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Role Of The Cytosolic Chaperonin Cct In The Folding Of Novel Substrates, Theresa M. Smith

Theses and Dissertations

All cells depend on properly folded proteins for survival and function. Misfolding of proteins results in loss of critical functions and may trigger the misfolding of other nearby proteins leading to toxic aggregation. While many proteins can fold on their own, others with complicated domain structures require assistance from protein folding machines called chaperones. The most complex and highly specialized of all chaperones is the eukaryotic chaperonin complex CCT which is necessary for the folding of a wide variety of essential proteins. These include the cytoskeletal proteins actin and tubulin as well as the Gβ subunit of the G protein …

Perspectives On Lifespan Religious And Spiritual Development From Scholars Across The Lifespan, Megan Gale, Justin J. Hendricks, David C. Dollahite, Loren D. Marks

Faculty Publications

The purpose of the article is to share our perspectives on the key influences of lifespan religious and spiritual development as scholars from across the lifespan (i.e., the four authors are from different generations, including Baby Boomers, Generation X, Millennials, and Gen Z). Our perspectives are heavily influenced by our combined 60+ years of research experience in examining the connections between religion and family life. Our discussion is organized around Bronfenbrenner’s bioecological framework and the process-person-context-time model. Within this framework, the key factors we discuss that influence religious/spiritual development include (a) process (i.e., person-religion mismatch and family processes), (b) person …

Genetic Stop Signs: Nontraditional Sequences That Terminate Rna Production, Christina Iverson, Samuel Scott

Library/Life Sciences Undergraduate Poster Competition 2023

3rd place open house

Gene expression can change everything about the identity of a bacterial cell. This process begins when the protein RNA polymerase reads a DNA strand and produces, or transcribes, a matching messenger RNA sequence. This RNA sequence will then be read by a protein-building complex which builds a protein encoded by the RNA. When RNA polymerase finishes producing the RNA sequence, the RNA polymerase will fall off the DNA strand, known as transcription termination. Currently, there are two known mechanisms for transcription termination. We believe that there may be more unknown mechanisms for termination.

Isolating Highly Specific Antibodies Against Cancer Target Hprt, Austin J. Hansen, Christopher J. Haynie, Kiara V. Whitley, Michelle Townsend, Abby Johnson, Hunter Lindsay, Laura Baird, Kim L. O'Neill

Library/Life Sciences Undergraduate Poster Competition 2023

Effective immunotherapeutic targeting of cancer cells requires identification of specific antigenic differences between cancerous and healthy cells. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is a cytoplasmic enzyme involved in the salvage pathway for DNA synthesis. Certain cancers (e.g., prostate and breast) upregulate and express HPRT on the cell membrane, making HPRT a potential cancer biomarker for cancer immunotherapies. Antibodies specific for unique cancer proteins are critical to develop targeted cancer immunotherapies. Using a yeast display library and cell sorting, we selected for high-affinity human single-chain (scFv) antibodies against HPRT that can be utilized in chimeric antigen receptor (CAR) T cell therapies and antibody-dependent …

Phage Host Interactions In Fhua Dependent Bacteriophages, Ian W. Baeten, Jessica M. Lewis, Kathryn E. Janda, David E. Kotter, Julianne H. Grose, William R. Mccleary

Library/Life Sciences Undergraduate Poster Competition 2023

Bacteriophages are the natural enemy of bacteria. They infect and kill bacterial cells similarly to how animal viruses infect and kill our (eukaryotic) cells. Being viruses, bacteriophages need to get inside of their host to be able to replicate and survive. To do this, phages use receptor binding proteins (RBPs) to bind to various molecules on the surface of bacterial cells, which allows them to attach and initiate the first step of infection. Several novel bacteriophages were isolated from sewage samples across the Wasatch Front of Utah that infect Escherichia coli strain MG1655 and are being used to gain greater …

Flipped Versus Online Instruction: A Comparative Analysis Of Student Performance, Noah Emery, Jamie L. Jensen

Library/Life Sciences Undergraduate Poster Competition 2023

The need for improved modes of online instruction has rapidly increased within the last decade. But whether online instruction is beneficial or as effective as in-person remains inconclusive (McCutcheon et al., 2015). Evidence would suggest that there are knowledge gaps with students who enroll in online courses (Jensen et al., 2022).

We designed and tested various models of an online introductory biology course for non-biology undergraduates in order to determine which method of online instruction would most improve student performance and close these knowledge gaps. We hypothesized that including instructor scaffolding (instructor organization and support), instructor feedback, and peer collaboration …

Higher Incidence Of Parasitic Copepods In Female Host Rockfish Species Call For Improved Restoration And Commercial Management Strategies, Alyssa Walters, Mark C. Belk

Library/Life Sciences Undergraduate Poster Competition 2023

Host-parasite interactions are key components in shaping ecosystem and community structure. In parasitism, the host maintains the life of the parasite and can have its fitness influenced as a result. This can be especially problematic for commercial fish projects, as well as species management.

New Species Discovery In Eriastrum (Polemoniaceae) In The Californian Red Mountains, Kaitlyn Pankratz, Leigh Johnson

Library/Life Sciences Undergraduate Poster Competition 2023

Characterized in the flowering plant family Polemoniaceae by wooly hairs on the calyces and bracts associated with the flowers and found in dry areas of western North America (1).

Staphylococcus Aureus Readily Shares Antibiotic Resistance Genes Via Transformation In Co Cultured Biofilms, Brooklyn Jones, Ashley Ball, Emillee Augenstein, Thompson Jared, Austin Wright, Brad Berges

Library/Life Sciences Undergraduate Poster Competition 2023

Staphylococcus aureus (SA) is a pathogenic bacterium which affects both humans and livestock, primarily affecting the blood, lungs, and soft tissues The CDC estimates 700 000 current deaths per year in the USA that are associated with antibiotic resistance (AR) infections, rising to 10 million/year by 2050 if no action is taken. SA can gain AR by obtaining a resistance gene from another organism, however, the process of such is not well understood The purpose of this project is to elucidate the process of gaining AR genes in SA strains SA strains can form biofilms an exterior, structural film, which …

Engineering And Characterization Of Antibodies Against Cancer Biomarker Thymidine Kinase 1, Joshua Bennett, Kiara V. Whitley, Christopher J. Haynie, Kim O'Neill

Library/Life Sciences Undergraduate Poster Competition 2023

Engineered antibodies used in immunotherapies have been increasingly successful due to their ability to uniquely target cells expressing specific cancer antigens Thymidine Kinase 1 (TK 1 is a DNA salvage enzyme typically found in the cytosol However, in certain types of cancer, TK 1 is surface expressed, making it a unique cancer biomarker By identifying antibodies with a high binding affinity for TK 1 we can target cancer cells expressing TK 1 on their surface Using cell sorting and a yeast display library expressing 109 human single chain antibody fragments, we have isolated ten unique single chain antibodies scFvs that …

The Effects Of Initiating A Fast With A High Fat Or A High Carbohydrate Shake On Mcp-1, Tnfa And Il-6 Levels, Gage Jensen, Landon S. Deru, Bruce Bailey

Library/Life Sciences Undergraduate Poster Competition 2023

Alzheimer’s disease, stroke, heart disease and diabetes all rank among the leading causes of death in the United States, particularly among the elderly. While many behavioral and pharmacological strategies have been employed to reduce the incidence of these conditions, increasing evidence indicates that entering a mild to moderate state of ketosis through fasting or a very low carbohydrate diet can improve the prognosis for these conditions.1-4 Our aim is to see the extent that carbohydrate composition in an initiatory meal has on inflammatory marker proteins in our participants. This study assessed the impact that pre-fast meals have on Monocyte chemoattractant …

Figures In Biological Journal Articles Are Often Unfriendly To People With Color Vision Deficiencies, Harlan Stevens, Arwen Oakley, Stephen Piccolo

Library/Life Sciences Undergraduate Poster Competition 2023

8% of men have red-green color vision deficiencies (CVD).

We focused on deuteranomaly and deuteranopia (deficiency in seeing green) since it is by far the most common CVD.

Colorblind unfriendly figures hinder equity in research and discourage individuals with CVD from pursuing science.

To determine how often researchers use colorblind-unfriendly figures, we classified and labeled 5000 images.

Our annotated dataset will be freely available in the hope that it will prove helpful to other researchers.

We created a computer vision model using a Convolutional Neural Network (CNN) to classify images as colorblind-friendly or not.

Urban Ecology Of Birds In Mexico City, E. Elias Johnson, Byron J. Adams, Jerald B. Johnson, J. Jaime Zuniga-Vega

Library/Life Sciences Undergraduate Poster Competition 2023

How organisms persist under extreme conditions has received a lot attention in ecology. Some extreme environments are natural and pristine (e.g., Antarctica or the Atacama Desert), while others are highly impacted by humans (e.g., large cities). Unfortunately, we know little about the ecology of species that live in urban environments relative to those in pristine environments.

Detecting And Characterizing Multisensory Integrating Optic Tectum Neurons In Zebrafish, Adeline Hamilton, Karianne Jex, Erika C. Marks., Suehelen A. Garcia, Jordan T. Yorgason, Tracianne B. Neilsen, Arminda Suli

Library/Life Sciences Undergraduate Poster Competition 2023

The superior colliculus (SC) is a mammalian midbrain structure involved in multimodal sensory integration and is implicated to have a role in neurodevelopmental disorders. Although the presence of multisensory integrating neurons (MINs) in the SC has been well documented by electrophysiology techniques, little is known about their morphological or molecular characterization. To identify and study MINs, we utilized SC’s non-mammalian homologous structure–the optic tectum (OT)–in the genetically tractable model organism zebrafish. In this process, we generated transgenic lines that allowed for fluorescent detection of neuronal activity by expressing the genetically engineered calcium indicators: cytoRGECO and H2B-jRGECO1a, respectively in mechanosensory hair …

Is God A Magician Or Scientist?, Sarah Palmer, Josh Oliver, Jessica Abele, Jamie Jensen Ph.D

Library/Life Sciences Undergraduate Poster Competition 2023

There is a body of evidence in biology education indicating that most American undergraduate students believe evolution acceptance to be an aesthetic position (1). Introductory biology professors at Brigham Young University have gathered essays written by students entering the class on their experiences with evolution since about 1980. Because BYU is a religious college, most of these students wrote about how their understanding of God impacts their acceptance of evolution. To learn whether student perceptions of God have changed in the past 30 years, we qualitatively analyzed these essays from a cohort of students in 1992 and another cohort of …

Heart Breaking: Rapid Discovery Of Novel Heart Development Genes In Zebrafish, Bryce Johnson, Andrew Jenkins, Ryan Halls, Cayden Bro, Jonathon T. Hill

Library/Life Sciences Undergraduate Poster Competition 2023

Congenital heart defects (CHD) impact approximately 1% with BioRender.com of the U.S. population. Identifying the genes and pathways involved in embryonic heart development is essential to better diagnose and treat CHD. Previous genetic screens were nonspecific and inefficient at finding novel genes To find genes associated with CHD, we ran a novel rapid genetic screening method on zebrafish, an established model for studying human heart development.

The Effect Of Menstruation Duration On The Achilles Tendon Cross-Sectional Area In Female Ballet Dancers, Li Kaitong, Aaron W. Johnson, Steven Allen, Shayla Bott, Chris Dillon, Joshua K. Sponbeck, Camille Nguyen Jones, Annie Allen

Library/Life Sciences Undergraduate Poster Competition 2023

Females are more likely to suffer Achilles tendon injury that consequently leads to more complications including pain or tendon rupture, and experiencing fewer benefits from therapeutic interventions. There is a lack of knowledge on how estrogen, which may limit collagen synthesis, can affect tendon health and growth. The duration and cross-sectional area (CSA) of the Acobjective of this study is to examine the relationship between menstruation hilles tendon over a 5-month period of intensive dance training.

Mystifying Mimics: The Influence Of Distribution On Mimicry, Taylor Probst, Dallin Kohler, Alison Whiting, Jacob Searcy

Library/Life Sciences Undergraduate Poster Competition 2023

Many animals display bright colors or patterns to advertise or warn predators that they are dangerous. Coral snakes effectively use bright red and yellow bands to warn of their venom. There are also many harmless snakes which try to copy or mimic the color patterns of the coral snakes to gain that same protection from predators without the venom. This is known as Batesian mimicry. It has long been thought that for mimicry to be effective, both the dangerous animals and their mimics need to be found in the same geographic area. This study focuses on two species of kingsnake, …

Thc On The Brain: Adult Vs. Adolescent Changes, Addison Smartt, Jeffrey Edwards Phd

Library/Life Sciences Undergraduate Poster Competition 2023

Δ9 -tetrahydrocannabinol (THC) has been demonstrated to cause elimination of cannabinoid 1 receptor (CB1) mediated long term depression (LTD) of GABA neurons in the ventral tegmental area (VTA) of the brain. Through electrophysiology and quantitative PCR experiments, this study reveals that LTD elimination is more pronounced in adolescents than adults, giving an explanation for the increased risk of THC dependency in adolescence. However, after a seven day withdrawal period, these effects were reversed. The data also supports the hypothesis that removal or desensitization of CB1 receptors from the synapse is an important mechanism of THC-induced neural and cognitive changes.

Custom Compression Algorithm Shows Potential To Reduce Tabular Data By A Magnitude Of 17 Using Huffman Coding And N-Grams, Maren Callaway, Stephen R. Piccolo

Library/Life Sciences Undergraduate Poster Competition 2023

Read file and rearrange its contents to a json file that sorts data by column.

Implement Huffman coding using the bitarray package’s canonical Huffman function.

Use the Huffman dictionaries for each column to encode all values.

Compress each line individually using zstandard

A Transcriptomic Analysis Of Triple Negative Breast Cancer Revealing Alternative Drug Therapeutics, Mauri Dobbs Spendlove, Jenna Birchall Poulsen, Naomi Rapier-Sharman, Brett Pickett

Library/Life Sciences Undergraduate Poster Competition 2023

Breast cancer is the most common tumor type in men and women combined this year the National Cancer Institute estimates there will be 290 560 new cases in the United States and 43 780 deaths 1 Triple Negative Breast Cancer ( lacks three typical surface markers of breast cancer estrogen receptor ( progesterone receptor ( and human epidermal growth factor receptor 2 (HER 2 which are common targets for endocrine or drug therapy, severely limiting TNBC treatment options 40 of TNBC patients will die within five years of diagnosis 2 Additionally, it has heightened risk for metastasis after neoadjuvant chemotherapy …

Has Coral Abundance In Hawaii Changed Since 2007?, Natalie Wride, Richard Gill Ph.D

Library/Life Sciences Undergraduate Poster Competition 2023

2nd place poster design

Hypothesis: Molokai, Hawaii’s southern fringing reef has experienced a decrease in coral abundance from 2007 to 2022.

Zero Torque Compliant Mechanisms Employing Pre-Buckled Beams, Pietro Bilancia, Samuel Porter Smith, Giovanni Berselli, Spencer P. Magleby, Larry L. Howell

Faculty Publications

The concept of a statically balanced mechanism with a single rotational degree of freedom is presented. The proposed device achieves static balancing by combining positive stiff- ness elements and negative stiffness elements within a nuclear domain. Two designs are discussed. The first is composed of an Archimedean spiral and two pinned-pinned pre-buckled beams. The overall mechanism is modeled via an analytical approach and the element dimensions are optimized. The optimal configuration is then tested through finite element analysis (FEA). A second approach replaces the spiral beam with elastic custom-shaped spline beams. An FEA optimization is performed to determine the shape …

Child Abuse In Residential Homes Of Ghana, Alyssa Minor

Ballard Brief

Children placed in residential homes in Ghana suffer from physical violence and physical neglect more often than children in family-based homes. In overcrowded residential homes, many basic needs are often not being met, and the use of physical violence is common due to inadequate funding, lack of training, lack of clear policies, and years of normalizing violent disciplinary actions. This problem of child abuse within residential homes of Ghana creates financial burdens on the country and negative psychosocial effects for children suffering from neglect or physical violence, hindering their ability to reach their full earnings potential. Very few interventions have …

The Role Of A Mutated Receptor, Ccrl2 And Its Correlation With A Risk Factor For Alzheimer’S Disease, Colby J. Hendrix, Christopher J. Haynie, Hunter G. Lindsay, Josue D. Gonzalez, Scott Weber

Library/Life Sciences Undergraduate Poster Competition 2023

Alzheimer’s Disease ( is the most common cause of dementia, which is the 5 th leading cause of death While the exact cause of AD is unknown, many suggest that inflammation could be a culprit 1 Inflammation is driven by our immune system A key component of inflammation is chemokine signaling These signaling molecules help guide immune cells to areas of infection and damage Cells use chemokine receptors to interact with secreted chemokines (Fig 1 Left) Some chemokine receptors are identified as atypical chemokine receptors ( because they have different functions than conventional chemokine receptors in the immune system (Fig …

Is There A Link Between Male Gonopodium Size And Mating Strategies Amongst Fish In The Family Poeciliidae?, Ryen Hunsaker, Jerald B. Johnson

Library/Life Sciences Undergraduate Poster Competition 2023

Have different male mating strategies led to evolutionary changes in male gonopodium size?

Natural selection should act strongly on any traits that affect successful reproduction. Fish species in the family Poeciliidae (livebearers) have a unique form of reproduction.

Valproic Acid Affects Neuronal Specification And Differentiation During Early Optic Tectum Development Of Zebrafish, Sierra C. Dixon, Bailey J. Calder, Shane M. Lilya, Brandon M. Davies, Annalie Martin, Maggie Peterson, Jason M. Hansen, Arminda Suli

Library/Life Sciences Undergraduate Poster Competition 2023

The mammalian superior colliculus and its non-mammalian homolog, the optic tectum (OT), are midbrain structures that integrate multimodal sensory inputs and guide non-voluntary movements in response to prevalent stimuli. Recent studies have implicated this structure as a possible site affected in Autism Spectrum Disorder (ASD). Interestingly, fetal exposure to valproic acid (VPA) has also been associated with an increased risk of ASD in humans and animal models. Therefore, we took the approach of determining the effects of VPA treatment on zebrafish OT development as a first step in identifying the mechanisms that allow its formation. We describe the normal OT …

Comorbid Mental Illness In Adults Correspond With Certain Demographics And Higher Rates Of Injuries And Poisoning, Mckay A. Ashton, Ray M. Merrill

Library/Life Sciences Undergraduate Poster Competition 2023

• Mental illness is a common problem among adults aged 18 years and older in the United States, with approximately 21% (15.8% men and 25.8% women) of the population living with a mental, behavioral, or emotional disorder.
• Comorbidity is the presence of at least one other mental health disorder in relation to the index disorder, and has been found to be present in 45% to 54% of those with a mental health disorder
• Although it is well understood that the prevalence of comorbid mental health disorders is common, there is less known about which conditions most commonly occur together and how …

A Comparative Analysis Of Black American Student Experiences And International Student Experiences During The Initial Months Of The Covid-19 Pandemic, Leah P. Hollis Edd

Comparative Civilizations Review

The Covid-19 pandemic created an indelible mark on K-12 education — specifically, high school students transitioning to college and career. The global scope of this pandemic presented an opportunity to compare how high school cultures across the world adapted to the emergency. Further, news reports highlighted how communities of color were more susceptible to the pandemic.

To better understand how the Black student experience in middle America compared to that of other students from the global community in responding to pandemic-related educational disruption, I used Krippendorff’s content analysis procedures (2018) and a phenomenological interview process to gather and analyze data …

Book Review: Katell Berthelot. Jews And Their Roman Rivals: Pagan Rome’S Challenge To Israel, Joseph Drew

Comparative Civilizations Review

This is a magisterial work, one which sets high the bar in the comparative study of civilizations. In it, Prof. Katell Berthelot covers the sweep of 600 years, from the second century, BCE, to the fourth century, CE, as she analyzes the extensive impact of Rome on Jewish ideas of law, religion, and peoplehood and, secondarily, the corresponding impact of their rivals, the Jews, on Roman society and history.