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Validation Of An Nbmp2 Mutant Mouse Model, Laura C. Bridgewater Mar 2015

Validation Of An Nbmp2 Mutant Mouse Model, Laura C. Bridgewater

Journal of Undergraduate Research

Work in the Bridgewater Lab over the last several years has focused on elucidating the function of a novel protein we discovered, nBmp2. The initial discovery presenting work performed in cultured cells (rather than whole animals) was published back in 2010 and we subsequently constructed a mutant mouse line in which nBmp2 is disrupted. Much evidence was accumulating to show that the mice have problems with muscle function, neurological function, and immune function, but some fundamental experiments necessary to validate the mouse model had been giving us problems. The absence of that data prevented us from publishing any reports on …

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The Role Of Wnt Signaling In Normal Muscle Development And Disease, Jeffery Barrow Mar 2015

The Role Of Wnt Signaling In Normal Muscle Development And Disease, Jeffery Barrow

Journal of Undergraduate Research

My laboratory studies the role of Wnt signaling in regulating important events during embryogenesis. In order to better understand the function of this pathway, we study mouse mutants that lack the Porcupine (Porcn) gene which encodes a protein that is required for the secretion of all Wnt molecules. Prior to obtaining the MEG grant entitled: The role of Wnt signaling in normal muscle development and disease, we had demonstrated that mice lacking Porcn activity in the ventral limb ectoderm exhibit a thinning of the ventral limb ectoderm, loss of epidermal appendages and loss of muscle and tendons in the underlying …

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Byu Meg Report, Emily Bates Mar 2015

Byu Meg Report, Emily Bates

Journal of Undergraduate Research

The academic objectives were met by the proposal. Students learned to sequence DNA and to interpret the sequence to know if there was a rare genetic change occurring in the sequence that they interpreted. Students learned to write academic abstracts, introductions, results, and conclusions in the format of an academic journal. Furthermore, together the students determined that the genetic change in a family with an inherited syndrome of birth defects was not one that had previously been identified or described.

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Mentoring Undergraduates Via Organic Synthesis, Steven L. Castle Mar 2015

Mentoring Undergraduates Via Organic Synthesis, Steven L. Castle

Journal of Undergraduate Research

This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2013 to the present. A total of eight undergraduates participated in the mentoring environment during this period.

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A Sequence Variant In Human Kalrn Impairs Protein Function And Coincides With Reduced Cortical Thickness, Derin J. Cobia, Theron A. Russell, Katherine D. Blizinsky, Michael Cahill, Zhong Xie, Robert A. Sweet, Jubao Duan, Pablo V. Gejman, Lei Wang, John G. Csernansky, Peter Penzes Mar 2015

A Sequence Variant In Human Kalrn Impairs Protein Function And Coincides With Reduced Cortical Thickness, Derin J. Cobia, Theron A. Russell, Katherine D. Blizinsky, Michael Cahill, Zhong Xie, Robert A. Sweet, Jubao Duan, Pablo V. Gejman, Lei Wang, John G. Csernansky, Peter Penzes

Faculty Publications

Dendritic spine pathology is a key feature of several neuropsychiatric disorders. The Rac1 guanine nucleotide exchange factor kalirin-7 is critical for spine morphogenesis on cortical pyramidal neurons. Here we identify a rare coding variant in the KALRN gene region that encodes the catalytic domain, in a schizophrenia patient and his sibling with major depressive disorder. The D1338N substitution significantly diminished the protein's ability catalyze the activation of Rac1. Contrary to wild-type kalirin-7, kalirin-7-D1338N failed to increase spine size and density. Both subjects carrying the polymorphism displayed reduced cortical volume in the superior temporal sulcus (STS), a region implicated in schizophrenia. …

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Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen Mar 2015

Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen

Journal of Undergraduate Research

The resistance of tumor cells to chemotherapy is a critical problem in the clinic and is a common cause of mortality in cancer. Emerging data suggests that resistance to chemotherapy is caused by a tumor-expressed protein called 14-3-3ζ, yet the mechanism to explain 14-3-3ζ-mediated chemoresistance is not completely understood (1). Rapid growing tumors often outgrow their blood supply resulting in regions of hypoxia (low glucose and oxygen). These cells must adapt or die and those that do adapt often become metastatic and chemoresistant. A recently proposed mechanism by which cancer cells are able to adapt to hypoxia is via autophagy, …

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Advancing Biomechanical Research Through A Camelid Model Of The Human Lumbar Spine, Dean K. Stolworthy Mar 2015

Advancing Biomechanical Research Through A Camelid Model Of The Human Lumbar Spine, Dean K. Stolworthy

Theses and Dissertations

The increasing incidence of disc degeneration and its correlation with lower back pain is an alarming trend in modern society. The research of intervertebral disc degeneration and low back pain would greatly benefit from additional methods to study its etiology and possible treatment methods. A large animal model that maintains the biological and mechanical environment that is most similar to the human lumbar spine could provide substantial improvements in understanding and resolving the problem of intervertebral disc related low back pain.This dissertation presents my doctoral work of investigating the potential for the camelid cervical spine to serve as a suitable …

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Exploring The Antibacterial, Antioxidant, And Anticancerproperties Of Lichen Metabolites, Gajendra Shrestha Mar 2015

Exploring The Antibacterial, Antioxidant, And Anticancerproperties Of Lichen Metabolites, Gajendra Shrestha

Theses and Dissertations

Natural products have been a significant source of new drugs, especially in treating cancer, infectious diseases, hypertension, and neurological disorders. Although many natural metabolites have been screened and yielded pharmaceutically important drugs, many potential sources of natural product drug therapies still need to be investigated, including lichens. Lichens are symbiotic systems consisting of a filamentous fungus and a photosynthetic partner (an eukaryotic alga and/or cyanobacterium). Lichens produce an impressive variety of unique secondary compounds and have been used as ingredients in folk medicines for centuries. Demonstrated biological roles based on lichen chemistry include: antibiotics, anti-proliferative, antioxidants, anti-HIV, anti-cancer, immunomodulation, and …

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Facilitative Implicit Rules And Adolescent Emotional Regulation, Lexie Y. Pfeifer Mar 2015

Facilitative Implicit Rules And Adolescent Emotional Regulation, Lexie Y. Pfeifer

Theses and Dissertations

Research has linked emotional regulation to the adaptive functioning of adolescents. Further research suggests that family processes, which include implicit rules, impact children's emotional regulation. The current study examined the impact of implicit rules that are facilitative of family connectedness on development of adolescents' emotional regulation. Data came from the Flourishing Families Project (FFP), a seven-year longitudinal study measuring family processes that impact adolescent development. The sample was collected in the northwestern United States and consisted of 500 families with a target child between the ages of 10 and 14 years. Participants filled out self-report measures on implicit family rules …

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Hydrologic Data Sharing Using Open Source Software And Low-Cost Electronics, Jeffrey Michael Sadler Mar 2015

Hydrologic Data Sharing Using Open Source Software And Low-Cost Electronics, Jeffrey Michael Sadler

Theses and Dissertations

While it is generally accepted that environmental data are critical to understanding environmental phenomena, there are yet improvements to be made in their consistent collection, curation, and sharing. This thesis describes two research efforts to improve two different aspects of hydrologic data collection and management. First described is a recipe for the design, development, and deployment of a low-cost environmental data logging and transmission system for environmental sensors and its connection to an open source data-sharing network. The hardware is built using several low-cost, open-source, mass-produced components. The system automatically ingests data into HydroServer, a standards-based server in the open …

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Brain Mapping Of The Latency Epochs In A Mcgurk Effect Paradigm In Music Performance And Visual Arts Majors, Lauren Donelle Nordstrom Mar 2015

Brain Mapping Of The Latency Epochs In A Mcgurk Effect Paradigm In Music Performance And Visual Arts Majors, Lauren Donelle Nordstrom

Theses and Dissertations

The McGurk effect is an illusion that occurs when an auditory /ba/ is combined with a visual /ga/. The two stimuli fuse together which leads to the perception of /da/, a sound in between /ba/ and /ga/. The purpose of this study was to determine whether music performance and visual arts majors process mismatched auditory and visual stimuli, like the McGurk effect, differently. Nine syllable pairs were presented to 10 native English speakers (5 music performance majors and 5 visual arts majors between the ages of 18 and 28 years) in a four-forced-choice response paradigm. Data from event-related potentials were …

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Rab Proteins And Alzheimer's: A Current Review Of Their Involvement In Amyloid Beta Generation With Focus On Rab10 Expression In N2a-695 Cells, Ivan Arano Rodriguez Mar 2015

Rab Proteins And Alzheimer's: A Current Review Of Their Involvement In Amyloid Beta Generation With Focus On Rab10 Expression In N2a-695 Cells, Ivan Arano Rodriguez

Theses and Dissertations

This thesis work describes the role of Rab proteins in amyloid processing and clearance in different cell pathways. It also describes an experimental approach used to analyze the expression effects of Rab10 in amyloid beta production. Since the main theory behind neurodegeneration in Alzheimer's disease claims that high levels of amyloid beta 42 (Aβ42) molecules trigger widespread neuronal death, control of Aβ42 has been a main target in Alzheimer's disease research. In addition, several studies show increased levels of particular Rab proteins in Alzheimer's pathogenesis. However, no review consolidates current findings in neurodegeneration of Alzheimer's with Rab protein dysfunction. The …

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Shakespeare's Art And Artifice: Passing For Real In As You Like It, Kristen Nicole Cardon Mar 2015

Shakespeare's Art And Artifice: Passing For Real In As You Like It, Kristen Nicole Cardon

Theses and Dissertations

Gender performativity, detailed by Judith Butler and accepted by most contemporary queer theorists, rests on an agentive model of gender wherein “genders are appropriated, theatricalized, worn, and done” (“Imitation and Gender Insubordination” 716). This academic orthodoxy is challenged, however, by the increasing presence of transgender persons joining the theoretical discourse, many of whom experience an essential gender as a central facet of their identity. I respond to Katie R. Horowitz’s recent modification of Butler’s theories—a theory of omniperformance to dissolve the distinction between performance and performativity, and thereby between artifice and “real life.” I argue that gender-as-art, a schema that …

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External Validity Of Grammatical Word Category Classification Using An Adaptation And Selection Model, Michelle Chatterton Mar 2015

External Validity Of Grammatical Word Category Classification Using An Adaptation And Selection Model, Michelle Chatterton

Theses and Dissertations

The process of acquiring language requires children to learn grammatical categories and apply these categories to new words. Researchers have proposed various explanations of this process in the form of algorithms and computational modeling. Recently, adaptation and selection models have been tested and applied as a possible explanation to the process of acquiring grammatical categories. These studies have proven promising, however, the external validity of this approach has not been examined by grammatically coding samples outside the training corpus. The current thesis applies an adaptation and selection model, which pauses the evolution of dictionaries after every thousand cycles to allow …

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Betende Hande: Albrecht Durer's Self-Portrait As A Gothic Church, Christine Heathcote Mar 2015

Betende Hande: Albrecht Durer's Self-Portrait As A Gothic Church, Christine Heathcote

Theses and Dissertations

In 1508 Albrecht Dürer, famed German printmaker and Nürnberg citizen, was commission by Jakob Heller of Frankfurt to paint a large altarpiece for a new church. The Heller Altarpiece was the second commission of the printer since his training in Venice, Italy (1504-1507) to paint like an Italian master. In order to prepare for such a commission, Dürer spent over a year creating drawings of black ink and white chalk on blue Venetian paper to serve as inspiration for the large painting. However once the painting was complete, the artist held onto these ink and chalk drawings as part of …

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The Biology Of Claudin 6 (Cldn6) In The Developing Mouse Lung, Felix Ruben Jimenez Rondan Mar 2015

The Biology Of Claudin 6 (Cldn6) In The Developing Mouse Lung, Felix Ruben Jimenez Rondan

Theses and Dissertations

The tight junctions (TJ), which are located in the apical region between epithelial and endothelial cells, regulate the paracellular diffusion of ions and small molecules and play an important role in maintaining cell polarity, cell-cell integrity, and permeability. In the lung, epithelial cells are attached by TJ structures. They provide a permeable barrier and cell communication. The loss of barrier integrity, which is maintained by the expression of claudins (Cldn), results in cellular permibilization and leads to paracellular diffusion of solutes and harmful molecules. There are 27 known Cldn homologous members in mice and human. Cldn6 is mostly expressed in …

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The Role Of Receptors For Advanced Glycation End-Products (Rage) And Ceramide In Cardiovascular Disease, Michael Bruce Nelson Mar 2015

The Role Of Receptors For Advanced Glycation End-Products (Rage) And Ceramide In Cardiovascular Disease, Michael Bruce Nelson

Theses and Dissertations

Type 2 diabetes and cigarette smoke exposure are associated with an increased risk of cardiovascular complications. The role of advanced glycation end-products (AGEs) is already well-established in numerous comorbidities including cardiomyopathy. Given the role of AGEs and their receptor, RAGE, in activating inflammatory pathways, we sought to determine whether ceramides could be a mediator of RAGE-induced altered heart mitochondrial function. Using an in vitro model, we treated H9C2 cardiomyocytes with carboxy-methyl lysine-BSA, followed by mitochondrial respiration assessment. We found that mitochondrial respiration was significantly impaired in AGE-treated cells, but not when co-treated with myriocin, an inhibitor of de novo …

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A Diachronic Analysis Of North And South Korean Monophthongs: Vowel Shifts On The Korean Peninsula, Jessica M. Morgan Mar 2015

A Diachronic Analysis Of North And South Korean Monophthongs: Vowel Shifts On The Korean Peninsula, Jessica M. Morgan

Theses and Dissertations

The linguistic situation on the Korean peninsula is one ripe for research. For the past 70 years the two halves of the peninsula have been isolated from one another, thus creating two very different environments for development and change within the Korean language. It is hypothesized that due to conflict, divide, and social turmoil on the peninsula, the Korean language will have undergone a period of change in the last 70 years. This particular investigation looks at North and South Korean monophthong systems for evidence of a phonological shift. Studies of North Korea's language planning (Yong, 2001; Kumatani, 1990) will …

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Modeling Children's Acquisition Of Grammatical Word Categories From Adult Input Using An Adaptation And Selection Algorithm, Nicole Adele Stenquist Mar 2015

Modeling Children's Acquisition Of Grammatical Word Categories From Adult Input Using An Adaptation And Selection Algorithm, Nicole Adele Stenquist

Theses and Dissertations

It is understood that children learn the use of grammatical categories in their native language, and previous models have only been partially successful in describing this acquisition. The present study uses an adaptation selection algorithm to continue the work in addressing this question. The input for the computer model is child-directed speech towards three children, ages ranging from 1;1 to 5;1 during the course of sampling. The output of the model consists of the input words labeled with a grammatical category. This output data was evaluated at regular intervals through its ability to correctly identify the grammatical categories of language …

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The Cascading Effects Of Invasive Grasses In North American Deserts: The Interactions Of Fire, Plants, And Small Mammals, Tiffanny R. Bowman Mar 2015

The Cascading Effects Of Invasive Grasses In North American Deserts: The Interactions Of Fire, Plants, And Small Mammals, Tiffanny R. Bowman

Theses and Dissertations

The landscapes of the Great Basin and Mojave Deserts are changing due to plant invasion. Highly flammable invasive grasses increase the size and frequency of fire causing a cascade of effects through the plant and animal communities. One of the most influential animal groups in desert systems is small mammals. We sought to learn how small mammals are impacted by fire and how their influence on the plant community differs between burned and unburned habitat. Small mammals did not have higher rates of mortality as a direct result of a controlled burn. In the Great Basin, there were short-term reductions …

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A Mathematical Model Of Amoeboid Cell Motion As A Continuous-Time Markov Process, Lynnae Despain Mar 2015

A Mathematical Model Of Amoeboid Cell Motion As A Continuous-Time Markov Process, Lynnae Despain

Theses and Dissertations

Understanding cell motion facilitates the understanding of many biological processes such as wound healing and cancer growth. Constructing mathematical models that replicate amoeboid cell motion can help us understand and make predictions about real-world cell movement. We review a force-based model of cell motion that considers a cell as a nucleus and several adhesion sites connected to the nucleus by springs. In this model, the cell moves as the adhesion sites attach to and detach from a substrate. This model is then reformulated as a random process that tracks the attachment characteristic (attached or detached) of each adhesion site, the …

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Optimization Of Nonadsorptive Polymerized Polyethylene Glycol Diacrylate As A Material For Microfluidics And Sensor Integration, Chad Rogers Mar 2015

Optimization Of Nonadsorptive Polymerized Polyethylene Glycol Diacrylate As A Material For Microfluidics And Sensor Integration, Chad Rogers

Theses and Dissertations

Microfluidics is a continually growing field covering a wide range of applications, such as cellular analysis, biomarker quantification, and drug discovery; but in spite of this, the field of microfluidics remains predominately academic. New materials are pivotal in providing tailored properties to improve device integration and decrease prototype turnaround times. In biosensing, nonspecific adsorption in microfluidic systems can deplete target molecules in solution and prevent analytes, especially those at low concentrations, from reaching the detector. Polyethylene glycol diacrylate (PEGDA) mixed with photoinitiator forms, on exposure to ultraviolet (UV) radiation, a polymer with inherent resistance to nonspecific adsorption. Optimization of the …

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Spiders Or Butterflies? Despite Student Preference, Gender-Biased Lesson Models Do Not Impact Interest, Attitude, And Learning In Biology, Amy N. Buxton Mar 2015

Spiders Or Butterflies? Despite Student Preference, Gender-Biased Lesson Models Do Not Impact Interest, Attitude, And Learning In Biology, Amy N. Buxton

Theses and Dissertations

Educational research often emphasizes the prevalent gender gap between males and females in science, technology, engineering, and mathematics (STEM) fields. While many studies have found a gender bias when it comes to specific areas of science, little has been done to analyze the effects of how we teach within each of these subjects. In our study, we took a new angle on gender research by specifically considering whether there is a gender gap in how the models (the specific lesson examples/content used to teach a broader biology topic) used to teach biology affect student interest, attitude, and learning. We first …

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Latitudinal Variation In Lifetime Survival And Reproduction In A Burying Beetle, Clinton T. Laidlaw Mar 2015

Latitudinal Variation In Lifetime Survival And Reproduction In A Burying Beetle, Clinton T. Laidlaw

Theses and Dissertations

Temperature variation experienced across a latitudinal range is tied to changes in lifespan and life history across multiple taxa. Two patterns of adaptation to latitudinal temperature variation have been documented – counter-gradient (or co-gradient) variation, and local adaptation. To determine how natural selection has shaped life history variation in a burying beetle, Nicrophorus orbicollis, we quantified lifetime patterns of reproduction in two populations that represent the geographic and temperature extremes occupied by the species. Lifetime reproduction was quantified at two temperatures that represented conditions typical for each population. Burying beetles from different extremes of their geographic range show considerable variation …

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The Chosen One: A Q-Method Analysis Of The “€œHarry Potter”€ Phenomenon, Cindy Phippen Mar 2015

The Chosen One: A Q-Method Analysis Of The “€œHarry Potter”€ Phenomenon, Cindy Phippen

Theses and Dissertations

This study examines how pop culture fandoms are formed, based on five communications theories: Escapism, Mood Management, Parasocial Relationships, Identification, and Social Capital. The researcher examined the Harry Potter fandom specifically because of its global pervasiveness. Using Q Methodology, 47 respondents fell into one of four categories: Relationship Experts, Happy Introverts, Identifying Isolationists, and Isolated Self-regulators. Relationship Experts like Harry Potter because of parasocial relationships with the characters as well as the story's capacity for escapism, and Happy Introverts focus on liking Harry Potter for their own enjoyment (not that of others) and mood management. Identifying Isolationists like Harry Potter …

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Stability Of Selected B Vitamins In Thermally-Treated Pinto Beans, Virginia Anne West Mar 2015

Stability Of Selected B Vitamins In Thermally-Treated Pinto Beans, Virginia Anne West

Theses and Dissertations

Beans are a commonly consumed food and a staple in many regions worldwide. Pinto beans (Phaseolus vulgaris), categorized as legumes, are dried seeds from plants and are high in protein, carbohydrate and fiber, and low in fat. They are also a good source of various minerals and well as thiamin, riboflavin, niacin, vitamin B6, and folate Beans are typically soaked and thermally processed before consumption. Different processing methods can impact the composition of beans. The purpose of this study was to examine the effect of thermal treatments on vitamin concentration in pinto beans. Beans were simmered, canned, dried-flaked, or dried-extruded, …

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Monophthongal Vowel Production In Females With Primary Sjögren's Syndrome Following A Hydration Treatment Of Nebulized Saline, Kara Rytting Mar 2015

Monophthongal Vowel Production In Females With Primary Sjögren's Syndrome Following A Hydration Treatment Of Nebulized Saline, Kara Rytting

Theses and Dissertations

Sjögren's Syndrome (SS) is an autoimmune disease that causes extreme dryness, or sicca,of the eyes and mouth, as well as other potential drying of the throat and intestines. Speech, voice, and swallowing problems are common in individuals with SS. Therefore, this study examined the possible changes in acoustic characteristics of monophthongs (/i, æ, α, u, ʌ/) in eight females with SS following laryngeal hydration treatments. An ABAB experimental design was implemented. Treatment consisted of nebulized isotonic saline immediately following completion of audio-recordings. Using acoustic analysis software the duration, formant frequencies, and vowel space area (VSA) was calculated for the participant's …

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Judicious Use Of Communication For Inherently Parallel Optimization, Andrew W. Mcnabb Mar 2015

Judicious Use Of Communication For Inherently Parallel Optimization, Andrew W. Mcnabb

Theses and Dissertations

Function optimization---finding the minimum or maximum of a given function---is an extremely challenging problem with applications in physics, economics, machine learning, engineering, and many other fields. While optimization is an active area of research, only a portion of this work acknowledges parallel computation, which is now widely available. Today, anyone with a modest budget can buy a cluster with hundreds of cores, pay for access to a supercomputer with thousands of processors, or at least purchase a laptop with 8 cores. Thus, an algorithm that works well in serial but cannot be parallelized is needlessly inefficient in real-life computationalenvironments.We address …

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Interactions Between Race, Gender, And Income In Relationship Education Outcomes, Andrew K. Thompson Mar 2015

Interactions Between Race, Gender, And Income In Relationship Education Outcomes, Andrew K. Thompson

Theses and Dissertations

Researchers and policymakers have become interested in the use of relationship education programs as a means to remedy the effects of family instability. Research suggests that relationship education produces positive outcomes with some groups. However, whether populations who are socially and economically more at-risk of relationship problems and relationship dissolution are gaining from relationship education remains an open question. Ecocultural Theory is used to conceptualize the research question and to illustrate the importance of studying diverse populations. The purpose of this study is to assess relationship education outcomes for select at-risk groups. The sample for this study (n=1,907) comes from …

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Hispanics At The Starting Line: Poverty Among Newborn Infants In Established Gateways And New Destinations, Daniel T. Lichter, Scott R. Sanders, Kenneth M. Johnson Feb 2015

Hispanics At The Starting Line: Poverty Among Newborn Infants In Established Gateways And New Destinations, Daniel T. Lichter, Scott R. Sanders, Kenneth M. Johnson

Faculty Publications

High rates of Hispanic fertility raise an important question: Do Hispanic newborn babies start life's race behind the starting line, poor and disadvantaged? To address this question, we link the newborn infants identified with the new fertility question in the 2006–2010 American Community Survey (ACS) to the poverty status of mothers. Our results document the disproportionately large share (40 percent) of Hispanic babies who are born into poverty. The prospect of poverty is especially high in new Hispanic destinations, especially those in rural areas. For Hispanic newborn babies, poverty cannot be reduced to supply-side explanations that emphasize maladaptive behavioral decision-making …

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