Digital Commons Network^™

Hegel And The Western Spirit, Ricardo Duchesne

Comparative Civilizations Review

No abstract provided.

Spengler's Philosophy And Its Implication That Europe Has "Lost Its Way", David L. Mcnaughton

Comparative Civilizations Review

No abstract provided.

What The West Doesn't Owe Islam, Toby E. Huff

Comparative Civilizations Review

No abstract provided.

Oprm1 Gene Variation Influences Hypothalamic-Pituitary-Adrenal Axis Function In Response To A Variety Of Stressors In Rhesus Macaques, Melanie L. Schwandt, Stephen G. Lindell, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr

Faculty Publications

The endogenous opioid system is involved in modulating a number of behavioral and physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. In humans, a functional variant in the OPRM1 gene (OPRM1 A118G) is associated with a number of outcomes, including attenuated HPA axis responses to stress. A nonsynonymous variant (OPRM1 C77G) in the rhesus macaque has been shown to have similar effects in vivo to the human variant. The current study investigated whether OPRM1 C77G influences HPA axis response to stress in rhesus macaques. We analyzed plasma adrenocorticotropic hormone (ACTH) and cortisol levels measured in response to three different stressors: 1) …

Application Of Seawinds Scatterometer Data To The Study Of Antarctic Icebergs, Keith Mitchell Stuart

Theses and Dissertations

Knowledge of iceberg location and size is important for safety reasons as well as for understanding many geophysical and biological processes. This dissertation analyzes large tabular icebergs in the Southern Ocean using the SeaWinds scatterometer. SeaWinds is a spaceborne radar designed to measure the microwave backscatter from the Earth's surface. Using resolution-enhancement techniques, backscatter measurements are processed into backscatter images in which icebergs can be observed. An iceberg detection methodology is formalized using daily scatterometer images. Radar profiles from common Antarctic scatterers are quantified and an iceberg detection methodology is formalized using daily scatterometer images. Iceberg positions are determined in …

Defining The Role Of Ultrasound In Drug Delivery, William G. Pitt

Faculty Publications

Ultrasound is a very effective modality for drug delivery because energy that is noninvasively transmitted through the skin can be focused on a specific location and employed to release drug at that site. Most of the drug delivery techniques employ one or both of the results of ultrasonic insonation – the generation of thermal energy, called hyperthermia, or the oscillation of gas bubbles, called acoustic cavitation. Cavitation perturbs cell membrane structures via several modes and increases the permeability to drugs or other solutes. Microconvection, caused by stable cavitation, shears cell membranes. The shock waves and fluid jets of inertial cavitation …

The Death Of A Disco Dancer; A Sense Of Order And Other Stories; The Scholar Of Moab, Shelah M. Miner, David M. Clark, Jack Harrell, Steven L. Peck

BYU Studies

DAVID CLARK. The Death of a Disco Dancer. Provo, Utah: Zarahemla Books, 2011.

JACK HARRELL. A Sense of Order and Other Stories. Salt Lake City: Signature Books, 2010.

STEVEN L. PECK. The Scholar of Moab. Torrey, Utah: Torrey House Press, 2011.

As an enthusiastic reader of literary fiction and as someone who is fascinated by Mormon culture, I am always on the lookout for works of literary fiction that contain Mormon themes or Mormon characters. While there are always plenty of new romances on the shelves at Deseret Book, and Mormon authors frequently find commercial and critical success writing science …

Compromising Scholarship: Religious And Political Bias In American Higher Education, George Yancey, Bruce A. Chadwick

BYU Studies

George Yancey, a professor of sociology at the University of North Texas, has focused his research on racial and ethnic bias. His recent books include Interracial Families: Current Concepts and Controversies and Interracial Contact and Social Change. Yancey's newest study in Compromising Scholarship documents the bias of university faculty against members of various groups. Professor Yancey, aware that scientists, just like other Americans, are hesitant to reveal any prejudice or bias, focused his study on "collegiality" in an attempt to distract respondents from the research interest in bias. Yancey conducted his study via Internet survey and blog analyses in the …

Loss Of The Lipopolysaccharide Core Biosynthesis Rfad Gene Increases Antimicrobial Chemokine Binding And Bacterial Susceptibility To Ccl28 And Polymyxin: A Model For Understanding The Interface Of Antimicrobial Chemokines And Bacterial Host Defense Avoidance Mechanisms, Cynthia S. Lew

Theses and Dissertations

In order to better understand the mechanism of antimicrobial chemokine activity, including binding to and killing of bacteria, random transposon mutagenesis was performed in Yersinia pseudotuberculosis. Resulting mutants were screened for increased binding to chemokine and high binding clones were selected for further study. One mutant, designated mutant 27, was found to have a single insertion mutation in the rfaD gene. The rfaD gene product is involved in heptose biosynthesis, one of the sugars of the inner core oligosaccharide of Gram- negative lipopolysaccharide (LPS). Mutant 27 was found to bind both CCL25 and CCL28, two antimicrobial chemokines, more efficiently than …

Membrane Properties Involved In Calcium-Stimulated Microparticle Release From The Plasma Membranes Of S49 Lymphoma Cells, Lauryl Elizabeth Campbell

Theses and Dissertations

The mechanism of microparticle shedding from the plasma membrane of calcium-loaded cells has been investigated in erythrocytes and platelets. Recent studies have revealed the physiological and clinical importance of microparticle release from nucleated cells such as lymphocytes and endothelium. The experiments of this study were designed to address whether simple mechanisms discovered in platelets and erythrocytes also apply to the more complex nucleated cells. Four such mechanisms were addressed: potassium efflux, transbilayer phosphatidylserine migration, cytoskeleton degradation, and membrane lipid order. The rate and amount of microparticle release in the presence of a calcium ionophore, ionomycin, was assayed by light scatter …

Automatic Generation Of Music For Inducing Emotive And Physiological Responses, Kristine Perry Monteith

Theses and Dissertations

Music and emotion are two realms traditionally considered to be unique to human intelligence. This dissertation focuses on furthering artificial intelligence research, specifically in the area of computational creativity, by investigating methods of composing music that elicits desired emotional and physiological responses. It includes the following: an algorithm for generating original musical selections that effectively elicit targeted emotional and physiological responses; a description of some of the musical features that contribute to the conveyance of a given emotion or the elicitation of a given physiological response; and an account of how this algorithm can be used effectively in two different …

Effectiveness Of Phosphorus Fertilizers In Hydroponics And Glasshouse Settings With Moderate And High Organic Matter Soils, Jeffrey Sean Christian Summerhays

Theses and Dissertations

Phosphorus (P) is poorly soluble in most soils and, thus, has poor plant uptake efficiency. AVAIL® and Carbond P (CBP) are new fertilizer products shown to increase P use efficiency (PUE) and increase crop yields when grown in P limiting soils. Carbond P has specifically been seen to increases P uptake and crop yields in soils low in P, although effectiveness in regards to soil organic matter is unknown. The objectives of these studies were to determine if the mode of action for these products is related to physiological response, to determine if Carbond P is toxic to plant roots …

A Confidence-Prioritization Approach To Data Processing In Noisy Data Sets And Resulting Estimation Models For Predicting Streamflow Diel Signals In The Pacific Northwest, Nathaniel Lee Gustafson

Theses and Dissertations

Streams in small watersheds are often known to exhibit diel fluctuations, in which streamflow oscillates on a 24-hour cycle. Streamflow diel fluctuations, which we investigate in this study, are an informative indicator of environmental processes. However, in Environmental Data sets, as well as many others, there is a range of noise associated with individual data points. Some points are extracted under relatively clear and defined conditions, while others may include a range of known or unknown confounding factors, which may decrease those points' validity. These points may or may not remain useful for training, depending on how much uncertainty they …

Characterizing The Role Of Hspb2 In Cardiac Metabolism And Muscle Structure Using Yeast And Mammalian Systems, Jonathan Paul Neubert

Theses and Dissertations

HspB2 is a small heat shock protein encoded on human chromosome 11. Less than 1000 base pairs away from HSPB2 and situated in a head-to-head orientation lies the gene encoding another small heat shock protein, CRYAB. Because they are uncommonly close to one another they share regulatory elements. In addition, they share protein homology as sHSPs, suggesting that they perhaps perform aimilar functions. SHSPs such as HspB2 and CryAB are traditionally thought to provide protective effects to cells in response to a variety of stress inducers. In response to stress they form complexes around misfolded proteins or proteins in danger …

Gas Phase Characterization Of Supramolecules Using Cross-Sectional Areas By Fticr And Sustained Off-Resonance Irradiation Collision Induced Dissociation Techniques In A Fourier Transform Ion Cyclotron Resonance Mass Spectrometer, Fan Yang

Theses and Dissertations

In my dissertation, I use a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR-MS) to investigate supramolecules. Cross-sectional areas by Fourier transform ICR (CRAFTI), a novel technique for measurements of collision cross sections by FTICR, is demonstrated for the first time. The CRAFTI method measures the total "dephasing cross section" for removal of the ions from the coherent packet in the FTICR cell, including contributions not only from momentum transfer but also from reactive collisions including those leading to collisional dissociation. Experimental CRAFTI collision cross sections correlate linearly with theoretically computed results and with results obtained using ion mobility measurements. …

Translocation Mortality And Local, Regional, And Continental Diet Of The Northern River Otter (Lontra Canadensis), Casey Craig Day

Theses and Dissertations

The northern river otter (Lontra canadensis) is a semi-aquatic carnivore whose range extends throughout most of the United States and Canada. The northern river otter experienced a severe range contraction post-European settlement, but due to widespread management has in recent decades begun to recover much of its former range and habitat. We translocated 27 river otters from Utah and Idaho to the Provo River, Utah from November 2009 through January 2012 in a reintroduction effort to restore the northern river otter to its native range. Of these 27 otters, 6 died as a result of effects related to the translocation. …

Flow Valve Diagnostics For Label-Free, Quantitative Biomarker Detection: Device Fabrication, Surface Modification, And Testing, Danielle Scarlet Mansfield

Theses and Dissertations

Diseases are often diagnosed by detection of disease-specific biomarkers in fluid samples. However, many state-of-the-art detection methods require a lab with complex machinery, trained operators, and/or lengthy analysis time. In contrast, point-of-care (POC) devices are brought to the patient's location, they are easy to use, and results are obtained almost immediately. Many current POC devices are too difficult to be used without a skilled assistant, and although many are able to detect analytes above a threshold value, they give little or no quantitative information. This work presents the development of polymer-based microfluidic devices capable of sensing and quantifying biomarkers in …

Characterization Of The Cellular And Organellar Dynamics That Occur With A Partial Depletion Of Mitochondrial Dna When Arabidopsis Organellar Dna Polymerase Ib Is Mutated, John D. Cupp

Theses and Dissertations

Plant mitochondrial genomes are large and complex, and the mechanisms for maintaining mitochondrial DNA (mtDNA) remain unclear. Arabidopsis thaliana has two DNA polymerase genes, polIA and polIB, that have been shown to be dual localized to mitochondria and chloroplasts but are unequally expressed within primary plant tissues involved in cell division or cell expansion. PolIB expression is observed at higher levels in both shoot and root apexes, suggesting a possible role in organelle DNA replication in rapidly dividing or expanding cells. It is proposed that both polIA and polIB are required for mtDNA replication under wild type conditions. An Arabidopsis …

Synthesis And Biological Evaluation Of Various Derivatives Of A Broad-Spectrum Anticancer Nucleoside, Jadd R. Shelton

Theses and Dissertations

Recently the Peterson lab discovered a promising anticancer adenosine derivative-- 2´,3´-bis-O-tert-butyldimethylsilyl-5´-deoxy-5´-[N-(methylcarbamoyl)amino]-N6-(N-phenylcarbamoyl)adenosine. This compound showed selective toxicity against human colon cancer cells in vitro with LC50's = 6--10 µM. It was hypothesized that the lead compound exerted its cytotoxic effects by interacting with a protein kinase. A systematic Structure Activity Relationship (SAR) was undertaken in an attempt to increase the kinase-binding affinity of the lead compound. Many regions of the lead compound were examined: the N6-phenyl urea moiety, the 5´-N-methyl urea group, the 2´,3´-bis-O-TBS groups, the nucleobase, and the ribose sugar. Results of these studies produced some promising new derivatives. In …

The Forgotten Medium: The Impact Of Reading Violent Literature On Aggressive Thoughts, Mckay Robert Stevens

Theses and Dissertations

Media violence in television, film, video games, and music has been linked to increased aggression. Only in recent years have researchers begun to investigate the impact that reading violent literature can have on individuals. The present study exposed individuals to either a violent or nonviolent story and measured aggressive cognitions. No significant effect was found for story type on aggressive cognitions but a gender effect for aggressive word completions was found. Discussion centers on possible differences between media types as well as future suggestions for investigations into violent literature.

The Longitudinal Stability Of Memory In Males With Autism Spectrum Disorder, Alexander J. Cramond

Theses and Dissertations

Previous research has demonstrated mixed evidence on impaired memory functioning in autism spectrum disorder (ASD), with the only consensus that there appears to be much heterogeneity. In addition, no research to date has examined the stability of memory in ASD. This study examined the stability of memory function in ASD compared to typically developing age-matched controls. Participants were administered the Test of Memory and Learning (TOMAL) twice, three years apart, in an established longitudinal NIH-supported investigation of ASD. Based on available research contrasting memory development in healthy individuals versus those with ASD, it was hypothesized that memory performance in the …

Fine-Scale Habitat Use Of Reintroduced Black-Footed Ferrets On Prairie Dog Colonies In New Mexico, Jennifer G. Chipault, Dean E. Biggins, James K. Detling, Dustin H. Long, Robin M. Reich

Western North American Naturalist

Black-footed ferrets (Mustela nigripes) are among the most endangered animals in North America. Reintroductions of captive-born ferrets onto prairie dog (Cynomys spp.) colonies are crucial to the conservation of the species. In September 2007, captive-born ferrets were released on a black-tailed prairie dog (Cynomys ludovicianus) colony at the Vermejo Park Ranch, New Mexico. Ferret kits experimentally released in areas of comparatively low and high prairie dog burrow densities were located via spotlight surveys. Some maturing ferret kits were subsequently translocated to areas of low and high burrow densities on nearby prairie dog colonies. For 2 …

Information On Black-Footed Ferret Biology Collected Within The Framework Of Ferret Conservation, Dean E. Biggins

Western North American Naturalist

Once feared to be extinct, black-footed ferrets (Mustela nigripes) were rediscovered near Meeteetse, Wyoming, in 1981, resulting in renewed conservation and research efforts for this highly endangered species. A need for information directly useful to recovery has motivated much monitoring of ferrets since that time, but field activities have enabled collection of data relevant to broader biological themes. This special feature is placed in a context of similar books and proceedings devoted to ferret biology and conservation. Articles include general observations on ferrets, modeling of potential impacts of ferrets on prairie dogs (Cynomys spp.), discussions on relationships …

Black-Footed Ferret Digging Activity In Summer, David A. Eads, Dean E. Biggins, Dustin Marsh, Joshua J. Millspaugh, Travis M. Livieri

Western North American Naturalist

Black-footed ferrets (Mustela nigripes) excavate soil from prairie dog (Cynomys spp.) burrows, thereby creating characteristic soil deposits at burrow openings. These soil deposits have been observed only rarely in summer. We monitored adult ferrets during June–October of the years 2007 and 2008 on a 452-ha colony of black-tailed prairie dogs (Cynomys ludovicianus) in the Conata Basin, South Dakota. We located and identified ferret excavations during nighttime spotlight surveys for ferrets and daytime sampling of prairie dog burrow openings around locations where ferrets were located via spotlight. We accumulated 48 observations of in-process or recently completed …

Digging Behaviors Of Radio-Tagged Black-Footed Ferrets Near Meeteetse, Wyoming, 1981–1984, Dean E. Biggins, Louis R. Hanebury, Kathleen A. Fagerstone

Western North American Naturalist

Intensive radio-tracking during August–December enabled us to collect detailed information on digging behaviors of a small sample of black-footed ferrets (Mustela nigripes) occupying colonies of white-tailed prairie dogs (Cynomys leucurus). A sample of 33 prairie dogs, also radio-tagged, progressively ceased aboveground activity during late summer and fall, presumably as they descended into burrows to hibernate. Most of the time ferrets spent digging was in November–December when >95% of the radio-tagged prairie dogs were inactive, suggesting that digging was primarily to excavate hibernating prey. Although 43.9% of the burrow openings were estimated to be in large mounds, …

Patterns Of Surface Burrow Plugging In A Colony Of Black-Tailed Prairie Dogs Occupied By Black-Footed Ferrets, David A. Eads, Dean E. Biggins

Western North American Naturalist

Black-tailed prairie dogs (Cynomys ludovicianus) can surface-plug openings to a burrow occupied by a black-footed ferret (Mustela nigripes). At a coarse scale, surface plugs are more common in colonies of prairie dogs occupied by ferrets than in colonies without ferrets. However, little is known about spatial and temporal patterns of surface plugging in a colony occupied by ferrets. In a 452-ha colony of black-tailed prairie dogs in South Dakota, we sampled burrow openings for surface plugs and related those data to locations of ferrets observed during spotlight surveys. Of 67,574 burrow openings in the colony between …

Importance Of Lunar And Temporal Conditions For Spotlight Surveys Of Adult Black-Footed Ferrets, David A. Eads, David S. Jachowski, Joshua J. Millspaugh, Dean E. Biggins

Western North American Naturalist

Black-footed ferrets (Mustela nigripes) spend most daylight hours underground in prairie dog (Cynomys) burrows and exhibit aboveground movements primarily at night. Moonlight can influence the activity patterns of ferrets and, consequently, might influence the efficiency of spotlight surveys used by biologists to monitor ferret populations. We related detection of adult ferrets during postbreeding spotlight surveys to lunar and temporal conditions. We most frequently located ferrets during surveys in which the moon breached the horizon. The data suggested intersexual differences in response to moonlight. We located male ferrets most frequently during nights with greater moon illumination, but …

Resource Selection Models Are Useful In Predicting Fine-Scale Distributions Of Black-Footed Ferrets In Prairie Dog Colonies, David A. Eads, David S. Jachowski, Dean E. Biggins, Travis M. Livieri, Marc R. Matchett, Joshua J. Millspaugh

Western North American Naturalist

Wildlife-habitat relationships are often conceptualized as resource selection functions (RSFs)—models increasingly used to estimate species distributions and prioritize habitat conservation. We evaluated the predictive capabilities of 2 black-footed ferret (Mustela nigripes) RSFs developed on a 452-ha colony of black-tailed prairie dogs (Cynomys ludovicianus) in the Conata Basin, South Dakota. We used the RSFs to project the relative probability of occurrence of ferrets throughout an adjacent 227-ha colony. We evaluated performance of the RSFs using ferret space use data collected via postbreeding spotlight surveys June–October 2005–2006. In home ranges and core areas, ferrets selected the predicted “very …

Challenges To Black-Footed Ferret Recovery: Protecting Prairie Dogs, Brian Miller, Richard P. Reading

Western North American Naturalist

The black-footed ferret (Mustela nigripes) recovery program is an example of single-species management to preserve flora and fauna. We argue that conservationists must move beyond that approach for success. In 1988, the U.S. Fish and Wildlife Service proposed a down-listing goal of 1500 adult black-footed ferrets in 10 wild populations by 2010. The recovery program has only reached 23% of that goal. The overriding reason is the lack of regulatory mechanisms for poisoning and shooting prairie dogs (Cynomys spp.) and our inability to control occurrence of plague (Yersinia pestis) in prairie dogs. We propose that …

Use Of Multi-Opening Burrow Systems By Black-Footed Ferrets, Dean E. Biggins

Western North American Naturalist

Multi-opening burrow systems constructed by prairie dogs (Cynomys) ostensibly provide escape routes when prairie dogs are pursued by predators capable of entering the burrows, such as black-footed ferrets (Mustela nigripes), or by predators that can rapidly dig into the tunnels, such as American badgers (Taxidea taxus). Because badgers also prey on ferrets, ferrets might similarly benefit from multi-opening burrow systems. Using an air blower, white-tailed prairie dog (Cynomys leucurus) burrow openings were tested for connectivity on plots occupied by black-footed ferrets and on randomly selected plots in Wyoming. Significantly more connected openings …