. Data were collected through in-depth interviews and from field and observation notes to capture reflections, ideas, and meanings. Content analysis was used to generate themes until saturation was reached with seven participants. The study was conducted at the Queen Sirikit National Institute of Child Health (QSNICH) in Bangkok, Thailand.

Results: The …


Educational Intervention Through Telemedicine And Its Impact On Kidney Function In Patients With Chronic Kidney Disease: A Systematic Review, Luh P.F. Larasanty, Anna W. Widayanti, Tri M. Andayani Mar 2025

Educational Intervention Through Telemedicine And Its Impact On Kidney Function In Patients With Chronic Kidney Disease: A Systematic Review, Luh P.F. Larasanty, Anna W. Widayanti, Tri M. Andayani

Journal of Health Research

Background: Educational intervention is a strategy that can be used to improve chronic kidney disease (CKD) patient adherence and can be provided through telemedicine. The goal of this study was to identify impact of educational intervention through telemedicine on kidney function of CKD patients.

Method: A systematic review of randomized and non-randomized controlled trials (2013–2022) was conducted using PubMed and Scopus, following PRISMA guidelines. Study quality was assessed with the Mixed Methods Appraisal Tool (MMAT).

Results: From a total 460 articles identified, 9 controlled trial articles using estimated glomerular filtration rate (eGFR) as a kidney function parameter were included …


Short-Term Effects Of Self-Thai Foot Massage And Foot Care On Balance And Proprioception Among Patients With Diabetic Peripheral Neuropathy, Saw Mya Soe, Sawitri Wanpen, Thiwabhorn Thaweewannakit, Punnee Peungsuwan, Uraiwan Chatchawan Mar 2025

Short-Term Effects Of Self-Thai Foot Massage And Foot Care On Balance And Proprioception Among Patients With Diabetic Peripheral Neuropathy, Saw Mya Soe, Sawitri Wanpen, Thiwabhorn Thaweewannakit, Punnee Peungsuwan, Uraiwan Chatchawan

Journal of Health Research

Background: Diabetic foot care involves complications such as impaired balance and proprioception, which can impact a patient's quality of life. This study investigated the short-term effects of self-administered Thai Foot Massage (STFM) on balance and proprioception in diabetic patients.

Methods: A randomized controlled trial was employed; ninety diabetic peripheral neuropathy (DPN) participants were randomly assigned to receive either STFM combined with standard foot care (STFM-SFC) or standard foot care alone (SFC). The intervention spanned four weeks, with two weeks at the hospital followed by an additional two weeks at home. Outcome measures included assessments of balance using the …


External Jugular Vein Catheterization Technique For Continuous Blood Sampling In Gilts, Preechaphon Taechamaeteekul, Yosua Kristian Adi, Chutikan Srisang, Pirada Virankabutra, Natchanon Dumniem, Jinda Singlor, Padet Tummaruk Mar 2025

External Jugular Vein Catheterization Technique For Continuous Blood Sampling In Gilts, Preechaphon Taechamaeteekul, Yosua Kristian Adi, Chutikan Srisang, Pirada Virankabutra, Natchanon Dumniem, Jinda Singlor, Padet Tummaruk

The Thai Journal of Veterinary Medicine

External jugular vein blood collection is common in gilts and sows, but continuous sampling for hormonal and pharmacokinetic research requires catheterization. The standard protocol has remained largely unchanged for nearly 40 years. This study aimed to develop a modified external jugular vein catheterization technique in gilts. Ten gilts (72.0 ± 3.4 kg) underwent surgery under general anesthesia after 12-hour fasting. Sedation was induced with intramuscular Xylazine (4.4 mg/kg) and Tiletamine–Zolazepam (2.2 mg/kg), followed by intravenous Thiopental sodium (10 mg/kg). Once anesthetized, gilts were placed in dorsal recumbency, and the external jugular fossa was prepared under sterile conditions. A 10 cm …


Restricted Feeding Of Goats During The Last Third Of Gestation And Trans-Generational Effects On Plasma Progesterone In Their Female Offspring, Andrew A. Ponter, Bérengère Laporte, Sabine Roussel, Winai Kaewlamun, Pascale Chavatte-Palmer, Christine Duvaux-Ponter Mar 2025

Restricted Feeding Of Goats During The Last Third Of Gestation And Trans-Generational Effects On Plasma Progesterone In Their Female Offspring, Andrew A. Ponter, Bérengère Laporte, Sabine Roussel, Winai Kaewlamun, Pascale Chavatte-Palmer, Christine Duvaux-Ponter

The Thai Journal of Veterinary Medicine

Feeding levels can vary in goat farms for several reasons. Underfeeding of gestating dairy goats can occur and may influence fetal follicle development and future reproductive performance in their offspring. The objective of this experiment was to study the effect of restricted feeding during the last third of gestation on some reproductive parameters in female offspring (F1). Two feeding groups were formed using 60 Alpine and Saanen dairy goats to produce the F1 female offspring. The control group (C, n = 30) was fed to requirements. The restricted group (R, n = 30) was given the same diet, but the …


Prevalence Study Of Feline Ab Blood Types In Bangkok And Vicinities Of Thailand By Rapid Immunochromatographic Test During 2022-2024, Suwarath Wadeerat, Sinittha Thongwandi, Thitima Tripipat, Teerawut Nedumpun Mar 2025

Prevalence Study Of Feline Ab Blood Types In Bangkok And Vicinities Of Thailand By Rapid Immunochromatographic Test During 2022-2024, Suwarath Wadeerat, Sinittha Thongwandi, Thitima Tripipat, Teerawut Nedumpun

The Thai Journal of Veterinary Medicine

The AB blood group system is a key classification for feline blood types, categorizing them as type A, B, or AB based on red blood cell surface antigens. This study aimed to update the prevalence of feline blood types among domestic and pedigreed cats in Bangkok and vicinities from 2022 to 2024. A total of 114 blood samples, including 76 Domestic Shorthairs (DSH) and 38 pedigreed cats, including 10 breeds, were analyzed using the rapid immunochromatographic feline blood typing. Results revealed that blood type A was predominant, present in 93.86% of cats, consistent with global findings. Blood types B and …


Stepwise Regression Analysis To Assess Various Factors Affecting On Fresh Sperm Quality In Ouled Djellal Ram, Yamina Belkhiri, Souheyla Benbia, Farida Bouzebda-Afri, Zoubir Bouzebda, Ramzi Lamraoui Mar 2025

Stepwise Regression Analysis To Assess Various Factors Affecting On Fresh Sperm Quality In Ouled Djellal Ram, Yamina Belkhiri, Souheyla Benbia, Farida Bouzebda-Afri, Zoubir Bouzebda, Ramzi Lamraoui

The Thai Journal of Veterinary Medicine

The aim of this study was to evaluate the effect of various factors on fresh semen quality in Ouled Djellal rams. Specifically, we examined the impact of semen collection method, season, ram age, testosterone levels, body weight , and testicular weight. Twelve mature Ouled Djellal rams were used in the trial. Six rams were trained for semen collection using an artificial vagina (AV), while semen from the other six rams was collected using an electroejaculator (EE) biweekly throughout the year. Stepwise regression analysis showed that 62.50% of the variation in sperm volume, 48.60% of the variation in mass motility, 62.70% …


Assessing The Feasibility Of Microneedle Patches For Gnrh Immunocontraception In Mixed-Breed Dogs (Canis Familiaris), Ai-Mei Chang, Hsiao-Hui Huang, Ding-Liang Hou, Zi-Yu Lin, Mei-Chin Chen, Chen-Chih Chen, Jai-Wei Lee Mar 2025

Assessing The Feasibility Of Microneedle Patches For Gnrh Immunocontraception In Mixed-Breed Dogs (Canis Familiaris), Ai-Mei Chang, Hsiao-Hui Huang, Ding-Liang Hou, Zi-Yu Lin, Mei-Chin Chen, Chen-Chih Chen, Jai-Wei Lee

The Thai Journal of Veterinary Medicine

The overpopulation of free-roaming dogs poses significant risks to endemic species, public health, and the environment through predation and disease transmission. While surgical castration is effective, it raises ethical concerns regarding animal welfare. Immuno-castration offers a humane and effective alternative for population control, but a more easily administered and cost-efficient method is needed to enable widespread vaccination efforts. In this study, we aimed to employ self-dissolving microneedle patches for a simple and potentially cost-effective immunization of a recombinant GnRH-based vaccine to control fertility. Eight mongrel dogs were randomly divided into 2 groups (n=4 each) and immunized with the recombinant GnRH-based …


Factor Influencing Pharmacist Engagement And Turnover Intention In Thai Community Pharmacist: A Structural Equation Modeling Approach, Tulakarn Nakpun, Tipaporn Kanjanarach, Tanattha Kittisopee Feb 2025

Factor Influencing Pharmacist Engagement And Turnover Intention In Thai Community Pharmacist: A Structural Equation Modeling Approach, Tulakarn Nakpun, Tipaporn Kanjanarach, Tanattha Kittisopee

The Thai Journal of Pharmaceutical Sciences

The objective of this study was to test the proposed hypothesized structural model of factor influencing pharmacist engagement and turnover intention in Thai community pharmacists. A cross-sectional study design with self-administered questionnaire was conducted in 209 fulltime community pharmacists. Data were analyzed using structural equation modeling technique. The hypothesized model comprised five constructs. Organizational resources were assessed by training and development, payment and recognition, and physical working condition. Job characteristics were assessed by autonomy, job skill variety, task significant, and task identity. Social supports were evaluated by supervisory support and peer support. Pharmacist engagement was assessed by vigor, dedication, and …


Factors Affecting Indonesian Community Pharmacists To Advise Patient About Herbal Medicine, Chilmia Nurul Fatiha, Tanattha Kittisopee Feb 2025

Factors Affecting Indonesian Community Pharmacists To Advise Patient About Herbal Medicine, Chilmia Nurul Fatiha, Tanattha Kittisopee

The Thai Journal of Pharmaceutical Sciences

Background: Herbal medicine (HM) is a part of Indonesian daily life. Contrary to the belief that HM is natural and totally safe, safety issues regarding HM are increasingly reported. There is a need for pharmacists to play a significant role by advising patients about HM to promote safe and effective use. Aims: This study aimed to explore Indonesian community pharmacist’s behavior in advising patients about HM and the factors behind it. Methods: A cross-sectional self-administered questionnaire was conducted toward Indonesian community pharmacists by online from May to June 2016 by convenience sampling. Of the 1044 emails sent, 168 responses were …


Impact Of Research-Based Learning On Student Knowledge And Assessment In Pharmacoepidemiology: A One Group Pretest-Posttest Experimental Study, Chuenjid Kongkaew, Charles Norman Scholfield, Teeraporn Supapaan, Claire Mann, Pajaree Mongkhon, Skonchai Chanunun Feb 2025

Impact Of Research-Based Learning On Student Knowledge And Assessment In Pharmacoepidemiology: A One Group Pretest-Posttest Experimental Study, Chuenjid Kongkaew, Charles Norman Scholfield, Teeraporn Supapaan, Claire Mann, Pajaree Mongkhon, Skonchai Chanunun

The Thai Journal of Pharmaceutical Sciences

Introduction: Research-based learning (RBL) is an active way of engaging students and engendering research skills. Objectives: The objectives of the study were to examine the impact of RBL on student knowledge and assessment. Materials and Methods: RBL was run as a one-group pre-test/post-test experimental study where the 4th-year pharmacy undergraduates (n = 84) taking the basic pharmacoepidemiology course were the participants. RBL was incorporated into the course as a strategy to build small-scale real-life research projects into undergraduate assignments. The RBL intervention was assessed as student knowledge of the selected topics and their assessments of the teaching. Results: Eighty-three valid …


Effective Antioxidant Production Through Submerged Fermentation Of Edible Mushrooms, Sukanya Jiamworanunkul Feb 2025

Effective Antioxidant Production Through Submerged Fermentation Of Edible Mushrooms, Sukanya Jiamworanunkul

The Thai Journal of Pharmaceutical Sciences

Objective: The present work was designed to apply the submerged fermentation of five edible mushrooms including Schizophyllum commune, Lentinus polychrous, Lentinula edodes, Ganoderma lucidum, and Lentinus squarrosulus for antioxidant production. Methods: The antioxidant activity and total phenolic content (TPC) of 30 different broth and mycelium extracts acquired from the submerged mushroom fermentation in three liquid media, malt extract broth (MEB), potato dextrose broth (PDB), and yeast extract sucrose broth, were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and Folin-Ciocalteu colorimetric method, respectively. Results: All the extracts were found to possess antioxidant properties and contain phenolic compounds. The percentage of DPPH …


The Evaluation On Anti-Platelet And Antithrombosis Activities Of Cinnamomum Sintoc Bark Extract, Nanang Fakhrudin, Tri Wiyono, Arbie Ristanto Putra, Sitarina Widyarini, Arief Nurrochmad Feb 2025

The Evaluation On Anti-Platelet And Antithrombosis Activities Of Cinnamomum Sintoc Bark Extract, Nanang Fakhrudin, Tri Wiyono, Arbie Ristanto Putra, Sitarina Widyarini, Arief Nurrochmad

The Thai Journal of Pharmaceutical Sciences

Introduction: One of the factors contributing to cardiovascular diseases is platelet aggregation. Although several antiplatelet agents have been introduced into clinical practices, discovery of antiplatelet agents is still challenging. Plants from the genus of Cinnamomum were previously reported to have antiplatelet activity. This study aimed to determine the activity of Cinnamomum sintoc (CS) bark extract inhibiting platelet aggregation and thrombosis. Materials and Methods: Antiplatelet activity of CS bark methanolic extract (CS methanolic extract [CSME]) (5–300 μg/mL) was determined by measuring the ability of the extract to inhibit platelet aggregation induced by epinephrine. Meanwhile, the antithrombosis activity was determined by calculating …


Investigation Of Lipophilic And Hydrophilic Leaf Extracts Of Portulaca Oleracea On Gestation In Albino Rats (Rattus Norvegicus), Victoria Chinenye Obinna, Hope Delesi Kagbo, Gabriel Ogaba Agu Feb 2025

Investigation Of Lipophilic And Hydrophilic Leaf Extracts Of Portulaca Oleracea On Gestation In Albino Rats (Rattus Norvegicus), Victoria Chinenye Obinna, Hope Delesi Kagbo, Gabriel Ogaba Agu

The Thai Journal of Pharmaceutical Sciences

Background: Portulaca oleracea Linn. is one of the indigenous plants currently gaining ground and recognition globally as both vegetable and medicinal herb. The scarcity of literature on the safety of P. oleracea uses in pregnancy prompted this research. Objective: This study investigated the effect of the lipophilic and hydrophilic leaf extracts of P. oleracea on gestation/fetal indices. Methods: The extracts were obtained using two extracting solvents – chloroform and 80% aqueous methanol in succession. Thirty-five successfully mated female rats were divided into seven groups. Group 1 (control) received 0.5 ml 20% Tween 80 (vehicle), Groups 2, 3, and 4 received …


Evaluation Of Anti-Epileptic Activity Of Lantana Camara (Linn.) Flowers In Swiss Albino Mice, Kundan Singh Bora, Baldev Singh Feb 2025

Evaluation Of Anti-Epileptic Activity Of Lantana Camara (Linn.) Flowers In Swiss Albino Mice, Kundan Singh Bora, Baldev Singh

The Thai Journal of Pharmaceutical Sciences

Introduction: Globally, approximately 50 million people are being affected by epilepsy and nearly 80% occurring in the developing countries. The plant Lantana camara Linn. (Family: Lamiaceae) is native to the tropical regions of the America, Africa, and Asia. It is found in Kumaon and Garhwal region of Uttarakhand, India. The plant has been used for various ailments in traditional systems of medicines for the treatment of epilepsy, wounds, tumor, stomach ache, and inflammation. Objective: The present study was planned with an objective to evaluate antiepileptic activity of L. camara flowers in mice. Methods: Maximum electric shock (MES) and pentylenetetrazoleinduced (PTZ) …


Challenges Of Pharmaceutical Supply Chain In A Developing Country: A Qualitative Study, Yaser Sarikhani, Peivand Bastani, Mahdiehsadat Ahmadzadeh, Hesam Dorosti, Jamal Abadi Sara Feb 2025

Challenges Of Pharmaceutical Supply Chain In A Developing Country: A Qualitative Study, Yaser Sarikhani, Peivand Bastani, Mahdiehsadat Ahmadzadeh, Hesam Dorosti, Jamal Abadi Sara

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical supply chain has a critical role in the procurement of medications, Iranian health‑care system encountered many challenges in this scope because of the national and international barriers. In this regard, this study aimed to determine challenges of the pharmaceutical supply chain in Shiraz, the largest southern metropolitan in Iran. Materials and Methods: In this qualitative study, we included 32 experts through purposeful sampling method. Data gathered using a semi‑structured interview and saturation level were achieved with these interviews. Thematic content analysis was used after data transcription. Related codes, subthemes, and themes were extracted applying MAXQDA 10. Findings: Seven …


Screening Of Antimicrobial And Antioxidant Properties Of Ethyl Acetate Extracts From Wild Edible Mushrooms, Sukanya Jiamworanunkul, Porntep Chomcheon Feb 2025

Screening Of Antimicrobial And Antioxidant Properties Of Ethyl Acetate Extracts From Wild Edible Mushrooms, Sukanya Jiamworanunkul, Porntep Chomcheon

The Thai Journal of Pharmaceutical Sciences

Objective: The current work was undertaken to evaluate in vitro antibacterial, antifungal and antioxidant properties, together with total phenolic contents of ethyl acetate extracts from wild edible mushrooms collected in September 2017 from the rehabilitated forest area in the northeast of Thailand. Results: All the wild edible mushrooms collected could be classified into 6 families and 13 species namely Macrolepiota rhacodes, Heimiella japonica, Boletus persoonii, Mycoamaranthus cambodgensis, Cantharellus cibarius, Amanita princeps, Amanita hemibapha, Russula cyanoxantha, Russula eburneureolata, Russula virescens, Russula emetica, Russula violeipes, and Termitomyces clypeatus. To the best of our knowledge, there have been no previous reports on the …