Digital Commons Network^™

Biological Pathway Involvement In Melanoma Heterogeneity And Drug-Induced Resistance, Sarah V. Pack

STAR Program Research Presentations

Tumors develop resistance to numerous drug therapies, and this remains a major obstacle in treating many types of non-surgical cancers. Melanoma provides a good model system for studying drug resistance in cancer due to its high propensity to incur resistance after a significant initial response to a drug. Genes that are highly expressed in melanoma cancer cells have been studied, but in order to further understand the collective function of these highly expressed genes we must analyze gene sets, or pathways. A single gene’s function is rarely independent of other genes, and pathway analysis takes this into account.

Our objective …

Baja Sae Ecvt Mechanical Design, Tyler Lee Connel, Will Daniel Antes, Matt Stephen Balboni, Benjamin James Colard, Julian Edward Finburgh

Mechanical Engineering

This objective of this project was to design, manufacture, and test the mechanical systems of an electronically-controlled continuously variable transmission (eCVT) for the Cal Poly Baja SAE vehicle.

Infestation Intensities, Attachment Patterns, And The Effect On Host Contest Behavior Of The Tick Ixodes Pacificus On The Lizard Sceloporus Occidentalis, Dylan M. Lanser

Master's Theses

Parasites often have profound effects on the survival and evolution of their hosts, and hence on the structure and health of entire ecosystems. Yet basic questions, such as the degree of virulence of a given parasite on its host, and factors influencing which hosts in a population are at the greatest risk of infection, are vexingly difficult to resolve. The western blacklegged tick-western fence lizard (Ixodes pacificus-Sceloporus occidentalis) system is important, primarily because I. pacificus, a vector of the Lyme disease spirochete Borrelia burgdorferi, is dependent on S. occidentalis for blood meals in its subadult stages, …

Examining The Effectiveness Of Electromyography Biofeedback At Improving The Upper Trapezius To Serratus Anterior Muscle Activation Ratio, Julia Evelyn Holton

Master's Theses

Purpose: The upper trapezius to serratus anterior muscle activation ratio is essential for optimal shoulder function. An alteration of this ratio, specifically a decrease in upper trapezius and increase in serratus anterior activation, is a main area of focus in shoulder rehabilitation (Kibler, 1998; Paine & Voight, 1993). Electromyography (EMG) biofeedback has been shown to be an effective rehabilitation technique to address many musculoskeletal disorders but there is limited research on the retention of improvements seen with EMG biofeedback (Ma et al., 2011; Lim et al., 2014; Weon, et al., 2011). The purpose of this study was to determine if …

Torture And The Corrida, Andrew Brei

Between the Species

In recent years the debate over the moral status of bullfighting has been focused on whether or not it should be characterized as a form of torture. Francis Wolff has argued that it should not be, and Gabriel Andrade has claimed that it should be. But in my view neither author adequately defines bullfighting or torture. In this essay I have three goals. The first is to provide an adequate account of bullfighting, including its structure and meaning. The second is to define the necessary conditions for torture. And the third is to show that bullfighting meets those conditions. Thus, …

Keeping Humans In The Loop: Pooling Knowledge Through Artificial Swarm Intelligence To Improve Business Decision Making, Lynn E. Metcalf, David A. Askay, Louis B. Rosenberg

Industrial Technology and Packaging

This article explores how a collaboration technology called Artificial Swarm Intelligence (ASI) addresses the limitations associated with group decision making, amplifies the intelligence of human groups, and facilitates better business decisions. It demonstrates of how ASI has been used by businesses to harness the diverse perspectives that individual participants bring to groups and to facilitate convergence upon decisions. It advances the understanding of how artificial intelligence (AI) can be used to enhance, rather than replace, teams as they collaborate to make business decisions.

Review Of The Oxford Handbook Of Food Ethics, Josh Milburn

Between the Species

The Oxford Handbook of Food Ethics, edited by Anne Barnhill, Mark Budolfson, and Tyler Doggett, contains 35 chapters over 8 sections. Many of these chapters are directly relevant to animal ethicists. Even many of those that do not initially appear to be, however, should be of interest. I thoroughly recommend The Oxford Handbook of Food Ethics to all animal ethicists interested in addressing food-related questions in their research or teaching.

Maternal Diet During Lactation And Breast-Feeding Practices Have Synergistic Association With Child Diet At 6 Years, Jacob P. Beckerman, Emily Slade, Alison K. Ventura

Kinesiology and Public Health

Objective: Children breast-fed during infancy consume more fruits and vegetables than formula-fed children. This pattern is likely due, in part, to infant learning from flavours of the mother’s diet transmitted through breast milk, but more research is needed to understand associations between early flavour exposures and later dietary patterns. We examined whether breast-feeding and maternal fruit and vegetable consumption during nursing were synergistically associated with higher child fruit and vegetable consumption.

Design: Prospective cohort study of breast-feeding duration, maternal diet postpartum and child diet. Complete breast-feeding and maternal diet data were available for 1396 mother–child dyads; multiple imputation was used …

Jet-Driven Galaxy-Scale Gas Outflows In The Hyperluminous Quasar 3c 273, Bernd Husemann, Vardha Nicola Bennert, Knud Jahnke, Timothy A. Davis, Jong-Hak Woo, Julia Scharwächter, Andreas Schulze, Massimo Gaspari, Martin A. Zwaan

Physics

We present an unprecedented view of the morphology and kinematics of the extended narrow-line region (ENLR) and molecular gas around the prototypical hyperluminous quasar 3C 273 (L _bol ~ 10⁴⁷ erg s⁻¹ at z = 0.158) based on VLT-MUSE optical 3D spectroscopy and ALMA observations. We find the following: (1) the ENLR size of 12.1 ± 0.2 kpc implies a smooth continuation of the size–luminosity relation out to large radii or a much larger break radius as previously proposed. (2) The kinematically disturbed ionized gas with line splits reaching 1000 km s⁻¹ out to 6.1 ± …

Teaching Top-Down Approaches To The Engineering Design Process, Joshua E. Katz, Joshua E. Katz

STAR Program Research Presentations

One of the main focuses of metacognition is to have students think about their learning. By bringing the engineering design process with educational psychology together, it can lead to a society that thinks more in-depth on various topics. The goal of the internship was to utilize and teach top-down educational and instructional objectives. Throughout the project, we followed a modified progression of the System Architecture Methodology to help other interns think in a top-down fashion. The purpose of this procedure is to create and induce new innovative and creative ideas for different projects. As teaching this methodology was tasked, research …

Beaver (Castor Canadensis) Of The Salinas River: A Human Dimensions-Inclusive Overview For Assessing Landscape-Scale Beaver-Assisted Restoration Opportunities, Stuart Christian Suplick

Natural Resources Management and Environmental Sciences

Across the western United States, researchers are increasingly working with beaver (Castor canadensis) for process-based stream and watershed restoration. One recently-developed geographic information system-based tool, the Beaver Restoration Assessment Tool (BRAT), analyzes opportunities for beaver-assisted restoration (BAR) at a landscape-scale. However, this tool benefits significantly from human dimensions-inclusive, basin-centralized beaver knowledge for proper interpretation. Unfortunately, this information is scattered or absent in most semi-arid and arid southern California basins. This study thus sought to gather and produce this information through an explorative, benefits-maximizing approach to landscape-scale BAR opportunities assessment in one of these basins, the Salinas River. 49.2 …

The Five Tribes Of Machine-Learning: A Brief Overview, Jens G. Pohl

Architecture

This paper reviews recent advances in automated computer-based learning capabilities. It briefly describes and examines the strengths and weaknesses of the five principal algorithmic approaches to machine-learning, namely: connectionism; evolutionism; Bayesianism; analogism; and, symbolism. While each of these approaches can demonstrate some degree of learning, a learning capability that is comparable with human learning is still in its infancy and will likely require the combination of multiple algorithmic approaches. However, the current state reached in machine-learning suggests that Artificial General Intelligence and even Artificial Superintelligence may indeed be eventually feasible.

Partnering Without Boundaries: Integrating Structures, Architecture, Practice, And Education, Thomas Fowler, Iv, Kevin Dong

Architecture

A college wide, studio-based engineering and design course is used as the mechanism for learning, experimentation, and exploration of the built environment. Student teams part- ner with design professional mentors to create viable solutions for real world projects. Students address architectural, structural, environmental, and construct-ability issues. For the highlighted project, students integrated laboratory research and fundamental engineering principles to develop building designs which recognized current building technology, sustainability, and cultural issues for a polytechnic college in rural Tanzania; then based on the design proposals, constructed a building proto-type. The school motto is “Learn by Doing” and with projects such as …

Advanced Structural Integration Collaboratory Model For Architecture Students, Thomas Fowler, Iv

Architecture

The architecture program at Cal Poly, San Luis Obispo, California, has a strong technology component (as part of the Polytechnic Mission of the University) over the years since its inception in the 1960’s, that led to the establishment of the College of Architecture andEnvironmental Design. The paper presents an advanced structural integration collaboratory model that works with recent changes in the curriculum. The history of the program is important, since the curriculum has always had a very intensive architectural engineering (structural systems focus) sequence of courses. While architecture students were definitely acquiring a strong knowledge of a wide range of …

Manipulating Fiber Orientation For The Reduction Of Warpage In Carbon Fiber Composite Sandwich Panels, Landon Burnley, Gabrielle Correia

Materials Engineering

Safran Cabin (Santa Maria, CA), previously known as Zodiac Aerospace, designs and manufactures interior cabin components for private and commercial aircraft. Carbon fiber face sheets have recently been incorporated in their overhead luggage bin assemblies which utilize a composite sandwich panel design, in order to provide additional stiffness to the previous glass fiber sandwich panels. Since the introduction of carbon fiber in these luggage bin panels, Safran has experienced an increase in warpage during manufacturing. When inspected by quality control, the panels are tested mimicking how they are installed in aircraft. If the panels do not meet specifications, the warped …

Integrated Aeration For Enhanced Nitrogen Conversion And Removal And The Effect Of Sampling Frequency On Productivity Estimates In Algae-Based Wastewater Treatment Systems, Lauren Parker

Master's Theses

Raceway ponds can be used to cultivate microalgae for purposes such as wastewater treatment and feedstock for animal feeds and biofuels. Besides nitrogen assimilation in biomass, nitrification can be a wastewater treatment mechanism but one that is hindered by the low nighttime dissolved oxygen concentrations (DO) common in wastewater treatment raceways. The large diel difference in pond conditions and changing influent wastewater quality also raises the question of the optimal frequency and timing of grab sample collection, to obtain representative water quality data. Three sets of triplicate pilot raceways (1,000-L, 0.30-m deep, fed primary clarifier effluent) were operated at an …

Implementation Of A Scale Semi-Autonomous Platoon To Test Control Theory Attacks, Erik Miller

Master's Theses

With all the advancements in autonomous and connected cars, there is a developing body of research around the security and robustness of driving automation systems. Attacks and mitigations for said attacks have been explored, but almost always solely in software simulations.

For this thesis, I led a team to build the foundation for an open source platoon of scale semi-autonomous vehicles. This work will enable future research into implementing theoretical attacks and mitigations. Our 1/10 scale car leverages an Nvidia Jetson, embedded microcontroller, and sensors. The Jetson manages the computer vision, networking, control logic, and overall system control; the embedded …

Development Of A Prolyl Endopeptidase Expression System In Lactobacillus Reuteri To Reduce The Clinical Manifestation Of Celiac Disease, Kara Lynn Jew

Master's Theses

Celiac Disease (CD) is an autoimmune disorder that emerges due to the ingestion of gluten, a protein found in a variety of common grains such as wheat, rye, and barley. Approximately 1 in 100 individuals in the US suffer from CD, making it the most commonly diagnosed gastrointestinal disorder (Ciclitira et. al., 2005). These proline-rich gluten peptides are resistant to proteolysis and accumulate in the duodenum of the small intestine. Once in the duodenum, these peptides illicit an autoimmune response resulting in villous atrophy. Current treatment for CD requires a rigorous adherence to a gluten-free diet. Nevertheless, gluten-containing grains are …

The Effects Of Atomic Oxygen On Patch Antenna Performance And Lifetime, Max J. Barta

Master's Theses

The space environment is a volatile and challenging place for satellites to survive in. For Low Earth Orbiting (LEO) satellites, atomic oxygen (AO) is a constant corrosive effect that degrades the outer surface of satellites over long durations. Atomic oxygen exists in the atmosphere between 180 and 675 km and has a relatively high energy at 4.5 eV, which allows AO to break molecular bonds in materials on the surfaces of spacecraft. As the number and complexity of CubeSat missions increase, there is an increased risk that AO degradation on commercial off the shelf parts (COTS), such as antenna, could …

Electronic Cvt - Controls, Alec William Hardy, Jessalyn Leora Ann Bernick, Nicholas Esteban Capdevila, Tristan Charles Perry

Mechanical Engineering

The following document outlines the design process, manufacturing, and testing of the control system for an electronically controlled continuously variable transmission (ECVT). This control system was integrated into the custom designed and manufactured mechanical transmission system created in parallel by another senior project group. The transmission was designed for use in the Cal Poly Baja SAE vehicle. Through researching customer needs, competition requirements, previous and alternate CVT designs, and vehicle characteristics, we were able to determine the requirements and specifications for our unique system. Input, output, speed, and durability requirements guided our hardware selection. The primary components which comprised our …

Data-Driven Database Education: A Quantitative Study Of Sql Learning In An Introductory Database Course, Andrew C. Von Dollen

Master's Theses

The Structured Query Language (SQL) is widely used and challenging to master. Within the context of lab exercises in an introductory database course, this thesis analyzes the student learning process and seeks to answer the question: ``Which SQL concepts, or concept combinations, trouble students the most?'' We provide comprehensive taxonomies of SQL concepts and errors, identify common areas of student misunderstanding, and investigate the student problem-solving process. We present an interactive web application used by students to complete SQL lab exercises. In addition, we analyze data collected by this application and we offer suggestions for improvement to database lab activities.

Brightest Cluster Galaxy Evolution Exploration: Comparing The Separation Of Cluster X-Ray Light And Visible Wavelength Galaxy Light With Spectral Data, Matthew Aaron Salinas

Physics

Brightest Cluster Galaxies (BCGs), the brightest galaxy in a cluster of hundreds to thousands of galaxies, are some of the biggest, brightest, and most massive galaxies in the universe. Characterizing a BCG can help discover more about galaxy evolution - the aging, changing, and possible merging (collisions) of galaxies. This project involves determining the separation of the peak of x-ray emission of the galaxy cluster, and the peak of visible emission of the BCG to characterize the system as being disturbed or undisturbed that can then lead to discoveries about its formation and evolution. We have found that 17.4% of …

A First Look At Sublimation Rates In Toss Island Region, Antarctica, Rebecca Baiman, Scott Landolt

STAR Program Research Presentations

70% of Earth’s fresh water is held in Antarctica ice sheet. If the sheet melts, it has the potential to raise global sea levels by 190 feet (Klekociuk and Wiennecke, 2016). As the climate changes, it is imperative that to understand precipitation systems of Antarctica in order to measure and predict weather around the world. One aspect of precipitation events that we do not understand fully in Antarctica is sublimation. Data was collected from four Ott Pluvio Precipitation Gauges with Belfort Double Alter Shields placed in and around the Ross Ice Shelf from November of 2017 to present. An R …

Short Term Shifts In Soil Nematode Food Feb Structure And Nutrient Cycling Following Sustainable Soil Management In A California Vineyard, Holly M. Deniston-Sheets

Master's Theses

Evaluating soil health using bioindicator organisms has been suggested as a method of analyzing the long-term sustainability of agricultural management practices. The main objective of this study was to determine the effects of vineyard management strategies on soil food web structure and function, using nematodes as bioindicators by calculating established nematode ecological indices. Three field trials were conducted in a commercial Pinot Noir vineyard in San Luis Obispo, California; the effects of (i) fertilizer type (organic and inorganic), (ii) weed management (herbicide and tillage), and (iii) cover crops (high or low water requirements) on nematode community structure, soil nutrient content, …

Design Principles And Preliminary Testing Of A Micropropulsion Electrospray Thruster Research Platform, Will Alan Mcgehee

Master's Theses

The need for micropropulsion solutions for spacecraft has been steadily increasing as scientific payloads require higher accuracy maneuvers and as the use of small form-factor spacecraft such as CubeSats becomes more common. Of the technologies used for this purpose, electrospray thrusters offer performance that make them an ideal choice. Electrosprays offer high accuracy impulse bits at low power and high efficiency, and have low volume requirements. Design choice reasoning and preliminary testing results are presented for two electrospray thruster designs. The first thruster, named the Demonstration thruster, is operated in atmospheric conditions and serves as a highly visible example of …

The Effects Of Edaphic And Climatic Factors On Secondary Lichen Chemistry: A Case Study Using Saxicolous Lichens, Alexander Paukov, Anzhelika Teptina, Maria Morozova, Ekaterina Kruglova, Sergio E. Favero-Longo, Cora Bishop, Nishanti Rajakaruna

Biological Sciences

Diversity of secondary lichen metabolites and their relationship to substrate and environmental parameters were studied in saxicolous lichens in the Middle and South Urals of Russia. Atranorin, usnic acid, gyrophoric acid, zeorin, norstictic acid, antraquinones and stictic acid were found in 73, 42, 41, 37, 36, 35 and 32 species, respectively, of 543 taxa collected. One hundred and ninety six species (i.e., 36% of total species documented) contained no secondary metabolites. Spectra of secondary metabolites of crustose lichens varied on different rock types, while in fruticose and foliose groups only those species without lichen acids were dependent on the substrate …

Diversity, Inclusion And The Exceed Teaching Workshop, Allen C. Estes

Architectural Engineering

The American Society of Civil Engineers (ASCE) Excellence in Civil Engineering Education (ExCEEd) Teaching Workshops are currently in their 20th year of existence and have been highly successful. There is a growing body of literature on creating a multi-cultural classroom that celebrates diversity, accounts for the global differences and experiences of students, and deliberately fosters inclusivity. This paper examines the content of the existing culturally inclusive literature and quantifies how much is already present in the current ETW curriculum. It then suggests how much more could be included if a deliberate effort is made to include diversity and inclusivity into …

Interactive Physical Experiments In An Advanced Undergraduate Structural Dynamics Course, Charles D. Facciolo, Anahid A. Behrouzi

Architectural Engineering

This paper describes a number of physical models and hands-on lab activities incorporated in an advanced undergraduate structural dynamics lecture and laboratory course pairing offered within the Architectural Engineering department at California Polytechnic State University – San Luis Obispo. These course modifications were designed and implemented in the Winter 2018 quarter to enable students to:

-Collect acceleration data during free or forced vibration tests using a smartphone accelerometer application to generate data plots in Matlab; -Conduct free vibration tests on various single-degree of freedom (SDOF) systems to investigate effects of varying mass, stiffness/height, material type, and damping type (pendulum or …

Exposing Undergraduates To Design, Fabrication, And Large-Scale Experimentation In A Structural Steel Design Course, Jenna Williams, Mark William Wright, Michael James Deigert, Anahid A. Behrouzi

Architectural Engineering

During Fall 2017, Spring and Fall 2018 quarters, various hands-on design, fabrication, and large-scale experimental projects were incorporated into a 10-week undergraduate structural steel design course offered in the Department of Architectural Engineering at California Polytechnic State University – San Luis Obispo. Through these projects students investigated one or two unique steel lateral force resisting systems (LFRS) consisting of either: special moment frame (SMF), special concentric braced frame (SCBF), and/or buckling restrained braced frame (BRBF). Students completed design calculations per the American Institute of Steel Construction steel building and seismic codes, visualized their final design using AutoCAD software, constructed and …

E-Learning Tools To Facilitate Instruction Of A Large Enrollment Structural Engineering Course, Maelle Van Thienen, James Boon Piang Lim, Anahid A. Behrouzi, Pablo Garcia, Wyatt Banker-Hix

Architectural Engineering

A significant challenge in teaching large civil engineering courses is engaging and providing feedback to students in a meaningful and timely manner. This paper presents a solution that uses e-learning tool Xorro-Q in the successful instruction of a Structures II course of 250+ second year students since 2016 at a research-intensive university in New Zealand.

During the course, Xorro-Q has been utilized as an online practice-based learning tool where students can repeat questions without penalty and automatically receive detailed instructor-developed feedback (diagrams, text, or link to website/video) in response to specific incorrect answers. Additionally, Xorro-Q permits a variety of questions …