Digital Commons Network^™

Diagnosis And The Role Of Chemokine Receptors In Alzheimer's Disease, Josue David Gonzalez Murcia

Theses and Dissertations

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is the main cause of dementia in the elderly population. AD is pathologically characterized by the accumulation of amyloid plaques and neurofibrillary tangles that results in neurodegeneration and loss of memory function. However, diagnosis of AD and characterization of biological mechanisms that lead to pathology and modulate risk for disease has proven to be extremely difficult. Cerebrospinal fluid (CSF) contains critical biomarkers for AD such as levels of amyloid beta (Aβ) phosphorylated-tau (p-tau), total-tau (t-tau), and neurofilament light chain (NfL). The CSF levels of these biomarkers are useful in determining …

Rage And Gas6/Axl Signaling In Obstetric Complications, Kelsey May Hirschi Budge

Theses and Dissertations

Current research spans a wide range of objectives whose diversity includes the understanding of global epidemiology and the detailing of molecular interactions leading to specific pathologies. This work aligns more closely with the goal of mechanistic clarity by elucidating several aspects of signaling pathways involved in inflammatory and obstetric pathologies. Prior research has confirmed the role of Receptors for Advanced Glycation End-Products (RAGE) activation in signaling leading to chronic inflammation such as that observed in chronic obstructive pulmonary disease (COPD). RAGE activation has also been identified in other disease states including diabetes, Alzheimer’s disease, osteoarthritis, and cancers. We examined the …

First Record Of Grasshopper Sparrow Ammodramus Savannarum Breeding In The Grasslands Of Durango, México, With Notes On Nesting Sites And Habitat, Samuel Ignacio Arroyo-Arroyo, Martin Emilio Pereda-Solis, José Hugo Martínez Guerrero, Daniel Sierra-Franco, Andrea Montes-Aldaba, Erin H. Strasser, Arvind O. Panjabi

Western North American Naturalist

Grassland birds are one of the most rapidly declining bird guilds in North America, likely as a result of the loss and degradation of native grasslands. The Grasshopper Sparrow (Ammodramus savannarum), a migratory grassland bird of North America, relies on dense, relatively tall grasses with low shrub densities. In Mexico, 4 subspecies of A. savannarum have been reported; however, the distribution of the species in the summer is poorly known, with only 2 records from northern Mexico within the states of Zacatecas and Chihuahua. Here, we report on the presence and nesting activity of A. savannarum in the …

Immobilization Of Copper Nanoparticles Onto Various Supports Applications In Catalysis, Anh Hoang Tu Nguyen Sorenson

Theses and Dissertations

Copper-based materials are one of the most promising catalysts for performing transformations of important organic compounds in both academic and industrial operations. However, it is challenging to consistently synthesize highly active and stable copper species as heterogeneous catalysts due to their relatively high surface energy. As a result, agglomeration usually occurs, which limits the catalytic activities of the copper species. The work presented in this dissertation shows different synthetic strategies for obtaining active and stable copper-based materials by modifying chemical/physical properties of copper nanoparticles (NPs). Emphasis is placed on discussing specific catalytic systems, including carbon-supported catalysts (monometallic and bimetallic copper-based …

The Investigation Of Functionalized Carbon Nanotubes For The Carbon Dioxide Capture And Ethane Oxidative Dehyrogenation Catalysts, Zheng Zhou

Theses and Dissertations

Carbon nanotubes (CNT) have gained interest for wide use as both support and catalyst due to the ease of uniquely tunable surface chemistry. Increasingly severe greenhouse effects have attracted attention to novel materials and technologies capable of capturing carbon dioxide (CO2). In this context, we develop a CNT based solid state amine for the CO2 capture. CNT are functionalized under various methods as a support for polymeric amines. Polyethyleneimine are physically adsorbed on CNT and are further characterized and studied for reversible CO2 capture. We obtain a high CO2 capture capacity (6.78 mmol∙g-1) for linear polyethyleneimine (LPEI) and 6.18 mmol∙g-1 …

Advances In The Systematics And Evolutionary Understanding Of Fireflies (Coleoptera: Lampyridae), Gavin Jon Martin

Theses and Dissertations

Fireflies are a cosmopolitan group of bioluminescent beetles classified in the family Lampyridae. The first catalogue of Lampyridae was published in 1907 and since that time, the classification and systematics of fireflies have been in flux. Several more recent catalogues and classification schemes have been published, but rarely have they taken phylogenetic history into account. Here I infer the first large scale anchored hybrid enrichment phylogeny for the fireflies and use this phylogeny as a backbone to inform classification. Several classification changes are made throughout the group with emphasis on morphological traits that support the AHE hypothesis. Building off of …

A Brief Overview Of Burst Suppression: Causes And Effects On Mortality In Critical Illness, Jake Hogan, Haoqi Sun, Hassan Aboul Nour, Stephen Piccolo, Jacob Crandall, Steven Peck, M Brandon Westover

Undergraduate Honors Theses

This thesis examines the effects of brain inactivation (burst suppression) on mortality in mechanically ventilated ICU patients. Past research has associated burst suppression with increased mortality. However, the effects of burst suppression on ICU patients while taking into account the relative contributions of propofol (a sedative), and critical illness to mortality, and whether preventing burst suppression might reduce mortality, has not yet been quantified. This thesis explores this relationship, and the effect of critical illness and propofol infusion on burst suppression to understand what drives burst suppression.

To measure the relationship between burst suppression, critical illness, propofol infusion, and mortality, …

Sunflower Seedlings Fail To Remove Uranium Pollution In The Navajo Nation: Participatory Science As A Path To Build Community And Address Environmental Injustice, Zak R. Webber

Undergraduate Honors Theses

Mid-20th century mining on Naabeehó Bináhásdzo (Navajo Nation) polluted groundwater with high concentrations of uranium and arsenic. The Navajo Nation and other rural residents of this region use groundwater for drinking, livestock, and irrigation. However, many individuals and communities must purchase and transport treated water from locations that are often hours away. Sunflowers have been shown to preferentially take up heavy metals, including uranium and arsenic, potentially representing a tool to improve water quality through on-site, low-cost phytoremediation. We carried out a collaborative research project with a high school class on the Navajo Nation in 2018 and 2019. The students …

Staphylococcus Aureus Metal Acquisition In Milk And Mammary Gland Tissue, Shalee Killpack

Theses and Dissertations

Mastitis resulting from mammary gland infection is a common and painful disease associated with lactation. In addition to the impact on human and animal health, mastitis causes substantial economic losses in the dairy industry. Staphylococcus aureus is a frequent cause of mastitis worldwide. Despite significant progress in understanding S. aureus pathogenesis in general, much remains to be learned regarding virulence factors relevant in the context of mastitis. In mammary gland infections, it is not fully understood which metal acquisition systems are required for S. aureus survival. To help understand molecular mechanisms by which S. aureus might acquire essential metals, such …

Evaluation And Improvement Of A Novel Method For Rapid Promoter Characterization In A Zebrafish Model, Hunter Giles

Undergraduate Honors Theses

This thesis examines a novel technique for characterizing promoters using a zebrafish model. The proximal upstream cis-regulatory elements, also known as promoters or promoter regions, are essential for the precise regulation and timing of gene expression. Often the characterization of these regions relies on imprecise methods involving large deletions or bioinformatic predictions rather than experimental data. However, high-throughput sequencing technology could potentially allow large libraries containing hundreds of thousands of variants of a single promoter to be simultaneously analyzed. We have been working to develop a novel method for promoter characterization that takes advantage of this technology. We tested this …

Women In The Early Mongol Empire: Female Types In The Secret History Of The Mongols, Aspen Greaves

Undergraduate Honors Theses

The Mongol Empire is highly susceptible to great-man history, placing all credit and blame on the figure of Genghis Khan and ignoring the contributions of others. Modern historians often read the primary texts through a patriarchal lens in assuming all decisions are made by men. However, the primary sources support a more feminist approach in emphasizing the importance of individual women, particularly Hö’elün, Börte, and the three regent-empresses. This research looks at how women are depicted in The Secret History of the Mongols. I identified four “types” of women in The Secret History, and therefore in medieval Mongolian culture. …

Strength Training And Insulin Resistance: The Mediating Role Of Body Composition, Mckayla Jean Niemann

Theses and Dissertations

OBJECTIVE: The main objective of the present study was to assess the association between varying amounts of strength training and insulin resistance. Another goal was to assess the influence of several potential confounding variables on the strength training and insulin resistance relationship. Lastly, the role of waist circumference, fat free mass, and body fat percentage on the association between strength training and insulin resistance was assessed. METHODS: This cross-sectional study included 6561 randomly selected men and women in the US. Data were collected using the precise protocol established by NHANES. HOMA-IR was used as the outcome variable. Both time spent …

What Role Should Philosophy Play In The Public Sphere? The Intrinsic Value Of Public Philosophy, Jonathan Engle

Undergraduate Honors Theses

Public philosophy is a relatively new area of meta-philosophy requiring further development. In this paper I seek to establish a clear definition of public philosophy and clarify what at times has become a muddled term. This is followed by laying a groundwork for how to view philosophical study and its consequences to the students. I primarily address Weinstein’s argument that public philosophy is primarily for entertainment. This is based on one of his points that public philosophy leads to self-knowledge (self-cultivation). Rather than peripheral to public philosophy, I will argue that this is central to public philosophy, establishing it as …

Evaluating Basin Wildrye Seed Sources Across Provisional Seed Zones, Native Forb Sowing Depth On Species Performance And Improving The Accuracy Of Collection Site And Seed Lot Identification For Big Sagebrush, Scott L Jensen

Theses and Dissertations

Identifying genetically appropriate plant materials for seed based restoration relies on the principle of local adaptation where the objective is to match adaptive genetic characteristics to variation in ecological clines pertinent to plant establishment and persistence. In this study, basin wildrye (Leymus cinereus (Scribn. & Merr.) Á. Löve) sources from 25 wild populations and 4 commercial varieties were planted at 4 test sites. We assessed initial establishment and short term persistance. Plantings failed at 2 sites in both 2013 and 2014, with too few plants to quantify differences. At the remaining 2 sites, local sources had higher initial establishment in …

Does Negative Frequency-Dependent Selection Maintain Gonopodial Asymmetry In A Livebearing Fish?, Mary-Elise Johnson

Undergraduate Honors Theses

How genetic variation is maintained in the face of strong natural selection is an important problem in evolutionary biology. Selection should erode genetic diversity, leading to more and more homogeneous populations. Yet in nature, we commonly see high degrees of genetic variation, even for traits that are important to fitness. Negative frequency-dependent selection, a balancing selective force that favors traits when they are rare but not when they are common, is a mechanism proposed to maintain polymorphisms in a population. However, there is little empirical data to demonstrate how negative frequency-dependent selection sustains variation. Xenophallus umbratilis is a bilaterally symmetrical …

Landscape Of The Data Industry, Porter Bagley

Marriott Student Review

No abstract provided.

The Rose: Artificial Intelligence In The Current Hiring Process, Denise Han

Marriott Student Review

No abstract provided.

Full Issue: Unscripted (Volume 3, Issue 3), Marianna Richardson

Marriott Student Review

No abstract provided.

Self-Compatibility In Lomatium Dissectum (Apiaceae) And The Diverse Andrena Bees That Dominate Regional Lomatium Pollinator Faunas, James H. Cane, Melissa Weber, Byron G. Love

Western North American Naturalist

Species of biscuitroot (Lomatium: Apiaceae) are endemic to western North America, where multiple species can be common members of perennial wildflower communities from basin sagebrush-steppe and juniper woodlands up to alpine meadows. Despite Lomatium being the largest genus of Apiaceae in North America, little is known about its pollination needs or pollinators. Manual pollinations of the tiny flowers of one species, desert parsley (L. dissectum), showed it to be a self-compatible species, akin to other genera of Apiaceae. Seed production, however, largely requires pollinators to move pollen within and between the andromonoecious umbels. Regional sampling …

Species Composition And Hybridization Among Native And Nonnative Catostomid Fishes In Two Streams Of The Gunnison River Basin, Colorado, Michael R. Schwemm, Kevin G. Thompson, Evan W. Carson, Megan J. Osborne, Thomas F. Turner

Western North American Naturalist

We report results from a 3-year field investigation to limit hybridization between native and nonnative suckers in 2 small tributaries of the Gunnison River basin, Delta County, Colorado. Upstream movement to spawning habitat was selectively impeded by picket weir in intermittent Cottonwood Creek. There, native suckers were identified based on morphological characters in the field and were transferred upstream of the weir, whereas nonnative fishes were excluded from upstream movement. Another stream, Potter Creek, was not impeded by weir. Genetic identification of adult fishes in both streams was consistent with morphological identification in the field. Larval genetic identification was consistent …

Distributions Of Eastern And Western Red Bats In Western North America, Donald I. Solick, Robert M.R. Barclay, Larisa Bishop-Boros, Quentin R. Hays, Cori L. Lausen

Western North American Naturalist

The known distributions of eastern red bats and western red bats in western North America have changed greatly over the past 2 decades, resulting in inaccurate range maps and uncertainty regarding the presence or probable absence of these species within states and provinces. We obtained capture and specimen records from the western United States and Canada for 276 eastern red bats and for 863 western red bats. We documented the expansion of the range of eastern red bats in northwestern Canada and clarified the northern and eastern limits of western red bat distribution in the United States. We found that …

Guest Editor’S Note

Comparative Civilizations Review

No abstract provided.

The Iscsc Celebrates The 130th Birth Anniversary Of Pitirim A. Sorokin, The Founding President, With A Contemporary View Of His Legacy, Andrew S. Targowski

Comparative Civilizations Review

This study analyzes the legacy of Pitirim Sorokin, founding President of the ISCSC, in terms of his methodology, the scope of his works, and his acceptance by his American peers. He was perceived as a prophet rather than a scientist. Furthermore, he was a hidden anti-Leninist who lived through and was obsessed with crises, and, being spiritually cultivated, he perceived altruism, the Absolute, God, love, duty, sacrifice, grace, and justice as the only solutions that can reconstruct and save humanity. His theory of social and cultural dynamics is like Marx’s socioeconomics; however, it was reconfigured to sound different, since he …

In The Brandeis University Psychology Department, 1962-65: Recalling A Great American Social Theorist, Kenneth Feigenbaum

Comparative Civilizations Review

Abraham H. Maslow is one of the best known psychologists of the 20th century. His theory of motivation, most cogently expressed in his hierarchy of needs, is based upon biological assumptions mainly devoid of cultural influences, and it is not sensitive to the role of civilizations effecting intellectual development and ideology. Critiques of these possible shortcomings in his theory are abundant (Trigs, 2004).

Cancer Mortality Risk, Fine Particulate Air Pollution, And Smoking In A Large, Representative Cohort Of Us Adults, Nathan Coleman

Undergraduate Honors Theses

Abstract

Purpose: Multiple studies have indicated that air pollution and smoking are associated with various types of mortality, including cancer. The current study utilizes a publicly accessible, nationally representative cohort to explore relationships between fine particulate matter (PM_2.5) exposure, smoking, and cancer mortality.

Methods: National Health Interview Survey and mortality follow-up data were combined to create a study population of 635,539 individuals surveyed from 1987 to 2014. A sub-cohort of 341,665 never-smokers from the full cohort was also evaluated. Individuals were assigned modeled PM_2.5 exposure. Cox proportional hazard models were utilized to estimate hazard ratios for cancer-specific …

Full Issue

The Bridge

No abstract provided.

Analysis Of Identification Method For Bacterial Species And Antibiotic Resistance Genes Using Optical Data From Dna Oligomers, Ryan L. Wood, Tanner Jensen, Cindi Wadsworth, Mark Clement, Prashant Nagpal, William G. Pitt

Faculty Publications

Bacterial antibiotic resistance is becoming a significant health threat, and rapid identification of antibiotic-resistant bacteria is essential to save lives and reduce the spread of antibiotic resistance. This paper analyzes the ability of machine learning algorithms (MLAs) to process data from a novel spectroscopic diagnostic device to identify antibiotic-resistant genes and bacterial species by comparison to available bacterial DNA sequences. Simulation results show that the algorithms attain from 92% accuracy (for genes) up to 99% accuracy (for species). This novel approach identifies genes and species by optically reading the percentage of A, C, G, T bases in 1000s of short …

Analysis Of Identification Method For Bacterial Species And Antibiotic Resistance Genes Using Optical Data From Dna Oligomers, Ryan L. Wood, Tanner Jensen, Cindi Wadsworth, Mark Clement, Prashant Nagpal, William G. Pitt

Faculty Publications

Bacterial antibiotic resistance is becoming a significant health threat, and rapid identification of antibiotic-resistant bacteria is essential to save lives and reduce the spread of antibiotic resistance. This paper analyzes the ability of machine learning algorithms (MLAs) to process data from a novel spectroscopic diagnostic device to identify antibiotic-resistant genes and bacterial species by comparison to available bacterial DNA sequences. Simulation results show that the algorithms attain from 92% accuracy (for genes) up to 99% accuracy (for species). This novel approach identifies genes and species by optically reading the percentage of A, C, G, T bases in 1000s of short …

Habitat-Dependent Search Behavior In The Colorado Checkered Whiptail (Aspidoscelis Neotesselata), Kaera Utsumi, Carina Kusaka, Rachael Pedersen, Catherine Staley, Lisa Dunlap, Sophia Gilbert Smith, Maria A. Eifler, Douglas A. Eifler

Western North American Naturalist

We compared the movement patterns of foraging Colorado Checkered Whiptails (Aspidoscelis neotesselata) in 2 different habitat types: shrub-grassland and pinyon pine–juniper woodland. We characterized movement by (1) segmenting movement paths into step lengths and turn angles and (2) determining first-passage times (FPTs). Lizards differed in their pattern of movement in the 2 habitats. FPTs were shorter in the pinyon pine–juniper woodland habitat and were positively correlated with ground cover. Lizards also moved more frequently, had longer step lengths, and traveled greater total distances in the pinyon pine–juniper woodland. There were no habitat differences in turn angles, net displacement, …

Reproductive Notes On Bats From The Genus Lasiurus In Louisiana, Ethan Reeves, Justin D. Hoffman

Western North American Naturalist

Little is known about the reproductive habits of the 4 species of bat in the genus Lasiurus that live in Louisiana. We examined reproductive notes from specimen records for the eastern red bat (L. borealis), the Seminole bat (L. seminolus), the northern yellow bat (L. intermedius), and the hoary bat (L. cinereus). We found that gestation and partuition happen between May and June for all species. Lactating and postlactating individuals and juveniles were mostly captured in late June or July. Typically, litter sizes range from 3 to 4 pups for both L. …