Digital Commons Network^™

Obesity And Cardiometabolic Risks In Thai Children: A Comprehensive Cross-Sectional Analysis, Nitiroj Bongkotwilawan, Nantika Paiboon, Therdpong Tempark, Orapa Suteerojntrakool, Chansuda Bongsebandhu-Phubhakdi

Journal of Health Research

Background: Childhood overweight and obesity are increasing globally, posing significant cardiometabolic risks. Despite extensive studies in developed countries, data on the prevalence and risk profiles of cardiometabolic abnormalities in children from Southeast Asia remain limited

Methods: This cross-sectional study involved 270 Thai children aged 6–13 years, recruited from primary schools in Bangkok. Anthropometric measurements were performed to determine weight, height, and BMI. Blood pressure and fasting blood samples were analyzed for lipid profiles, glycated hemoglobin (HbA1c), and serum glutamic pyruvic transaminase (SGPT) levels. Participants were categorized into normal weight, overweight, and obese groups based on BMI standard deviation scores (SDS). …

Brief State And Trait Happiness Scales: Validation And Work Arrangement Differences In Thai Workers, Rapinpat Yodlorchai, Panrapee Suttiwan, Sompoch Iamsupasit

Journal of Health Research

Background: This study aimed to develop and validate brief measures of state (CUHI-S-SF) and trait (CUHI-T-SF) happiness derived from the Chulalongkorn University Happiness Inventory and to examine differences in happiness and psychological distress across work arrangements among Thai working adults.

Methods: A cross-sectional online survey collected data from 452 participants using convenience sampling. Exploratory factor analysis (EFA) was conducted with Sample I (n ¼ 250; Mage ¼ 33.04) to examine internal structure, followed by confirmatory factor analysis with Sample II (n ¼ 202; Mage ¼ 35.29). Independent-samples t tests compared on-site and non—on-site workers on happiness and psychological …

The Enhancement Of Learning Inspiration By Strategic Life Planning Using After Model Assembly With Goodness Based Learning For The Lower Secondary Students In Buriram’S Private School, Adisorn Bansong

Journal of Education Studies

This pre-experimental research aimed to compare the students’ learning Inspiration before, and after using AFTER model assembly with Goodness Based Learning (GBL) on the Strategic Life Planning lesson plans to enhance student’s learning inspiration, A one-group pretest-posttest design was conducted on 40 lower secondary students using a lesson plan with IOC = 0.80-1.00, high-level quality was implemented 1 period a week for 15 weeks. The Learning Inspiration Scales with IOC = 0.90-1.00 and Cronbach's Alpha Coefficient = .86 were utilized as instruments for data collection. Percentage, mean, standard deviation, and t-test were used for data analysis. The findings were as …

Factors Related To Self-Care Behaviors Among Older Adults For Communicable Disease (Cd) Protection In The Eastern Economic Corridor (Eec) Of Thailand: A Case Study Of Covid-19, Surasingha Sombat Suranartwatchawong, Sane Saengngoen, Supaporn Sudnongbua

Journal of Health Research

Background: The impact of COVID-19 is particularly severe for older adults, who represent the most vulnerable demographic. Using COVID-19 as a case study, this research investigates the factors influencing self-care behaviors for preventing communicable diseases (CD) among older adults in the EEC.

Methods: The study with a cross-sectional design involving 387 older adults aged 60 years was conducted between January and March 2025. The questionnaire was valid and reliable based on objective congruence (IOC) index and Cronbach’s alpha coefficients. Data analysis utilized both descriptive and inferential statistics.  Frequency, percentage, standard deviation, and multiple linear regression analysis were employed …

Colostrum Fatty Acid Composition And Its Association With Reproductive Traits In Sows Under Tropical Conditions, Dwi Sunu Datrianto, Kunaporn Homyog, Surasak Jittakhot, Padet Tummaruk

The Thai Journal of Veterinary Medicine

Colostrum provides essential nutrients and immune factors that newborn piglets can absorb only within the first 24 h after birth. Fatty acids are essential for neonatal physiology, supporting thermoregulation, neurodevelopment, and immune function, and serving as a key energy source to reduce hypothermia and mortality in piglets. However, information on the fatty acid composition of sow colostrum under tropical conditions and its relationship with reproductive performance remains limited, warranting further investigation to improve piglet survival. This study evaluated the fatty acid profile of sow colostrum under tropical production conditions and examined its associations with reproductive traits. Colostrum samples were collected …

Strategies To Enhance Health-Promoting Schools Based On The Global Standards For School Administrators, Nachanan Suphasirisuk, Piyapong Khaikleng

Journal of Health Research

Background: Health-promoting schools (HPS) are a key strategy for improving student health and supporting national education policy. Despite its importance, evidence on the implementation of global HPS standards (GSHPS) in diverse school settings in Thailand remains limited.

Method: A quantitative-dominant, two-phase design was used. Quantitative data were obtained from 498 school administrators using validated assessment tools (S-CVI = 4.62–5.00; α = 0.935–0.967). Data were analyzed using descriptive statistics, t-test, ANOVA, and multiple regression. Qualitative data were collected through focus groups with nine administrators and experts to contextualize quantitative patterns and provide practice-oriented insights regarding implementation feasibility.

Results: HPS implementation across …

Epidemiological Survey Of Abortion In Camels (Camelus Dromedarius) And Histopathological Investigation Of Toxoplasmosis And Neosporosis In Those Animals From Slaughterhouses In Southeastern Algeria, Amira Djeddou-Benabid, Hind Houssou, Omar Bennoune, Ferhat Nouicer, Amel Djaout

The Thai Journal of Veterinary Medicine

Toxoplasma gondii and Neospora caninum are heteroxenous apicomplexan parasites recognized as major causes of reproductive disorders in numerous mammalian species. The present study aimed to assess through an epidemiological survey, the prevalence of reproductive losses in 75 dromedary herds during the period 2022-2025, as well as the associated risk factors, and to detect these protozoa by histopathological analysis in 63 dromedaries slaughtered at the slaughterhouse of El Oued province (126 samples: 63 hearts and 63 diaphragms). The survey revealed that 80% of the herds had a history of abortions, of which 60% also reported cases of stillbirth. Risk factor analysis …

Court-Type Traditional Thai Massage Versus Wrist Splinting For Carpal Tunnel Syndrome: A Randomized Controlled Trial, Phiyaphon Poonsuk, Sunyarn Niempoog, Jurairat Boonruab, Watchara Damjuti

Journal of Health Research

Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy at the wrist that affects palmar function. Court-type traditional Thai massage (CTTM) is a deep-pressure method that may alleviate nerve compression. However, its efficacy remains inadequately established. This study aimed to compare the effectiveness of CTTM and wrist splinting (WS) in CTS patients.

Methods: Eighty patients were randomly assigned into two groups and underwent a 4-week. In the first group, patients received CTTM twice a week, while the second group received WS every day at night only. Pain intensity (VAS), symptom severity scale (Thai BCTQ-S), functional status scale …

Ultrasound-Guided Percutaneous Sclerotherapy Of A Canine Hepatic Cyst Using Lower-Concentration Ethanol: A Case Report, Minyoung Kim, Dongyeong Lee, Seulgi Bae, Sang-Kwon Lee, Kija Lee

The Thai Journal of Veterinary Medicine

A 10-year-old female Pomeranian was referred after a hepatic cyst was incidentally identified during a routine health check. Ultrasound-guided simple drainage was initially performed, and cytological examination of the aspirated fluid confirmed a simple cyst. However, the cyst re-expanded to its original size within 2 weeks. Therefore, ultrasound-guided percutaneous sclerotherapy was elected using lower-concentration ethanol (83%), a readily available medical disinfectant, rather than conventional high-concentration ethanol. Approximately 50% of the aspirated volume was replaced with 83% ethanol and retained for 20 min to achieve effective epithelial ablation. Post-procedural follow-up revealed a transient increase in cyst size and serum alanine aminotransferase …

Ultrasonography Accompanied By Genetic Testing In Feline Polycystic Kidney Disease, Thao Phuong Vu, Thong Quang Le, Ha Nguyen Nhat Tran, Khoa Hoang Dang Le, Anh Phu Nam Bui

The Thai Journal of Veterinary Medicine

Autosomal dominant polycystic kidney disease (ADPKD), caused by the PKD1 c.10063C>A mutation, is a prevalent inherited feline disorder, but its allele frequency in Vietnam remains unidentified. This study aimed to determine the carrier frequency of this variant in British Shorthair, Maine Coon, and Ragdoll cats in Ho Chi Minh City and to correlate genotype with ultrasonographic phenotype. Ninety-seven client-owned cats were genotyped for the pkd1 mutation using PCR-RFLP. A subset of 47 cats also underwent abdominal ultrasonography to detect renal cysts. Genotypic results were correlated with sonographic findings, and risk factors were analyzed using chi-square tests and odds ratios …

Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo

Chulalongkorn Medical Journal

Abstract

Background: The biomedical sciences represent a dynamic and multidisciplinary field pivotal to advancing human health through research, education, and innovation.

Objective(s): This review explores the evolving landscape of biomedical education and career pathways, driven by technological advancements, interdisciplinary integration, and global health demands.

Methods: We examine the distinctions between biomedical science, biomedicine, and biomedical engineering, highlighting their historical origins and contemporary roles. The education and career trajectories of biomedical laboratory scientists (BLS) are analysed, emphasising diverse competencies, core curricula, and the impact of regional policies on professional qualifications. Emerging trends and ethical/regulatory challenges are discussed.

Result(s): Key trends include …

Sequential Presentation Of Diabetic Ketoacidosis, Acute Ischemic Stroke, And St-Elevation Myocardial Infarction: A Case Report, Ichlasul Mahdi Fardhani, Putu Aditya Darmawan Kuntadi, Hammam Arif Shabri, Muhammad Isra Rafidin Rayyan, Zarrah Yuniar Qolbi Harris, Tristi Lukita Wening, Azham Purwandhono

Chulalongkorn Medical Journal

Cardio-cerebral infarction (CCI), the simultaneous occurrence of acute ischemic stroke (AIS) and acute myocardial infarction (AMI), is a rare and life-threatening emergency. Management becomes even more challenging when accompanied by metabolic complications like diabetic ketoacidosis (DKA). We report a case of a 45-year-old man with hypertension and a chronic smoking history, found unresponsive with right-sided hemiparesis. He was last seen well six hours before arrival. On examination, he was hypertensive, tachypneic, had a ketotic breath odor, GCS 12, and NIHSS 15. Laboratory results confirmed DKA, with a random blood glucose of 412 mg/dL and metabolic acidosis. Non-contrast brain CT revealed …

Malignant Transformation Of Giant Epidermal Cyst In The Gluteal Region - A Case Report, Xin Zen Ong Dr., Wan Mokhzani Wan Mokhter Mr., Jing Wen Loh Mr., Ruhana Amirah Abdul Halim Dr.

Chulalongkorn Medical Journal

Epidermal cyst is a very common cutaneous lesion. Giant epidermal cyst is defined by its size of more than 5 cm in diameter. Buttock is an unusual site for epidermal cyst. Malignant transformation of epidermal cyst is an exceedingly rare phenomenon. Clinicians should be vigilant of such entity especially in giant epidermal cyst despite a seemingly benign imaging finding. Long term outcome of surgery for such tumor remains an uncertainty.

Artificial Intelligence Decision Support In Automated Breast Ultrasound: Improving Diagnostic Accuracy And Reducing Unnecessary Biopsies, Chayaporn Hasdiseve, Jenjeera Prueksadee

Chulalongkorn Medical Journal

Background: Emerging roles of artificial intelligence support in breast imaging leads to improved radiologists’ performance

Objective: To assess the diagnostic performance of the artificial intelligence decision support in the evaluation of breast masses using automated breast ultrasound (ABUS).

Methods: 182 patients (415 breast masses) who received ABUS were included. Two readers, including the experienced breast radiologist (reader1) and the breast imaging fellow (reader2), separately reviewed the ABUS images and the artificial intelligence decision support according to the ACR BI-RADS 5^th edition.

Results: All of the 415 masses; 395 masses (95.2%) were benign and 20 masses …

Effect Of Music Therapy On Biophysical Profile And Oxygen Consuption In Preterm Babies In A Rural Hospital., Mahaveer Singh Lakra, Roshan Prasad, Ashwini Lakra, Amar Taksande, Revat J. Meshram, Sagar Karotkar, Mayur Wanjari

Chulalongkorn Medical Journal

Introduction: Music therapy in preterm babies helps in early weight gain, stabilization of heart and respiratory rates, and affect the biophysiological profile. It has a beneficial effect on oxygen consumption and hospital stay. Objectives: This study aimed to assess the effect of music therapy on biophysical profile and oxygen requirement in preterm babies. Methodology: The present comparative, observational study was carried out in the department of neonatology, a rural tertiary care hospital, Sawangi Meghe, Wardha, Maharashtra, India, for one year. All the relevant data was collected and analyzed using the prevalidated Performa. Results and observations: The male-to-female ratio both …

Performance And Cost Comparison Of A Rapid Diagnostic Test For Malaria And Microscopy. A Cross-Sectional Diagnostic Study, Abubakar Sunusi Ishak, Habibu U. Isgogo, Abubakar A. Lawan, Yuda Chongpison

Chulalongkorn Medical Journal

Background: The shift from traditional microscopy to rapid diagnostic tests (RDTs) for malaria diagnosis is gaining popularity, especially in resource-limited settings with unstable electricity and limited expertise. However, trust issues arise due to the inconsistent performance of different RDT kits.

Objectives: This study identified the variations in performance and cost of an RDT brand for malaria among different population demographics: pregnant women, young children, and adults, when compared with microscopy as a gold standard.

Method: The research was carried out in northwestern Nigeria and involved 360 participants stratified into 3 groups: children (5–17 years), adults (≥ 18 years), and pregnant …

Clinical Characteristics Of Cystic Biliary Atresia, Kanokrat Thaiwatcharamas, Sinobol Chusilp, Katawaetee Decharun, Pachareeporn Tanming, Nimmita Srisan, Paisarn Vejchapipat

Chulalongkorn Medical Journal

Background & Objective: Cystic biliary atresia (BA) is a unique form of BA. Our objective was to review the clinical characteristics of cystic BA in order to better understand its nature.

Methods: We retrospectively reviewed all infants diagnosed with cystic BA during January 2005 to December 2019. The diagnosis of BA was confirmed in all cases by laparotomy. Clinical data, pre-operative laboratory and imaging, intraoperative findings, and post-operative outcome were recorded. Data were expressed as mean and SD.

Results: There were 14 cystic BA patients out of the 227 BA patients (6.2%) during the studied period. The mean pre-operative ultrasound …

Superior Mediastinal Cut-Off Measurements In Chest Radiographs For Screening Of Silent Thoracic Aortic Diseases, Kantheera Leesmidt, Boonyarit Sintuvikaiwong, Apichaya Sripariwuth

Chulalongkorn Medical Journal

Objective: To determine cut-off values for superior mediastinal width and the mediastinal width-to-thoracic cage ratio from chest radiographs for the early detection of unrecognized thoracic aortic diseases. Additionally, this study aims to enhance diagnostic strategies for identifying aortic abnormalities.

Materials and Methods: This retrospective analysis included 152 subjects who underwent both computed tomography angiography (CTA) of the thoracic aorta and chest radiograph between April 2007 and January 2021. Superior mediastinal width was measured at 3 levels on chest radiographs. Thoracic CTA findings were categorized into normal and abnormal groups, the latter comprising aortic dissection, intramural hematoma, penetrating atherosclerotic …

การปฏิรูปงานแก้ไขฟื้นฟูผู้กระทำผิด: การประเมินผลกระทบจากการแปรรูปรัฐวิสาหกิจแบบบางส่วนในงานคุมประพฤติของสหราชอาณาจักร (Transforming Rehabilitation: Evaluating The Impact Of Part-Privatisation In The Probation Services Of The United Kingdom), Suphat Phoophanichjaroenkul

Chulalongkorn University Law Journal

บทความนี้วิเคราะห์ผลลัพธ์ของนโยบาย “Transforming Rehabilitation” ซึ่งเป็นการปฏิรูปโครงสร้างงานคุมประพฤติในสหราชอาณาจักรโดยให้ภาคเอกชนเข้ามามีส่วนร่วมในการดำเนินงาน ภายใต้ความประสงค์ในการลดอัตราการกระทำผิดซ้ำ เพิ่มประสิทธิภาพในการปฏิบัติงาน และเสริมสร้างนวัตกรรมในการบริหารจัดการผู้กระทำผิด การปฏิรูปนี้ได้มอบหมายหน้าที่โดยให้บริษัทเอกชนที่เป็นผู้รับผิดชอบในการดูแลผู้กระทำผิดที่มีความเสี่ยงต่ำถึงปานกลางผ่านวิสาหกิจเพื่อการแก้ไขฟื้นฟูผู้กระทำผิดในชุมชน (Community Rehabilitation Companies) ในขณะที่หน่วยงานคุมประพฤติแห่งชาติ (National Probation Service) ยังคงรับผิดชอบผู้กระทำผิดที่มีความเสี่ยงสูง การประยุกต์ใช้เครื่องมือทางการเงิน เช่น “ค่าตอบแทนตามการให้บริการ” และ “การจ่ายเงินตามผลลัพธ์” ถูกนำมาใช้เพื่อดึงดูดการลงทุนจากภาคเอกชนและคาดหวังว่าจะเกิดนวัตกรรมด้านเทคโนโลยี จากการศึกษาพบว่าผลการดำเนินงานตามแผนปฏิรูปไม่เป็นไปตามเป้าหมายที่กำหนด ผู้ให้บริการเอกชนไม่สามารถจัดทำบริการเพื่อสนับสนุนการกลับคืนสู่สังคมได้อย่างเพียงพอ ส่งผลให้ผู้กระทำผิดที่ได้รับการแก้ไขฟื้นฟูไม่ได้รับความช่วยเหลือ การให้บริการงานคุมประพฤติขาดความคิดริเริ่มใหม่ และมาตรฐานงานและคุณภาพลดลง ซึ่งสาเหตุหลักเกิดจากการขาดการทดลองนำร่องที่เพียงพอก่อนการขยายผล รวมถึงข้อบกพร่องในกระบวนการประเมินความเสี่ยง ปัญหาทางการเงินทำให้วิสาหกิจเพื่อการแก้ไขฟื้นฟูผู้กระทำผิดในชุมชนหลายแห่งล้มละลาย ผลกระทบต่อเสถียรภาพของงานคุมประพฤติและความเชื่อมั่นของประชาชนที่ลดลง จนกลายเป็นปัจจัยให้แนวคิดการลงโทษได้รับความนิยม ขณะที่แนวทางการแก้ไขฟื้นฟูผู้กระทำผิดในชุมชนถูกลดบทบาทลง บทความเสนอแนวทางแก้ไขที่สำคัญ ได้แก่ การจำกัดบทบาทของภาคเอกชนให้เป็นเพียงผู้สนับสนุนงานคุมประพฤติ เสริมสร้างความแข็งแกร่งให้กับหน่วยงานคุมประพฤติแห่งชาติในฐานะผู้ให้บริการในการจัดทำงานคุมประพฤติ และการออกแบบเครื่องมือทางการเงินใหม่ที่สร้างแรงจูงใจและส่งเสริมการมีส่วนร่วมของภาคีเครือข่ายและภาคประชาชน นอกจากนี้ บทความยังเสนอแนะให้มีการนำร่องอย่างเป็นระบบเพื่อให้สามารถประเมินความเสี่ยงได้อย่างแม่นยำ และสร้างกลไกการกำกับดูแลที่มีประสิทธิภาพ เพื่อรักษาคุณภาพบริการและสร้างความเชื่อมั่นต่องานคุมประพฤติอย่างยั่งยืน

Epidemiologic Evaluation Of Canine Urate Urolithiasis In Thailand: A Comparative Cross-Sectional Study Between 2016-2023, Nattaporn Chaysakul, Jody P. Lulich, Vachira Hunprasit

The Thai Journal of Veterinary Medicine

A comparative cross-sectional study aimed to describe the epidemiological data of canine urate urolithiasis in Thailand by evaluating the change in proportion over the year and identifying risk-associated factors, including age, breed, sex, and neutered status, through comparisons with multiple comparison groups. The urate and non-urate group was dogs whose uroliths were submitted from Thailand to the Minnesota Urolith Center between 2016 and 2023, and the hospital group was dogs that were visited at the Small Animal Hospital, Chulalongkorn University, between 2020 and 2023. Of 6,171 canine urolith submissions, 210 samples (3.4%) were urate-containing uroliths submitted from twenty-eight canine breeds. …

Reproductive Performance And Its Association With Esr, Prlr, Fshb Genes In Indigenous “I” Pigs, Do Duc Luc, Phan Thi Tuoi, Nguyen Thai Anh, Do Thi Hue, Nguyen Hoang Thinh

The Thai Journal of Veterinary Medicine

Improving the reproductive performance of sows plays an important role in the pig industry, and it applies not only to commercial pigs but also to indigenous pigs. In this study, the polymorphisms of three genes, namely estrogen receptor (ESR), prolactin receptor (PRLR), and follicle-stimulating hormone beta subunit (FSHB) in the “I” pig population were investigated, and their associations with reproductive performance were evaluated. Ear tissue samples were collected from 151 fattening pigs and 126 sows across breeding farms in Vietnam for polymorphisms of the ESR, PRLR and FSHB genes. Three genotypes (AA, AB, and BB) were detected at the …

Evaluation Of Serum Microrna-375 Concentration In Dogs With Diabetes Mellitus: A Pilot Study, Hyeongyeong Lee, Dohee Lee, Jayeon Park, Yeon Chae, Byeong-Teck Kang, Taesik Yun, Hakhyun Kim

The Thai Journal of Veterinary Medicine

Serum microRNAs (miRNAs) serve as diagnostic and prognostic biomarkers for various diseases. The serum concentration of miRNA-375 (miR-375), which is abundantly expressed in pancreatic islet cells, is increased in dogs with experimentally induced pancreatic injury and naturally occurring acute pancreatitis. However, this has not been reported in dogs with diabetes mellitus (DM). This study aimed to compare the expression of serum cfa-miR-375 between dogs with DM and healthy dogs and examine changes in serum cfa-miR-375 levels after insulin administration in dogs with DM. Twenty dogs with DM and 18 healthy dogs were included. The relative expression of serum cfa-miR-375 using …

Drug Procurement Methods And Challenges In Asian Low And Lower-Middle-Income Countries: A Systematic Review, Ferina Septiani Damanik, Anna Wahyuni Widayanti, Muhammad Qowiyul Amin

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical procurement plays a pivotal role in healthcare within Asian low and lower-middle-income countries (LLMICs), ensuring accessibility to essential, cost-effective, and high-quality medicines. Tailored approaches are imperative due to specific challenges inherent in these countries.
Objectives: This review examines several drug procurement systems in Asian countries with LLMICs while identifying and evaluating any potential challenges that might arise within the systems.
Materials and Methods: This review using the preferred reporting items for systematic reviews and meta-analyses guidelines and three search engines (PubMed, Science Direct, and Research Gate) employing Boolean search terms. The search focuses on drug procurement, medicine procurement, …

Efficacy And Safety Of Stem Cell-Based Interventions For Burn Wound Healing: A Systematic Review And Meta-Analysis Of Pre-Clinical And Early Clinical Evidence, Prayuth Poowaruttanawiwit, Patsanan Kulla, Naveeya Pakpoomkamonlert

The Thai Journal of Pharmaceutical Sciences

Background: Burn injuries remain a major therapeutic challenge, with conventional treatments often failing to achieve complete functional skin regeneration. Stem cell-based interventions, including mesenchymal stem cells (MSCs) and exosome derivatives, have demonstrated regenerative and immunomodulatory potential, yet their translation to clinical practice remains limited.
Objectives: To systematically evaluate the efficacy and safety of stem cell-based therapies for burn wound healing across pre-clinical and clinical studies.
Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, four databases (PubMed, Embase, Scopus, and Cochrane) were searched through April 2025. Eligible studies included randomized controlled trials and controlled pre-clinical …

Characteristics Of Drug-Related Problems And The Impact Of Pharmacist Interventions On Hospital Drug Costs In The Medical Intensive Care Unit, Sirima Sitaruno, Wanrada Binyala, Pattama Phetsuk, Nisrin Ni-Ngoh, Worakarn Nukong, Asama Saiwaree, Nawaporn Assanangkornchai, Tanatape Wanishayakorn

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical care activities have been reported to enhance treatment outcomes and cost-effectiveness in critically ill patients. However, relevant and timely data on this topic are still lacking in Thailand.
Objectives: The objective of the study is to investigate the characteristics of drug-related problems (DRPs) identified during pharmaceutical care activities at the medical intensive care unit (MICU) of a tertiary care teaching hospital in Thailand. In addition, we aimed to quantify the impact of pharmacist interventions on hospital drug costs.
Materials and Methods: DRPs identified during pharmaceutical care activities over 3 years were reviewed and classified by the Pharmaceutical Care …

Optimization Of Solvent Extraction For Polyphenols And Antioxidant Activity From Zanthoxylum Acanthopodium Leaves Using Simplex Centroid Design, Waras Nurcholis, Indah Z. Septiawati, Roni Kartiman, Surya Diantina

The Thai Journal of Pharmaceutical Sciences

Background: Zanthoxylum acanthopodium DC., locally known as andaliman, is an indigenous spice from North Sumatra, Indonesia, recognized for its high antioxidant potential. Despite its bioactive richness, optimization of solvent extraction for phenolic and flavonoid compounds from its leaves remains underexplored, even though these compounds are valuable for food and pharmaceutical applications. The use of solvents such as acetone in analytical extraction contexts is acceptable; however, further purification steps would be required for applications in food and pharmaceutical products.
Objectives: The main objective of this study was to optimize solvent combinations – comprising water, ethanol, and acetone – to maximize the …

Pharmacognostic Analysis And Thin-Layer Chromatographic Study Of The Thai Antipyretic Herbal Formula Khiao-Bencha-Khan, Sirinapa Chaisri, Tassanee Paraput, Pravit Akarasereenont, Pinpat Tripatara

The Thai Journal of Pharmaceutical Sciences

Background: Khiao-bencha-khan formula (KBF) is an herbal formula recorded in Thai scriptures and used to treat fever, including exanthematous fever, and aphthous ulcers. It consists of Limnophila rugosa (Roth) Merr., Bacopa monnieri (L.) Wettst., Gossypium arboreum L., Pogostemon cablin (Blanco) Benth., Eupatorium japonicum L., and Justicia gendarussa Burm.f.
Objectives: This study aimed to identify the pharmacognostic and chemical profiles of the herbal components found in KBF.
Methods: All authentic plant materials were collected, and samples were prepared under Pharmaceutical Inspection Co-operation Scheme/good manufacturing practice guidelines. The materials were identified using macroscopic, microscopic, and thin-layer chromatography (TLC) methods.
Results: Microscopic analysis …

Design Of Experiments Based Reversed-Phase High-Performance Liquid Chromatography Method For Estimation Of Metformin And Glimepiride In Combined Dosage Forms, Neela Manish Bhatia, Rachana Patil, Harinath More, Rutuja Dattatray Chougale

The Thai Journal of Pharmaceutical Sciences

Background: The present study aimed to systematically develop and validate a robust, rapid, and stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of metformin and glimepiride in fixeddose combination tablets. Method development was guided by a design of experiments (DoE) approach using the Box-Behnken design (BBD) to ensure optimal analytical performance.
Materials and Methods: Chromatographic separation was achieved on a Cosmosil C18 column using an optimized mobile phase of acetonitrile and water (80:20, v/v) adjusted to pH 3.5. The flow rate was 1 mL/min, and detection was performed at 221 nm. The BBD approach systematically evaluated the …

Development Of Aqueous Dispersions Of Zein–Inulin Nanoparticles: Influence Of Formulation Variables On Physical Properties, Wanarat Sayamol, Supakarn Chamni, Jittima Chatchawalsaisin

The Thai Journal of Pharmaceutical Sciences

Background: Zein-based nanoparticles exhibit considerable potential for pharmaceutical and food applications. Incorporating inulin, a prebiotic polysaccharide, can improve their functional performance. Owing to the distinct solubilities of zein and inulin in aqueous ethanol, zein– inulin nanoparticles can be prepared through precipitation using their respective anti-solvents.
Objectives: This study aimed to systematically develop zein–inulin nanoparticles using the antisolvent precipitation method, with a focus on investigating the effects of formulation variables on particle characteristics and dispersion properties.
Materials and Methods: Zein–inulin nanoparticles were prepared using an anti-solvent precipitation method. Zein and inulin were separately dissolved in aqueous ethanol and water, respectively. The …

Medicines Security And Bioprospecting: A Future Agenda For Pharmaceutical Research, Geoffrey A. Cordell

The Thai Journal of Pharmaceutical Sciences

Humanity is at an extraordinary moment in history, where our interwoven future in Gaia depends on showing reverence for the modulation of our resource limits after significant losses of biodiversity and encroaching environmental change, including disappearing glaciers, rising sea levels, and changing climates. Engaging with the interconnectedness of all life on Earth and integrating sustainability and optimization of the valuable, renewable resources for future generations are essential beginning actions. Fostering economic and resource sustainability deepens the focus for contemporary research priorities toward assuring access to biological agents needed by the consumer/patient. Based on the outcomes of the COP28/29/30 and COP15/16 …