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Facile Synthesis And Characterization Of A Thermally Stable Silica-Doped Alumina With Tunable Surface Area, Porosity, And Acidity, Maryam Khosravi Mardkhe

Theses and Dissertations

Mesoporous γ-Al2O3 is one of the most widely used catalyst supports for commercial catalytic applications. The performance of a catalyst strongly depends on the combination of textural, chemical and physical properties of the support. Pore size is essential since each catalytic system requires a unique pore size for optimal catalyst loading, diffusion and selectivity. In addition, high surface area and large pore volume usually result in higher catalyst loading, which increases the number of catalytic reaction sites and decreases reaction time. Therefore, determination of surface area and porosity of porous supports is critical for the successful design and optimization of …

Different Expression Of Placental Pyruvate Kinase M2 In Normal, Preeclamptic, And Intrauterine Growth Restriction Pregnancies, Brigham L. Bahr

Theses and Dissertations

This thesis will be organized into two chapters discussing the placental expression of two proteins, pyruvate kinase M2 (PKM2) and heat shock protein 27 (HSP 27), in human placentas. Understanding the mechanisms of placental metabolism in healthy and diseased placentas helps us understand how placenta disorders occur and how we can treat these disorders. The goal is to investigate these proteins to gain an understanding of their roles in placental disorders and help decrease maternal and fetal mortality rates. Chapter one covers the background of pyruvate kinase M2 (PKM2) in cancer and embryonic tissues, and the expression of PKM2 in …

The Relationship Between Partner Perceptions Of Marital Power And Sexual Satisfaction As Mediated By Observed Hostile Interaction, Amanda Claire Christenson

Theses and Dissertations

Using a sample of 322 married couples (644 spouses) from The Flourishing Families project, this study examined the relationship between marital power and sexual satisfaction as mediated by observed hostile interaction. More specifically, an actor-partner interdependence model (APIM) was used in which husband and wife perceptions of their partner's power were hypothesized to be related to husband and wife self-report of sexual satisfaction, with husband and wife observed hostile interaction as possible mediating variables. Results showed that husband and wife perceptions of power were positively related to their respective husband and wife sexual satisfaction and positively related to their respective …

Romantic Relational Aggression In Parents And Adolescent Child Outcomes, Jennifer Nicole Hawkley

Theses and Dissertations

The purpose of this study was to examine marital romantic relational aggression in parents and its impact on adolescent relational aggression, adolescent romantic relational aggression, internalizing, and school engagement with self-regulation as a potential mediator. Gender differences were also examined. Adolescents were from 328 two-parent families in a large north-western city in the United States and were between 12 and 17 years of age (M=14.24, SD=1.00, 51% female) at time 4. All independent variables except adolescent self-regulation were measured at wave 4, and all adolescent variables were measured at wave 5. Results indicate that higher levels of romantic relational aggression …

Fire Severity And Size Alter Quaking Aspen (Populus Tremuloides) Regeneration And Defense Against Ungulate Herbivory, Ho Yi Wan

Theses and Dissertations

Human activities and rapid global climate change are altering fire regimes with potential threat to the stability of aspen ecosystems in North America. Aspen is an early successional species that plays an important role in post-fire forest reestablishment, but chronic browsing on juvenile aspen by large ungulate herbivores after fire can be detrimental and lead to regeneration failure. Although larger and more severe fires are expected to become more prominent, whether and how this may influence aspen and ungulate communities remains unclear. The objective of this research was to examine how the relationship between aspen and ungulate communities might be …

Parturition Of Mule Deer In Southern Utah: Management Implications And Habitat Selection, Eric D. Freeman

Theses and Dissertations

Mule deer (Odocoileus hemionus) are an ecologically, economically, and socially important species across much of the western United States. As such, populations and habitat are intensely managed by state game agencies. However, populations have been declining in recent decades and several factors have been implicated (e.g., climate, predation, competition, and habitat availability). Population dynamics of mule deer are driven by a combination of survival of adults and juveniles and reproductive rates. While adult female mule deer typically have consistently high annual survival rates (85% annually), juveniles are more easily affected by stressors (biotic and abiotic conditions) and therefore …

Achilles Tendon Changes In Downhill, Level And Uphill Running, Katy Andrews Neves

Theses and Dissertations

In this study, we examined how hill running affects the Achilles tendon, which is a common location for injuries in runners. Twenty females ran for 10 min on three randomly selected grades (-6%, 0%, +6%). Achilles tendon (AT) cross-sectional area (CSA) was imaged using Doppler ultrasound and peak vertical forces were analyzed using high-speed (240 Hz) videography. A metabolic cart and gas analyzer ensured a similar metabolic cost across grades. Data were analyzed using a forward selection regression. Results showed a decrease in AT CSA from pre-run to post-run (p = .0001). Peak vertical forces were different across grades (p …

Sense Of Community In A Blended Technology Integration Course: A Design-Based Research Study, John Buckley Harrison

Theses and Dissertations

This design-based research study explored whether Sense of Community was maintained while flexibility in the course was increased through an adoption of a unique blended learning model. Data collected in this study show a significant drop in the sense of connectedness score from a mean of 50.8 out of 66 to a mean of 39.68 in the first iteration. The score then began to gradually increase, reaching 50.65 in the third iteration. Results indicate that transitioning to a blended learning environment may be a suitable option to increase flexibility while maintaining a Sense of Community in a project-based course. Future …

Soil Fertility Status And Degradation Of 2, 4, 6-Trinitrotoluene Contaminated Soils, Chelsea Kae Katseanes

Theses and Dissertations

Current models for predicting the environmental fate of munitions constituents (MC) in soils are based mostly on chemical distribution parameters and neglect the larger considerations of other soil parameters. We are working towards a new approach based on the whole soil activity for predicting the long-term residence time and fate of MC in soils with connection to agronomic soil fertility concepts. These relationships are demonstrated by correlating experiments involving full physical and chemical characterization of eight taxonomically distinct soils, with batch reactor studies determining MC degradation potential. Soils were incubated in a slurry for 10 days in a closed reactor …

Nascent Peptides That Induce Translational Arrest, Christopher J. Woolstenhulme

Theses and Dissertations

Although the ribosome is a very general catalyst, it cannot synthesize all protein sequences equally well. Certain proteins are capable of stalling the ribosome during their own synthesis. Stalling events are used by both prokaryotic and eukaryotic cells to regulate gene expression. Characterization of natural stalling peptides shows that only a few strategically placed amino acids are needed to inactivate the ribosome. These motifs share little sequence similarity suggesting that there are more stalling motifs yet to be discovered. Here we use two genetic selections in E. coli to discover novel stalling peptides and detail their subsequent characterization. Kinetic studies …

A Modified Approach To The Implementation Of Dynamic Written Corrective Feedback, Brooke Elizabeth Eddington

Theses and Dissertations

Grammatical accuracy in second language (L2) writing is one of the key issues that English as a Second Language (ESL) learners struggle with, both in intensive English language programs and continuing after their university matriculation. Numerous instructional methodologies exist that center around the concept of error correction—how can or should ESL instructors correct grammatical errors in L2 students' writing to best facilitate improvements in written linguistic accuracy? Error correction in L2 writing has been a controversial issue for over a decade (e.g., Ferris, 1999; Truscott, 1996), and in an effort to contribute to an understanding of this controversial topic, this …

Aircraft Route Optimization For Formation Flight, Jia Xu, Andrew Ning, Geoffrey Bower, Ilan Kroo

Faculty Publications

We quantify the fuel and cost benefits of applying extended formation flight to com- mercial airline operations. Central to this study is the development of a bi-level, mixed integer-real formation flight optimization framework. The framework has two main components: 1) a continuous domain aircraft mission performance optimization and 2) an integer optimization component that selects the best combination of optimized missions to form a formation flight schedule. The mission performance reflects the effects of rolled-up wakes, formation heterogeneity, and formation-induced compressibility. The results show that an airline can use formation flight to reduce fuel burn by 5.8% or direct operating …

Post-Den Emergence Behavior And Den Detection Of Polar Bears (Ursus Maritimus) In Northern Alaska And The Southern Beaufort Sea, Rusty Wade Robinson

Theses and Dissertations

Pregnant polar bears (Ursus maritimus) construct maternal dens out of snow in the autumn where they give birth to and raise altricial young. In recent years, there has been a decrease in polar sea ice extent and thickness, which has led to changes in denning behavior. One such change in the southern Beaufort Sea (SBS) is that polar bears are selecting maternal den sites on land, rather than on unstable sea ice. This change, coupled with expanding petroleum exploration along Alaska's North Slope, heightens the likelihood of bear-human interactions at maternal den sites. The purpose of this research …

The Effects Of Aging On Skeletal Muscle Ampk Activation And An Analysis Of Chronic Aicar Treatment On The Aging Phenotype, Shalene E. Hardman

Theses and Dissertations

AMP-activated protein kinase (AMPK), a metabolic regulator, acts in opposition to many of the effects of aging and may provide insights into the development of sarcopenia. However, the effect of aging on AMPK activation is unclear. The purpose of this dissertation was to: 1) clarify the controversy concerning the activation of AMPK in response to endurance-like exercise in aged skeletal muscle; 2) address mechanisms for the age-associated alterations in AMPK activation; and 3) address the known benefits of chronic AICAR treatment in aged skeletal muscle. First, to clarify the effect of age on AMPK activation, young adult (YA) (8 mo.) …

Endocannabinoid Biosynthetic Enzyme Mrna: Patterns Of Expression In Hippocampus And Ventral Tegmental Area And Effects On Synaptic Plasticity, Collin Brutch Merrill

Theses and Dissertations

Endocannabinoids (eCBs) are lipophilic signals that are produced by postsynaptic neurons in an activity-dependent manner, and signal in a retrograde fashion to modulate neurotransmitter release. As such, eCBs are highly involved in synaptic plasticity, a process that strengthens or weakens synapses. eCB-mediated synaptic plasticity is involved in many brain processes including learning, short-term memory, and adaptive reward, which are processed in the hippocampus and ventral tegmental area (VTA), respectively. However, the expression of eCB biosynthetic enzyme mRNA within hippocampal and VTA neurons, as well as the relationship between these mRNA species and the occurrence of synaptic plasticity, remains unclear. The …

High-Resolution Mri For 3d Biomechanical Modeling: Signal Optimization Through Rf Coil Design And Mr Relaxometry, James A. Badal

Theses and Dissertations

Computed Tomography (CT) is often used for building 3D biomechanical models of human anatomy. This method exposes the subject to a significant x-ray dose and provides limited soft-tissue contrast. Magnetic Resonance Imaging (MRI) is a potential alternative to CT for this application, as MRI offers significantly better soft-tissue contrast and does not expose the subject to ionizing radiation. However, MRI requires long scan times to achieve 3D images at sufficient resolution, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). These long scan times can make subject motion a problem. This thesis describes my work to reduce scan time while achieving sufficient …

Morphological Divergence Driven By Predation Environment Within And Between Species Of Brachyrhaphis Fishes, Spencer J. Ingley, Eric J. Billman, Mark C. Belk, Jerald B. Johnson

Faculty Publications

Natural selection often results in profound differences in body shape among populations from divergent selective environments. Predation is a well-studied driver of divergence, with predators having a strong effect on the evolution of prey body shape, especially for traits related to escape behavior. Comparative studies, both at the population level and between species, show that the presence or absence of predators can alter prey morphology. Although this pattern is well documented in various species or population pairs, few studies have tested for similar patterns of body shape evolution at multiple stages of divergence within a taxonomic group. Here, we examine …

Inhibition Of Pim And Axl Kinases As Potential Treatments For A Variety Of Hematological Malignancies And Solid Tumors, Kent James Carpenter

Theses and Dissertations

This thesis is divided into three chapters. In each case, the goal is to achieve inhibition of a growth kinase (PIM or AXL) and subsequent arrest of cell growth and induction of apoptosis (in vitro cell culture models) or decrease in tumor volume (in vivo xenograft studies). Chapter one and chapter two discuss inhibition of proviral integration site for Moloneymurine leukemia virus (PIM) kinases. The three PIM kinases, PIM-1, PIM-2, and PIM-3, are a subfamily of serine/threonine kinases that are known to be involved in signaling pathways as downstream effectors of signal transducer and activator of transcription-5 (STAT5) signaling and …

Molecular Characterization Of Pathways Involved In Pas Kinase Regulation And Function, Julianne H. Grose

Journal of Undergraduate Research

The academic objectives of this MEG were to provide novel findings in the field of metabolic regulation while training both graduate and undergraduate students. We were able to meet these objectives as evidenced by one published scientific article, one article accepted upon minor revision, and one in preparation. In addition, fifteen oral presentations or posters were presented at scientific meetings on findings directly obtained from this MEG. Furthermore, these findings helped obtain NIH funding in 2012 that will continue through 2015, allowing for further scientific advance and training of students.

The Role Of The Kshv Lana Protein In Development Of Persistent Infections In Vivo, Bradford Berges

Journal of Undergraduate Research

Several of my students have moved on to future positions, as follows: Medical school: Marshall Sheide, Stanton Nielsen, German Cuadra Graduate school: Jamie Gardiner, Steve Hallam (still interviewing) Currently employed: Joel Gardner, Wittnee Estes

Meg Final Report, Jeff Edwards, John Smith

Journal of Undergraduate Research

The objectives of this award were met, especially in regard to the mentoring focus of the award. The students have been mentored and trained in an effective manner as outlined in my Mentoring Plan (see below). This includes mentoring students in research, writing, publishing, presenting at conferences, acceptance to professional schools, etc. Indeed, all the students graduating from my lab during this time were accepted to the professional school of their choice (see students listed below). Research, especially where the students are actually involved in all aspects of it including data collection and analysis, as well as publishing can play …

Mentoring Undergraduates Via Organic Synthesis, Steven L. Castle

Journal of Undergraduate Research

This report summarizes the results of the mentoring environment in my laboratory that were generated from January 2012 to present. During this period, a total of seven undergraduates performed research in my laboratory. Their names and accomplishments are listed below.

Role Of Primary Cilia In Osteoarthritis, David Kooyman

Journal of Undergraduate Research

Mentoring in my lab in 2012 has led to both tangible and intangible results. The tangible results for this year include two posters presented at an international meeting by undergraduate students, ORCA grants received by two students, international recognition by a team of undergraduate students, two papers published, three papers in preparation to be submitted within 30 days. The intangible results come as students return from interviews to medical and dental schools with stories of how confident they felt talking about their research. They also come in the form of the excitement I see in students when they talk about …

Student Mentoring In Research: Laser-Activated Drug Delivery To Cancer Cells, William G. Pitt

Journal of Undergraduate Research

Summary of Scope of Proposal This proposal was submitted in October of 2011 to organize and fund a mentoring group in the Pitt lab in Chemical Engineering. Marjan Javadi, then a PhD candidate in Chemical Engineering, and 5 uldergraduate students participated in this research group. The purpose was 2-­‐fold, both scientific and pedagogical. On the scientific side, Marjan was working on her PhD research to develop a novel drug delivery system called an eLiposome that encapsulated a drug along with a nanoemulsion that turns from liquid to gas upon exposure to ultrasound. The ultrasound can be non-­‐invasively (no surgery or …

Computational Health Science Collaborative: Interdisciplinary Mentoring For Public Health And Computer Science Students, Michael D. Barnes

Journal of Undergraduate Research

Computational health science, as we define it, represents the application of innovative computer science tools, including social media and data mining, to addressing health-­‐ related questions and problems. With multidisciplinary student mentoring as our aim, we have established the BYU Computational Health Science Research Collaborative (CHeSRC), which integrates the analytical strengths and skills of health scientists and computer scientists, supported by complementary expertise from other researchers, practitioners, and disciplines as applicable (http://dml.cs.byu.edu/chs/). As stated on the CHeSRC website, our mission is to better understand how technology can affect human interactions and enhance supporting environments by conducting innovative research that will …

Effect Of Epigenetic Modification Of Dna On Nucleosome Formation, Steven M. Johnson

Journal of Undergraduate Research

The following two specific Aims are from my 2011 MEG. We made great progress and completed Aim 1 and modified our Aim 2. Below I will give a status report for each Aim.

Targeting Iga Antibody Responses To Mucosal Tissues Through Chemokine Receptor Manipulation, Eric Wilson

Journal of Undergraduate Research

Proper functioning of cells of the immune system is highly dependent on their efficient accumulation to tissues where infection may occur. These cells migrate throughout the body to sites of possible infection via arteries and blood vessels, much like commuters travel to their places of employment via highways and city streets. Just as commuters must take the appropriate off-ramps to get to their desired destination and then enter their work place, white blood cells must also exit the blood vessels of the body at appropriate locations and enter their destination tissues to effectively protect the host from infection.

Creating Student-¬‐Experts In Hydroecology, Richard Gill

Journal of Undergraduate Research

The National Research Council, in its report on how people learn, identified key differences between novices and experts (Bransford et al. 2000; Donovan and Bransford 2005). One of the grand challenges of education is to shepherd students through the process of becoming experts. Mentored research experiences are a critical component of this process as students “grow in skills and increase in responsibility” (Mentoring Principle #3) and participate in projects that “extend well beyond the routine” and “[develop] of new concepts of learning” (Mentoring Principle #5). Bransford et al. (2000) emphasized that developing into an expert requires, among other things, (1) …

Ampk Activation In Aged Skeletal Muscle After Muscle Contraction, David M. Thomson

Journal of Undergraduate Research

The purpose of this mentoring environment grant was to determine the effect of aging on skeletal muscle AMPK intracellular localization and activation by muscle contraction. Funding for the project is now completed. The primary research objectives and findings are listed below:

Mechanisms And Consequences Of Conifer Expansion In Aspen Forests, Sam St. Clair

Journal of Undergraduate Research

We fully met the objectives of the study and have published numerous papers from the proposed work.

The mentoring environment was highly successful based on the high number of student co-authors and the more than 15 undergraduate students mentored during that two year period.