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A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage Aug 2022

A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage

Theses and Dissertations

Identification of novel cancer driver mutations is crucial for targeted cancer therapy, yet a difficult task especially for low frequency drivers. To identify cancer driver mutations, we developed a machine learning (ML) model to predict cancer hotspots. Here, we applied the ML program to 32 non-receptor tyrosine kinases (NRTKs) and identified 36 potential cancer driver mutations, with high probability mutations in 10 genes, including ABL1, ABL2, JAK1, JAK3, and ACK1. ACK1 is a member of the poorly understood ACK family of NRTKs that also includes TNK1. Although ACK1 is an established oncogene and high-interest therapeutic target, the exact mechanism of …

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Interprofessional Education For School-Based Settings, Brittney M. Mack Aug 2022

Interprofessional Education For School-Based Settings, Brittney M. Mack

Theses and Dissertations

Teamwork is essential to provide quality services to individuals with disabilities (Morrison & Gleddie, 2019). Deficits across a variety of domains make interprofessional practice even more crucial (Dobbs-Oates & Morris, 2016). Interprofessional education (IPE) provides preprofessionals the opportunity to gain experience collaborating with various disciplines, better preparing them for interprofessional practice (Anderson et al., 2011; Ruebling, et al., 2014). Most IPE research has been completed with preprofessionals engaged in medical cases. The existing evidence for IPE in school-based settings is limited, which creates a gap for speech-language pathologists (SLPs) who are pursuing work in school-based settings. The first purpose of …

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What If I Liked It Better Before? An Analysis Of Consumer Reactance To Brand Logo Redesigns, Lauren Bushnell Aug 2022

What If I Liked It Better Before? An Analysis Of Consumer Reactance To Brand Logo Redesigns, Lauren Bushnell

Undergraduate Honors Theses

Past research has explored the relationship between logo redesigns and consumer behavior, specifically detailing the influence of brand connection on consumer processing of logo redesigns. Such research has found that variations in logo design have key implications on consumer connection to brands in ways that influence brand attitude. Key constructs explored include brand loyalty and commitment, the extent or style of changes in redesigns, and visual processing of logos as a means of determining future behaviors. While prior research emphasizes the influence of loyalty and connection to brands in relation to consumer processing of logo redesigns, research has not fully …

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Mechanical Actuation Via Resorbable Materials, Bethany Parkinson Aug 2022

Mechanical Actuation Via Resorbable Materials, Bethany Parkinson

Undergraduate Honors Theses

Resorbable materials—or materials which diffuse into their surroundings—present a promising means of actuating mechanical systems. In current practice, such as in the realm of in vivo surgical devices, resorbable materials are often intended to perform a temporary function and completely dissolve when that function is completed (e.g. resorbable sutures). In this paper, resorbable materials are proposed for use in a different way: as a means for actuating mechanical systems. We create several prototypes which demonstrate that resorbable materials, combined with stored energy, can be used to actuate mechanical systems under several loading conditions and in various applications. We also present …

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Sequencing The Guts Out Of Covid-19; The Evolution Behind The Covid-19 Pandemic, Madelyn Purnell Aug 2022

Sequencing The Guts Out Of Covid-19; The Evolution Behind The Covid-19 Pandemic, Madelyn Purnell

Undergraduate Honors Theses

The global COVID-19 pandemic has led to an urgent need for scalable methods for clinical diagnostics and tracking of virus variants. In this paper, we attempted a novel method of sequencing using Large Reverse Transcriptase-based cloning (LRTC). Although our methodology ended up not working due to high amount and fast degradation of RNA, we were able to sequence multiple variants of COVID-19 Positive samples from the BYU Student Health Center and 4 sewage samples to check for variant outbreaks in corresponding times. We were able to find several corresponding variants and track the progression of mutation in our local population.

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Gradient Conditioning In Deep Neural Networks, Michael Vernon Nelson Aug 2022

Gradient Conditioning In Deep Neural Networks, Michael Vernon Nelson

Theses and Dissertations

When using Stochastic Gradient Descent (SGD) to train Artificial Neural Networks, gradient variance comes from two sources: differences in the weights of the network when each batch gradient is estimated and differences between the input values in each batch. Some architectural traits, like skip-connections and batch-normalization, allow much deeper networks to be trained by reducing each type of variance and improving the conditioning of the network gradient with respect to both the weights and the input. It is still unclear to which degree each property is responsible for these dramatic stability improvements when training deep networks. This thesis summarizes previous …

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Teacher Judgment Accuracy Of Student Perceptions Of Closeness And Conflict In Teacher-Student Relationships, Collin Seastrand Aug 2022

Teacher Judgment Accuracy Of Student Perceptions Of Closeness And Conflict In Teacher-Student Relationships, Collin Seastrand

Theses and Dissertations

Teacher decisions are largely influenced by the judgments that they make regarding their students' states of mind. Thus, it is important for teachers to be accurate in their judgments. The current study investigated the teacher judgment accuracy of student perceptions of the teacher-student relationship. In a Western state of the United States, 40 teachers used a prediction form to predict how their 4th "“ 6th grade students would rate the closeness and the conflict of their teacher-student relationship via the Student Perception of Affective Relationship with Teacher Scale (SPARTS, Koomen & Jellesma, 2015). Students then took the survey, and teacher …

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Mediation In A Science Classroom, David Ray Davis Aug 2022

Mediation In A Science Classroom, David Ray Davis

Theses and Dissertations

Languaging and translanguaging are very important concepts in science classrooms when considering their role as mediational tools for supporting emergent bilingual students' needs. Languaging, including translanguaging, has to do with how people perceive, connect, and understand the activities and utterances around them through verbal and non-verbal communication in any language. This study positions languaging and translanguaging as mediational tools that can be used for supporting the use of science terms and overcoming second language challenges with them. Emergent bilingual students can benefit from the implementation of languaging characteristics that promote classroom discourse spaces where all their repertoire for responding, and …

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Thriving In College: The Contribution Of Career Services To Student Success, Jodi M. Chowen Aug 2022

Thriving In College: The Contribution Of Career Services To Student Success, Jodi M. Chowen

Theses and Dissertations

Career services in higher education has a long history of supporting student development and post-graduation success (American Council on Education, 1937; Rayman, 1999; Dey & Cruzvergara, 2014). However, there is a dearth of research identifying specific connections between engagement with career services and student success. College student thriving has been established in previous studies as positively contributing to traditional measures of college student success, including intention to persist, grade point average, institutional fit and satisfaction, and self-reported learning gains (Schreiner, 2013). Examining the relationship of student experience with career services and thriving provides a new way to evaluate the contribution …

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The Effects Of Parents' Socialization Goals, Responsiveness, And Psychological Control On Chinese Adolescents' Anxiety, Chunyue Tu Aug 2022

The Effects Of Parents' Socialization Goals, Responsiveness, And Psychological Control On Chinese Adolescents' Anxiety, Chunyue Tu

Theses and Dissertations

This study investigated the relationship of parents' achievement-oriented and self- development goals (for their children) on youth reported anxiety, while taking parents' psychological control and responsiveness into account as possible mediating factors. More specifically, the purpose of this study was to further investigate the direct/indirect effects of (a) parents' reported achievement-oriented goals on youth anxiety via parental psychological control in two types of schools (key school for more academically advanced students and typical school for students with lower academic achievement); and (b) parents' reported self-development goals on youth anxiety via parental psychological control in key and typical schools. The current …

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Introgression Or Incipient Speciation? Using Geometric Morphometrics And Gene Expression To Characterize Mouth Development In Larval June Sucker And Utah Sucker, Peter C. Searle Aug 2022

Introgression Or Incipient Speciation? Using Geometric Morphometrics And Gene Expression To Characterize Mouth Development In Larval June Sucker And Utah Sucker, Peter C. Searle

Theses and Dissertations

Understanding how biodiversity evolves is a major goal in evolutionary developmental biology because changes in developmental processes are tightly linked with evolutionary diversification. Heterochrony--alteration to the rate or timing of development--can significantly alter the appearance of descendant species. Heterochronic shifts in gene expression and associated morphological change may explain the morphological divergence between the threatened June sucker (Chasmistes liorus) and the sympatric Utah sucker (Catostomus ardens) in Utah Lake, UT, USA. June sucker are endemic to Utah Lake and have subterminal mouths adapted for pelagic feeding, while Utah sucker (Catostomus ardens) have ventral mouths adapted for benthic feeding. As larvae, …

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Recent Records Of Anthony’S Mexican Mole (Scapanus Anthonyi Allen, 1893) In Sierra San Pedro Mártir, Baja California, México, Jonathan A. Villarreal-Fletes, Aldo Guevara-Carrizales, Gorgonio Ruiz-Campos, Gonzalo De Leon-Giron, Scott B. Tremor Aug 2022

Recent Records Of Anthony’S Mexican Mole (Scapanus Anthonyi Allen, 1893) In Sierra San Pedro Mártir, Baja California, México, Jonathan A. Villarreal-Fletes, Aldo Guevara-Carrizales, Gorgonio Ruiz-Campos, Gonzalo De Leon-Giron, Scott B. Tremor

Western North American Naturalist

We describe 2 recent records with specimens for the endangered endemic mole Scapanus anthonyi in Sierra San Pedro Mártir, Baja California, México. A comparison of cranial measurements with previous specimens is given to illustrate within-species variation and to provide taxonomic corroboration.


Describimos 2 registros recientes con espécimen para el topo endémico en peligro de extinción, Scapanus anthonyi, en la Sierra de San Pedro Mártir, Baja California, México. Una comparación de mediciones craneales con especímenes previos es proveída para variación y corroboración taxonómica.

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Prosodic Modeling For Hymn Translation, Michael Abraham Peck Aug 2022

Prosodic Modeling For Hymn Translation, Michael Abraham Peck

Theses and Dissertations

Prosody is known in linguistics as the "suprasegmental" features of language such as syllable stress and intonation. It is also known in the fields of poetics and musicology with alternate definitions and modeling practices. Concepts of prosody are further compounded when considering prosodic phenomena throughout the languages of the world. While the resulting lack of a universal concept of prosody may be tolerable in such a variety of paradigms, there is one paradigm that requires a unified model of prosody. This is the paradigm of hymn translation, which requires prosodic features to align not only musically, poetically, and linguistically, but …

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Use Of Seed Coating Technologies To Improve Cercocarpus Ledifolius (Curl-Leaf Mountain Mahogany) Seed Germination And Emergence To Reclaim Mine Lands, Emily M. Nielson Aug 2022

Use Of Seed Coating Technologies To Improve Cercocarpus Ledifolius (Curl-Leaf Mountain Mahogany) Seed Germination And Emergence To Reclaim Mine Lands, Emily M. Nielson

Theses and Dissertations

Globally, mining is vital to human interests, but its practice can cause landscape alteration which may look unnatural or engineered. The reintroduction of native plants to these areas is needed to restore the visual appeal and ecological function back into these altered mine lands. Cercocarpus ledifolius (curl-leaf mountain mahogany) is one desirable native species in the Intermountain West that is prized for its potential to grow on step and rocky hillsides and for the habitat it provides for wildlife. Unfortunately, C. ledifolius does not establish well from seed, which has been attributed to seed dormancy. The first objective of this …

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External Laryngeal Oscillation And Aerodynamic Measures Of Voice Onset: A Translational Study, Erik Mcleod Christensen Aug 2022

External Laryngeal Oscillation And Aerodynamic Measures Of Voice Onset: A Translational Study, Erik Mcleod Christensen

Theses and Dissertations

The purpose of this study was to examine external laryngeal oscillation and its potential effects on phonation threshold pressure (PTP; cm H2O) and phonation threshold flow (PTF; L/sec). Measures of PTP and PTF have inherent limitations due to the nonlinear nature of phonation, influencing their clinical and experimental utility. This is true particularly for tracking relatively small changes in voice function because variability in the measure itself can be larger than that resulting from voice change. Elevated PTP and PTF are associated with a variety of voice disorders and correlate with self-reported vocal effort and fatigue. Prior studies involving silicone …

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Crossing The Threshold: Factors That Influence The Beliefs Of First Year Teachers Regarding Reform-Based Mathematics Instruction, Quinn H. Braden Aug 2022

Crossing The Threshold: Factors That Influence The Beliefs Of First Year Teachers Regarding Reform-Based Mathematics Instruction, Quinn H. Braden

Theses and Dissertations

Teacher preparation programs invest significant resources to influence the beliefs of preservice teachers, including clinical faculty who mentor preservice teachers during practicum experiences. Despite the work of university personnel to guide preservice teachers' beliefs, their influence wanes once preservice teachers cross the threshold into inservice teaching. New mentors, including mentor teachers, instructional coaches, and administrators take the place of university personnel. This quantitative study examined how the beliefs of 77 novice inservice teachers changed toward reform-based mathematics instruction during their first year of teaching. Of the 77 subjects, 50 were interns and 27 had completed student teaching. Near the end …

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Field Based Study Of Gravel Liquefaction, Jashod Roy Aug 2022

Field Based Study Of Gravel Liquefaction, Jashod Roy

Theses and Dissertations

Characterization and assessment of liquefaction potential of gravelly soil in a reliable cost-effective manner has always been a great challenge for the geotechnical engineers. The typical laboratory investigation techniques have proven to be ineffective for characterizing gravelly soil due to the cost and difficulty of extracting undisturbed sample from gravelly deposits. The traditional in-situ tests like SPT or CPT are not very suitable for gravelly soil because of interference with large size gravel particles which can artificially increase the penetration resistance. The Becker Penetration Test, well known for gravelly soil characterization, is cost-prohibitive for routine projects and is not available …

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Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt Aug 2022

Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt

Theses and Dissertations

Iron is an essential nutrient for energy and DNA replication. Its homeostasis is commonly perturbed by chronic inflammatory mechanisms. Chronic inflammation upregulates a cytokine, hepcidin, that degrades the iron export protein ferroportin. Without a way to export iron into the bloodstream iron availability in blood becomes depleted. Iron depletion in the blood stream hinders erythropoiesis and is termed anemia. Herein I investigate and inhibit the mechanism of hepcidin activation. Inhibition of hepcidin activation has released iron from tissues and alleviated anemic conditions in a cancer model. I have laid the foundation to investigate this pathway in a 3D spheroid model. …

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Estimating Age In Mule Deer: Accuracy And Influence On Reproduction, Morgan S. Hinton Aug 2022

Estimating Age In Mule Deer: Accuracy And Influence On Reproduction, Morgan S. Hinton

Theses and Dissertations

Accurate estimates of parameters and demographic rates of wildlife populations are crucial to management and conservation. One parameter of interest is age because it influences multiple demographic rates and behaviors including reproduction, dispersal, migration, and disease transmission. There are a number of methods used to estimate ages of wildlife. One of the most common methods used for mammals is evaluation of patterns in dental eruption and tooth wear. In the first chapter, we evaluate the accuracy associated with estimates of age from dental eruption and patterns of tooth wear for mule deer (Odocoileus hemionus). In the second chapter, we use …

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Analysis Of Using V2x Dsrc Equipped Snowplows To Request Signal Preemption, Samantha Kathleen Lau Aug 2022

Analysis Of Using V2x Dsrc Equipped Snowplows To Request Signal Preemption, Samantha Kathleen Lau

Theses and Dissertations

Dedicated short-range communication (DSRC) systems, a form of vehicle-to-everything (V2X) systems, were placed on Utah Department of Transportation (UDOT) snowplows to request signal preemption. The study took place along five state routes in the Salt Lake City metropolitan area. Snowplows and intersections were equipped with the technology to communicate and process requests for signal preemption. Signal performance and vehicle performance analysis were performed to understand the impacts that snowplows requesting signal preemption had. Signal performance analysis was done to determine how snowplows with V2X systems using DSRC affected signals. Vehicle performance analysis was done to see if plowing and traffic …

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The Association Of Psychotherapist Cultural Humility And Client Experiences And Outcomes In Psychotherapy: A Meta-Analysis, Lisa Michelle Scott Aug 2022

The Association Of Psychotherapist Cultural Humility And Client Experiences And Outcomes In Psychotherapy: A Meta-Analysis, Lisa Michelle Scott

Theses and Dissertations

Psychotherapist multicultural competence has been given increasing attention in the field of psychology since the 1970s. However, individuals and communities who are Black, Indigenous, or People of Color are still less likely to attend psychotherapy and often drop out earlier than White clients. These trends highlight the importance of the ongoing research on therapist multicultural competence. There are many multicultural competencies, however, the current study focuses on therapist cultural humility. Specifically, we systematically searched all the current research on the association between cultural humility and client experiences and outcomes in therapy. Our literature search yielded eight studies that met our …

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Effects Of A High School Yoga Program On Student-Reported Stress, Resilience, And Academic Outcomes, Stephanie Martha Vance Aug 2022

Effects Of A High School Yoga Program On Student-Reported Stress, Resilience, And Academic Outcomes, Stephanie Martha Vance

Theses and Dissertations

High school yoga programs are gaining popularity throughout the United States. The many perceived benefits of such programs among adolescent groups have shown promising outcomes. This mixed-method evaluation of a high school yoga program aims to evaluate the effects of the program on student-reported stress, resilience, and academic outcomes. Program participants include high school students in yoga classes (n = 61) and comparison classes (n = 37), who completed pre- and post-measure surveys along with social validity measures. Overall findings showed a decrease in stress levels among yoga students compared to comparison students, which approached statistical significance, no significant differences …

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To What Degree Does Martial Quality Predict Longevity? A Meta-Analysis Of Prospective Studies, Rachel E. Jensen Aug 2022

To What Degree Does Martial Quality Predict Longevity? A Meta-Analysis Of Prospective Studies, Rachel E. Jensen

Theses and Dissertations

Strong social relationships consistently predict the quality of both physical and mental health. Society commonly recognizes the marriage relationship as one of the most committed, enduring relationships. While marital status alone can strongly predict health, it appears that moderating factors exist in this association. The quality of one's marriage can have a greater effect on health than marital status alone. We conducted a meta-analysis examining the strength of the influence that marital quality has on physical health, specifically indicated by mortality rates. To identify relevant articles, we searched multiple online databases (Embase, Psycinfo, Family and Society Studies Worldwide, and Academic …

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Long-Term Soil Fungal Community Recovery After Fire Is Impacted By Climate Change, Spencer Mcgee, Alyssa Tidwell, Erin Riggs, Hannah Veltkamp, Geoffrey Zahn Aug 2022

Long-Term Soil Fungal Community Recovery After Fire Is Impacted By Climate Change, Spencer Mcgee, Alyssa Tidwell, Erin Riggs, Hannah Veltkamp, Geoffrey Zahn

Western North American Naturalist

Though much is known about fungal importance to forest health, there is very little information about factors that impact recovery times of soil fungal communities after a fire. Soil samples were taken from burn sites within one ecotype of temperate coniferous forest in Utah over a 20-year chronosequence. Sites were selected from available historic burns and were similar in plant community structure, elevation, slope, and aspect. Fungal DNA from these samples was compared to soil from paired unburned sites nearby to measure community similarity and estimate soil fungal recovery rates. Differences between paired burned and unburned sites remained fairly stable …

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Bittersweet Experiences For Brazilian Newcomers: Positive Interactions, Microaggressions, And Isolation In English-Only And Dual Language Bilingual Education Programs, Rose Renee Whitney Aug 2022

Bittersweet Experiences For Brazilian Newcomers: Positive Interactions, Microaggressions, And Isolation In English-Only And Dual Language Bilingual Education Programs, Rose Renee Whitney

Theses and Dissertations

With the rise of the number of immigrant children in schools across the U.S., education research has directed its attention to understanding these newcomers' social experiences at school. Though Brazilian immigrant populations are growing, research on their unique social experiences remains limited. Grounded in critical sociocultural theory, this interpretive phenomenological study shares the social experiences of four Brazilian newcomers in elementary school. Participants were adolescents who had immigrated to the U.S. as children and attended English-only and/or Dual Language Bilingual Education (DLBE) programs. As adolescents, participants were able to look back on their experiences as a newcomer in elementary school …

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The Role Of Social Response To Disclosure In Relgious And Spiritual Coping And Recovery From Sexual Assault, Megan Wolfe Aug 2022

The Role Of Social Response To Disclosure In Relgious And Spiritual Coping And Recovery From Sexual Assault, Megan Wolfe

Theses and Dissertations

Many factors can discourage survivors of sexual assault from reporting their assaults. Even those survivors who disclose, their reporting experiences may not leave them feeling empowered or that they have received adequate support to begin the healing process after disclosure. Using a mixed methods approach, we examined the relationship between religious and spiritual coping strategies, the experience of social disclosure, and symptoms of posttraumatic stress disorder (PTSD) and depression using confirmatory factor analysis (CFA) and structural equation modeling (SEM). We further used qualitative data examining the ways that participants used religious/spiritual coping strategies in response to the trauma of sexual …

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Interference Between Speaking And Computer Tasks And Their Effects On Physiologic Arousal, Tiana Walker Bateman Aug 2022

Interference Between Speaking And Computer Tasks And Their Effects On Physiologic Arousal, Tiana Walker Bateman

Theses and Dissertations

This study examined the effects of concurrent speech and computer tasks on each other and on measures of physiologic arousal in 30 young adults. Physiologic measures included galvanic skin response, heart rate, and heart rate variability. Participants completed a speech-only task, two computer-based tasks, and combined speech and computer-based tasks. Participants spoke for 60 seconds on a procedural discourse prompt. Acoustic measures included the mean and standard deviation of intensity and fundamental frequency as indices of prosody, speaking time ratio to reflect pausing, and speech rate. The primary computer task (with two levels of difficulty) involved making formatting changes to …

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Mirror Symmetry For Some Non-Abelian Groups, Kyle John Niendorf Aug 2022

Mirror Symmetry For Some Non-Abelian Groups, Kyle John Niendorf

Theses and Dissertations

The goal of this thesis is to investigate a conjecture about Mirror Symmetry for Landau Ginzburg (LG) models with non-abelian gauge groups. The conjecture predicts that the LG A-model for a polynomial-group pair $(W,G)$ is equivalent to the LG B-model for the dual pair $(W^*, G^*)$. In particular, the A-model and B-model include the construction of a Frobenius algebra. The LG mirror symmetry conjecture predicts that the A-model Frobenius algebra for $(W,G)$ will be isomorphic to the B-model Frobenius algebra for the dual pair $(W^*,G^*)$. Part of the conjecture includes a rule describing how to construct the dual pair. Until …

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Designing, Implementing, And Evaluating A Unit That Utilizes Effective History Teaching Practices, Haley Holland Aug 2022

Designing, Implementing, And Evaluating A Unit That Utilizes Effective History Teaching Practices, Haley Holland

Theses and Dissertations

Because elementary teachers are viewed as subject-matter generalists who are not specialized in teaching history, this qualitative action research project explored my practice as I designed, implemented, and evaluated a unit that utilized effective history teaching practices. The study took place in my fourth-grade classroom which resides in the Intermountain West. The data was analyzed with Cochran-Smith and Lytle's (1999) three types of knowledge as a priori codes. Inductive processes were then used to find patterns and themes. The study found that designing this unit involved engaging in historical practices and using traditional lesson planning techniques. Further, implementing the study …

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Genomics-Informed Nursing Care: A Survey Of Nicu Nurses' Experience And Perspectives Related To Genomic Sequencing, Rachel I. Anderson Aug 2022

Genomics-Informed Nursing Care: A Survey Of Nicu Nurses' Experience And Perspectives Related To Genomic Sequencing, Rachel I. Anderson

Theses and Dissertations

Background: Genomic sequencing is used in the Neonatal Intensive Care Unit (NICU) to diagnose babies with genetic disorders. Purpose: To explore the experiences and knowledge of nurses working in NICUs related to genomic sequencing. Methods: This was a mixed-methods, cross-sectional descriptive survey of NICU nurses attending a national conference. Quantitative data were analyzed using descriptive statistics. Qualitative data were coded into categories and themes. Results: Of 188 NICU nurses, nearly half reported experience with genomic sequencing. Among nurses with experience, 62.7% rated the amount of discussion they had with families about genomic sequencing as "0". Additionally, 72.7% of participants reported …

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