Digital Commons Network^™

Does Belarusian-Ukrainian Civilization Belong To The Western Or The Latin Civilization?, Piotra Murzionak

Comparative Civilizations Review

No abstract provided.

Effects Of Ice Massage Prior To An Iontophoresis Treatment Using Dexamethasone, Brady Michael Smith

Theses and Dissertations

Context: Low current intensity iontophoresis treatments have shown an increase in skin perfusion over 700% from baseline potentially increasing drug clearance from the targeted area. Objective: To determine the effects of a 10-minute ice massage on subcutaneous dexamethasone sodium phosphate (Dex-P) concentration and skin perfusion during and after a 4 mA iontophoresis treatment. Design: Controlled laboratory study. Setting: Research Laboratory. Patients or Other Participants: 26 individual participants (Males = 15, Females = 11, age = 25.6 ± 4.5 y, height = 173.9 ± 8.51 cm, mass = 76.11 ± 16.84 kg). Interventions: Participants were randomly assigned into two groups: 1) …

Application Of Mixture Design Response Surface Methodology For Combination Chemotherapy In Pc-3 Human Prostate Cancer Cells, Richard Vernon Oblad

Theses and Dissertations

Combining chemotherapeutics to treat malignant tumors has been shown to be effectivein preventing drug resistance, tumor recurrence, and reducing tumor size. We modeledcombination drug therapy in PC-3 human prostate cancer cells using mixture design responsesurface methodology (MDRSM), a statistical technique designed to optimize compositions thatwe applied in a novel manner to design combinations of chemotherapeutics. Conventionalchemotherapeutics (mitoxantrone, cabazitaxel, and docetaxel) and natural bioactive compounds(resveratrol, piperlongumine, and flavopiridol) were used in twelve different combinationscontaining three drugs at varying concentrations. Cell viability and cell cycle data werecollected and used to plot response surfaces in MDRSM that identified the most effectiveconcentrations of each …

Dynamics For A Random Differential Equation: Invariant Manifolds, Foliations, And Smooth Conjugacy Between Center Manifolds, Junyilang Zhao

Theses and Dissertations

In this dissertation, we first prove that for a random differential equation with the multiplicative driving noise constructed from a Q-Wiener process and the Wiener shift, which is an approximation to a stochastic evolution equation, there exists a unique solution that generates a local dynamical system. There also exist a local center, unstable, stable, centerunstable, center-stable manifold, and a local stable foliation, an unstable foliation on the center-unstable manifold, and a stable foliation on the center-stable manifold, the smoothness of which depend on the vector fields of the equation. In the second half of the dissertation, we show that any …

Quantifying Grain Boundary Atomic Structures Using The Smooth Overlap Of Atomic Positions, Jonathan Lake Priedeman

Theses and Dissertations

In this work, the relationship between grain boundary crystallography and grain boundary atomic structure is examined, using [1 0 0] - symmetric tilt grain boundaries in nickel. The structural unit model is used as a benchmark to evaluate the atomic structure description capacities of an emerging structural descriptor, the local environment representation, which itself is a refinement of the also-emergent Smooth Overlap of Atomic Positions (SOAP) descriptor. We show that the local environment representation encodes both the information of the structural unit model and additional information, such as distortion in the structural units and the arrangement of the structural units …

Improving Post-Wildfire Seeding Success Using Germination Modeling And Seed Enhancement Technologies, William Charles Richardson

Theses and Dissertations

Arid and semi-arid rangelands are important ecosystems that are consistently degraded through disturbances such as wildfires. After such disturbances, the invasion and dominance of annual grasses, like cheatgrass (Bromus tectorum L.), can lead to an overall loss of ecosystem productivity and an increase in fire frequency. To reduce weed dominance, native and introduced perennials species are typically be seeded in the fall. High mortality is seen from these seeded plant communities due to germinated seed being exposed to freezing, drought, fungal pathogens, and other biotic and abiotic stressors during winter months. We utilized wet-thermal accumulation models to first further …

Comparison Of Functional, Nutritional, And Sensory Properties Of Spray-Dried And Oven-Dried Cricket (Acheta Domesticus) Powder, Fred Stephen Bassett

Theses and Dissertations

Three dried cricket products – Oven-roasted Cricket Meal (ORCM), Oven-roasted Cricket Powder (ORCP), and Spray-dried Cricket Powder (SDCP) – were prepared and compared to assess their relative nutritional, functional, and sensory properties. The range of particle sizes in SDCP was wider than that of ORCP; while SDCP had more particles in the 7.78-22.0 µm range, it also had more particles in the 176-498 µm range, which contributed to differences in functional and sensory properties. ORCM and SDCP meet the FDA definition of an "excellent source" of vitamin B₂, ORCP is a "good source" of vitamin B₂, …

Cultural Differences In Russian And English Magazine Advertising: A Pragmatic Approach, Emily Kay Furner

Theses and Dissertations

Many American companies looking to increase sales and achieve growth targets consider expanding the reach of their product lines to other countries. However, expansion on a global scale often requires much trial and error as English-speaking companies try to market their goods to a foreign audience. In order to ease this process, localization experts are often hired to "localize" or change advertisements in order to make them more culturally relevant to consumers. Because the field of localization is relatively new, there is little research done on the degree and extent to which advertisements are localized. The purpose of this study …

Multiplexed Optofluidics For Single-Molecule Analysis, Matthew Alan Stott

Theses and Dissertations

The rapid development of optofluidics, the combination of microfluidics and integrated optics, since its formal conception in the early 2000's has aided in the advance of single-molecule analysis. The optofluidic platform discussed in this dissertation is called the liquid core anti-resonant reflecting optical waveguide (LC-ARROW). This platform uses ARROW waveguides to orthogonally intersect a liquid core waveguide with solid core rib waveguides for the excitation of specifically labeled molecules and collection of fluorescence signal. Since conception, the LC-ARROW platform has demonstrated its effectiveness as a lab-on-a-chip fluorescence biosensor. However, until the addition of optical multiplexing excitation waveguides, the platform lacked …

The Meaning Of Sexuality: A Critique Of Foucault's History Of Sexuality Volume 1, Anne E. Grow

Theses and Dissertations

Michel Foucault is a celebrated post-structuralist theorist that has helped shape gender and sexual theory. In A History of Sexuality Volume 1 Foucault dismantles many longstanding sexual traditions and morals by exposing them as societal constructs. According to Foucault, anonymous yet fully invasive power sources have shaped and continue to shape sexual culture and more importantly, individual beliefs about sexuality. However, Foucault's obsession with the influence of power limits his sexual theory in three particular ways. First, he disregards the female sexual experience; second, he undermines individual agency; and third, he undermines the innate desire for love and family. The …

Hospital And Meat Associated Staphylococcus Aureus And Their Biofilm Characteristics, Trevor Michael Wienclaw

Theses and Dissertations

Biofilm phenotypes were studied in 32 Staphylococcus aureus strains isolated from store-bought meats and 22 from diseased patients in hospitals. Of the meat-associated strains, 21 were methicillin-resistant Staphylococcus aureus (MRSA) and 11 were methicillin-susceptible Staphylococcus aureus (MSSA). The hospital-associated strains included 15 MRSAs and 7 MSSAs. We studied the robustness and composition of the biofilms produced by these strains. We found that on average hospital-associated strains form more robust biofilms than meat associated strains. The model often used to describe S. aureus biofilm composition includes two biofilm types defined by the presence or absence of polysaccharide intercellular adhesin (PIA), PIA-dependent …

Lithofaces And Sequence Architecture Of The Upper Paradox Formation (Middle Pennsylvanian)In The Subsurface Northern Blanding Subbasin, Paradox Basin, Utah, Geoffrey William Ritter

Theses and Dissertations

THE PARADOX Basin is a northwest-southeast trending intracratonic basin that formedin southwestern Colorado, southeastern Utah and adjacent parts of Arizona and New Mexicoduring the late Paleozoic Era. During rise of the adjacent Uncompahgre Uplift (Ancestral RockyMountains) the rapidly subsiding basin was filled with over 2000 m of Permo-Pennsylvaniansediments. Stacked depositional sequences accumulated in three roughly parallel facies belts: anortheastern clastic belt (adjacent to uplift), a central salt and black shale belt, and asouthwestern carbonate belt. Over 400 million barrels of oil have been extracted from upperParadox (Desert Creek and Ismay) carbonates in the southern Blanding Subbasin (Greater AnethField) since 1956. …

Analysis Of Whole Exome Sequence Data In Affected Cousin Pairs From High-Risk Alzheimer's Pedigrees, Lyndsay Ann Staley

Theses and Dissertations

Genetic factors account for about half of Alzheimers Disease (AD) risk and only about a quarter of that heritability is accounted for by known variants. Family based approaches to understanding AD genetics may be an effective way to identify additional risk factors. Here we report the results of whole exome sequencing (WES) and analyses done on pairs of AD affected cousins from 19 families from the Utah Population Database (UPDB) with a statistical excess of AD risk. WES variants passing quality control were additionally filtered by population frequency (minor allele <<> 0.01) and concordance between cousin pairs, resulting in 564 variants …

Stress And Anxiety Interventions For Classical Musicians, Tara Ashley Austin

Theses and Dissertations

This meta analysis looks at the results of performance anxiety related interventions with musicians. This meta analysis results from all found studies on computerized databases including National Library of Medicine's PubMed, Dissertations and Theses (ProQuest), PsycINFO, and Oxford Journals Database. They range from cognitive interventions, behavioral interventions, mediation, and biofeedback. The results are primarily drawn from participants self report before and after the intervention. They were coded for length of intervention, number of participants, level of participant (students or professionals), type of intervention, self report measures used, and the effect size of the intervention. The overall effect of all 17 …

Multi-Tissue Examination Of Exercise Or Metformin On The Consequences Of Doxorubicin Treatment, Amy Dee Mackay

Theses and Dissertations

Doxorubicin (DOX) is an effective chemotherapeutic treatment with lasting deleterious side effects in heart and skeletal muscle. As an increased percentage of patients live many years past their cancer treatments, addressing the long-term side effects of chemotherapy treatment becomes critical. In an attempt to prevent heart and skeletal muscle damage caused by DOX, two co-treatments, exercise (EX) or metformin (MET) were studied for their effectiveness in maintaining muscle function, mitochondrial respiration and iron regulation. DOX is known to bind with iron, contributing to oxidative damage resulting in cardiac and skeletal muscle toxicity. However, the degree to which the toxic side …

Crispr-Cas9 Transfection Optimization And Use In A Forward Genetic Screen To Identify Telomere Length Maintenance Genes, Kelsey Phillips

Theses and Dissertations

Mutations in the telomere length maintenance pathway can lead to a spectrum of diseases called telomere syndromes, however, the pathway is not fully understood and there may still be unknown components. We designed a forward genetic screen to identify new genes involved in telomere length maintenance. Of the top ranked genes, ZNF827, a zinc finger protein, is the most promising candidate gene. The possible discovery of a new component involved in telomere length maintenance increases our understanding of the pathway and opens new avenues of research. Recent advances in molecular biology techniques, such as the use of RNA-guided nuclease CRISPR …

Emerging Seed Enhancements To Reduce The Risk Of Sagebrush Post-Fire Seeding Failure, Ryan Scott Call

Theses and Dissertations

The sagebrush (Artemisia spp.) steppe is undergoing rapid ecological change. The degradation of sagebrush steppe rangelands has resulted in the listing of more than 350 animals and plants as species of conservation concern. In addition, there has been a decrease in recreational values, reduced forage production, degraded water resources, and an increase in fire frequency. In the sagebrush steppe, success rates for seeding sagebrush after wildfire are notoriously low. Not only are sagebrush seeds hard to sow due to their small size and associated flower parts, but seedlings are exposed to numerous stresses that lowers their survivability. To improve …

The Evolutionary Significance Of Body Size In Burying Beetles, Ashlee Nichole Momcilovich

Theses and Dissertations

Body size is one of the most commonly studied traits of an organism, which is largely due to its direct correlation with fitness, life history strategy, and physiology of the organism. Patterns of body size distribution are also often studied. The distribution of body size within species is looked at for suggestions of differential mating strategies or niche variation among ontogenetic development. Patterns are also examined among species to determine the effects of competition, environmental factors, and phylogenetic inertia. Finally, the distribution of body size across the geographic range of a species or group of closely related is looked at …

“Nourished By My Mother”: Zitkala-Ša And The Indian Sterilization Project, Lainey Wardlow

Criterion: A Journal of Literary Criticism

No abstract provided.

'Fashionable Piety': Theological Modernism In Evelyn Waugh's Decline And Fall And Vile Bodies, Deirdre Murphy

Criterion: A Journal of Literary Criticism

No abstract provided.

Survival Of Neonate Mule Deer Fawns In Southern Utah: Effects Of Coyote Removal And Synchrony Of Parturition, Jacob Tyler Hall

Theses and Dissertations

Mule deer (Odocoileus hemionus) are an iconic species of wildlife, and populations of mule deer across much of the western U.S. have experienced recent fluctuations in size. Factors that affect the survival and subsequent recruitment of juveniles may be the preeminent cause of population fluctuations for mule deer in many areas. Many factors, including habitat loss, extreme weather, intense predation, timing and synchrony of parturition, and competition with other species may be influencing these changes. We studied two potential factors that can influence the survival of neonate mule deer in southern Utah. To better understand how predation affects …

Measuring And Calculating Current Atmospheric Phosphorous And Nitrogen Loadings On Utah Lake Using Field Samples, Laboratory Methods, And Statistical Analysis: Implication For Water Quality Issues, Jacob Milton Olsen

Theses and Dissertations

Atmospheric nutrient loading and transport though precipitation and dry deposition is one of the least understood yet one of the most important pathways of nutrient transport into many lakes. These nutrients, phosphorus and nitrogen, are essential for aquatic life and often play major roles in algae blooms that occur in lakes and reservoirs. Often heavy algal growth intensifies a variety of water quality problems. Utah Lake may be even more susceptible to atmospheric deposition due to its large surface area to volume ratio and proximity to Great Basin dust sources. In this study, eight months of atmospheric deposition data were …

Neuroimmune-Mediated Alcohol Effects On Ventral Tegmental Area Neurons, Stephanie Bair Williams

Theses and Dissertations

Dopamine (DA) transmission is a key player in the rewarding aspects of ethanol as well as ethanol dependence. The current dogma is that DA transmission is increased during ethanol via the inhibition of ventral tegmental area (VTA) GABA neurons and that excitation of VTA GABA neurons during withdrawal results in decreased DA transmission. Microglia, the major neuroimmune effector in the brain, may be a key mediator in this process by releasing cytokines following activation. We evaluated the effect of ethanol on cytokine concentrations in the VTA and NAc using a cytometric bead array, and found that low dose ethanol (1.0 …

A Content-Analytic Meta-Analysis Of Gender Stereotyping In Screen Media, Lee Whitney Essig

Theses and Dissertations

Thousands of studies have investigated the gendered portrayals in various forms of media. Researchers believe that considering gendered media content is important, as gender stereotypes have been found to influence development, often with adverse outcomes. Although a vast body of research on gender stereotypes has accumulated, little effort has been made to synthesize this literature. The purpose of this paper is to collect and analyze the results of content-analytic studies of gender portrayals across several forms of media including television, television commercials, movies, video games, music videos, and various forms of print media into a comprehensive paper on gender stereotypes …

Creation And Use Of Software For Analysis Of Kinetic Proteomic Experiments, Bradley C. Naylor

Theses and Dissertations

In this dissertation, I will review the history and general strategies for performing kinetic proteomics. I will then demonstrate that I have published an open source, user-friendly program for other scientists to use to perform kinetic proteomics data analysis, as well as publishing a novel discovery of key ribosomal subunits being replaced within the lifetime of the ribosome, which was discovered through use of kinetic proteomics. Finally, I will discuss work that is ongoing to improve my software tool for use in human subjects, and work being done to combine kinetic proteomics with other global analysis methods to make novel …

"Love On The Brain":? Exploring The Influence Of Lyrics On Sexting And Risky Sexual Behavior, Savannah Leigh Kroff

Theses and Dissertations

While some research has been done on the influence of music lyrics on sexual behaviors in general, none has explored the lyrical influence on sexting. The goal of the current study is to explore the longitudinal influence of sexual and sexually objectifying lyrics on adolescent sexting behaviors. Participants were 125 14-year-old adolescents who were recruited from high schools in Texas. Participants completed questionnaires on music preferences, sexual behaviors and impulsivity and were given BlackBerry devices through which frequency of sexual text message utterances was obtained. Music preferences were then quantitatively analyzed using the Linguistic Inquiry Word Count (LIWC) software. Logistic …

Progress Toward Synthetically Simplified Natural Anticancer Peptide, David W. Kastner, Steven L. Castle

Library/Life Sciences Undergraduate Poster Competition 2018

Yaku’amide A was isolated in late 2010 from the deep-sea sponge Ceratopsion sp. and exhibits potent inhibitory activity against 39 human cancer cell lines via a potentially novel mode of action. However, the total synthesis requires many steps and produces low yields. In this study, we determined two simpler YA analogues that may retain its anticancer properties and can be synthesized in larger quantities. The analogues replace dehydroisoleucine with either dehydroethylnorvaline or dehydrovaline.

14-3-3zeta Role In Promoting Survival Of Cells To Facilitate Progression Of Cancer, Katie Pennington, Eranga Roshan, Joshua Andersen, Katherine K. Mccormack

Student Works

The regulatory protein 14-3-3z promotes cellular growth and survival, and high expression levels of 14-3-3z are associated with mortality in multiple cancer types. 14-3-3z binds cellular proteins in a phosphorylation-dependent manner to modulate their functions. We have been characterizing the interactome of 14-3-3z which will likely lead to candidates for novel therapies for chemoresistant cancers. Tumor cells must be able to survive in a variety of stresses within the tumor microenvironment, including hypoxia, which occurs when tumors lack adequate blood supply. Previous data from our lab suggested that 14-3-3z promotes the adaptation of tumor cells to hypoxic stress. Our hypothesis …

Povidone-Iodine Vapor Kills Mrsa, Benjamin Ogilvie, Jon Mitton, Jordan Tucker, Dennis L. Eggett, Richard A. Robison

Student Works

Povidone-iodine is an antiseptic that is frequently used to clean skin prior to surgery. Current FDA regulations require that hospitals dispense povidone-iodine from single-use bottles, rather than large, multi-use containers, to prevent microbial contamination. This results in hospitals generating lots of product waste. However, if povidone-iodine vapor can kill microbes, then multi-use containers may be safe to use, since any bacteria that contaminated the inside of the container would soon die. The purpose of this research was to determine whether vapor from povidone-iodine could kill methicillin-resistant Staphylococcus aureus (MRSA), a common cause of hospital-associated infections.

In summary, this experiment demonstrated …

Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2), Juan Mejia, Parker Hall, Kelsey Hirschi, Paul R. Reynolds, Juan Arroyo

Student Works

The Pyruvate kinase isozymes M2 (PKM2) protein is a metabolic enzyme that regulates the final step of glycolysis. This enzyme is present in highly proliferating cells such as those present in embryonic tissues, cancer and in the placental trophoblast. We recently studied PKM2 protein in the human placenta at term. Our results demonstrated upregulated placental PKM2 during preeclampsia (PE) where trophoblast invasion is decreased and hypoxia is present. Our objective was to determine the cytosolic and nuclear PKM2 expression pattern and determine PKM2 regulation of trophoblast cell invasion. Trophoblast cells were cultured in normoxic and hypoxic conditions and real time …