Digital Commons Network^™

Navigating Structure, Function, And Stability: Bridging Immunotherapy And Protein Engineering In The Era Of Machine Learning, Christopher J. Haynie

Theses and Dissertations

The immune system is a remarkably adaptive network, yet it often fails to function optimally due to evasion strategies of pathogens or mutated cells. Many of these evasion strategies involve alterations in protein expression and function. Protein design is an area of computational biology with potential applications in improving protein function and therapeutic protein engineering. This thesis explores methods to enhance immune function and protein design across multiple scales, from molecular engineering of antibody fragments and chimeric antigen receptors (CARs) to cellular immune responses, and computational approaches for protein structure optimization. We characterize Thymidine Kinase 1-specific single-chain antibodies, highlighting both …

Strategic Management And Profit Optimization In Major League Baseball: A Framework For Sustainable Franchise Success, Cole Bourne

Undergraduate Honors Theses

This thesis examines the strategic, economic, and operational forces that drive profitability in Major League Baseball (MLB), positioning franchises not merely as sports teams but as complex, multi-revenue businesses. As the league evolves into a multi-billion-dollar industry shaped by expanding media rights, rising player salaries, and increasing market disparities, financial sustainability requires a blend of data-driven decision-making and modern business strategy. Through analysis of revenue streams, cost structures, market dynamics, and case studies, this work identifies the key levers that differentiate successful franchises from struggling ones.

The study outlines how media contracts—both national and local—serve as the backbone of MLB …

Our Teens Are Not Okay, But They Can Be: An Application Of The Family Firo Method To Improve Parent-Adolescent Communication About Suicide, Janene Pack Lpc, Cmhc, Peder Schillemat

Issues in Religion and Psychotherapy

This article explores the critical role of parent-teen communication in the mental well-being of teenagers, with a particular focus on its connection to suicide risk. A particular focus is on teens who live in Utah as the suicide rate for Utah teens and young adults is almost twice the national average. Despite the focus on families and religion in Utah, a significant number of teens continue to struggle with loneliness, hopelessness, and even thoughts of suicide. One key contributing factor to this struggle is the lack of open, supportive communication between Utah teens and their parents. The absence of effective …

Scrupulosity Ocd And How It Can Affect Our Clients’ Relationship With God, Annabella Hagen

Issues in Religion and Psychotherapy

This article explores various aspects of scrupulosity OCD, starting with the misconceptions about OCD that persist in society and their impact on treatment, along with a discussion of the disorder’s prevalence. It examines common OCD themes, provides a deeper understanding of religious scrupulosity, and clarifies how individuals become trapped in the scrupulosity OCD cycle. Specific triggers within the LDS Church are highlighted, alongside religious considerations such as distinguishing scrupulosity from genuine religiosity and discerning between spiritual promptings and OCD-driven thoughts. The article also addresses barriers to care unique to the LDS community and offers clinician recommendations, including an overview of …

Parental Grief And Loss After Gender Transition: Navigating Ambiguous And Disenfranchised Loss In Latter-Day Saint Families, David Haralson, Chelsea Johnson, Jeff Bennion, Orion Maxfield

Issues in Religion and Psychotherapy

Parents of transgender or gender nonconforming children sometimes experience profound grief and loss, particularly within religious communities that hold specific doctrines regarding gender. This article examines the unique challenges faced by parents in The Church of Jesus Christ of Latter-day Saints (LDS Church) when a child undergoes gender transition. By exploring the concepts of ambiguous loss and disenfranchised grief, we aim to provide a framework for understanding these parents' emotional experiences. The intersection of LDS doctrines and policies on gender with contemporary gender theories creates complex emotional environments for families to navigate. We present the Integrity and Investment Model as …

Helping Clients Grieve The Loss Of Their "Happily Ever After", Karen J. Gilmore, Joseph Chamberlain

Issues in Religion and Psychotherapy

ABSTRACT

Helping Clients Grieve the Loss of Their “Happily Ever After”

One of the most prominent attacks on marriage comes in the form of pornography and sex addiction. In this article I will explore what pornography and sex addiction is, why it can be highly addictive, how pornography and sex addiction can impact the marriage and lead to betrayal trauma, and how to understand the losses that can come from this type of trauma as well as the ensuing grief which may accompany this process. Additionally, I will identify ways to understand how grief presents in betrayal trauma, how to …

Love At A Distance: Exploring Perceptions Of Long-Distance Relationships Through Q Methodology, Ljubica Ivanovic Klobcic

Theses and Dissertations

With technology advancing and making it easier for individuals to connect and keep in touch, long-distance romantic relationships (LDRRs) have become increasingly common. While some people thrive in these relationships despite physical separation, others find the experience stressful and unsatisfying. This study explores how individuals perceive and navigate LDRRs and what their experiences are. Using Q methodology, participants sorted and ranked statements related to their experiences. Factor analysis revealed three unique groups: Traditional Romantics, who see their relationships in traditional terms despite technology use; Debbie Downers, who perceive distance as a burden and do not feel that technology improves their …

Modeling Xilinx 7-Series Fpgas Within The Verilog To Routing Project, Joshua Peter Fife

Theses and Dissertations

Verilog to Routing (VTR) is the most widely used open-source tool for experimenting with FPGA placement and routing algorithms, as well as assessing how architectural changes impact routability, timing, and power consumption.

Historically, VTR has been tailored specifically for Intel’s Altera-like FPGAs, lacking support for key features that would enable greater flexibility in describing other architectures. In this work, we introduce a fully functional 7-Series architecture capture from the Xilinx family, utilizing VTR’s scalable architecture description language. We detail the necessary upgrades to achieve this description, including the ability to describe L and T-shaped wires and target hard multipliers with …

Moiselle Renstrom, Myrna J. Layton

Faculty Publications

Katherine Moiselle Renstrom (June 23, 1889 – September 28, 1956) was a Utah educator, author, lyricist and composer of music for children.

Newel Kay Brown, Myrna J. Layton

Faculty Publications

Newel Kay Brown (February 29, 1932 – ) is an American composer, conductor, and arranger. He was chair of the Composition Division in the College of Music at the University of North Texas before his retirement.

Georgia Mae Wahlin Bello, Myrna J. Layton

Faculty Publications

Georgia Mae Wahlin Bello (February 13, 1924 – November 5, 2007) was an accomplished vocalist and pianist who was also a “one hit wonder” composer.

Earl C. Hazelle, Myrna J. Layton

Faculty Publications

Earl Charles Hazelle (February 1, 1906 – November 22, 1993) was a pianist, organist, accordionist and a composer of music for all three instruments as well as vocal music. He was also an accomplished painter in oils. Hazelle taught both music and art lessons for many years.

Frances K. Thomassen Taylor, Myrna J. Layton

Faculty Publications

Frances Eliza Warren Kingsbury Thomassen Taylor (January 21, 1870 – November 17, 1952) was an organist, composer and member of the General Board of the Primary Associations.

Mildred Tanner Pettit, Myrna J. Layton

Faculty Publications

Laura Mildred Tanner Pettit (August 9, 1895 – April 9, 1977) is best known as the composer of the iconic Primary song, I am a Child of God. Much of the music composed by Sister Pettit was aimed at children and can be found in various publications of the Primary Association of the Church of Jesus Christ of Latter-day Saints. However, Sister Pettit wrote dance music and operettas which were performed widely. She sometimes choreographed and directed the productions as well.

Marie Nelson Bennett, Myrna J. Layton

Faculty Publications

Marie Nelson Bennett (June 15, 1926 – November 18, 2018) was an American composer.

Edwin F. Parry, Myrna J. Layton

Faculty Publications

Edwin Francis Parry (June 11, 1860 – September 16, 1935) was a Utah typesetter, printer and writer who also loved music. He sang, played the organ and piano, wrote song lyrics and composed many songs and hymns.

Irene (Christopherson) Tempest, Myrna J. Layton

Faculty Publications

Irene Ellen Nelson Christopherson Tempest (January 19, 1904 – February 9, 1988) was a Utah pianist, organist and composer.

Marie Manwaring Anderson, Myrna J. Layton

Faculty Publications

Teresa Marie Manwaring Anderson (July 8, 1913 – February 23, 2002) was an Idaho composer, pianist, music teacher and choral director.

Maurine Dewsnup, Myrna J. Layton

Faculty Publications

Grace Maurine Dewsnup (February 8, 1909 – February 1, 1998) was a Utah piano soloist, dance accompanist, composer, music theorist and teacher.

Chronosort: Revealing Hidden Dynamics In Alphafold3 Structure Predictions, Matthew J. Argyle, William P. Heaps, Corbyn Kubalek, Spencer Gardiner, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Protein function emerges from dynamic conformational changes, yet structure prediction methods provide only static snapshots. While AlphaFold3 (AF3) predicts protein structures, the potential for extracting dynamic information from its ensemble predictions has remained underexplored. Here, we demonstrate that AF3 structural ensembles contain substantial dynamic information that correlates remarkably well with molecular dynamics simulations (MD). We developed ChronoSort, a novel algorithm that organizes static structure predictions into temporally coherent trajectories by minimizing structural differences between neighboring frames. Through systematic analysis of four diverse protein targets, we show that root-mean-square fluctuations derived from AF3 ensembles can correlate strongly with those from MD …

Contextual Bandits For Non-Stationary Multi-Agent Environments Using Assumptions-Alignment Tracking, Ethan Pedersen

Theses and Dissertations

A common challenge in AI is that of an agent possessing N distinct behaviors, each of which works effectively in certain tasks and circumstances, to choose from at any particular time. A popular approach to learn optimal selections in such contexts is found in bandit algorithms. However, traditional bandits often (1) assume the environment is stationary, (2) focus on asymptotic performance, and (3) do not incorporate available external information about the environment. While contextual bandits that do consider external information are designed to combat one of these challenges, the others remain problematic in realistic domains. This is especially true of …

An Analysis Of Large Language Model Hallucination And Creativity: Linear Representations And Causal Roles, Mckay Bowcut

Theses and Dissertations

Large language models (LLMs) show remarkable abilities in both factual and creative tasks, yet the problem of hallucination persists despite advances in training and post-training methods. Recent progress in model interpretability suggests that model behavior can be predicted and influenced by analyzing and manipulating internal activations. In this thesis, we address three questions: (1) Can we identify linear representations of hallucination and creativity in the model’s latent space? (2) Do these representations play a causal role in model behavior when manipulated? (3) Are creativity and hallucination causally intertwined? To answer these, we construct a novel dataset of factual, hallucinated, and …

On The Derivation Of The Ungerboeck Observation Model For Offset Qpsk, Michael Rice

Faculty Publications

This report derives maximum likelihood sequence estimator for Offset QPSK (OQPSK) operating over frequency selective channel. The maximum likelihood sequence estimator takes the form of the Viterbi Algorithm operating on a trellis defined intersymbol interference caused by the frequency selective channel. Because the distorted pulse shape does not satisfy the Nyquist no-ISI criterion, the matched filter output samples contain correleted noise. The derivation uses Ungerboeck’s method to create a recursive causal metric suitable for use with the Viterbi Algorithm.

Publication News

Journal of East Asian Libraries

No abstract provided.

New Appointments

Journal of East Asian Libraries

No abstract provided.

The Chinese Research Library In Transition: Yuan Tongli: A Chronicle, Mindi Zhang

Journal of East Asian Libraries

No abstract provided.

From Curiosity To Research: Exploring The Papers Of The University Librarian At Uva, Veronica Fu

Journal of East Asian Libraries

This article traces an exploratory journey into the Papers of the University Librarian at the University of Virginia (UVA), shedding light on lesser-known aspects of Harry Clemons’ contributions beyond his tenure at UVA. A chance conversation led to a deeper investigation, which eventually developed into a research project. This article provides an overview of that research as well as reflections on the intellectual and emotional rewards of the exploration. It also touches on challenges in archival access and the importance of enhancing discoverability for future researchers.

From The President, Su Chen

Journal of East Asian Libraries

No abstract provided.

Front Matter

Swiss American Historical Society Review

No abstract provided.

Revisiting The Geneva Summit 40 Years Later:, Thomas Quinn Marabello, Jonah S. Schaller

Swiss American Historical Society Review

Forty years ago this month, U.S. President Ronald Reagan and Soviet General Secretary Mikhail Gorbachev met for the first time in Geneva, Switzerland. What became known as the “Geneva Summit” was an important Cold War meeting between the two superpowers that would reset and impact their relations to this day. The Geneva Summit, some would argue, was the beginning of the end of the Cold War, as both leaders began working towards arms reduction, peace, and cultural and educational exchanges between both countries. It is hard to believe that November 1985 was forty years ago. The world watched as the …