Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Brigham Young University

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 2911 - 2940 of 11000

Full-Text Articles in Entire DC Network

Responding To Bullying By Gender Dec 2017

Responding To Bullying By Gender

Intuition: The BYU Undergraduate Journal of Psychology

The present literature review examines how the construction of gender influences bullying among children and adolescents, as w ell as the possible effects of bullying on children, both as bullies an d victims. An in-depth, theoretical analysis of gender stereotype and gender construction is presented, through a review of cognitive development theory, social learning theory, and cultivation theory. Gender construction leads children to adopt different behaviors and to interact with peers in various ways (Emilson et al., 2016; Fagot, 1994; Tobin et al., 2010). Among children and adolescents, the two most prominent forms of bullying that result from gender construction …

Go to article

Effects Of Teacher Praise And Reprimand Rates On Classroom Engagement And Disruptions Of Elementary Students At Risk For Emotional And Behavioral Disorders, Kade Rolan Downs Dec 2017

Effects Of Teacher Praise And Reprimand Rates On Classroom Engagement And Disruptions Of Elementary Students At Risk For Emotional And Behavioral Disorders, Kade Rolan Downs

Theses and Dissertations

In the United States educators often feel underprepared to manage student behavior in the classroom, which management is crucial for students with or at risk for Emotional and Behavioral Disorders (EBD) to learn effectively. Research on School-wide Positive Behavior Support (SWPBS) programs has reflected how effective simple principles, such as increasing teacher praise and decreasing teacher reprimands, can be. The current study is a secondary analysis of data originally gathered from 65 teachers and 239 students across three states. Results of these analyses bring principles of effective SWPBS programs and educator needs together by identifying how teacher behaviors correlated with …

Go to article

Human-Bear Interactions Among Black Bears In Bryce Canyon National Park, Utah, And Polar Bears On Alaska's North Slope, Wesley G. Larson Dec 2017

Human-Bear Interactions Among Black Bears In Bryce Canyon National Park, Utah, And Polar Bears On Alaska's North Slope, Wesley G. Larson

Theses and Dissertations

Human-bear interactions are an important consideration of bear biology, as interactions can lead to destruction of property as well as injury or death for both human and bear. Successful analysis of why these interactions occur can lead to appropriate preventative measures and mitigation of further conflict. Bryce Canyon National Park (BRCA) is comprised of relatively poor bear habitat, but a black bear population exists on the Paunsaugunt Plateau, on which the park occupies the eastern edge. Park managers expressed interest in learning more about bear movements and, specifically, bear use of anthropogenic features following a number of human-bear incidents located …

Go to article

Idioms Or Open Choice? A Corpus Based Analysis, Kaitlyn Alayne Vanwagoner Dec 2017

Idioms Or Open Choice? A Corpus Based Analysis, Kaitlyn Alayne Vanwagoner

Theses and Dissertations

The ambiguous nature of idioms has been a persistent challenge for English language learners and researches alike. Problematic issues include identifying which idioms are most pertinent for study, and the question of how frequently idiom forms found in dictionaries and other canonized resources actually function as idioms in real language use. This study differentiates between idiom forms used idiomatically (idiom-principle) versus literally (open-choice principle), and provides quantitative data to assess this difference. The data was obtained through a corpus analysis of 1,000 randomly-selected idioms in 10,000 randomly-selected contexts (10 contexts per idiom), and revealed that the majority of idiom forms …

Go to article

Quantitative Morphological Classification Of Planetary Craterforms Using Multivariate Methods Of Outline-Based Shape Analysis, Thomas Joseph Slezak Dec 2017

Quantitative Morphological Classification Of Planetary Craterforms Using Multivariate Methods Of Outline-Based Shape Analysis, Thomas Joseph Slezak

Theses and Dissertations

Craters formed by impact and volcanic processes are among the most fundamental planetary landforms. This study examines the morphology of diverse craterforms on Io, the Moon, Mars, and Earth using quantitative, outline-based shape analysis and multivariate statistical methods to evaluate the differences between different types of. Ultimately, this should help establish relationships between the form and origin of craterforms. Developed in the field of geometric morphometrics by paleontological and biological sciences communities, these methods were used for the analysis of the shapes of crater outlines. The shapes of terrestrial ash-flow calderas, terrestrial basaltic shield calderas, martian calderas, Ionian paterae, and …

Go to article

Influence Of Epstein-Barr Virus On Systemic Lupus Erythematosus Disease Development And The Role Of Depression On Disease Progression, Caleb Cornaby Dec 2017

Influence Of Epstein-Barr Virus On Systemic Lupus Erythematosus Disease Development And The Role Of Depression On Disease Progression, Caleb Cornaby

Theses and Dissertations

Systemic Lupus Erythematosus (SLE) is an autoimmune disease affecting 20 to 250 individuals per 100,000 worldwide. Symptomology includes dermatological manifestations such as discoid lesions, acute cutaneous rashes, and oral and nasal ulcers, along with musculoskeletal, pulmonary, and renal complications. Abnormal T and B lymphocyte function and apoptosis, immune complex clearance, complement function, and nucleosome processing are typical of disease pathophysiology. SLE is the result of both environmental and genetic factors, which together create the conditions leading to disease onset and progression. Of these environmental factors, Epstein-Barr virus (EBV) infection is known to cause the genesis of cross-reactive antibodies in SLE …

Go to article

Computational Exploration Of Vortex Nucleation In Type Ii Superconductors Using A Finite Element Method In Ginzburg-Landau Theory, Alden Roy Pack Dec 2017

Computational Exploration Of Vortex Nucleation In Type Ii Superconductors Using A Finite Element Method In Ginzburg-Landau Theory, Alden Roy Pack

Theses and Dissertations

Using a finite element method, we numerically solve the time-dependent Ginzburg-Landau equations of superconductivity to explore vortex nucleation in type II superconductors. We consider a cylindrical geometry and simulate the transition from a superconducting state to a mixed state. Using saddle-node bifurcation theory we evaluate the superheating field for a cylinder. We explore how surface roughness and thermal fluctuations influence vortex nucleation. This allows us to simulate material inhomogeneities that may lead to instabilities in superconducting resonant frequency cavities used in particle accelerators.

Go to article

A Comparative Literature Review Of Intelligent Tutoring Systems From 1990-2015, Brice Robert Colby Dec 2017

A Comparative Literature Review Of Intelligent Tutoring Systems From 1990-2015, Brice Robert Colby

Theses and Dissertations

This paper sought to accomplish three goals. First, it provided a systematic, comparative review of several intelligent tutoring systems (ITS). Second, it summarized problems and solutions presented and solved by developers of ITS by consolidating the knowledge of the field into a single review. Third, it provided a unified language from which ITS can be reviewed and understood in the same context. The findings of this review centered on the 5-Component Framework. The first component, the domain model, showed that most ITS are focused on science, technology, and mathematics. Within these fields, ITS generally have mastery learning as the desired …

Go to article

A Molecular Simulation Study Of Antibody-Antigen Interactions On Surfaces For The Rational Design Of Next-Generation Antibody Microarrays, Derek B. Bush Dec 2017

A Molecular Simulation Study Of Antibody-Antigen Interactions On Surfaces For The Rational Design Of Next-Generation Antibody Microarrays, Derek B. Bush

Theses and Dissertations

Antibody microarrays constitute a next-generation sensing platform that has the potential to revolutionize the way that molecular detection is conducted in many scientific fields. Unfortunately, current technologies have not found mainstream use because of reliability problems that undermine trust in their results. Although several factors are involved, it is believed that undesirable protein interactions with the array surface are a fundamental source of problems where little detail about the molecular-level biophysics are known. A better understanding of antibody stability and antibody-antigen binding on the array surface is needed to improve microarray technology. Despite the availability of many laboratory methods for …

Go to article

Faculty Perceptions Of Open Educational Resources Quality By Peer Review, Olga Maria Belikov Dec 2017

Faculty Perceptions Of Open Educational Resources Quality By Peer Review, Olga Maria Belikov

Theses and Dissertations

In this paper, 936 faculty free response reviews of open textbooks from the Open Textbook Library were analyzed for content and themes. The reviews were completed by faculty members at institutions in the United States and Canada. The textbooks were evaluated regarding their comprehensiveness, content accuracy, relevance longevity, clarity, consistency, modularity, organization structure flow, interface, grammatical errors, and cultural relevance. The results of the reviews found that the across 9360 comments regarding the quality of open textbooks, of these comments 97.3% reflected adequate or exceptional reviews of the textbooks. Faculty often compared the texts to traditional textbooks and in all …

Go to article

Acetobacter Fabarum Genes Influencing Drosophila Melanogaster Phenotypes, Kylie Makay White Dec 2017

Acetobacter Fabarum Genes Influencing Drosophila Melanogaster Phenotypes, Kylie Makay White

Theses and Dissertations

Research in our lab has predicted hundreds of bacterial genes that influence nine different traits in the fruit fly, Drosophila melanogaster. As a practical alternative to creating site-directed mutants for each of the predicted genes, we created an arrayed transposon insertion library using a strain of Acetobacter fabarum DsW_054 isolated from fruit flies. Creation of the Acetobacter fabarum DsW_054 gene knock-out library was done through random transposon insertion, combinatorial mapping and Illumina sequencing. Successful mapping of transposon insertion was achieved for 6418 mutants with hits within 63% of annotated genes within Acetobacter fabarum DsW_054. Insertion sites were verified in …

Go to article

Emotional And Cognitive Engagement In Higher Education Classrooms, Kristine C. Manwaring Dec 2017

Emotional And Cognitive Engagement In Higher Education Classrooms, Kristine C. Manwaring

Theses and Dissertations

This is a multi-article format dissertation that explores emotional and cognitive engagement in higher education classrooms. Student engagement in higher education classrooms has been associated with desired outcomes such as academic achievement, retention, and graduation. Student engagement is a multi-faceted concept, consisting of behavioral, emotional, and cognitive components. A deeper understanding of how these components interact would allow instructors and course designers to facilitate more engaging learning experiences for students. The first article is an extended literature review that investigates the extant empirical research on the relationship between emotional and cognitive engagement, and between emotional engagement and academic outcomes in …

Go to article

The Effects Of Family Stressors On Depression In Latino Adolescents As Mediated By Interparental Conflict, Jenny Carolina Mondragon Dec 2017

The Effects Of Family Stressors On Depression In Latino Adolescents As Mediated By Interparental Conflict, Jenny Carolina Mondragon

Theses and Dissertations

Extensive literature suggests that Latino youth experience higher levels of depression when compared to youth from other ethnic backgrounds yet relatively little is known regarding why this particular population is especially susceptible to depression. This study focused on family level stressors and the link between interparental conflict and adolescent depressive symptoms in Latino families. The sample consisted of 400 girls and 290 boys, they were distributed into four groups based on gender and family structure. Written surveys were completed in their respective English classes measuring the aforementioned variables. Results indicated a significant relationship across all four groups between family stressors …

Go to article

Phosphate Signaling Through Alternate Conformations Of The Pstscab Phosphate Transporter, Ramesh Krishna Vuppada Dec 2017

Phosphate Signaling Through Alternate Conformations Of The Pstscab Phosphate Transporter, Ramesh Krishna Vuppada

Theses and Dissertations

Phosphate is an essential compound for life. Escherichia coli employs a signal transduction pathway that controls the expression of genes that are required for the high-affinity acquisition of phosphate and the utilization of alternate sources of phosphorous. These genes are only expressed when environmental phosphate is limiting. The seven genes for this signaling pathway encode the two-component regulatory proteins PhoB and PhoR, as well as the high-affinity phosphate transporter PstSCAB and an auxiliary protein called PhoU. As the sensor kinase PhoR has no periplasmic sensory domain, the mechanism by which these cells sense environmental phosphate is not known. This paper …

Go to article

Using Remote Cameras To Estimate The Abundance Of Ungulates, Jace C. Taylor Dec 2017

Using Remote Cameras To Estimate The Abundance Of Ungulates, Jace C. Taylor

Theses and Dissertations

Many wildlife populations globally are experiencing unprecedented declines, and without accurate and precise estimates of abundance, we will not be able to conserve these vulnerable species. Remote cameras have rapidly advanced as wildlife monitoring tools and may provide accurate and precise estimates of abundance that improve upon traditional methods. Using remote cameras to estimate abundance may be less expensive, less intrusive, less dangerous, and less time consuming than other methods. While it is apparent that remote cameras have a place in the future of wildlife monitoring, research, and management, many questions remain concerning the proper use of these tools. In …

Go to article

Dissolved Organic Carbon And Dissolved Metal Pulses During Snowmelt Runoff In The Upper Provo River Watershed, Utah, Usa, Hannah Nicole Checketts Dec 2017

Dissolved Organic Carbon And Dissolved Metal Pulses During Snowmelt Runoff In The Upper Provo River Watershed, Utah, Usa, Hannah Nicole Checketts

Theses and Dissertations

Snowmelt river systems exhibit seasonal fluxes in water chemistry, potentially affecting the water supply of one-sixth of the worlds population. In this study, we examined water chemistry of the upper Provo River, northern Utah, which supplies water to over two million people along the urban Wasatch Front. Seasonal changes in water chemistry were characterized by analyzing discharge and dissolved organic carbon (DOC) with dissolved trace metal and cation concentrations (La, Pb, Cu, Al, Be, Sr and K) over three consecutive water years 20142016, with intensive sampling during snowmelt runoff. To better understand links between metal movement and DOC, we sampled …

Go to article

Assembly, Annotation And Optical Mapping Of The A Subgenome Of Avena, Rebekah Ann Lee Dec 2017

Assembly, Annotation And Optical Mapping Of The A Subgenome Of Avena, Rebekah Ann Lee

Theses and Dissertations

Common oat (Avena) has held a significant place within the global crop community for centuries; although its cultivation has decreased over the past century, its nutritional benefits have recently garnered increased interest for human consumption. No published reference sequences are available for any of the three oat subgenomes. Here we report a quality sequence assembly, annotation and hybrid optical map of the A-genome diploid Avena atlantica Baum and Fedak. The assembly is composed of a total of 3,417 contigs with an N50 of 11.86 Mb and an estimated completeness of 97.6%. This genome sequence will be a valuable research tool …

Go to article

Capacity Of Human Immunodeficiency Virus Targeting Chimeric Antigen Receptor T Cells To Eliminate Follicular Dendritic Cells Bearing Human Immunodeficiency Virus Immune Complexes, Matthew T. Ollerton Dec 2017

Capacity Of Human Immunodeficiency Virus Targeting Chimeric Antigen Receptor T Cells To Eliminate Follicular Dendritic Cells Bearing Human Immunodeficiency Virus Immune Complexes, Matthew T. Ollerton

Theses and Dissertations

An important obstacle to a functional cure for HIV/AIDS is the persistence of viral reservoirs found throughout the body in various cells and tissues. Reservoirs can be latently infected cells, or in the case of follicular dendritic cells (FDC), non-infected cells that trap infectious virus on their surface through immune complexes (HIV-IC). Although several strategies have been employed to target and eliminate viral reservoirs, they are short-lived and ineffective. In an attempt to provide a long-term approach, chimeric antigen receptor T (CAR-T) cells were designed to eliminate native HIV on FDCs. Although effective at eliminating HIV-infected cells, and halting spreading …

Go to article

Laying The Foundation For A Fremont Phytolith Typology Using Select Plant Species Native To Utah County, Madison Natasha Pearce Dec 2017

Laying The Foundation For A Fremont Phytolith Typology Using Select Plant Species Native To Utah County, Madison Natasha Pearce

Theses and Dissertations

Archaeobotanical evidences for the presence of wild plants at Fremont archaeological sites are numerous. However, little can be positively argued for why those plants are present, if they were used by site inhabitants, and how they were used. Additionally, there are likely several wild plants that were used but that do not appear in the archaeobotanical record as pollen or macrobotanicals, the two most commonly identified plant remains. I argue that it is possible to provide better interpretations for how and why the Fremont used plants by researching how their historic counterparts, the Goshute, Shoshone, Ute, and Southern Paiute, used …

Go to article

Understanding Community And Ecophysiology Of Plant Species On The Colorado Plateau, Hannah Elizabeth Yokum Dec 2017

Understanding Community And Ecophysiology Of Plant Species On The Colorado Plateau, Hannah Elizabeth Yokum

Theses and Dissertations

The intensification of aridity due to anthropogenic climate change is likely to have a large impact on the growth and survival of plant species in the southwestern U.S. where species are already vulnerable to high temperatures and limited precipitation. Global climate change impacts plants through a rising temperature effect, CO2 effect, and land management. In order to forecast the impacts of global climate change, it is necessary to know the current conditions and create a baseline for future comparisons and to understand the factors and players that will affect what happens in the future. The objective of Chapter 1 is …

Go to article

Eigenblades: Application Of Computer Vision And Machine Learning For Mode Shape Identification, Alex W. La Dec 2017

Eigenblades: Application Of Computer Vision And Machine Learning For Mode Shape Identification, Alex W. La

Theses and Dissertations

On August 27, 2016, Southwest Airlines flight 3472 from New Orleans to Orlando had to perform an emergency landing when a fan blade separated from the engine hub and destroyed the cowling and punctured the fuselage. Initial findings from the metallurgical examination conducted in the National Transpiration Safety Board Materials Laboratory found that the fracture surface of the missing blade showed curving crack arrest lines consistent with fatigue crack growth. Fatigue is often cause by resonate vibrations. Modal analysis is a method that can model the natural frequencies and bending modes of turbomachinery blades. When performing modal analysis with finite …

Go to article

Supporting Individuals With Autism Spectrum Disorder In Understanding And Coping With Complex Social Emotional Issues, Kaitlyn P. Ahlers, Terisa P. Gabrielsen, Danielle Lewis, Anna M. Brady, April Litchford Nov 2017

Supporting Individuals With Autism Spectrum Disorder In Understanding And Coping With Complex Social Emotional Issues, Kaitlyn P. Ahlers, Terisa P. Gabrielsen, Danielle Lewis, Anna M. Brady, April Litchford

Faculty Publications

Core deficits in autism spectrum disorder (ASD) center around social communication and behavior. For those with ASD, these deficits complicate the task of learning how to cope with and manage complex social emotional issues. Although individuals with ASD may receive sufficient academic and basic behavioral support in school settings, supports for dealing with complex social emotional issues are more difficult to access, even though these issues significantly impact student learning. When addressing these challenging social- and emotional-based issues, school and professional personnel need more specific instructional skill sets and resources to effectively and compassionately support students with ASD. In this …

Go to article

Bringing Santa Rosa Island Into Channel Islands National Park: The Written Documents 1979–1987, Kate Roney Faulkner Nov 2017

Bringing Santa Rosa Island Into Channel Islands National Park: The Written Documents 1979–1987, Kate Roney Faulkner

Western North American Naturalist

The National Park Service (NPS) purchased Santa Rosa Island from private landowners Vail & Vickers in 1986. Immediately following the purchase, NPS personnel stated that they and the former landowners were negotiating a 5- to 10-year phaseout of cattle ranching and hunting of introduced deer and elk. Later, NPS staff stated that the former landowners had a 25-year right to presale land uses. This unsubstantiated “right” became the justification for the NPS issuing a series of permits that continued the operations of the former landowner. Over time, questions arose regarding the environmental impacts of the cattle, deer, and elk on …

Go to article

Reaching In Clutter With Whole-Arm Tactile Sensing, Advait Jain, Marc D. Killpack, Aaron Edsinger, Charles Kemp Nov 2017

Reaching In Clutter With Whole-Arm Tactile Sensing, Advait Jain, Marc D. Killpack, Aaron Edsinger, Charles Kemp

Faculty Publications

Clutter creates challenges for robot manipulation, including a lack of non-contact trajectories and reduced visibility for line-of-sight sensors. We demonstrate that robots can use whole-arm tactile sensing to perceive clutter and maneuver within it, while keeping contact forces low. We first present our approach to manipulation, which emphasizes the benefits of making contact across the entire manipulator and assumes the manipulator has low-stiffness actuation and tactile sensing across its entire surface. We then present a novel controller that exploits these assumptions. The controller only requires haptic sensing, handles multiple contacts, and does not need an explicit model of the environment …

Go to article

The Intrigue Of Paradigmatic Similarity: Leibniz And China, Yu Liu Nov 2017

The Intrigue Of Paradigmatic Similarity: Leibniz And China, Yu Liu

Comparative Civilizations Review

The cosmology of China is indeed strikingly similar to the metaphysics of Leibniz, but precisely where the two resemble each other, the former is unmistakably different from Christianity. Scholars of Leibniz have so far generally taken it for granted that he was ideologically aligned with Christianity, but his paradigmatic similarity to China should alert us of a surprisingly different story. Leibniz was indisputably “the greatest of the seventeenth century sinophiles” and key Chinese cosmological ideas were introduced to Europe long before he formulated his worldview. Together, these two facts can help us decide whether he “owes to Chinese organic naturalism …

Go to article

Andrew Scull, Madness In Civilization: A Cultural History Of Insanity From The Bible To Freud From The Madhouse To Modern Medicine. Princeton University Press, 2015., Michael Palencia-Roth Nov 2017

Andrew Scull, Madness In Civilization: A Cultural History Of Insanity From The Bible To Freud From The Madhouse To Modern Medicine. Princeton University Press, 2015., Michael Palencia-Roth

Comparative Civilizations Review

No abstract provided.

Go to article

Book Review: Goodbye Days, Courtney Jones Nov 2017

Book Review: Goodbye Days, Courtney Jones

The Utah English Journal

Carver Briggs is an aspiring writer attending a prestigious school of the arts for the young and gifted in Jeff Zentner’s Goodbye Days. Carver pours hours into his work and future career, but never imagines that just two sentences could change his life forever: “Where are you guys? Text me back.” These become the most influential words he ever writes, because they result in the deaths of his three best friends.

Go to article

Book Review: The Lady Of The Lakes, Shannon Taylor Nov 2017

Book Review: The Lady Of The Lakes, Shannon Taylor

The Utah English Journal

Falling in love can be a tumultuous experience, what with utter elation in one moment and crushing insecurity in the next. In Josi Kilpack’s novel The Lady of the Lakes, the young Sir Walter Scott experiences this tumult of falling in love not once but twice, discovering that finding true love does not always happen as one would hope or expect. When Walter first sees Mina Stuart, a young heiress, he is immediately enthralled and devotes his heart to her entirely, writing to her for years and preparing for the day when he can ask for her hand in …

Go to article

Book Review: The Inexplicable Logic Of My Life, Maddison Driggs Nov 2017

Book Review: The Inexplicable Logic Of My Life, Maddison Driggs

The Utah English Journal

For Sal, the protagonist of Benjamin Saenz’s novel, The Inexplicable Logic of My Life, nothing has ever been simple. Raised by his gay adoptive father, with the support of extended family and friends, the beginning of his senior year proves to be unusually challenging for Sal. A generally calm and collected boy, Sal finds that violent tendencies have begun arising in his life. Punch after punch, these violent encounters lead Sal to question who his biological father was — and more importantly, who he is himself.

Go to article

Combating Subclonal Evolution Of Resistant Cancer Phenotypes, Samuel W. Brady, Jasmine A. Mcquerry, Yi Qiao, Stephen Piccolo, Gajendra Shrestha, David F. Jenkins, Ryan M. Layer, Brent S. Pedersen, Ryan H. Miller, Amanda Esch, Sara R. Selitsky, Joel S. Parker, Layla A. Anderson, Brian K. Dalley, Rachel E. Factor, Chakravarthy B. Reddy, Jonathan P. Boltax, Dean Li, Philip J. Moos, Joe W. Gray, Laura M. Heiser, Saundra S. Buys, Adam L. Cohen, W. Evan Johnson, Aaron R. Quinlan, Gabor Marth, Theresa L. Werner, Andrea H. Bild Nov 2017

Combating Subclonal Evolution Of Resistant Cancer Phenotypes, Samuel W. Brady, Jasmine A. Mcquerry, Yi Qiao, Stephen Piccolo, Gajendra Shrestha, David F. Jenkins, Ryan M. Layer, Brent S. Pedersen, Ryan H. Miller, Amanda Esch, Sara R. Selitsky, Joel S. Parker, Layla A. Anderson, Brian K. Dalley, Rachel E. Factor, Chakravarthy B. Reddy, Jonathan P. Boltax, Dean Li, Philip J. Moos, Joe W. Gray, Laura M. Heiser, Saundra S. Buys, Adam L. Cohen, W. Evan Johnson, Aaron R. Quinlan, Gabor Marth, Theresa L. Werner, Andrea H. Bild

Faculty Publications

Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. This acquired drug resistance is largely due to drug-refractory sub-populations (subclones) within heterogeneous tumors. Here, we track the genetic and phenotypic subclonal evolution of four breast cancers through years of treatment to better understand how breast cancers become drug-resistant. Recurrently appearing post-chemotherapy mutations are rare. However, bulk and single-cell RNA sequencing reveal acquisition of malignant phenotypes after treatment, including enhanced mesenchymal and growth factor signaling, which may promote drug resistance, and decreased antigen presentation and TNF-α signaling, which may enable immune system avoidance. Some of these …

Go to article

First Prev Next Last