Digital Commons Network^™

Physiologically-Based Pharmacokinetic Modeling For Predicting Caffeine/Theophylline-Ciprofloxacin Interactions, David M. Ng, Ali Navid

STAR Program Research Presentations

Dynamics of interactions between the drugs caffeine, theophylline, and ciprofloxacin are predicted using physiologically-based pharmacokinetic (PBPK) modeling. Pharmacokinetic means the model determines where the drugs are distributed in the body over time. Physiologically-based means the anatomy and physiology of the human body are reflected in the structure and functioning of the model. Multiple drugs can interact to increase or decrease their beneficial and/or undesired effects. This is important because some common substances, such as caffeine in coffee, soft drinks, and energy drinks, are actually drugs that affect the body. Ciprofloxacin is an inhibitor of caffeine and theophylline metabolism; such inhibition …

The Effects Of Variation In Collagen D-Spacing On Compact Bone Viscoelasticity: A Finite Element Analysis, Miguel A. Mendoza

Master's Theses

The D-spacing that is characteristic of collagen and its structural arrangement was previously thought to be a constant value. Much research is revealing that it is actually a distribution of values in biological tissues. Recent ovine experimentation has also shown that the D-spacing distribution is significantly altered following estrogen depletion. While ewes contain some major biological differences between their human counterparts, they are an economical and robust large animal model for postmenopausal osteoporosis. So, the exploration of the possible implications that D-spacing has on the mechanical properties of the whole bone utilizing animal models and computational methods is warranted. Six …

A Lateral Flow Smart Phone Image Analysis Diagnostic, Christina Holly Tyrrell

Master's Theses

A low cost compact diagnostic has many implications in today’s society. Smart phone technology has exponentially grown and with it the imaging capabilities associated with smart phones. The goals of this research are i) to determine the feasibility of combining in the field smart phone images with color dependent assay results, ii) to develop a MatLab® image analysis code to analyze these results, and iii) compare limits of detection between the un-aided eye and MatLab® image analysis software.

Orange G dye is used to create a stock solution and subsequent titers for analysis. Autocad is used to design an assay …

Letter To The Editor: The Function Of Animal Ethics Committee, David G. Allen, Rebecca Halligan

Between the Species

No abstract provided.

Letter To The Editor: Animal Ethics Committees - Reassurances Rejected, Denise Russell

Between the Species

No abstract provided.

Introduction To Special Issue 16(1), John Nolt

Between the Species

No abstract provided.

The Water Footprint Of Biofuel Produced From Forest Wood Residue Via A Mixed Alcohol Gasification Process, Yi-Wen Chiu, May Wu

Natural Resources Management and Environmental Sciences

Forest residue has been proposed as a feasible candidate for cellulosic biofuels. However, the number of studies assessing its water use remains limited. This work aims to analyze the impacts of forest-based biofuel on water resources and quality by using a water footprint approach. A method established here is tailored to the production system, which includes softwood, hardwood, and short-rotation woody crops. The method is then applied to selected areas in the southeastern region of the United States to quantify the county-level water footprint of the biofuel produced via a mixed alcohol gasification process, under several logistic systems, and at …

Class Notes

Cal Poly Magazine

No abstract provided.

An Evening Of Green And Gold, Larry Peña

Cal Poly Magazine

No abstract provided.

The Apprentices Become The Masters, Rachel Henry

Cal Poly Magazine

No abstract provided.

A Collective Vision Comes To Life, Rachel Henry

Cal Poly Magazine

No abstract provided.

Assessing Coral Reef Fish Population And Community Changes In Response To Marine Reserves In The Dry Tortugas, Florida, Usa, Jerald S. Ault, Steven G. Smith, James A. Bohnsack, Jiangang Luo, Natalia Zurcher, David B. Mcclellan, Tracy A. Ziegler, David E. Hallac, Matt Patterson, Michael W. Feeley, Benjamin I. Ruttenberg, John Hunt, Dan Kimball, Billy Causey

Biological Sciences

The efficacy of no-take marine reserves (NTMRs) to enhance and sustain regional coral reef fisheries was assessed in Dry Tortugas, Florida, through 9 annual fishery-independent research surveys spanning 2 years before and 10 years after NTMR implementation. A probabilistic sampling design produced precise estimates of population metrics of more than 250 exploited and non-target reef fishes. During the survey period more than 8100 research dives utilizing SCUBA Nitrox were optimally allocated using stratified random sampling. The survey domain covered 326 km², comprised of eight reef habitats in four management areas that offered different levels of resource protection: the …

Do Open Access Electronic Theses And Dissertations Diminish Publishing Opportunities In The Social Sciences And Humanities? Findings From A 2011 Survey Of Academic Publishers, Marisa Ramirez, Joan T. Dalton, Gail Mcmillan, Max Read, Nancy H. Seamans

Library Scholarship

An increasing number of higher education institutions worldwide are requiring submission of electronic theses and dissertations (ETDs) by graduate students and are subsequently providing open access to these works in online repositories. Faculty advisors and graduate students are concerned that such unfettered access to their work could diminish future publishing opportunities. This study investigated social sciences, arts, and humanities journal editors’ and university press directors’ attitudes toward ETDs. The findings indicate that manuscripts that are revisions of openly accessible ETDs are always welcome for submission or considered on a case-by-case basis by 82.8 percent of journal editors and 53.7 percent …

Teaching Archtecture, Engineering And Construction Disciplines: Using Various Pedagogical Styles To Unify The Learning Process, Jill Nelson, John W. Lawson

Architectural Engineering

The Architectural Engineering Department at the California Polytechnic State University, San Luis Obispo (Cal Poly) teaches introductory sophomore level statics and mechanics of materials courses to students in three departments in the College of Architecture and Environmental Design. These courses are unique in that students in the Architectural Engineering Department share coursework with students in the Architecture and Construction Management Departments. While learning and problem solving in these multidisciplinary courses have many advantages, they also offer many challenges. The learning preference of the students in these three distinctly different disciplines requires a fresh approach to the course structure. The courses …

Microbial Communities In Pre-Columbian Coprolites, Tasha M. Santiago-Rodriguez, Yvonne M. Narganes-Storde, Luis Chanlatte, Edwin Crespo-Torres, Gary A. Toranzos, Rafael Jiménez-Flores, Alice Hamrick, Raul J. Cano

Biological Sciences

The study of coprolites from earlier cultures represents a great opportunity to study an “unaltered” composition of the intestinal microbiota. To test this, pre-Columbian coprolites from two cultures, the Huecoid and Saladoid, were evaluated for the presence of DNA, proteins and lipids by cytochemical staining, human and/or dog-specific Bacteroides spp. by PCR, as well as bacteria, fungi and archaea using Terminal Restriction Fragment analyses. DNA, proteins and lipids, and human-specific Bacteroides DNA were detected in all coprolites. Multidimensional scaling analyses resulted in spatial arrangements of microbial profiles by culture, further supported by cluster analysis and ANOSIM. Differences between the microbial …

Book Review Of This Is Not Sufficient, Frank Garrett

Between the Species

No abstract provided.

Cal Poly Magazine, Summer 2013

Cal Poly Magazine

No abstract provided.

The Effect Of Mulch Type And Thickness On The Soil Surface Evaporation Rate, Michael Mcmillen

Horticulture and Crop Science

There is a continual drive to conserve water and improve irrigation efficiency in agriculture, especially in regions where water resources are limited and regulated. Mulching is one cultural practice which can be used to reduce water needs. Using certain agricultural byproducts as mulch is a sustainable practice which can provide other benefits as well such as improving soil. Wheat straw, grass clippings, and leaf debris are fairly abundant byproducts which can be used as mulch. An experiment was conducted to determine which of these readily available mulching materials would be best at conserving soil moisture, and at which thicknesses, 5, …

Lower San Luis Obispo Creek Stewardship Plan, Raven Lukehart, Daniel Bohlman

Natural Resources Management and Environmental Sciences

No abstract provided.

Recreation Displacement Of Bass Fishermen From Central Coast Lakes, Erin Gray

Recreation, Parks, and Tourism Administration

The purpose of this study was to assess the impacts of aquatic invasive species preventative measures on recreation displacement of bass fishermen from Central Coast lakes. A self-administered questionnaire was distributed to participants at a local bass fishing tournament. Thirty-six respondents completed the questionnaire. The results indicated that boat inspection procedures do not necessarily cause bass fishermen to displace. This study found that fishermen are likely to avoid recreating at a Central Coast lake in fishing practice conditions rather than in tournament conditions, and are likely to avoid tournaments at their least favorite lake if boat inspection procedures take too …

Preparation Of A Polylactic Acid With Hydroxyapatite Reinforcement Composite, Odessa N. Quezon

Materials Engineering

Biodegradable polymers are a prime material choice for temporary biomedical devices due to its ability to degrade into non-toxic products for their use in vivo. However, polylactic acid (PLA) by itself lacks the sufficient strength and stiffness to permit their use as its properties begin to decrease as the polymer degrades. To improve the polymer’s mechanical properties, hydroxyapatite (HA) will be added to the PLA solution to act as reinforcement. The chemical property, glass transition temperature of a polymer, also plays a key role in the mechanical properties of the polymer. PLA’s glass temperature is 130⁰F. A polymer that …

Strength Testing And Material Characterization Of Cactus Spines, Mary Cooper, Jeff Goldstein, Thomas Tarlton

Materials Engineering

Twelve different species of cactus spines from 6 different genera were collected from living specimens and maintained in a dry storage environment. Spines from each species underwent 3-point bend testing, XRD testing, and SEM imaging. XRD analysis was used to verify the presence of cellulose whisker like nanocrystals and to calculate the percent crystallinity of each spine. SEM images were captured of fracture surfaces at viewing angles of 90° and 45° relative to the fracture surface, with magnifications ranging between 150x and 4,000x. A total of six spines from each species were tested in three point bending using a high-resolution …

Sustainability Trends For Museums, Zoos, And Aquariums: A Website Evaluation, Alison Sunahara

Recreation, Parks, and Tourism Administration

Sustainability is an emerging trend that is accessible through programs and practices for the public and organizations. Museums, zoos, and aquariums exhibit and maintain collection pieces for observation and study. The purpose of the study was to analyze the top museum, zoo, and aquarium websites to determine their sustainability practices. This study was conducted through a website checklist developed by the researcher. Data were collected using a representative sample of the top museum, zoos, and aquariums within the United States. The sample was based upon the Travel Channel’s “Top 10 Free U.S. Museums”, “America’s Wildest Zoos”, and “Best Aquariums in …

Benefits Of Pre-Lecture Assignments And Inquisition Based Learning In Comparison To Traditional Lecture Modes In Science Education, Lance Toppen

Biological Sciences

Experiment was an assessment of the efficacy of two different teaching styles: traditional lecturing and a question based approach. In a traditional lecture class students frequently come to class with little or no previous exposure to the lecture topic. This may limit comprehension, retention, and the development of critical thinking skills. The questioning approach we used involved flipping the classroom where students were expected learn the lecture material at home by answering a comprehensive list of questions from textbook chapters. They were expected to come to each class period prepared to engage in a discussion of the subject matter, prompted …

Variability In Soil Climate And Respiration On Managed Timber Stands: A Case Study In Southwest Oregon, Scott Pensky, Adrian Gallo

Natural Resources Management and Environmental Sciences

Thinning of forested lands and timber stands in the Pacific Northwest have taken place for centuries with a limited understanding of how the alterations may affect ecosystem functions. The goal of this study was to examine the soil climate and microbial activity on a seasonal timescale of thinning practices examined at different stages of succession. Two timber stands in Southwestern Oregon within the Grayback Creek Watershed were chosen because of identical forest management techniques separated by a 10-year treatment interval (40% variable density thinning). Field methods and equipment measured canopy coverage, soil moisture and temperature at 3 depths (5, 15, …

Application Of Systems Engineering And Project Management For Algae Photo Bioreactors, Andrew S. Balberchak

Industrial and Manufacturing Engineering

EXECUTIVE SUMMARY

Today there is much talk about different sources for biofuel to replace the decreasing supply of fossil fuels. Algae seem very promising with its abundance across the globe and relatively simple growing conditions. Lipids can be extracted from this organism which is then converted to biofuel. Although biofuel production from algae is not economically viable at this stage, researchers are suggesting using the by-products of algae for supplemental and healthcare use. If true, this could justify the economics of obtaining fuel from algae by creating more markets from various algae products.

Cal Poly State University’s Food Science and …

Reason-To-Reuse: A Sustainable To-Go Food Storage Container System For Restaurants, Ryan Christopher Labuda

Industrial and Manufacturing Engineering

A food storage container (FSC), also known as a to-go box, is a very popular way for Americans to pick up food when in a rush and take it with them or store leftovers after dining. Some of the more popular materials that make up FSCs include Styrofoam, paper and plastic. These FSCs are meant for one time use and subsequently the majority end up as waste in their local regions. Reason-To-Reuse is a sustainable business that provides an alternative to the current model of disposable FSCs at restaurants by cutting down on waste. The objective of the Reason-To-Reuse project …

Evaluation Of High Phosphorus Electroless Nickel Platings To Protect Carbon Steel Heat Exchangers In Seawater Service, Nathan Brink

Materials Engineering

The purpose of this project was to determine the suitability of using a high phosphorus electroless nickel (HPEN) coating to prevent corrosion in carbon steel heat exchangers in seawater service. 1 in. x 4 in. samples were cut from ¼ in. SA-516-70 pressure vessel plate, pickled to remove mill scale, dressed with 300 grit sand paper and sent out for plating with 2 mils of HPEN. Due to a clerical error during plating, samples were plated to a significantly lesser extent than requested. Samples were plated with approximately 0.6 mils of HPEN versus the 2 mils requested, however this was …

Interactive Museum Exhibit To Introduce K-6 Grade Students To Circuits And The Electric Conductivity Of Various Materials, Thien Vu-Nguyen

Materials Engineering

The SciTechatorium (SciTech) is a museum filled with interactive exhibits for visitors to learn science informally. A new exhibit was developed to explore electric conductivity and circuits. The design was made based on the size of the material sample the students will use and to allow interactions with multiple users. The materials the students will use were selected using Cambridge Engineering Selector (CES) to sort the materials by resistivity, the inverse of conductivity. After sorting the materials by resistivity, five different materials (balsa wood, polystyrene, polyester, stainless steel, and copper) were chosen for the exhibit. The target size of the …

Development Of A High Precision Quantum Dot Synthysis Method Utilizing A Microfluidic Reactor And In-Line Fluorescence Cell, Harry Lafferty, Jonny Hoadley

Materials Engineering

Quantum dots show great potential for use as spectral converters in solar cells, lighting applications and biological imaging. These applications require precise control of quantum dot size to maximize performance. The fluorescence profile of quantum dots in solution correlates directly with particle size. An alternative, high precision process was developed for the synthesis of cadmium-selenide quantum dots using a microfluidic reactor and fluorescence flow through cell. The process required creating separate cadmium and selenium precursors that were then mixed in a nitrogen environment at 17± 1°C. Using an NE-300^® syringe pump, the solution was pumped through a microfluidic reactor …