Digital Commons Network^™

Effectiveness Of A Health Literacy Enhancement Program For Older Adults In Northern Thailand, Kasama Pooseesod, Sayambhu Saita, Supa Vittaporn, Jirapat Longkul, Ruchirada Changkwanyeun, Nattagorn Choochouy, Chaiwat Phadermrod, Patsiri Srivieng, Supang Wattanasoei

Journal of Health Research

Background: The aim of this study was to evaluate the effectiveness of a health literacy enhancement program on the health literacy and 3E2S health behaviors (eating, emotion, exercise, stop smoking and stop drinking). We also explored the facilitators and barriers for older adults in developing health literacy and self-care behaviors.

Methods: The study utilized a mixed methods sequential explanatory design. The participants (n = 60) were people aged 60 years and older living in the Hang Chat District, Lampang Province, which located in northern Thailand. The data were collected using pre- and post-questionnaires and an in-depth interview. Quantitative …

Children's Self-Report And Caregivers' Perception Of Chemotherapy Symptoms In Children Receiving Chemotherapy For Cancer Treatment, Lita Sherdsang, Sudaporn Payakkaraung, Wanlaya Thampanichawat

Journal of Health Research

Background: Chemotherapy is the common cancer treatment in childhood. During chemotherapy, symptoms may vary in severity each day. This study aimed to compare children's self-reports and caregivers' perceptions of symptoms of children with cancer on their first day and the third day of chemotherapy.

Methods: This study was a comparative descriptive study. The convenience sampling method was used to recruit 51 children with cancer, aged 8 to 15 years old, who received chemotherapy at a super-tertiary hospital in Bangkok, Thailand, and their caregivers. Data were collected using the Thai version of the Symptom Screening in Pediatrics Tool (SSPedi) for …

Prevalence And Predictive Factors Of Poor Sleep Quality Among The Elderly In The Urban Areas Of Lampang Province, Northern Thailand, Pornrapath Jamwong, Punyanuch Borisuth, Kunyanut Chaiwoot, Supang Wattanasoei, Supa Vittaporn, Ruchirada Changkwanyeun, Kasama Pooseesod, Patcharin Khamnaun, Surangrat Pongpan, Sayambhu Saita

Journal of Health Research

Background: The rapidly increasing aging population and urbanization may affect the sleep quality of the elderly. This study aimed to identify predictive factors of poor sleep quality among the elderly living in the urban areas of Lampang Province, Northern Thailand.

Methods: A cross-sectional study was conducted among 220 elderly people in Mueang Lampang District, Lampang Province. The participants were interviewed using constructive questionnaires and the Thai version of the Pittsburgh Sleep Quality Index (PSQI). Predictive factors were examined using multivariable logistic regression with a backward elimination process.

Results: Overall, 35.91% of the participants had poor sleep quality (PSQI >5). …

Factors Associated With Health Literacy And Self-Care Behaviors Among Patients With Type 2 Diabetes: A Mixed Method Study In Ko Kha District, Lampang Province, Northern Thailand, Patcharaporn Sangkawichai, Peerada Kamchang, Kamonpan Paisawaeng, Premkait Wongpimkham, Sayambhu Saita, Supa Vittaporn, Surangrat Pongpan, Ruchirada Changkwanyeun, Patcharin Khamnuan, Supang Wattanasoei, Kasama Pooseesod

Journal of Health Research

Background: A key component for better risk factor management in improving the quality of life of type 2 diabetes mellitus (T2DM) patients is having a comprehensive understanding of the relevant health information. This study examined diabetes health literacy (HL), self-care behaviors and associated factors among T2DM patients in a community in Lampang Province, Northern Thailand.

Methods: A cross-sectional study was conducted among 183 T2DM patients. Data on sociodemographic variables, diabetes HL and self-care behavior were collected using questionnaires and in-depth interviews. In order to identify factors significantly associated with HL and self-care practices, an ordinal logistic regression analysis was …

Factors Predicting The Intention To Engage In Self-Protective Behavior Against Monkeypox Infection Among Thai People, Awirut Singkun, Wichan Phibarn, Wichaporn Intharachuti, Arunothai Derramon, Thitika Kimise

Journal of Health Research

Background: An emerging monkeypox outbreak in many countries caused the WHO to declare the disease an international public health problem. This study aimed to explore knowledge of monkeypox and its transmission, intention to engage in self-protection, and factors predicting the intention to engage in self-protective behavior among Thai people.

Methods: A cross-sectional design was conducted between September and October 2022 with a self-administered questionnaire through an online survey. A total of 581 respondents were included in the data analysis. Descriptive statistics, and a binary logistic regression were used.

Results: Most respondents had good knowledge of monkeypox and its transmission …

Development And Validation Of Cell-Based Method For The Determination Of Nimotuzumab Potency, Ing-Orn Prasanchaimontri, Phannarak Khruaplao, Boontarika Boonyapiwat

The Thai Journal of Pharmaceutical Sciences

Nimotuzumab has been used for treating squamous cell carcinoma of the head and neck. Its efficacy is attributed to its mechanism of action, which involves the binding to the epidermal growth factor receptor. Ensuring the quality of nimotuzumab is crucial for its safety and efficacy. Utilizing a binding assay to measure its efficacy is a valid approach since it directly correlates with its potency. Here, we developed and validated the cell-based binding assay to determine the potency of nimotuzumab. A-431 cells and fluorescein isothiocyanate mouse anti-human immunoglobulin G antibody were used and the fluorescent intensity was measured to evaluate the …

A Survey Of Perceptions And Expectations Of Hospital Pharmacists To The Roles Of Ward-Based Pharmacists In Thailand, Siddhibhong Jongkraijakra, Tanavij Pannoi, Kansamorn Wongsiripolkul, Kanchanok Aengchuan, Phurit Saisap

The Thai Journal of Pharmaceutical Sciences

Background: Ward-based pharmacists have fostered patient-centered care. In 2011, the Pharmacy Council of Thailand established the standard criteria for pharmacist practitioners. Nevertheless, Thailand still needs to clarify the perceptions and expectations of ward-based pharmacists’ roles. Objectives: This study aimed to explore the perceptions and expectations of ward-based pharmacists’ roles among Thailand’s hospital pharmacists. Materials and Methods: The method was a cross-sectional study conducted with a director of the pharmacy department or a representative among tertiary and secondary hospitals under the supervision of the Ministry of Health in Thailand. The questionnaires were divided into four sections: the first section covered information …

Development Of Quercetin-Loaded Nanostructured Lipid Carrier For The Protection Of Dna Damage Induced By Particulate Matter, Suwisit Manmuan, Nattaya Chaothanaphat, Yotsanan Weerapol, Sukannika Tubtimsri

The Thai Journal of Pharmaceutical Sciences

Quercetin (QE) is a flavonoid found in several fruits and vegetables such as shallot, onion, and apple with proven antioxidant and anti-inflammatory properties that protect against and treat airway inflammation induced by particulate matter. Nanostructured lipid carriers (NLCs) with various liquid lipid types were employed to deliver QE into the respiratory tract. Physical properties of NLC formulations including particle size, stability, and entrapment efficiency were compared. Particle size of B_VCO and B_OLO formulations was 308.0 ± 0.4 nm and 104.8 ± 1.5 nm, respectively. After the temperature cycling test, particle size of B_OLO increased, while B_VCO was not significantly different. …

A Narrative Review Of Polycystic Ovarian Syndrome, Prudence A. Rodrigues, M. Madhusri, M. Anjali

The Thai Journal of Pharmaceutical Sciences

A common endocrine-gynecology problem affecting many women is polycystic ovary syndrome (PCOS). The precise etiology and pathophysiology of PCOS have not yet been fully understood, despite the discovery of some of the relevant mechanisms in its formation. We looked up the etiology, pathophysiology, diagnostic procedures, and therapy of PCOS in PubMed. All the causative elements of PCOS were carefully examined. This disease affects women from the time of conception until death, putting their health at risk and lowering their quality of life. In addition, it raises the morbidity and death rates. The earliest signs of PCOS appear throughout the puberty …

Unraveling The Potential Of Natural Anti-Obesity Agents: An Insight, Naveen Kumar, Pranav Shah, Shweta Agarwal

The Thai Journal of Pharmaceutical Sciences

This review delves into the contemporary advancements and research on anti-obesity agents sourced from natural origins. Obesity, a pressing global health concern, necessitates effective interventions due to its association with various comorbidities such as hypertension and diabetes. Scientific data gathered from databases including PubMed and Scopus, as well as search engines such as Google and Google Scholar, focused on keywords such as “anti-obesity agents,” “herbal anti-obesity agents,” and “mechanism of action of anti-obesity agents.” The review highlights the escalating research efforts toward formulating safe and efficient dosage forms to combat obesity, with synthetic agents often linked to adverse effects. Natural …

Analysis Of Inequality In Household Internet Utilization And Policy Implications, Shanisara Chamwong, Thoedsak Chomtohsuwan, Narissara Charoenphandhu

Journal of Demography

This research investigates the pervasive inequality in household internet access and use that contributes to the digital divide. As the internet becomes an integral part of daily life, variations in access and use carry significant implications for social and economic opportunities. A quantitative approach is applied, analyzing data from The National Statistical Office of Thailand to capture a comprehensive understanding of inequality in household internet access and use, as measured by the Gini coefficient. Five aspects of internet access and use are considered as the determinants of inequality, including internet connectivity, internet affordability, internet quality, device availability, and flexibility and …

Inhibitors Angptl3 And Their Effects To Hyperlipidemia And Atherosclerosis, Wanee Plengpanich

Chulalongkorn Medical Journal

Angiopoietin-like protein 3 (ANGPTL3) has emerged as important regulators of lipid metabolism. Current innovative therapeutic options using monoclonal antibodies, antisense oligonucleotide (ASO) or vaccine approaches to block this protein may minimize the risk of atherosclerosis in dyslipidemic individuals. The purpose of this review is to discuss the effectiveness of these new ANGPTL3 inhibitors.

Implications Of Face Mask Usage On Diverse Populations: Challenges And Considerations, Simaporn Promsarn, Walaiporn Wongsrisakunkaew

Chulalongkorn Medical Journal

The COVID-19 pandemic has underscored the importance of face mask usage as a preventive measure against viral transmission. Extensive studies have confirmed the efficacy of face masks in curtailing respiratory infections caused by viruses, including influenza and COVID-19. The significance of consistent face mask implementation over extended periods has become evident, particularly in high-risk environments such as healthcare facilities and public spaces. Despite their effectiveness, it is imperative to acknowledge the potential challenges and side effects that different populations may experience during prolonged mask usage. This comprehensive review examines the implications of face mask usage across diverse groups, encompassing healthy …

Effectiveness Of The Novel Ventilation System In The Ambulance For Airborne Particle Reduction, Dhanadol Rojanasarntikul

Chulalongkorn Medical Journal

Background: During the Coronavirus disease (COVID-19) pandemic, emergency medical service (EMS) workers areexposed to infectious particles in closed spaces such as in the ambulance. Few studies have demonstrated the effectiveness of ambulance ventilation system in reducing airborne particles.

Objective: To assess the effectiveness of an ambulance ventilation system in reducing the volume density of airborne particles and return-to-background time.

Methods: Aerosol particles of various sizes were administered into the cabin via nebulization for one minute. The aerosol volume concentrations of particles at 0.5-1; 1-2.5; and 2.5-5 microns were measured with three different ventilation rates (switched off, medium and maximum) …

Beyond Mitragynine: Composition Survey And Stability Assessment Of Kratom Tea Ordered Via Food Delivery Platforms In Bangkok, Thailand, Yuta Tokuda, Apinya Tubtimrattana, Nat Tansrisawad, Kornvalee Meesilpavikkai, Parath Thirati

Chulalongkorn Medical Journal

Background: Kratom is a native tree to Southeast Asia. Kratom leaves have long been used medicinally and recreationally due to their stimulative and opioid-like effects attributed to high endogenous levels of mitragynine and related alkaloids. Kratom is widely consumed as tea and is now publicly sold, including on food delivery platforms, after recent decriminalization despite selling of kratom products being still considered illegal by other acts.

Objectives: To assess the formulas of kratom teas sold on Thai food delivery platform together with their consistency and the stability of refrigerated teas.

Methods: Kratom alkaloids, mitragynine and 7-hydroxymitragynine, and additive contents of …

High Carotenoid Values In People With Flexibility Training, Chanachai Lohasaptawee Mr., Ponlapat Rojnuckarin Professor Dr., Natthaya Lekhawatthanapong Miss

Chulalongkorn Medical Journal

Background: Free radicals play essential roles in the aging and various pathological processes. Antioxidants may be helpful to prevent these conditions. Therefore, the body should have high antioxidant values and carotenoids can be a representative of antioxidants.

Objectives: The purpose of the study was to use the BioPhotonic Scanner S3 and resonant Raman spectroscopy technology for comparing the skin carotenoid values between those who exercised frequently and those who did not exercised within a 6-month period.

Methods: Four equal groups of six hundred male and female volunteers, ages 20 to 60 years, who resided in Bangkok Metropolitan Region were formed, …

Determination Of Initial Hepatitis B Surface Antigen (Hbsag) Cutoff Index (Coi) Threshold For Reporting Hbsag Reactivity, Piya Wongchampa, Arkom Chaiwongkot, Rangsima Reantragoon

Chulalongkorn Medical Journal

Background: The Hepatitis B surface antigen (HBsAg) commercially-available screening test suggests a confirmatory testing in all cases that are reactive, but this will take a long time to reporting of results and increase the total test cost.

Objectives: To investigate the correlation between cutoff index (COI) values of initial HBsAg screening test and their corresponding confirmatory neutralization results in order to identify a COI value for distinguishing samples that truly need confirmatory neutralization testing.

Methods: A retrospective study of 72,496 HBsAg screening test results using the Elecsys HBsAg II kit of patients at King Chulalongkorn Memorial Hospital, the Thai Red …

Organizational Executions And Policies On Workplace Health Promotion: A Cross-Sectional Study In Thailand, Taechit Taechamanodom, Pornchai Sithisarankul, Jate Ratanachina

Chulalongkorn Medical Journal

Background: The workplace, as an environment, exerts a profound impact on the health and well-being of the workforce, thereby assuming a pivotal role in both economic prosperity and societal advancement. Within organizational contexts, the human resources (HR) department assumes a pivotal role in the holistic care and administration of the workforce, encompassing multifaceted dimensions of health and well-being.

Objectives: This study aimed to investigate the executions and potential of workplace health promotion policies in workplaces in Thailand.

Methods: A cross-sectional study was undertaken among the human resources (HR) executives and personnel across listed 814 enterprises located in Rayong province and …

The Prosperity Aspect Of Sustainable Agronomy Towards Sustainable Development: An Analytical Approach To The Future Of Thai Population When Deaths Are Greater Than Births, Anil Dhammasakiyo, Kua Wongboonsin, Piyachart Phiromsawad, Patcharawalai Wongboonsin, Pojjamarn Keattitorn

Journal of Demography

This study aims to present a futuristic analytical approach towards a society of sustainable agronomy in Thailand with a focus on its prosperity along the Buddhist practices of the Noble Path so as to achieve the UN Sustainable Development Goals (SDGs). Based on the Harrison analytical framework, it presents an evaluation of the relationship between sustainable agronomy and SDGs as classified by opportunities, threats, and factors for an increasingly aging population and population shrinkage, followed by corresponding strategies with action plans for the achievement of SDGs via sustainable agronomy over a three-year term for development practices in families, villages, and …

Development Of Thai Consumer Protection Indicators With The Current Situation Of Related Consumer Protection., Wanna Sriwiriyanupap, Sorachai Jamniandamrongkarn, Suntaree Watcharadamrongkun, Sareerarote Sukamolson, Usawadee Sutapuk, Itthaboon Onwongsa, Jiratchaya Kammee, Tanatporn Apipakdee

The Thai Journal of Pharmaceutical Sciences

Background: In Thailand, consumer protection activities are carried out by government agencies, civic groups, and academic institutions. However, there has been no development of National Consumer Protection Indicators to assess and monitor the effectiveness of consumer protection activities and to forecast their future development. This study aimed to develop Thai consumer protection indicators (TCPI) aligned with international standards and to analyze the current situation of consumer protection in Thailand. Methods: This study was conducted with two qualitative methods (documentary research and group discussion) and held between August 2022 and October 2023. The process of developing a National Consumer Protection Indicator …

Dried Saliva Spot As An Effective Tool In The Diagnosis And Management Of Chronic Disease., Naveen Chaurasia, Ankit Jain, Nitin Dubey

The Thai Journal of Pharmaceutical Sciences

In recent decades, there has been significant progress in non-invasive sampling techniques, which serve as effective tools in treating and managing various chronic diseases. Among these techniques, dried saliva spot (DSS) sampling of human saliva has emerged as a prominent alternative to serum for detecting targeted molecules. The diagnostic potential of saliva has been extensively studied, highlighting its applicability across a spectrum of diseases. In addition to DSS, other sampling methods, such as dried plasma spots, dried blood spots, and dried matrix spots, have been explored. Various types of filter papers have been employed in DSS sampling procedures, with notable …

Cost–Benefit Analysis Of Inpatient Medication Reconciliation Among Patients With Chronic Non-Communicable Disease At Ta Phraya Hospital, Sa Kaeo, Thailand., Somruthai Kammanat, Aroonrut Lucksiri, Unchalee Permsuwan

The Thai Journal of Pharmaceutical Sciences

Medication error (ME) can occur throughout the patient care process. Medication reconciliation (MR) is widely accepted as a tool to prevent the occurrence of ME by 63–66%. Currently, a computer-based process has been used for MR, making it convenient and quick to operate more than usual recording. In 2019, it was used for the 1st time in Ta Phraya Hospital but it has not been evaluated. Therefore, the researcher is interested in analyzing net-benefit in inpatients with chronic non-communicable diseases by comparing patients receiving and not receiving MR and study MEs. This retrospective study collected data in the admission and …

Skin Irritation Of Capsicum Patches By In Vitro Study And Human Repeated Insult Patch Test., Apirada Sucontphunt, Tun Chusut, Thaniya Wannakup, Paninee Chetprayoon, Laksana Charoenchai

The Thai Journal of Pharmaceutical Sciences

The use of capsaicin, a natural active compound for pain management, in various health products has continuously increased. Capsaicin has been shown to suppress pain by decreasing substance P; however, the safety information of capsaicin formulations requires support from numerous studies. For that reason, in this research, the skin irritancy of a capsaicin hydrogel transdermal patch was evaluated and compared to that of a commercial relief patch by in-vitro skin irritation and a human repeated insult patch test (HRIPT). In-vitro skin irritation of samples was performed using reconstructed human epidermis. The percentage of tissue viability was evaluated and compared. For …

Response Rate Of Imatinib Among Patients With Chronic Myeloid Leukemia In Thailand: A Retrospective Study., Natthawat Yodsurang, Narawadee Niamhun, Thanawat Rattanathammethee, Buntitabhon Sirichanchuen

The Thai Journal of Pharmaceutical Sciences

Background: In Thailand, imatinib (IMT) is used as the first-line therapy for all risk scores of chronic myeloid leukemia (CML). IMT is typically effective but is only recommended for lowrisk CML in the international recommendations to treat CML. Consequently, the response rate of IMT may vary for patients with intermediate-to-high risk CML. Notably, the response rate of IMT in Thailand remains limited. Objectives: This retrospective study aimed to determine the response rate of IMT and the response rate when stratified by risk for CML treatment in Thailand. Materials and Methods: Patients with newly diagnosed CML treated with IMT as the …

Assessment Of Contamination In Ophthalmic Drops And The Development Of Preventive Measures And Detection Methods For Nosocomial Infections Arising From The Use Of Ophthalmic Drops In Hospital Settings., Prayuth Poowaruttanawiwit, Nattarikar Tilanuttanun, Thawanporn Chimsud, Jeerawat Sawatdiwithayayong, Kitti Panmanee, Niratcha Chaisomboon, Janyut Srihirun

The Thai Journal of Pharmaceutical Sciences

Objectives: This research aims to assess the prevalence of microbial contamination related to the usage of eye drops in hospital settings and identify strategies to manage such undesirable incidents. Research Methodology: A systematic literature review was conducted, followed by a planned analysis to see if sufficient data were available. Subsequently, research and development were undertaken to innovate a solution for detecting or preventing microbial contamination of eye drops before usage. Research Findings: Six selected studies met the inclusion criteria, displaying internal validity and practical applicability. However, there is a moderate to low level of bias present. The studies collectively suggest …

A New Potential Skin-Lightening Extract From Artocarpus Spp. Fruit And Skinlightening Activity Of Southern Thailand Plant Extracts., Apirada Sucontphunt, Thidarat Phetmanee, Akkarapol Butsuri

The Thai Journal of Pharmaceutical Sciences

The global skin-lightening product market is expanding every year resulting in a high demand for skin-lightening herbal extracts that are effective and safe. Moreover, herbal plants are very popular in Thailand and can bring Thai farmers satisfactory income. This research hence aimed to discover new plant extracts with potential skin-lightening properties. Extractions of different parts of five plants originally cultivated in Southern Thailand including Artocarpus integer Spreng. (AI), Artocarpus heterophyllus Lam., Garcinia atroviridis Griff. Ex T. Anderson, Glycyrrhiza glabra Linn., and Anacardium occidentale L. were performed and determined for their anti-tyrosinase, anti-melanogenesis, anti-oxidant activity, and cell toxicity. It was found …

Perceptions Of Emergency Physician Professionalism Among Healthcare Providers And Patients: A Multicenter Study In Thailand And The Us, Khuansiri Narajeenron Md, Mhpe, Tanawat Tarapan Md, Jasmina Dukovic, Krongkarn Sutham Md, Intanon Imsuwan Md, Ar-Aishah Dadeh Md, Tanyaporn Nakornchai Md, Deena Bengiamin Md, Bharath Chakravarthy Md, Mph, Craig Anderson Phd, Mph, Somchit Eiam-Ong Phd, Wirachin Hoonpongsimanont Md, Ms

Chulalongkorn Medical Journal

Background: Universal standards for emergency physician professionalism (EPP) amongst different groups of healthcare workers do not exist.

Objective: The aim of this study was to explore perceptions of EPP among attending physicians (APs), emergency medicine (EM) residents, first- and fourth-year medical students (MS1s and MS4s, respectively), EM nurses and emergency department (ED) patients.

Methods: A multicenter, cross-sectional study conducted at seven university-based EDs in Thailand and the US from July 2016 - January 2018. We created 39 cards (13 core elements) describing behaviors derived from a global literature review. Subjects ranked each card from the most to least important for …

Online Student-Centered Learning And Assessment During The Covid-19 Pandemic Through Perspectives Of Higher Education Teachers And Students, Nuttaporn Lawthong, Purin Thepsathit, Chanut Poondej, Thanita Lerdpornkulrat, Ittipaat Suwathanpornkul

Journal of Education Studies

This study aimed to 1) analyze student-centered learning and assessment of higher education teachers and students during the COVID-19 pandemic as well as their ability to meet learning objectives, and 2) compare the online learning efficiency of students with four psychological attributes, consisting of student-teacher engagement, online learning characteristics, self-directed learning, and self-assessment. The sample included 1,409 university students and 274 teachers. The research instrument was a student-centered online learning and assessment scale. Data were analyzed via descriptive statistics and a chi-squared test. The results revealed that the sample struggled with unstable Internet or WIFI connection, a lack of technological …

The Study Of Online Assessment For Research Skills Of Higher Education, Faculty Of Education, Ramkhamhaeng University, Juthamas Saengngam

Journal of Education Studies

Research skills are crucial for students in higher education as they play a pivotal role in fostering critical thinking, problem-solving, and the ability to contribute to the creation and development of new knowledge or innovation. The shift to the new normal, which includes changes in teaching and learning arrangements, requires adjustments in how research skills are taught, practiced, and evaluated. Here are some considerations for adapting to the evolving educational landscape. This study aimed to 1) investigate the conditions affecting the research skills of tertiary students 2) examine an online assessment model of the research skills of higher education students, …

A Case Report : Rosai-Dorfman Disease Of The Breast, Jenjeera Prueksadee

Chulalongkorn Medical Journal

Abstract

A case report of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) of the breast is one of the rare diseases, characterized by benign proliferative disorder of histiocyte. Most occur within lymph nodes whereas the rest involve extranodal sites. Breast involvement is considered extremely rare but considerable because of radiological findings simulating breast cancer. We report the case of a 59-year-old Thai woman who underwent screening mammography. Her biopsy resulted in abnormal histiocytes with S-100 protein expression, some of them with emperipolesis (lymphophagocytosis). Recognition of Rosai-Dorfman disease leads to correct diagnosis and further appropriate proper treatment strategy.