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Acoustofluidics-Based Intracellular Nanoparticle Delivery, Zhishang Li, Zhenhua Tian, Jason N. Belling, Joseph Rich, Haodong Zhu, Zhehan Ma, Hunter Bachman, Liang Shen, Yaosi Liang, Xiolin Qi, Liv K. Heidenreich, Yao Gong, Shujie Yang, Wenfen Zhang, Peiran Zhang, Yingchun Fu, Yibin Ying, Steven J. Jonas, Yanbin Li, Paul S. Weiss, Tony J. Huang Dec 2024

Acoustofluidics-Based Intracellular Nanoparticle Delivery, Zhishang Li, Zhenhua Tian, Jason N. Belling, Joseph Rich, Haodong Zhu, Zhehan Ma, Hunter Bachman, Liang Shen, Yaosi Liang, Xiolin Qi, Liv K. Heidenreich, Yao Gong, Shujie Yang, Wenfen Zhang, Peiran Zhang, Yingchun Fu, Yibin Ying, Steven J. Jonas, Yanbin Li, Paul S. Weiss, Tony J. Huang

Faculty Publications

Controlled intracellular delivery of biomolecular cargo is critical for developing targeted therapeutics and cell reprogramming. Conventional delivery approaches (e.g., endocytosis of nano-vectors, microinjection, and electroporation) usually require time-consuming uptake processes, labor-intensive operations, and/or costly specialized equipment. Here, we present an acoustofluidics-based intracellular delivery approach capable of effectively delivering various functional nanomaterials to multiple cell types (e.g., adherent and suspension cancer cells). By tuning the standing acoustic waves in a glass capillary, our approach can push cells in flow to the capillary wall and enhance membrane permeability by increasing membrane stress to deform cells via acoustic radiation forces. Moreover, by coating …


Stress, Screens, And Social Skills: Parental Stress As A Longitudinal Predictor Of Preschool Social Behavior Mediated By Parental Technoference, Sarah Ashby Dec 2024

Stress, Screens, And Social Skills: Parental Stress As A Longitudinal Predictor Of Preschool Social Behavior Mediated By Parental Technoference, Sarah Ashby

Theses and Dissertations

This study examines the longitudinal relationship between parental stress, parental technoference, and preschool children's social behavior, including physical aggression, relational aggression, and prosocial behavior. Using data from Project M.E.D.I.A., the study explores how parental stress may be linked to disruptions in parent-child interactions through increased use of digital media, termed "technoference." It was predicted that an increase in parental stress would increase physical and relational aggression, and decrease prosocial behavior over time, as mediated by parental technoference. A sample of 460- parent-child dyads was analyzed across three time points using structural equation modeling. Despite expectations, results did not find significant …


Climate Change Impacts On Dryland Ecosystems, Tanner Tainui Aiono Dec 2024

Climate Change Impacts On Dryland Ecosystems, Tanner Tainui Aiono

Theses and Dissertations

Dryland ecosystems are some of the most prevalent ecosystems on Earth and have recently shown stress indicators from climate change. These water-limited systems are vulnerable to increases in temperature and changes in precipitation, especially when looking at carbon cycling dynamics across biological sol crusts and vegetation mortality patterns. This dissertation aims to 1) evaluate how precipitation dynamics, vegetation location, and microclimate conditions influence biological soil crust carbon conditions, and 2) evaluate how topographic influences drive patterns of plant mortality during prolonged drought on the Colorado Plateau. Using high-resolution monitoring of long-term NEE chambers, we found that intermediately disturbed biocrusts are …


How Do Religious Women Cope With Marital Conflict And Hardship? Article 2, Elizabeth M. Lyman, Loren D. Marks, David C. Dollahite, Chelom E. Leavitt, Tamara M. Chamberlain, Christina N. Cooper Dec 2024

How Do Religious Women Cope With Marital Conflict And Hardship? Article 2, Elizabeth M. Lyman, Loren D. Marks, David C. Dollahite, Chelom E. Leavitt, Tamara M. Chamberlain, Christina N. Cooper

Faculty Publications

Frequent and unresolved conflict is a significant relationship risk factor for divorce, but it has also been shown that religion strengthens marriages, specifically in ways that give direction and motivation for couples in resolving marital conflict or other marital hardships. Thus, a study of how successful religious couples resolve conflict is pertinent in helping us better understand how to strengthen marriages and families. Our qualitative study of 113 highly religious women of diverse faiths and races found that women’s perceived relationship or connection with God reportedly impacted conflict resolution and coping with marital hardship. Results suggest greater reconciliation and unity …


Recommendations For Adapting Religious Materials For People With Aphasia, Allison Dahl Dec 2024

Recommendations For Adapting Religious Materials For People With Aphasia, Allison Dahl

Undergraduate Honors Theses

This study aimed to discover whether text adaptations for aphasia commonly applied to secular texts are also applicable to religious texts, as religious texts are often held in a special regard by religious people. This research included five participants with aphasia who consider themselves members of The Church of Jesus Christ of Latter-day Saints. These participants indicated preferences using a 7-point scale between paired samples of religious text formatted using common aphasia-friendly text adaptations. These quantitative data were analyzed for preference trends. Additionally, qualitative data were collected through semi-structured interviews focused on adaptation preferences as well as aphasia’s effects on …


Sulfhydryl-Containing Compounds And Iron Homeostasis: Mechanisms Of Labile Iron Pool Dysregulation And Consequences For Cellular Health, Steven Lowell Mann Christiansen Dec 2024

Sulfhydryl-Containing Compounds And Iron Homeostasis: Mechanisms Of Labile Iron Pool Dysregulation And Consequences For Cellular Health, Steven Lowell Mann Christiansen

Theses and Dissertations

While iron's unique coordination chemistry and redox activity have resulted in its broad incorporation into biological systems, dysfunction in key iron-regulating mechanisms can transform these biochemical advantages into factors that contribute to several pathological conditions. This dissertation explores the complex interactions between iron and sulfhydryl-containing compounds (SCCs), with particular focus on glutathione's (GSH) role in stabilizing iron reactivity juxtaposed with homocysteine's (Hcy) ability to disrupt iron homeostasis and promote disease progression. Through rigorous biochemical analysis and experimentation, we demonstrate that Hcy disrupts iron regulation through several mechanisms: (1) Hcy competitively displaces protective iron-binding molecules in the Labile Iron Pool (LIP), …


Assessing Client Satisfaction In University Counseling: Factor Structure Of A Survey Developed For A Private, Religious-Affiliated Institution, Wai Man Cheng Dec 2024

Assessing Client Satisfaction In University Counseling: Factor Structure Of A Survey Developed For A Private, Religious-Affiliated Institution, Wai Man Cheng

Theses and Dissertations

This study examined the factor structure of a client satisfaction survey developed by BYU Counseling and Psychological Services (CAPS). The survey included (a) universal, (b) individual, (c) couple, and (d) group subscales. Only the universal and individual subscales were analyzed. The couple and group subscales were excluded due to limited sample sizes. For the universal subscale, the analysis supported a first-order model with three factors: (a) clarity, (b) cultural competence, and (c) progress. For the individual subscale, the analysis supported a second-order model. Three first-order factors including (a) symptom relief, (b) insight and awareness, and (c) guidance and coping skills, …


Raman Characterization Of Elastomeric Materials, Shane Michael Drake Dec 2024

Raman Characterization Of Elastomeric Materials, Shane Michael Drake

Theses and Dissertations

Raman spectroscopy is often used for material identification but may be used for characterization. This document focuses on using Raman measurements to characterize polymers, specifically the curing and aging mechanism for hydroxyl-terminated polybutadiene (HTPB). HTPB is a well-known elastomer used in sealants, non-slip surfaces, rocket repellants and plastic explosives. Raman spectroscopy was used to monitor urethane linkages that form from curing HTPB with a cyanate curing agent to suggest a curing mechanism for HTPB. Since this polymer is highly susceptible to oxidation, the methods used to characterize curing were also used for the aging process to see if urethane breakages …


Traveling-Wave Vibration Control And Comparison Of Individuals With Insomnia And Good Sleepers Using Eeg Spectral Power And Sample Entropy, Joseph T. Lecheminant Dec 2024

Traveling-Wave Vibration Control And Comparison Of Individuals With Insomnia And Good Sleepers Using Eeg Spectral Power And Sample Entropy, Joseph T. Lecheminant

Theses and Dissertations

This thesis explores the intersection of whole-body vibration (WBV) and neurophysiological analysis to improve sleep quality and understanding of insomnia. The work is divided into two primary areas: the development of a novel traveling-wave vibration system for sleep enhancement and the analysis of electroencephalography (EEG) metrics in individuals with insomnia versus good sleepers. A vibrating sleep system capable of generating programmable traveling-wave patterns is designed and prototyped. Through iterative development and user trials, the system enables highly controlled mechanical stimulation in the form of traveling-wave vibration. Key advancements include independent amplitude and speed modulation and customizable wave patterns. Simple wave …


Cellular Air Quality Sensors With Lora Backchannel A Robust Sensor Suited For Remote Deployment In Harsh Environments, Joseph R. Miera Dec 2024

Cellular Air Quality Sensors With Lora Backchannel A Robust Sensor Suited For Remote Deployment In Harsh Environments, Joseph R. Miera

Theses and Dissertations

Air quality significantly impacts health and overall quality of life, making its measurement essential. However, most affordable air quality devices are designed only for use within WiFi range and cannot handle extreme temperatures, limiting their usefulness for people in remote or extreme environments, such as regions with harsh winter climates. This limitation is concerning, as winter often brings worse air quality due to temperature inversions that trap pollutants and increase fuel burning for heating. Inversion is a problem as close to home as Utah Valley, and as far away as Ulaanbaatar, Mongolia. Most low-cost air quality sensors are not built …


University Department Chair Perceptions Of Open Access Journals And Open Textbooks, Rebecca Nicole Nissen Dec 2024

University Department Chair Perceptions Of Open Access Journals And Open Textbooks, Rebecca Nicole Nissen

Theses and Dissertations

This study investigated the perceptions of university department chairs regarding open access journals and open textbooks. It was conducted as a qualitative single case study analysis using semistructured, in-person, one-on-one interviews. The six participants interviewed are department chairs from a large, private university in the western United States. Five levels of coding were used with thematic codes drawing from the TAM2 model. Findings revealed participant perceptions on (a) personal values, (b) university mission alignment, (c) predatory journals, and (d) promotion and tenure. The results obtained from this study can inform and influence institutional change and can also help inform future …


The Effect Of Applied Mental Health Courses On College Student Anxiety And Perfectionism, Nathan Thomas Rhees Dec 2024

The Effect Of Applied Mental Health Courses On College Student Anxiety And Perfectionism, Nathan Thomas Rhees

Theses and Dissertations

University students face a variety of mental health challenges, including increasingly high rates of anxiety. As demand for college counseling services among student populations rises, universities have an increasing need for effective and resource-efficient methods of intervention that support student mental health on their campuses. One area in need of research is that of using university classes themselves as a form of preventive intervention. If effective, this kind of preventive measure might be a particularly attractive method of reducing incidence of mental illness on campus and decreasing demand on university therapy resources. This study involves students at a private university …


The Long Shadow Of Infection: The Long-Term Implications Of Herpes Simplex Virus And M. Tuberculosis Infection, Lydia Howell Dec 2024

The Long Shadow Of Infection: The Long-Term Implications Of Herpes Simplex Virus And M. Tuberculosis Infection, Lydia Howell

Theses and Dissertations

Infectious diseases and autoimmune diseases, such as multiple sclerosis (MS) and type 1 diabetes (T1D), have traditionally been seen as distinct, with separate etiologies and courses of disease. Recent research has shown that infection and autoimmune disease are more closely woven together than previously thought; certain pathogens like Epstein-Barr virus and M. tuberculosis have been shown to cause long-term disruption to the immune system, for example (Bordignon et al 2011, #1) (Zhang et al 2023, #2) (Bjornevik et al 2023, #3). Conversely, a distinct pattern has emerged in developed countries where as rates of infection fall, rates of autoimmune disease …


Family Ties: How Families Of Origin And Procreation Influence Women’S Migration And Integration, Becca Goldrup Dec 2024

Family Ties: How Families Of Origin And Procreation Influence Women’S Migration And Integration, Becca Goldrup

Undergraduate Honors Theses

Women's migration is an increasingly important focus of interest in understanding the family-level factors shaping individual and family-level migration decisions. Utilizing interviews with 30 immigrant women residing in Utah who migrated to the US at three different ages (childhood, young adulthood, and later adulthood), I ask: “How do familial relationships impact the immigration experience for women in the US, and how does this vary by age at migration?” I find that family significantly shapes women's migration decisions and experiences post-migration for women of all ages, but this influence has subtle differences based on their age at migration. Women who migrated …


Cross-National Prevalence And Legality Of Consanguinity & Its Implications For State Security, Emma Dart Dec 2024

Cross-National Prevalence And Legality Of Consanguinity & Its Implications For State Security, Emma Dart

Undergraduate Honors Theses

This thesis examines the impact of cousin marriage prevalence on state stability and the development and behaviors of terrorist organizations, with a special focus on the destabilization of states through the power of kinship networks. Cousin marriage, often intertwined with other social practices such as patrilocality and polygyny, creates an isolated power structure that reinforces the fraternal structure present in kinship networks. The kinship network then uses the power gained through the trust in the community to undermine the legitimate rule of law. This research emphasizes the importance of understanding cousin marriage and its contribution to state stability and finds …


Making The World A Happy Place, Noah Passey Dec 2024

Making The World A Happy Place, Noah Passey

FHSS Mentored Research Conference

This study investigated different possible causes of happiness as is is measured by the World Happiness Survey. Country-level measurements of GDP, life expectancy, social support, and government trust all have significant positive relationships with happiness, even when controlling for region. Region fixed-effects and time analysis further supports those relationships.


The Impacts Of Co-Occurring Developmental Language Disorder On The Academic, Interpersonal, And Behavioral Profiles Of Children With Adhd, Kirsten M. Hannig Russell, Sean M. Redmond Dec 2024

The Impacts Of Co-Occurring Developmental Language Disorder On The Academic, Interpersonal, And Behavioral Profiles Of Children With Adhd, Kirsten M. Hannig Russell, Sean M. Redmond

Faculty Publications

Purpose: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial disorder that has been linked to increased risk for behavioral, academic, and interpersonal problems. Developmental language disorder (DLD) has also been linked to poor outcomes in these areas. The presence of co-occurring disorders in children’s profiles is generally associated with poorer outcomes relative to profiles consisting of only one disorder. This study investigated the extent to which co-occurring DLD in children already identified with ADHD presented increased risk for severity of their primary ADHD symptoms, the presence of secondary behavioral problems, and/or increased problems in the tertiary areas of academic performance and interpersonal …


Responding Through Listening: Promoting Listening Skills Through Lightning Talks And 2x2x2 Storytelling, Elizabeth L. Angeli Dec 2024

Responding Through Listening: Promoting Listening Skills Through Lightning Talks And 2x2x2 Storytelling, Elizabeth L. Angeli

Journal of Response to Writing

Current scholarship in writing pedagogy and peer review focuses on how and what to write and say. What is often left unaddressed in these discussions are how we listen and how we teach our students to listen, making listening an often overlooked and understudied piece of the peer review and writing response process. Yet, the quality of the feedback we receive and offer is directly tied to how well we listen to what is said and written. To this fill this gap, this teaching article offers two activities, Lighting Talks and 2x2x2 Storytelling, that promote students’ listening skills so that …


Behind The Screen: Exploring Parental Roles In K-12 Online Education, Barbara T. Sandberg, Charles R. Graham, Jered Borup, Richard E. West, Rocio Quiroga Velasquez Dec 2024

Behind The Screen: Exploring Parental Roles In K-12 Online Education, Barbara T. Sandberg, Charles R. Graham, Jered Borup, Richard E. West, Rocio Quiroga Velasquez

Faculty Publications

Independent engagement can be challenging for K-12 online students. Parents’ physical presence makes them an important source of engagement support. Previous research on parental support in online courses is limited and focused on asynchronous learning within a single program. Since the COVID-19 pandemic, online enrollments have grown and instructional modalities have evolved. To better understand parental support post-Covid, we interviewed 21 parents across eight online programs with asynchronous, synchronous, and bichronous course offerings. Parents identified their affective, behavioral, cognitive, and other support roles. Implications for parental roles in addressing the academic engagement gap are provided to both researchers and practitioners.


Soil Biogeography And Community Assembly In Polar Regions, Jesse Jorna Nov 2024

Soil Biogeography And Community Assembly In Polar Regions, Jesse Jorna

Theses and Dissertations

The polar regions provide community ecologists with natural microcosms, that include reduced species diversity, steep environmental gradients and limited human perturbance. Soil biodiversity in the polar regions is poorly understood, and the driving forces behind community compositions can range in scale from glacial forces 20,000 years ago to the impact of a researcher's footstep. Here, we present the results of an investigation of the driving factors behind biodiversity in Arctic and Antarctic soils, with specific attention to the role of community assembly processes. We suggest a framework for investigating the effects of inter-bacterial community processes like facilitation and argue for …


Capturing Creativity: An Exploration Of The Positive Impact Of Art Integration In Elementary Education, Christina Zander Nov 2024

Capturing Creativity: An Exploration Of The Positive Impact Of Art Integration In Elementary Education, Christina Zander

Theses and Dissertations

My thesis focuses on the necessity of including art in education and the positive impact integrating art has on students mentally and academically. Over the past 2 years, I have seen the major impact integrating art has on students and how essential it is to keep creativity in the classroom. My research explains how incorporating art helps increase both student engagement and retention of concepts. I have also studied how integrating art with mindfulness can help students develop essential SEL skills including emotion management. My research expands on how utilizing art allows individuals and students to better cope with challenges …


Enhancing Muscle Health And Modulating Immune Response With Galectin-1 In Lgmd2b/R2 Models, Stefannia Esparza Pulido Nov 2024

Enhancing Muscle Health And Modulating Immune Response With Galectin-1 In Lgmd2b/R2 Models, Stefannia Esparza Pulido

Theses and Dissertations

Limb-Girdle Muscular Dystrophy Type 2B/R2 (LGMD2B/R2) is a type of dysferlinopathy, a progressive muscle-wasting disorder caused by mutations in the dysferlin gene. Hallmarks of the disease include chronic inflammation, impaired muscle regeneration, and eventual muscle degeneration. Currently, no FDA-approved therapies are available for dysferlinopathies. Recombinant human Galectin-1 (rHsGal-1) has shown multiple roles in maintaining skeletal muscle homeostasis, promoting muscle repair, enhancing myogenesis, and modulating inflammation by downregulating the NF-κB pathway. The ability of rHsGal-1 to modulate the immune response is particularly promising for therapeutic applications in patients with LGMD2B/R2. In this study, we evaluated the effects of rHsGal-1 in a …


Lost, Or Found? Seeking And Preserving The Education Of Artisanal Arts, Jennie Doezie Nov 2024

Lost, Or Found? Seeking And Preserving The Education Of Artisanal Arts, Jennie Doezie

Theses and Dissertations

Crafts and the artisanal arts have a complex relationship with art and art education. Nevertheless, hands-on crafts have an important and often overlooked contribution to visual art education. In addition to their value as cultural icons, the artisanal arts can contribute to cognitive development, emotional well-being, and mental health. The practice of a craft can balance some of the negative effects of 21st century screen culture. This thesis explores the following regarding crafts education: its value, its relationship to traditional art education, and its future potential. In addition to the traditional elements of literature review and research methodology, this thesis …


Implementing The Safe System Approach At Intersections In Utah, Ian Patrick Macgregor Nov 2024

Implementing The Safe System Approach At Intersections In Utah, Ian Patrick Macgregor

Theses and Dissertations

This thesis investigates the principles and elements of the Safe System Approach, a new paradigm in roadway safety. A compendium of practice was created to determine recommendations on how to implement the Safe System Approach at intersections and observe how other jurisdictions are implementing it. Several strategies identified include the Safe Systems at Intersections (SSI) methodology, Safe System Alignment Frameworks, Vision Zero communities, incorporating the Safe System Approach into the Strategic Highway Safety Plan (SHSP) or Highway Safety Improvement Program (HSIP), mandating the Safe System Approach be considered in all projects, and the Organizational Safety Culture Self-Assessment. These policies do …


Barbie, Taylor Michelle Gale Nov 2024

Barbie, Taylor Michelle Gale

Theses and Dissertations

The stereotypes placed over men and women throughout various forms of media, including film and TV, song, printed media, and even through objects like toys, have a large impact on society as a whole. Kumari and Joshi (2015) explain that media plays an important role in sharing information concerning what deems to be the fabric of contemporary culture, which can aid in changing, or perpetuating long standing societal norms. This study identifies how Greta Gerwig's Barbie (2023) approaches the themes of the portrayal of women in the media through the Barbie film, examining themes such as objectification, self-objectification, and the …


"We Are All About Equality": D/Deaf Inclusivity In Little Wimmin, Ruth Ann Leber Nov 2024

"We Are All About Equality": D/Deaf Inclusivity In Little Wimmin, Ruth Ann Leber

Theses and Dissertations

Figs in Wigs integration of a British Sign Language interpreter in their performance of Little Wimmin is a compelling example of inclusive theatre for D/deaf audiences. By examining the works of foundational D/deaf studies scholars Neil Glickman and Paddy Ladd alongside the works of contemporary D/deaf scholars such as Tom Humphries, Carol Padden, and Michael Richardson we can gain valuable insight into the evolution of the D/deaf culture and identity. This paper will refer to diversity scholar Susanne Ricee when defining the difference between accommodation, access, accessibility, and inclusivity. It will explore the current advantages and limitations of D/deaf accommodations …


Rare Sugars And Dairy Ingredients: A Synergistic Pairing For The Reduction Of Food Waste And Sugar Consumption, Melinda Michelle Moss Nov 2024

Rare Sugars And Dairy Ingredients: A Synergistic Pairing For The Reduction Of Food Waste And Sugar Consumption, Melinda Michelle Moss

Theses and Dissertations

In the future, sustainability in the dairy industry will require creative and scale-able solutions for better utilization of the primary solid component in milk: lactose. One promising avenue of “up-cycling” underutilized lactose is converting it to valuable rare sugars. Rare sugars like D-tagatose and D-allulose are increasing in popularity extremely quickly. D-tagatose and D-allulose are hexose sugars, D-allulose being an epimer of D-fructose and D-tagatose an isomer of D-galactose. They have excellent functional properties in food systems with clean sweetness profiles similar to sucrose. Critically, they also have excellent nutritional characteristics, such as low caloric values and low glycemic indices. …


Compliant Structures Facilitate Less Invasive And Biomechanically Improved Lumbar Spinal Implants, Daniel J. Orr Nov 2024

Compliant Structures Facilitate Less Invasive And Biomechanically Improved Lumbar Spinal Implants, Daniel J. Orr

Theses and Dissertations

Implants used in lumbar spinal fusion and lumbar total disc replacement procedures have improved substantially over the years, however, the opportunity remains to improve either the adjustability, durability, motion, or minimally invasive characteristics which could aid in achieving optimal surgical outcomes. It is hypothesized that the inherent advantages of compliant mechanisms specifically Deployable Euler Spiral Connectors (DESCs) and a new mechanism known as the interior contact aided rolling element (I-CORE) are well suited for each of these applications and will be explored and utilized as the basis of these proposed designs. By addressing these challenges, the research endeavors to improve …


Full Issue Nov 2024

Full Issue

Marriott Student Review

No abstract provided.


Sticker Shock: Why Affordable Access To Insulin Is Critical For Both Patients And Employers, Sean Moss Nov 2024

Sticker Shock: Why Affordable Access To Insulin Is Critical For Both Patients And Employers, Sean Moss

Marriott Student Review

“How can I afford to stay alive?” My thoughts raced as I sat with the weight of the information that my endocrinologist had just given me. I was diagnosed with type 1 diabetes in the winter of 2022, and I suddenly realized I had been thrust into a world that was much more complicated than before. Not only did I need to manage my blood sugar to avoid lethal consequences, but I also realized how much it would cost for me to survive. While I knew that insulin prices were high, I didn’t fully grasp the extent of the problem …