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Organic Synthesis As A Platform For Mentoring Undergraduates, Steven L. Castle Mar 2016

Organic Synthesis As A Platform For Mentoring Undergraduates, Steven L. Castle

Journal of Undergraduate Research

This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2014 to the present. A total of six undergraduates participated in the mentoring environment during this period. Their names and accomplishments are listed below.

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Development And Application Of New Solid-State Models For Low-Energy Vibrations, Lattice Defects, Entropies Of Mixing, And Magnetic Properties, Jacob M. Schliesser Mar 2016

Development And Application Of New Solid-State Models For Low-Energy Vibrations, Lattice Defects, Entropies Of Mixing, And Magnetic Properties, Jacob M. Schliesser

Theses and Dissertations

Low-temperature heat capacity data contain information on the physical properties of materials, and new models continue to be developed to aid in the analysis and interpretation of heat capacity data into physically meaningful properties. This work presents the development of two such models and their application to real material systems. Equations describing low-energy vibrational modes with a gap in the density of states (DOS) have been derived and tested on several material systems with known gaps in the DOS, and the origins of such gaps in the DOS are presented. Lattice vacancies have been shown to produce a two-level system …

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Trace Element Inputs From Natural And Anthropogenic Sources In An Agricultural Watershed, Middle Provo River, Utah, Timothy Holman Goodsell Mar 2016

Trace Element Inputs From Natural And Anthropogenic Sources In An Agricultural Watershed, Middle Provo River, Utah, Timothy Holman Goodsell

Theses and Dissertations

Water chemistry in rivers is impacted by a variety of natural and anthropogenic processes including agricultural runoff, urban runoff, storm runoff, groundwater inputs, and the built environment. In this study we used trace element concentrations (including As, B, Ce, Co, Cu, Li, Mn, Rb, Sb, Sr, Tl, V, and Zn) and continuous measurements of flow rates and specific conductance to investigate dynamic processes affecting water quality in a rapidly urbanizing agricultural area typical of the western U.S. The middle Provo River, located in northern Utah, USA, was selected as the study area because it is well instrumented with water quality …

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Improving Cotton Agronomics With Diverse Genomic Technologies, Aaron Robert Sharp Mar 2016

Improving Cotton Agronomics With Diverse Genomic Technologies, Aaron Robert Sharp

Theses and Dissertations

Agronomic outcomes are the product of a plant's genotype and its environment. Genomic technologies allow farmers and researchers new avenues to explore the genetic component of agriculture. These technologies can also enhance understanding of environmental effects. With a growing world population, a wide variety of tools will be necessary to increase the agronomic productivity. Here I use massively parallel, deep sequencing of RNA (RNA-Seq) to measure changes in cotton gene expression levels in response to a change in the plant's surroundings caused by conservation tillage. Conservation tillage is an environmentally friendly, agricultural practice characterized by little or no inversion of …

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Discovery Of Low-Molecular Weight Novel Serum Biomarkers For Diagnosing Preeclampsia And Alzheimer's Disease, Swati Anand Mar 2016

Discovery Of Low-Molecular Weight Novel Serum Biomarkers For Diagnosing Preeclampsia And Alzheimer's Disease, Swati Anand

Theses and Dissertations

Preeclampsia (PE), a life threatening pregnancy-related disorder, is characterized mainly by new onset of hypertension and proteinuria after 20 weeks of gestation. Currently, PE cannot be predicted prior to onset of symptoms and there is no cure for the disease. There is a clear value in having biomarkers able, early in a pregnancy, to identify women at risk for PE so that proper treatment therapies could be developed. Although a number of serum candidate markers have been proposed to be altered in PE patients, their use is limited due to poor sensitivity and specificity. Therefore, there is ongoing need for …

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The Role Of Hypoxia On Pyruvate Kinase M2, Mammalian Target Of Rapamycin, Mitochondrial Function, And Cell Invasion In The Trophoblast, Rebecca Lutz Kimball Mar 2016

The Role Of Hypoxia On Pyruvate Kinase M2, Mammalian Target Of Rapamycin, Mitochondrial Function, And Cell Invasion In The Trophoblast, Rebecca Lutz Kimball

Theses and Dissertations

This thesis will be organized into two chapters discussing the role of hypoxia in the human placenta. The goal of this thesis is to characterize pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in hypoxic conditions in the trophoblast. Understanding the mechanisms of placental metabolism can lead to further treatments for placental diseases. Chapter one covers the background of intrauterine growth restriction, hypoxia, placental metabolism, and pyruvate kinase M2 (PKM2). Little is currently understood about the role of the mitochondria in placental diseases. Expression of PKM2, trophoblast cell invasion, and mitochondrial function is shown to be …

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The Gratification Niches Of Traditional And Digital Radio, Don G. Shelline Mar 2016

The Gratification Niches Of Traditional And Digital Radio, Don G. Shelline

Theses and Dissertations

We live in an age where science fiction is quickly becoming science fact. Dick Tracy's 2-way wrist TVs are Apple Watches. Automated smart homes are plentiful. Cars are now able to drive themselves. And in those cars, riders no longer need to depend on a deejay to choose their music for them; these listeners build their own radio stations, on the spot, out of any music and conversation they want to hear, all at the touch of a button that is fully connected to Wi-Fi, the internet, and unlimited cell data plans.This research will examine digital radio's impact upon traditional …

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In Vitro Molecular Modification Of Human Cultured And Primary Cells Using Lance Array Nanoinjection, John W. Sessions Mar 2016

In Vitro Molecular Modification Of Human Cultured And Primary Cells Using Lance Array Nanoinjection, John W. Sessions

Theses and Dissertations

Fundamentally altering cellular function at a genetic level is a major area of interest in the biologic sciences and the medical community. By engineering transfectable constructs that can be inserted to dysfunctional cellular systems, scientists can mitigate aberrant genetic behavior to produce proper molecular function. While viral vectors have been a mainstay in the past, there are many limitations, particularly related to safety, that have changed the focus of genome editing to incorporate alternative methods for gene delivery. Lance Array Nanoinjection (LAN), a second-generation microfabricated transfection biotechnology, is one of these alternative technologies. LAN works by utilizing both simultaneous electrostatic …

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A Neuroimaging Investigation Of The Effects Of Age And Sleep On Pattern Separation, Christopher Robert Doxey Mar 2016

A Neuroimaging Investigation Of The Effects Of Age And Sleep On Pattern Separation, Christopher Robert Doxey

Theses and Dissertations

Effective memory representations must be specific to prevent interference between episodes that may overlap in terms of place, time, or items present. Pattern separation, a computational process performed by the hippocampus overcomes this interference by establishing non-overlapping memory representations. This project explores pattern separation and how it is impacted by age and sleep. Experiment 1. Structures of the medial temporal lobe (MTL) are known to be involved in declarative memory processes. However, little is known about how age-related changes in MTL structures, white matter integrity, and functional connectivity affect pattern separation processes in the MTL. In the present study, we …

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The Effect Of Whole Body Vibration On Exercise-Induced Muscle Damage And Delayed-Onset Muscle Soreness, Ryan Darin Magoffin Mar 2016

The Effect Of Whole Body Vibration On Exercise-Induced Muscle Damage And Delayed-Onset Muscle Soreness, Ryan Darin Magoffin

Theses and Dissertations

Current scientific evidence suggests that when whole body vibration (WBV) is used as a warm-up prior to performing eccentric exercise, delayed-onset muscle soreness (DOMS) is mitigated and strength loss recovers faster. These benefits were observed primarily in nonresistance-trained individuals. The aim of this study was to determine if WBV could mitigate soreness and expedite strength recovery for resistance-trained individuals when used as a warm-up prior to eccentric exercise. Thirty resistance-trained males completed 300 maximal eccentric contractions of the quadriceps after warming up with (WBV) or without (CON) WBV. Both CON and WBV experienced significant isometric (27.8% and 30.5%, respectively) and …

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Extracellular Matrix From Whole Porcine Heart Decellularization For Cardiac Tissue Engineering, Nima Momtahan Mar 2016

Extracellular Matrix From Whole Porcine Heart Decellularization For Cardiac Tissue Engineering, Nima Momtahan

Theses and Dissertations

Heart failure is one of the leading causes of death in the United States. Every year in the United States, more than 800,000 people are diagnosed with heart failure and more than 375,000 people die from heart disease. Current therapies such as heart transplants and bioartificial hearts are helpful, but not optimal. Decellularization of porcine whole hearts followed by recellularization with patient-specific human cells may provide the ultimate solution for patients with heart failure. Great progress has been made in the development of efficient processes for decellularization, and the design of automated bioreactors. In this study, the decellularization of porcine …

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Rab8 Mediates Trpv4 Vesicle Trafficking To The Plasma Membrane In Hgf-Stimulated Mdck Cells, Hillary Jean Haws Mar 2016

Rab8 Mediates Trpv4 Vesicle Trafficking To The Plasma Membrane In Hgf-Stimulated Mdck Cells, Hillary Jean Haws

Theses and Dissertations

Epithelial to mesenchymal transition (EMT) is a process whereby epithelial cells, which act collectively through robust cell–cell interactions, take on mesenchymal characteristics, breaking cell–cell junctions to become solitary, invasive and motile. Our previous results show that a transient increase in calcium influxes through TRP channels at the plasma membrane is required for hepatocyte growth factor (HGF)– stimulated EMT. Since this transient increase requires an intact microtubule cytoskeleton, we propose that HGF stimulation results in the mobilization of calcium channels to the plasma membrane from an intracellular compartment via microtubule–dependent vesicle trafficking. Through immunofluorescence, we show that prior to HGF treatment, …

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Phylogenetic Relationships Of Cottids (Pisces: Cottidae) In Upper Snake River Basin Of Western North America, Sun Yeong Oh Mar 2016

Phylogenetic Relationships Of Cottids (Pisces: Cottidae) In Upper Snake River Basin Of Western North America, Sun Yeong Oh

Theses and Dissertations

Freshwater sculpins (Cottus) are common throughout temperate regions of the Northern Hemisphere. Their broad distribution in the Western North America makes them a good model for understanding phylogeographic relationships among western fishes. Within much of the interior west three lineages, C. bairdii, C. confusus, and the C. beldingii complex, are most prevalent. The distribution of these three overlap in the Snake River Basin. All occur below Shoshone Falls on the Snake River. However, only two currently reside in the Upper Snake River above the falls. An exception are the Lost River streams of central Idaho. While …

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Manfred, Don Juan, And The Romantic Tragedy Of The Subject, Trenton Robert Leinenbach Mar 2016

Manfred, Don Juan, And The Romantic Tragedy Of The Subject, Trenton Robert Leinenbach

Theses and Dissertations

While the Romantic lyric has long been understood as an exploration of human subjectivity, the era's dramatic works have been viewed as more oriented toward objective or mimetic representation. As such, scholarship on Romantic subjectivity from Harold Bloom to Andrea Henderson has bypassed dramatic and quasi-dramatic explorations of subjectivity. These explorations, however, add to the conversation about subjectivity in powerful ways by addressing the paradoxes of mimetically representing subjectivity. These difficulties spring from a question that surrounds mimetically represented subjectivity: how can a supposedly objective medium portray experience that is by definition non-objective, purely interior, and therefore incommunicable? This paradox …

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Forward Chemical Genetics Drug Screen Yields Novel Proteases And Proteolytic Inhibitors Of Hgf–Induced Epithelial–Mesenchymal Transition, Jeffrey Thomas Schuler Mar 2016

Forward Chemical Genetics Drug Screen Yields Novel Proteases And Proteolytic Inhibitors Of Hgf–Induced Epithelial–Mesenchymal Transition, Jeffrey Thomas Schuler

Theses and Dissertations

Hepatocyte Growth Factor (HGF)–induced Epithelial–Mesenchymal Transition (EMT) is a complex cellular pathway that causes epithelial cell scattering by breaking cell–cell contacts, eliminating apical–basal polarity, and replacing epithelial markers and characteristics with mesenchymal markers. Early EMT events include a brief period of cell spreading, followed by cell compaction and cell–cell contact breaks. A forward chemical genetics drug screen of 50,000 unique compounds measuring HGF–induced cell scattering identified 26 novel EMT inhibitors, including 2 proteolytic inhibitors. Here, we show that B5500–4, one of the EMT inhibitors from the screen, blocks HGF–induced EMT by a predicted blocking of the protease furin, in addition …

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Immunization Status Of Nicu Graduates At A Tertiary Care Children's Hospital, Leslie Jane Huggins Mar 2016

Immunization Status Of Nicu Graduates At A Tertiary Care Children's Hospital, Leslie Jane Huggins

Theses and Dissertations

The objectives of this study were to determine the current rates of immunization and identify variables associated with immunizations of NICU graduates who were 60 days of age or older at time of discharge. This is a descriptive pilot study utilizing retrospective paper chart review. The relationships between immunization status and study variables were examined using logistic regression. Of 43 infants discharged at least 60 days of age or older from the NICU, 74.4% were up to date for immunizations in accordance with AAP recommendations. Additional variables were not significant. Immunization needs to be a priority in order to give …

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Resilience And Internalizing Symptoms Among Adolescent Girls In Residential Treatment: An Evaluation Of Strong Teens, Luke Andrew Marvin Mar 2016

Resilience And Internalizing Symptoms Among Adolescent Girls In Residential Treatment: An Evaluation Of Strong Teens, Luke Andrew Marvin

Theses and Dissertations

Strong Teens is an evidence-based social and emotional learning (SEL) curriculum designed to target internalizing disorders by promoting emotional resilience and social competence. In this study, Strong Teens was implemented among 36 adolescent girls during group therapy in a residential treatment center (RTC). A non-equivalent, quasi-experimental wait-list control group design was used. The curriculum was evaluated by tracking the girls' social and emotional knowledge, internalizing symptoms, and resilience from the perspectives of the girls, group therapists, and a supervisor who was blind to the study. Although the results indicated that exposure to Strong Teens was not effective in increasing the …

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Evaluating The Effects Of Strong Teens On High School Student Levels Of Internalizing Symptoms And Resilience, Austin J. Millet Mar 2016

Evaluating The Effects Of Strong Teens On High School Student Levels Of Internalizing Symptoms And Resilience, Austin J. Millet

Theses and Dissertations

Many adults suffering from mental health problems often report that the onset of these concerns began in adolescence, highlighting the importance of identifying and treating mental health concerns from an early age. In high schools, some students are identified as having externalizing or internalizing disorders. The majority of these students, especially those with internalizing symptoms, go untreated. One potential reason may be that limited school resources are used to correct behavior problems, leaving those with internalizing disorders to silently suffer, which often exacerbates the issues. Recent research suggests many individuals have high levels of resilience which can be taught, and …

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Aminoacyl-Trna Synthetase Production For Unnatural Amino Acid Incorporation And Preservation Of Linear Expression Templates In Cell-Free Protein Synthesis Reactions, Andrew Broadbent Mar 2016

Aminoacyl-Trna Synthetase Production For Unnatural Amino Acid Incorporation And Preservation Of Linear Expression Templates In Cell-Free Protein Synthesis Reactions, Andrew Broadbent

Theses and Dissertations

Proteins—polymers of amino acids—are a major class of biomolecules whose myriad functions facilitate many crucial biological processes. Accordingly, human control over these biological processes depends upon the ability to study, produce, and modify proteins. One innovative tool for accomplishing these aims is cell-free protein synthesis (CFPS). This technique, rather than using living cells to make protein, simply extracts the cells' natural protein-making machinery and then uses it to produce protein in vitro. Because living cells are no longer involved, scientists can freely adapt the protein production environment in ways not otherwise possible. However, improved versatility and yield of CFPS protein …

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Semantic And Syntactic Processing In A Patient With Left Temporal Lobe Damage Secondary To Traumatic Brain Injury: An Fmri Study, Caitlin Moizer Mar 2016

Semantic And Syntactic Processing In A Patient With Left Temporal Lobe Damage Secondary To Traumatic Brain Injury: An Fmri Study, Caitlin Moizer

Theses and Dissertations

The ability of the brain to change and form new neuropathways after brain injury is remarkable. The current study investigates the brains ability to form new pathways for language processing following traumatic brain injury (TBI), specifically a left temporal lobectomy. Two subjects participated in this study; one participant with TBI and one age-matched control. Sentence stimuli consisted of four types: semantically correct, semantically incorrect, syntactically correct, and syntactically incorrect. Participants underwent a fMRI scan while the auditory stimuli were presented in four blocks. Participants were asked to record if the sentence was correct or incorrect by pressing the corresponding button. …

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Association Between Polymorphisms Associated With Major Depression, Cognitive Function, And Stress Regulation And Telomere Length In Older Community-Dwelling Adults And In Older Competitive Athletes, Cynthia Elizabeth Perry Mar 2016

Association Between Polymorphisms Associated With Major Depression, Cognitive Function, And Stress Regulation And Telomere Length In Older Community-Dwelling Adults And In Older Competitive Athletes, Cynthia Elizabeth Perry

Theses and Dissertations

Many factors detrimental to healthy aging have been proposed including depression, stress, cognitive decline, and telomere shortening. Of specific interest are the genetic factors that may contribute to these factors and subsequently lead to accelerated telomere shortening and aging, namely the Bcl1, 5-HT, DRD2, and ApoE polymorphisms. We sought to: 1) further clarify the role of depression, stress tolerance, and cognitive decline in aging by examining the effect of associated polymorphisms (Bcl1, 5-HT, DRD2, and ApoE) on telomere length in two samples of older adults and 2) determine the difference in absolute telomere length between the two groups. We examined …

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14-3-3Ζ Regulation Of Metastasis Through Mediation Of Liprin-Α And Liprin-Β, Rachel Hynes Mar 2016

14-3-3Ζ Regulation Of Metastasis Through Mediation Of Liprin-Α And Liprin-Β, Rachel Hynes

Theses and Dissertations

Cancer is a set of varied and diverse diseases that share common characteristics, such as active proliferation, increased replicative potential, and tissue invasion or metastasis. One protein, 14-3-3ζ, is shown to be upregulated in a number of different cancers and also correlates with poor patient prognosis, recurrence, and mortality. This protein comes from a family of adapter proteins known for their scaffolding ability, pro- and anti-oncogenic capabilities, and affinity for phosphorylated substrates. It has been shown previously to participate in cancer progression, subversion of apoptosis, and to increase chemoresistance. Herein we will discuss the ability of 14-3-3ζ to promote distant-site …

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Polymer Coated Urea In Kentucky Bluegrass, Jessica Chelise Buss Mar 2016

Polymer Coated Urea In Kentucky Bluegrass, Jessica Chelise Buss

Theses and Dissertations

Nitrogen (N) is the most commonly over-applied nutrient in urban environments because of the large visual and growth increases. This over-application has led to an increase in the loss of N gas in the forms of ammonia and nitrous oxide, as well as an increase in nitrate leaching to surface and groundwater. Furthermore, excess N results in increased maintenance costs and landfill volume due to increased shoot growth from mowed clipping removal. Polymer coated urea (PCU) has proven to be an excellent source to these losses of N to the environment, but rate and timing parameters need study. A two-year …

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Art From The Macchiaioli To The Futurists: Idealized Masculinity In The Art Of Signorini And Balla, Melissa Ann Bush Mar 2016

Art From The Macchiaioli To The Futurists: Idealized Masculinity In The Art Of Signorini And Balla, Melissa Ann Bush

Theses and Dissertations

Beginning around 1850, Italians found themselves in the midst of an identity crisis. Europeans in France and England had surpassed Italians in terms of political, economic, and social progress. Italians seemed trapped in the past, clinging to their magnificent artistic heritage. However, new cultural and social movements were on the rise in Italy that attempted to throw off the domination of other European entities and forge a promising future for Italy. The Macchiaioli, a group of Italian modern artists who painted from 1853 to 1908, were the first group to address contemporary social issues such as class struggle and national …

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Examining The Link Between Exercise And Marital Arguments In Clinical Couples, Bailey Alexandra Selland Mar 2016

Examining The Link Between Exercise And Marital Arguments In Clinical Couples, Bailey Alexandra Selland

Theses and Dissertations

This study examines the following research question: Are couples that exercise on a given day more likely to experience fewer and less intense arguments in their relationship that day? Other variables examined include relationship effect, stress level, and argument topics. Participants were 36 couples in a treatment-as-usual setting who completed the Daily Diary of Events in Couple Therapy (DDECT). Results suggested that female hours of exercise were significantly related to increased report of relationship argument intensity for both men and women. Male hours of exercise were not significantly related to any variables, however male daily stress was significantly related to …

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Population Structure, Genetic Diversity, Geographic Distribution, And Morphology Of Two Boechera (Brassicaceae) Parental Species (Boechera Thompsonii And Boechera Formosa) And Of Their Resultant Hybrid Boechera Duchesnensis, Christina Elizabeth Fox Call Mar 2016

Population Structure, Genetic Diversity, Geographic Distribution, And Morphology Of Two Boechera (Brassicaceae) Parental Species (Boechera Thompsonii And Boechera Formosa) And Of Their Resultant Hybrid Boechera Duchesnensis, Christina Elizabeth Fox Call

Theses and Dissertations

Background: Over the relatively short period of its evolutionary history, Boechera (Brassicaceae) has undergone rapid radiation that has produced 70+ morphologically distinct, sexual diploids. However, reproductive isolation has moved more slowly than morphological divergence in this group and the diploids appear to hybridize frequently where they coexist. Boechera duchesnensis appears to be the result of hybridization between its putative parents Boechera thompsonii and Boechera formosa. Objectives: The objectives of this study are to (i) analyze and document genetic diversity patterns in the population structure, - including allelic and heterozygosity frequencies - of B. thompsonii and B. formosa …

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A Qualitative Study Of Women’S Attitudes And Experiences Regarding Body Image And Disordered Eating Behaviors, Natalie Ann Kirtley Mar 2016

A Qualitative Study Of Women’S Attitudes And Experiences Regarding Body Image And Disordered Eating Behaviors, Natalie Ann Kirtley

Theses and Dissertations

The current research study is responding to recent findings wherein, Fischer et al. (2013) report a risk rate based on EAT-26 scores in the range of 9.2% to 10.8% at BYU in comparison to the 15% they found reported in the literature using samples from other college campuses. Risk rates based on BSQ scores were reported in the 27.2% to 31.1% range, which was on par with a risk rate of 28.7% reported at a comparable university (Fischer et al., 2013). Fischer et al. (2013) conclude that while body shape concerns were estimated to be equal to or lower than …

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Towards Dimensionality In Psychosis: A Conceptual Analysis Of The Dimensions Of Psychosis Symptom Severity, Jessica Abigail Carmona Mar 2016

Towards Dimensionality In Psychosis: A Conceptual Analysis Of The Dimensions Of Psychosis Symptom Severity, Jessica Abigail Carmona

Theses and Dissertations

Given the heterogeneity of symptoms allowed in the diagnosis of psychotic disorders, as well as other challenges of categorical diagnosis (e.g., First et al., 2002; Krueger, 1999), the increased specificity brought by dimensional ratings of underlying features is often important. Models using the factorial structure of psychotic symptoms perform as good as or better than traditional categorical models (Allardyce, Suppes, & Van Os, 2007). DSM-5 has provided such a system of ratings to aid clinicians, the Clinician Rated Dimensions of Psychosis Symptom Severity Scale (PSS; APA, 2013). In this approach, the clinician rates symptom severity in eight domains which emphasize …

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Identification And Characterization Of Serum Biomarkers Associated With Breast Cancer Progression, Adhari Abdullah Alzaabi Mar 2016

Identification And Characterization Of Serum Biomarkers Associated With Breast Cancer Progression, Adhari Abdullah Alzaabi

Theses and Dissertations

Despite the recognized advances in the treatment of breast cancer, it still accounts for 15% of all cancer-related deaths. 90% of breast cancer deaths are due to unpredicted metastasis. There is neither successful treatment for metastatic patients nor a specific test to predict or detect secondary lesions. Patients with primary tumor will be either over-treated with cytotoxic side effects or under-treated and risk recurrence. This necessitates the need for personalized treatment, which is hard to offer for such heterogeneous disease. Obstacles in treating breast cancer metastasis are mainly due to the gaps exist in the understanding of the molecular mechanism …

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Sleep In The Context Of Healthy Aging And Psychiatric Syndromes, Daniel Kay, Joseph M. Dzierzewski Mar 2016

Sleep In The Context Of Healthy Aging And Psychiatric Syndromes, Daniel Kay, Joseph M. Dzierzewski

Faculty Publications

Humans spend approximately 1/3 of their lives asleep. Whether due to evolutionary or ontogenetic factors, sleep and psychiatric disorders change with age. While much of sleep remains an enigma, the field of sleep research is experiencing an exponential increase in its understanding of the causes, correlates, and consequences of sleep disturbances. Although the relationship between age-related sleep and psychiatric conditions is a common clinical observation, empirical investigations into these associations remain scarce. Thus, treating patients with symptoms of sleep disorders in the context of psychiatric conditions remains a major challenge. This chapter reviews the state-of-the-science of sleep disorders in the …

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