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Promoter Polymorphisms In Interferon Regulatory Factor 5, Daniel N. Clark Jun 2013

Promoter Polymorphisms In Interferon Regulatory Factor 5, Daniel N. Clark

Theses and Dissertations

The promoter region of interferon regulatory factor 5 (IRF5) contains the rs2004640 T or G single nucleotide polymorphism (SNP) and a CGGGG indel. Both of these polymorphisms have been implicated as genetic risk factors for several autoimmune diseases, including systemic lupus erythematosus, whose pathology involves altered apoptosis and cytokine signaling. The polymorphisms' overall effect is to increase IRF5 levels. IRF5 is a transcription factor of several cytokines, including interferon, and is pro-apoptotic. Thus an alteration of cytokine levels and apoptosis signaling due to high IRF5 levels is the proposed source of autoimmune risk. Each of IRF5's four first exons (1A, …

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Application Of One Dimensional Turbulence (Odt) To Model Fire Spread Through Biomass Fuel Bed, Abinash Paudel Jun 2013

Application Of One Dimensional Turbulence (Odt) To Model Fire Spread Through Biomass Fuel Bed, Abinash Paudel

Theses and Dissertations

Each year fires destroy millions of acres of woodland, lives, and property, and significantly contribute to air pollution. Increased knowledge of the physics and properties of the flame propagation is necessary to broaden the fundamental understanding and modeling capabilities of fires. Modeling flame propagation in fires is challenging because of the various modes of heat transfer with diverse fuels, multi-scale turbulence, and complex chemical kinetics. Standard physical models of turbulence like RANS and LES have been used to understand the flame behavior, but these models are limited by computational cost and their inability to resolve sub-grid scales. Application of several …

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Understanding Chinese Language And Culture: A Guidebook For Teachers Of English In China, Austin Cody Pack Jun 2013

Understanding Chinese Language And Culture: A Guidebook For Teachers Of English In China, Austin Cody Pack

Theses and Dissertations

Many experts on English teaching in China argue that native-English-speaking teachers are too unfamiliar with Chinese culture and the Chinese language. Many of the resources available for these teachers do not address these issues and are not adequately tailored to the native-English-speaking teachers' specific needs. This 35 page guidebook in printable pdf form addresses three key issues with English teaching in China. First, the guidebook helps teachers understand how to bridge the gap that exists between their teaching styles and their Chinese students' learning styles. Second, the guidebook provides explanations of common errors Chinese students make in English because of …

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Couples' Experience Of Attachment-Related Change In Context Of Couple-Centered, Enactment-Based Therapy Process And Therapist-Centered Therapy Process: A Qualitative Study, James Waid Ballard Jun 2013

Couples' Experience Of Attachment-Related Change In Context Of Couple-Centered, Enactment-Based Therapy Process And Therapist-Centered Therapy Process: A Qualitative Study, James Waid Ballard

Theses and Dissertations

Enactments consist of episodes of direct couple engagement being carefully monitored and coached by the therapist. Enactments have been identified and studied as a potential common factor in marriage and family therapy. Attachment security is considered to be a foundational marker of marital health. This study explored what role enactments play in promoting attachment-related outcomes in therapy. A qualitative group hermeneutic approach was used to analyze the interviews of twelve participants (six couples) who had participated in six experimental sessions: three sessions with a preponderance of therapist-centered process and three of enactment-based process. The results of this analysis provide a …

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Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy, Joshua Christopher Vert Jun 2013

Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy, Joshua Christopher Vert

Theses and Dissertations

From acid seeps and deep-sea thermal vents to glacial ice and hypersaline lakes, extreme environments contain relatively simplified communities consisting of extremophiles that have evolved to survive and thrive under adverse abiotic conditions. In more neutral environments, microorganisms use dormancy as a common life history strategy to weather temporal fluctuations of resources or stresses until more 'optimal' conditions are present. It is unclear if dormancy is an essential survival mechanism for microorganisms in extreme environments; however, recent studies suggest that extreme environments may create stable conditions for extremophiles to the extent that dormancy is of less ecological importance. Using lake …

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Thymidine Kinase 1: Diagnostic And Prognostic Significance In Malignancy, Melissa Marie Alegre Jun 2013

Thymidine Kinase 1: Diagnostic And Prognostic Significance In Malignancy, Melissa Marie Alegre

Theses and Dissertations

Thymidine kinase 1 (TK1) is a cancer biomarker which has diagnostic and prognostic potential in a variety of malignancies. TK1 is significantly elevated in the serum and tumor tissue of most malignancies. This increase in TK1 can be detected in the very early stages of malignancy, including in pre-malignant disease with an increased risk for progression. Several studies have demonstrated that elevated TK1 is found in serum months before any clinical symptoms of malignancy. It has also been demonstrated that TK1 is elevated months before clinical recurrence of malignancy. This work first sought to demonstrate the early nature of TK1 …

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Resource Legacies And Priming Regulate Microbial Communities In Antarctica's Dry Valleys, Sabrina Deni Saurey Jun 2013

Resource Legacies And Priming Regulate Microbial Communities In Antarctica's Dry Valleys, Sabrina Deni Saurey

Theses and Dissertations

Multiple mechanisms control bacterial community structure but two in particular, the "legacy" of past environmental conditions, and the "priming" of bacteria to respond to seasonal or reoccurring fluctuations in resources, have the potential to determine both bacterial communities, as well as, temporal shifts in active bacterial taxa. To begin to evaluate the legacy effects of resources on microbial communities, we added four limiting resources annually (i.e., water only; C-mannitol + water; N-NH4NO3 + water; and C, N + water) and measured shifts in bacterial community composition after seven years in a cold desert ecosystem in the McMurdo Dry Valleys, Antarctica. …

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Ethical Metafiction In Dickens's Christmas Hauntings, Mark Brian Sabey Jun 2013

Ethical Metafiction In Dickens's Christmas Hauntings, Mark Brian Sabey

Theses and Dissertations

Many critics have examined metanarrative aspects of Dickens's writing, and many have studied Dickens's ethics. None, however, has yet assessed the ways in which Dickens's directly interrogates the ethics of fiction. Surprisingly philosophical treatments of the ethics of fiction take place in A Christmas Carol and A House to Let, both of which turn the ghost story of the traditional winter's tale to metafictional purposes. No one has yet dealt with Dickens's own meta-commentary on the ethics of fiction with the degree of philosophical nuance it deserves. Writings about the ethics of Dickens's fiction (and of fiction generally) often involves …

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Women And The Wiener Werkstätte: The Centrality Of Women And The Applied Arts In Early Twentieth-Century Vienna, Caitlin J. Perkins Bahr Jun 2013

Women And The Wiener Werkstätte: The Centrality Of Women And The Applied Arts In Early Twentieth-Century Vienna, Caitlin J. Perkins Bahr

Theses and Dissertations

In this thesis I explore the importance of elite women in early twentieth-century Vienna in relation to the Wiener Werkstätte. My research has led me to believe that the Werkstätte held a more egalitarian view of women than other contemporary European applied arts workshops. Unfortunately the art-historical canon has generally overlooked the applied arts of the Wiener Werkstätte, as well as the significant roles of women in the Werkstätte as artists, clients, patrons, and promoters. In this thesis, I consider cases of women in these roles in early twentieth-century Vienna in order to gain a greater understanding of Viennese women's …

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Documenting The Dissin's Guest House: Esther Bubley's Exploration Of Jewish-American Identity, 1942-43, Vriean Diether Taggart Jun 2013

Documenting The Dissin's Guest House: Esther Bubley's Exploration Of Jewish-American Identity, 1942-43, Vriean Diether Taggart

Theses and Dissertations

This thesis considers Esther Bubley's photographic documentation of a boarding house for Jewish workingmen and women during World War II. An examination of Bubley's photographs reveals the complexities surrounding Jewish-American identity, which included aspects of social inclusion and exclusion, a rejection of past traditions and acceptance of contemporary transitions. Bubley presented these residents, specifically the females, as modern Americans shedding the stereotypes surrounding their Jewish heritage and revealing their own perspective and reality. Through their communal support as a group sharing multiple values these residents dealt with multivalent isolation all while maintaining their participation in mainstream American cultural norms. Working …

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Herbert Hoover And Belgian Relief, Albert Winkler Jun 2013

Herbert Hoover And Belgian Relief, Albert Winkler

Swiss American Historical Society Review

Two Presidents of the United States, Dwight Eisenhower and Herbert Hoover, are known to have Swiss ancestry. Eisenhower is noted for his generalship in the Second World War and his presidential administration in a time of prosperity for the nation, while Hoover is often remembered only for his unpopular presidency during the Great Depression . This is unfortunate because Hoover contributed to the well-being and survival of many millions of people during times of grave food shortages. His efforts, which began with the feeding of the nation of Belgium during World War I, prevented starvation in many areas of the …

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How Miracles Are Wrought: Reflections On Faith, Prayer, And Priesthood Jun 2013

How Miracles Are Wrought: Reflections On Faith, Prayer, And Priesthood

Religious Educator: Perspectives on the Restored Gospel

No abstract provided.

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What's On The Other Side? A Conversation With Brent L. Top On The Spirit World Jun 2013

What's On The Other Side? A Conversation With Brent L. Top On The Spirit World

Religious Educator: Perspectives on the Restored Gospel

No abstract provided.

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Herbert Hoover And Belgian Relief, Albert Winkler Jun 2013

Herbert Hoover And Belgian Relief, Albert Winkler

Faculty Publications

Herbert Hoover was an orphan, who retained great empathy for the weak and hungry his entire life. Working without pay, he organized and administered Belgian Relief starting in 1914 to get food to ten million Belgians and Frenchmen behind German lines. His efforts doubtlessly saved hundreds of thousands from starvation. This was only the starting point in his career as the "Great Humanitarian." He got food to Germany at the end of both world wars, aided Russia in their great famine, and reportedly got food to hundreds of millions of people in his lengthy career. No one has ever done …

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Thomas K. Mccraw. The Founders And Finance: How Hamilton, Gallatin, And Other Immigrants Forged A New Economy, L.B. (Bud) Kuppenheimer Jun 2013

Thomas K. Mccraw. The Founders And Finance: How Hamilton, Gallatin, And Other Immigrants Forged A New Economy, L.B. (Bud) Kuppenheimer

Swiss American Historical Society Review

In 1789, thirteen independent states became a nation, but one lacking any sense of national purpose. The economy of the former colonies remained overwhelmingly agricultural and, despite their having ratified a federal constitution, the first loyalties of most individuals were to their states. Many also feared that an empowered central authority would lead to a return of monarchy and a class-based society.

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Mommy Blogs And Rhetoric: Reading Experiences That Shape Maternal Identities, Brighton Joan Capua May 2013

Mommy Blogs And Rhetoric: Reading Experiences That Shape Maternal Identities, Brighton Joan Capua

Theses and Dissertations

The transition to motherhood is difficult and jarring for many women. Not only does this transition demand life-altering changes to a woman's life, but especially in more recent times, this transition offers nothing but uncertainty. As the role and understanding of women continues to change, what motherhood means becomes increasingly difficult to define; additionally, the traditional narratives of stay-at-home mothers who are always happy to do housework and nurture their children no longer apply for many 21st-century women, leaving new mothers feeling uncertain about who they are and who they want to become. Since the turn of the century, mothers …

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Cultural Aspects Of Latino Early Childhood Obesity, Lauren Clark, Susan L. Johnson, Mary E. O'Connor, Jane H. Lassetter May 2013

Cultural Aspects Of Latino Early Childhood Obesity, Lauren Clark, Susan L. Johnson, Mary E. O'Connor, Jane H. Lassetter

Faculty Publications

The problem of Latino childhood obesity is well known, and experts agree that the sooner it is addressed in a child’s life, the better. Strong evidence from nationwide studies suggests that obesity begins in infancy for Mexican Americans. National data demonstrate the dramatic increase in weight-for-recumbent length above the 95th percentile (using the NCHS growth chart) among Mexican American children between National Health and Nutrition Examination Survey (NHANES) and the Third National Health and Nutrition Examination Survey (NHANES III) (Ogden et al., 2006). High rates of childhood obesity affect the long-term health potential of children, since childhood obesity tracks into …

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Isolation, Characterization And Synthesis Of Asthma Inducing Fungal Glycolipid And Analytical Method Development For Novel Antimicrobial Peptide Mimics, Vinod Chaudhary May 2013

Isolation, Characterization And Synthesis Of Asthma Inducing Fungal Glycolipid And Analytical Method Development For Novel Antimicrobial Peptide Mimics, Vinod Chaudhary

Theses and Dissertations

NKT cells are an important part of human immune system and recognize a specific set of antigens called glycolipids. Only a handful of "natural" NKT cell antigens are known till date. Although NKT cells play a protective role against pathogenic organisms, imbalances in NKT cell functions are implicated in many diseases including asthma. Allergic asthma, a Th2 driven inflammation of airways, is primarily caused by inhalation of environmental allergens. In the last decade, inhaled allergen Aspergillus fumigatus has been under scrutiny for the presence of NKT cell antigens that might trigger asthma. We successfully isolated, characterized and synthesized a "natural" …

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Devastating Diva: Pauline Viardot And Rewriting The Image Of Women In Nineteenth-Century French Opera Culture, Rebecca Bennett Fairbank May 2013

Devastating Diva: Pauline Viardot And Rewriting The Image Of Women In Nineteenth-Century French Opera Culture, Rebecca Bennett Fairbank

Theses and Dissertations

Historically vilified, the vocalizing woman developed a stereotyped image with the emergence of the prima donna in eighteenth-century opera. By the nineteenth century, the prima donna became the focal point for socio-cultural polemics: women sought financial and social independence through a career on the operatic stage while society attempted to maintain through various means the socio-cultural stability now threatened by women's mobility. The prima donna represented both a positive ideal for women as well as a great threat to western patriarchy. A discourse emerged in which the symbol of female independence and success ”the prima donna" became the site of …

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Using Topology Optimization To Numerically Improve Barriers To Reverse Engineering, Devin Donald Lebaron May 2013

Using Topology Optimization To Numerically Improve Barriers To Reverse Engineering, Devin Donald Lebaron

Theses and Dissertations

Here explored is a method by which designers can use the tool of topology optimization to numerically improve barriers to reverse engineering. Recently developed metrics, which characterize the time (T) to reverse engineer a product, enable this optimization. A key parameter use din the calculation of T is information content (K). The method presented in this thesis pursues traditional topology optimization objectives while simultaneously maximizing K, and thus T, in the resulting topology. This thesis presents new algorithms to 1) evaluate K for any topology, 2)increase K for a topology by manipulating macro-scale geometry and micro-scale crystallographic information for each …

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The Effects Of Intervention Involving A Robot On Compliance Of Four Children With Autism To Requests Produced By Their Mothers, Holly Jeanne Nelson May 2013

The Effects Of Intervention Involving A Robot On Compliance Of Four Children With Autism To Requests Produced By Their Mothers, Holly Jeanne Nelson

Theses and Dissertations

The current study presents the use of a humanoid robot to facilitate compliant behaviors to two types of directives in four children with autism. The children participated in a three-month intervention program that incorporated core components of the SCERTS model in order to facilitate social communication (Prizant, Wetherby, Rubin, & Laurent, 2003). Treatment sessions were comprised of 40 minutes of traditional treatment and 10 minutes of interaction with a humanoid robot. Pre- and post-intervention assessment were conducted, each involving a 5 minute interaction with the child's mother, in which they were presented with directives in the form of physical manipulation …

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Analysis Of An Improved Imu-Based Observer For Multirotor Helicopters, John Charles Macdonald, Robert C. Leishman, Randal W. Beard, Timothy W. Mclain May 2013

Analysis Of An Improved Imu-Based Observer For Multirotor Helicopters, John Charles Macdonald, Robert C. Leishman, Randal W. Beard, Timothy W. Mclain

Faculty Publications

Multirotor helicopters are increasingly popular platforms in the robotics community. Making them fully autonomous requires accurate state estimation. We review an improved dynamic model for multirotor helicopters and analyze the observability properties of an estimator based on this model. The model allows better use of IMU data to facilitate accurate state estimates even when updates from a sensor measuring position become less frequent and less accurate. We demonstrate that the position update rate can be cut in half versus typical approaches while maintaining the same accuracy. We also find that velocity estimates are at least twice as accurate no matter …

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“William Clark: Reflections On His Interactions With Family, Native Nations, And Landscapes.”, Jay H. Buckley May 2013

“William Clark: Reflections On His Interactions With Family, Native Nations, And Landscapes.”, Jay H. Buckley

Faculty Publications

W hen William Clark was born on August 1,1770, the Virginia Colony encompassed a territory that stretched from the Atlantic Ocean to the Mississippi River, including all of what would become Kentucky and portions of West Virginia, Ohio, Indiana, Wisconsin, Illinois, and Indiana. When Clark was 17, the ratification of the U.S. Constitution created the United States of America. Five years later, Kentucky entered the union as the fifteenth state. The 1803 Louisiana Purchase effectively doubled the size of America. Clark was instrumental in exploring this new territory, negotiating with its original inhabitants, encouraging American settlement, and establishing his home …

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A Theory Of Motivated Recall: Determinants Of Recall Of Political Information, Robert Richards, Dr. Christopher Karpowitz Apr 2013

A Theory Of Motivated Recall: Determinants Of Recall Of Political Information, Robert Richards, Dr. Christopher Karpowitz

Journal of Undergraduate Research

A great deal of political research has analyzed how people form their opinions about candidates and issues. Two models, drawing heavily from cognitive psychology have emerged: the memory-based model (Zaller and Feldman 1992; Huckfeldt et al 1999) and the on-line model (Taber, Lodge, and Glathar 2001). Though the mechanics differ, both models assume a person recalls some sort of information when forming or reporting an opinion. Thus, political opinions depend largely on recall of political information.

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Family And Principle: The Blood And Iron Of The Empress Frederick, Aileen Christensen, Paul Kerry Apr 2013

Family And Principle: The Blood And Iron Of The Empress Frederick, Aileen Christensen, Paul Kerry

Journal of Undergraduate Research

The Empress Frederick was a remarkably intelligent woman, who uniquely responded to her parents educational system and ideas, making her the bright hope for the future generation, particularly for the future of Prussia. Her lofty English ideals, however, led her into conflict and defeat at the hands of Otto von Bismarck. The core of the contrast between the Empress Frederick’s and Prince Bismarck’s convictions are best expressed by Vicky (the Empress) herself: “What has been brought about with blood and iron could have been achieved by moral conquests.” Bismarck’s commanding vision of unification through blood and iron is fairly concrete …

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An Alternative Method To Prepare Cobalt Catalysts Using Salt Precursors, Trevor Seegmiller, Dr. Calvin Bartholomew Apr 2013

An Alternative Method To Prepare Cobalt Catalysts Using Salt Precursors, Trevor Seegmiller, Dr. Calvin Bartholomew

Journal of Undergraduate Research

Fischer-Tropsch synthesis (FTS) is the process for converting syngas (carbon monoxide and hydrogen) into liquid fuels such as gasoline and diesel. A cobalt or iron catalyst is required for the process. Cobalt catalysts have the highest effectiveness and stability in FTS; however, they are more expensive due to higher materials cost as well as the time-consuming and complex processes generally associated with manufacture.

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Welfare To Votes: Does Tanf Depress Political Participation?, Taylor Bambas Rosecrans, Dr. Christopher Karpowittz Apr 2013

Welfare To Votes: Does Tanf Depress Political Participation?, Taylor Bambas Rosecrans, Dr. Christopher Karpowittz

Journal of Undergraduate Research

The purpose of my study is to find a link between government welfare programs and the political participation of recipients. This kind of study is called a policy feedback analysis. It examines a public policy to see what effect it had on human behavior. There is basis for this sort of research in political science. One highly respected work that was one of the first policy feedback studies was Suzanne Mettler’s book “Soldiers to Citizens” (2005). Mettler found that after WWII, the G.I. bill helped former soldiers to feel like highly valued citizens, funding their education and inspiring them to …

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Facies And Reservoir Characterization Of The Permian White Rim Sandstone, Black Box Dolomite, And Black Dragon Member Of The Triassic Moenkopi Formation For Co2 Storage And Sequestration At Woodside Field, East-Central Utah, Walter Andrew Harston Apr 2013

Facies And Reservoir Characterization Of The Permian White Rim Sandstone, Black Box Dolomite, And Black Dragon Member Of The Triassic Moenkopi Formation For Co2 Storage And Sequestration At Woodside Field, East-Central Utah, Walter Andrew Harston

Theses and Dissertations

Geologic sequestration of anthropogenic carbon dioxide (CO2) greenhouse gas emissions is an engineering solution that potentially reduces CO2 emissions released into the atmosphere thereby limiting their effect on climate change. This study focuses on Woodside field as a potential storage and sequestration site for CO2 emissions. The Woodside field is positioned on a doubly plunging, asymmetrical anticline on the northeast flank of the San Rafael Swell. Particular focus will be placed on the Permian White Rim Sandstone, Black Box Dolomite and Black Dragon Member of the Triassic Moenkopi Formation as the reservoir/seal system to store and sequester CO2 at Woodside …

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The Villain Iago As The Pinnacle Of Badness, Lauren Remington Apr 2013

The Villain Iago As The Pinnacle Of Badness, Lauren Remington

Student Works

Shakespeare's Othello, one of Shakespeare's most popular tragedies, showcases the works and cunning of one well-known and even well-loved villains, Iago. Iago is a chameleon of a character easily capable of manipulating those around him to meet his ends. All the cleverness and cold calculation homaged, he lacks any definitive motive or driving purpose, merely revenge on the seemingly guiltless Othello. This determined denial of a motive and extremity of action reflects well Carl Jung, a well-celebrated personality psychologist, and his theory on personality, specifically the "shadow" archetype. The shadow is an amoral, metaphorical storage center of humankind's propensity to …

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Pretenders To Birthright, Heirs To Virtue: The Legitimacy Of The Tudors And Shakespeare's Characters, Elizabeth Cole Apr 2013

Pretenders To Birthright, Heirs To Virtue: The Legitimacy Of The Tudors And Shakespeare's Characters, Elizabeth Cole

Student Works

The struggles of the Tudor dynasty of sixteenth-century England were created by the need of the monarchs to secure individual and legal legitimacy. William Shakespeare examines the issue in several of his plays, including King Lear, Richard III, and King John. Through recreating the legitimacy battles of the Tudors in his plays, Shakespeare demonstrates that it is not bastardy which corrupts a person's character but the betrayal of family ties and falsifying legitimacy, and that legitimacy does not make a person good but virtue and loyalty to one's country does. Legitimacy is not merely a label associated with birth but …

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