Digital Commons Network^™

The Novel Protein Crystallization Chaperone Telsam Stabilizes Weak Crystal Contacts, Accelerates Crystallization Of Fused Target Proteins, And Solves The Crystallographic Phase Problem, Supeshala Dilrukshi Sarath Nawarathnage

Theses and Dissertations

We studied the usefulness of genetic fusion to TELSAM polymers as an effective protein crystallization strategy. We observed novel properties in crystals of two TELSAM-target protein fusions. TELSAM as a crystallization chaperone shows rapid crystallization when it's fused to target proteins and possibly with a greater propensity. Some TELSAM-target fusions crystallized more rapidly than the same target protein alone. TELSAM-target proteins can be crystallized at relatively low protein concentrations such as 0.1 mg/mL. TELSAM requires no TELSAM polymers touching one another in the crystal lattice in order to form well-diffracting crystals. This lack of crystal contacts has not been observed …

Using Connections To Make Predictions On Dynamic Networks, Rebecca Dorff Jones

Theses and Dissertations

Networks are sets of objects that are connected in some way and appear abundantly in nature, sociology, and technology. For many centuries, network theory focused on static networks, which are networks that do not change. However, since all networks transform over time, static networks have limited applications. By comparison, dynamic networks model how connections between objects change over time. In this work, we will explore how connections in dynamic networks change and how we can leverage these changes to make predictions about future iterations of networks. We will do this by first considering the link prediction problem, using either Katz …

Statistical Properties Of 2d Navier-Stokes Equations Driven By Quasi-Periodic Force And Degenerate Noise, Rongchang Liu

Theses and Dissertations

We consider the incompressible 2D Navier-Stokes equations on the torus driven by a deterministic time quasi-periodic force and a noise that is white in time and extremely degenerate in Fourier space. We show that the asymptotic statistical behavior is characterized by a uniquely ergodic and exponentially mixing quasi-periodic invariant measure. The result is true for any value of the viscosity ν > 0. By utilizing this quasi-periodic invariant measure, we show the strong law of large numbers and central limit theorem for the continuous time inhomogeneous solution processes. Estimates of the corresponding rate of convergence are also obtained, which is the …

Stabilizing Controlled Systems In The Presence Of Time-Delays, Isaac Becker Pardo

Theses and Dissertations

A dynamical system's state evolves over time, and when the system stays near a particular state this state is known as a stable state of the system. Through control methods, dynamical systems can be manipulated such that virtually any state can be made stable. Although most real systems evolve continuously in time the application of digital control methods to these systems is inherently discrete. States are sampled (with sensors) and fed back into the system in discrete-time to determine the input needed to control the continuous system. Additionally, dynamical systems often experience time delays. Some examples of time delays are …

Parental Perceptions Of Elementary Aged Children Learning To Code, David Daniel

Theses and Dissertations

Little research has been conducted to understand the role that parents play in children learning to code even though coding has become a necessary skill for students to successfully study STEM (Science, Technology, Engineering, Math) subjects. After identifying five factors that would influence parental perceptions, we developed a survey and administered it to parents of elementary aged children. We validated the survey using a confirmatory factor analysis and structural equation modeling. To be considered valid, factors needed to meet three of the following four fit statistics: RSMEA < 0.08, SRMR < 0.08, CFI > 0.9, TLI > 0.9. Items needed to have a factor loading > 0.3 with a …

Computationally Assisted Nmr Crystallography: A Path To Unusually High-Resolution Crystal Structures, Luther Wang

Theses and Dissertations

Crystallography has traditionally been studied by diffraction methods involving X ray or neutron radiation. These methods have some limitations, from requiring the substance under study to form single crystals to the limited ability of X rays to locate hydrogen atoms. While neutron radiation can characterize hydrogens, it is expensive, not readily available and has its own particular limits on resolution. It this dissertation, it is demonstrated that NMR is extraordinarily sensitive to atomic positions, with variations of mere tens of femtometers creating statistically distinguishable chemical shift changes. To date, no other means of measurement can detect structural changes at this …

Gas Phase Structure Characterization Of Host-Guest Systems Using Ion Mobility Spectrometry, Jamir Shrestha

Theses and Dissertations

This dissertation focuses on the investigation of gas-phase characteristics of cucurbituril host-guest systems using ion mobility spectrometry (IMS) and related techniques. Collision cross-sections (CCS) of alkylammonium complexes of cucurbit[n]uril (CB[n]) are measured to understand the allosteric interactions that induce conformational changes in the complex in the presence of metal cations on one of the portals of the cucurbit[6]uril (CB[6]) host. Cationic species on one CB[6] rim sterically force longer linear alkylammonium guests out of the cucurbituril cavity during complex formation. Similarly, rigid cucurbituril-metal complexes were studied using IMS to demonstrate the effect of long-range ion-neutral interactions on the gas phase …

Gradient-Based Wind Farm Layout Optimization, Jared Joseph Thomas

Theses and Dissertations

As wind energy technology continues to mature, farm sizes grow and wind farm layout design becomes more difficult, in part due to the number of design variables and constraints. Wind farm layout optimization is typically approached using gradient-free methods because of the highly multi-modal shape of the wind farm layout design space. Gradient-free method performance generally degrades with increasing problem size, making it difficult to find optimal layouts for larger wind farms. However, gradient-based optimization methods can effectively and efficiently solve large-scale problems with many variables and constraints. To pave the way for effective and efficient wind farm layout optimization …

Developing The Next Generation Of Heterogeneous Catalysts: Metal-Organic Framework Thin Films And Their Derivatives, Hans Christian Anderson

Theses and Dissertations

Metal-Organic Frameworks (MOFs) are an important class of materials that are gaining increasing relevance for many fields including energy storage, CO2 capture, photovoltaics, and catalysis. MOF mediated synthesis (MOFMS) is the decomposition of a MOF to form an amorphous carbon material decorated with metal nanoparticles. MOF thin films are an area where MOFMS has not been thoroughly explored, yet they are likely to be industrially relevant due to their potential application as highly dispersed, sinter resistant supported catalysts. In this work, we have developed a method for the growth of copper- and zinc-based MOF thin films on silicon- and aluminum- …

Atg9a And Atg13 Cooperate To Drive Basal Autophagy, Daniel Morgan Poole

Theses and Dissertations

Autophagy, as the name suggests, is a cellular process of self-eating in which cytoplasmic debris is engulfed by a double membrane vesicle dubbed the autophagosome and is ultimately degraded and recycled by proteases in the lysosome. The process is initiated by a group of core ATG proteins, including a multi-pass transmembrane protein called ATG9A. Although ATG9A has been shown to be essential for both stress induced and basal autophagy, its mechanism and interaction network remain largely illusive. Our current study employs BioID proteomics to identify a network of interactors, including regulators of membrane fusion and vesicle trafficking, such as TRAPP, …

On The Development And Use Of A Micro-Surface Probe For Measurement Of Li-Ion Battery Electrical Properties, John Eric Vogel

Theses and Dissertations

Rechargeable lithium-ion batteries are a staple of modern society, providing power to a significant portion of the world's electronics and rapidly replacing older power sources. The advent of widely available electric cars with batteries of up to 200 kWh, with an increasing emphasis on fast charging, has only increased their importance. Lithium-ion battery electronic and ionic properties are largely determined by the microstructure of the battery electrode film and can be heavily influenced by relatively small variations in film makeup, including the formation of voids or distribution of carbon and binder. Prior to this research, electrical properties, which are some …

Musical Phrase Segmentation Via Grammatical Induction, Reed James Perkins

Theses and Dissertations

Procedural generation algorithms can infer rules based on a dataset of examples when each example is made up of labeled components. Unfortunately, musical sequences resist potential inclusion in these kinds of datasets because they lack explicit structural semantics. In order to algorithmically transform a musical sequence into a sequence of labeled components, a segmentation process is needed. We outline a solution to the challenge of musical phrase segmentation that uses grammatical induction algorithms, a class of algorithms which infer a context-free grammar from an input sequence. We study five different grammatical induction algorithms on three different datasets, one of which …

Peg + Cat: The Pirate Problem, Ashley Mckenzie

Children's Book and Media Review

Enjoying a relaxing day on an island, Peg and Cat realize they brought only one cheese and pickle sandwich. The problem is solved when the sandwich is torn into two equal pieces. But their problems don't end there; soon a band of hungry and cranky pirates arrives. Searching the island for food, they soon find 16 peaches, which they learn they can easily divide among the pirates. That is, until a mischievous monkey steals some of the peaches, and they must add back some of the delicious food to make everything equal again.

November 2019 Cbmr Reviews, Various Reviewers

Children's Book and Media Review

No abstract provided.

Hybrid Suspension Tissue Engineering Of A 3d Alveolar Model For Lung And Vascular Disease Modeling, Jonard Corpuz Valdoz

Theses and Dissertations

Tissue engineering is a dichotomy of scaffold-based and scaffold-free cultures. Scaffold-based cultures form highly organotypic structures but with low uniformity and throughput. Conversely, scaffold-free cultures create consistently sized and shaped cell aggregates with limited spheroid-like structure and function, thus restricting their use for accurate disease modeling. We hypothesized that combining aspects of each culturing format, we would produce highly organotypic structures of consistent size and shape for use in pulmonary modeling. First, to improve on culture consistency and output, we created a novel easily scalable, minimalistic design for a micropatterned hydrogel dish that increases reliability and efficiency in 3D cell …

Enhancing The Opportunities For Adults With Autism To Find Jobs Using A Job-Matching Algorithm, Joseph T. Bills

Theses and Dissertations

Adults with autism face many difficulties when finding employment, such as struggling with interviews and needing accommodating environments for sensory issues. However, autistic adults also have unique skills to contribute to the workplace that companies have recently started to seek after, such as close attention to detail and trustworthiness. To work around these difficulties and help companies find the talent they are looking for we have developed a job-matching system. Our system is based around the stable matching of the Gale-Shapley algorithm to match autistic adults with employers after estimating how both adults with autism and employers would rank the …

Entropic Interactionist Theory: Reading Social Constructionism Through Thermodynamics And Samuel Beckett, Brie Barron

Criterion: A Journal of Literary Criticism

This essay aims to explain the breakdown of social constructs through the concept of Entropic Interactionist Theory. EIT argues that it is the nature of creations to be vulnerable to the same forces as their creator, and that social constructions (like identity, for example) are subject to the very same physical forces that give rise to humanity’s creative impulse. At its core, EIT is informed by social constructionism and Nietzschean sociological theory, but it names the second law of thermodynamics and the concept of entropy as the driving force behind societal disintegration. The complication with this theory is that it …

Datadescription-Detection Of Sulfur Dioxide By Broadband Cavity-Enhanced Absorption Spectroscopy (Bbceas), Ryan Thalman, Nitish Bhardwaj, Callum Flowerday, Jaron C. Hansen

ScholarsArchive Data

Files archived include the following:

Figure1.txt This file contains all the data used to make Figure 1 in the paper.

Figure4.txt This file contains all the data used to make Figure 4 in the paper.

Figure5.txt This file contains all the data used to make Figure 5 in the paper.

Figure6.txt This file contains all the data used to make Figure 6 in the paper.

Figure7.txt This file contains the code, written in Igor, that was used to generate this figure.

Figure8.txt This file contains all the data used to make Figure 8 in the paper.

Figure9.txt This file contains …

Identification Of Sources Of Air Pollution Using Novel Analytical Techniques And Instruments, Nitish Bhardwaj

Theses and Dissertations

This dissertation is a collection of studies that investigates the issue of air pollution in the field of environmental chemistry. My thesis consists of research works done to measure the concentration of particulate matter (PM) and gas-phase species in ambient air. High concentrations of PM is a significant problem in Utah and in other regions of the world. Particles having an aerodynamic diameter of 2.5 micrometers and smaller play a crucial role in air pollution and pose serious health risks when inhaled. PM is composed of both organic and inorganic components. The organic fraction in PM ranges from 10-90% of …

U-Splines: Splines Over Unstructured Meshes, Steven K. Schmidt

Theses and Dissertations

U-splines are a novel approach to the construction of a spline basis for representing smooth objects in Computer-Aided Design (CAD) and Computer-Aided Engineering (CAE). A spline is a piecewise-defined function that satisfies continuity constraints between adjacent cells in a mesh. U-splines differ from existing spline constructions, such as Non-Uniform Rational B-splines (NURBS), subdivision surfaces, T-splines, and hierarchical B-splines, in that they can accommodate local variation in cell size, polynomial degree, and smoothness simultaneously over more varied mesh configurations. Mixed cell types (e.g., triangle and tetrahedron and quadrilateral and hexahedral cells in the same mesh) and T-junctions are also supported. The …

State Courts And Education Finance: Past, Present And Future, Michael A. Rebell

BYU Education & Law Journal

Fifty years ago, few legal analysts would be predicted this spate of creative state court activity regarding educational rights.

John Serrano Did Not Vote For Proposition 13, William A. Fischel

BYU Education & Law Journal

Rather than advancing new arguments, this essay will review my work on this subject in the form of a memoir (with popular-song headings that betray my vintage) about my evolving interest in the Serrano and Proposition 13 connection.

Confronting Barriers To Human-Robot Cooperation: Balancing Efficiency And Risk In Machine Behavior, Tim Whiting

Theses and Dissertations

In strategically rich settings in which machines and people do not fully share the same preferences, machines must learn to cooperate and compromise with people to establish mutually successful relationships. However, designing machines that effectively cooperate with people in these settings is difficult due to a variety of technical and psychological challenges. To better understand these challenges, we conducted a series of user studies in which we investigated human-human, robot-robot, and human-robot cooperation in a simple, yet strategically rich, resource-sharing scenario called the Block Dilemma, a game in which players must balance fairness, efficiency, and risk. While both human-human and …

A Comparison Of Square-Wave Voltammetry Models To Determine The Number Of Electrons Exchanged In Metal Deposition, Ranon Fuller, Tyler Williams, Mark H. Schvaneveldt, Devin Rappleye

Faculty Publications

A comparison of square-wave voltammetry models for calculating the number of electrons exchanged in a metal deposition reaction. Experiments were conducted for silver deposition on platinum in an aqueous HNO₃ solution and for nickel and lanthanum deposition on platinum in molten LiCl. Diffusion coefficients for Ni²⁺ and La³⁺ in LiCl at 700^oC are calculated. Accuracy of soluble-soluble models versus a soluble-insoluble model is discussed. A simple method for determining the number of electrons exchanged under the constraint of well-compensated ohmic drop is proposed and evaluated.

Variability In Variables: An Analysis Of Variable Use In A Middle School Mathematics Textbook, Annalisa G. Lavin

Undergraduate Honors Theses

Variables are an important part of mathematics as they allow mathematicians to generalize and more easily express mathematical ideas, however research has shown that students struggle with understanding variables. One way to study variable use is to classify variables into different types based on how they are used. This study uses variable types to investigate variable usage in a middle school mathematics textbook. This study identified 9 variable types and 3 algebraic processes that variable types are tied to. This analysis also found evidence of a growing complexity in variable use, starting with sophisticated variable use in grade 6 and …

Implementing A High-Performance Quantum Computing Emulator, Reece Robertson

Undergraduate Honors Theses

We implement a quantum computing emulator after the manner described by Häner et al. with the goal of temporal and spatial savings. The emulator is compared to the Intel Quantum Simulator to verify speedup and spatial savings over the simulator method. We also implement Shor's algorithm in the emulator and use it to solve a nontrivial factoring problem. This demonstrates that the emulator makes quantum computing more accessible on at least two accounts: it allows users to solve nontrivial problems quickly and it provides those looking to enter quantum computing with an accessible place to start. Finally, we outline future …

Symbolic Semantic Memory In Transformer Language Models, Robert Kenneth Morain

Theses and Dissertations

This paper demonstrates how transformer language models can be improved by giving them access to relevant structured data extracted from a knowledge base. The knowledge base preparation process and modifications to transformer models are explained. We evaluate these methods on language modeling and question answering tasks. These results show that even simple additional knowledge augmentation leads to a reduction in validation loss by 73%. These methods also significantly outperform common ways of improving language models such as increasing the model size or adding more data.

The Effect Of Soot Models In Oxy-Coal Combustion Simulations, Kamron Groves Brinkerhoff

Theses and Dissertations

Soot in coal combustion simulations is often ignored due to its computational complexity, despite significant effects on flame temperature and radiation. In this research, a 40 kW oxy-coal combustion system is modeled using Large Eddy Simulations (LES) and a semi-empirical monodisperse coal soot model. Simulation results are compared to experimental measurements of temperature, species concentrations, and soot concentration. Cases where soot is modeled are compared with cases where soot is neglected to determine the accuracy benefits of modeling soot. The simulations were able to replicate experimental results within an acceptable level of error. Including soot in the simulations did not …

Multipath Mitigation In Frequency Selective Channels With An Emphasis On 5g Cellular Mobile Networks And Aeronautical Mobile Telemetry Applications, Farah Arabian

Theses and Dissertations

This dissertation explores the role of polarization, combining, and equalization operating over frequency-selective channels to improve the reliability of wireless communications systems in terms of BER for two applications: 5G mobile networks (operating in the mmWave band and NR FR1), and aeronautical mobile telemetry systems (operating in L band). The equivalent discrete-time models for a variety of spatial combining techniques at 5G mmWave bands were derived to investigate the performance of co-located cross-polarized antenna elements when polarization diversity is used and also when a combination of spatial and cross-polarized antennas is exploited. In both cases, ML combining has the lowest …

Evaluation Of A High School Wellness Center, Malka S. Moya

Theses and Dissertations

High school students are often burdened with academic, home, and peer stressors. With adolescent mental health issues and suicide on the rise, administrators have worked with nonprofits and the community to solve these problems. School-based wellness centers are tranquil rooms for students to decompress for up to 20 minutes during the school day with various sensory activities, calming nature scenes, and sounds for relaxation purposes. Wellness centers are meant to be a haven for self-regulation so students can come back to class with a calmer frame of mind. So far, there has not been a formal evaluation of school-based wellness …