Digital Commons Network^™

Enhancing Muscle Health And Modulating Immune Response With Galectin-1 In Lgmd2b/R2 Models, Stefannia Esparza Pulido

Theses and Dissertations

Limb-Girdle Muscular Dystrophy Type 2B/R2 (LGMD2B/R2) is a type of dysferlinopathy, a progressive muscle-wasting disorder caused by mutations in the dysferlin gene. Hallmarks of the disease include chronic inflammation, impaired muscle regeneration, and eventual muscle degeneration. Currently, no FDA-approved therapies are available for dysferlinopathies. Recombinant human Galectin-1 (rHsGal-1) has shown multiple roles in maintaining skeletal muscle homeostasis, promoting muscle repair, enhancing myogenesis, and modulating inflammation by downregulating the NF-κB pathway. The ability of rHsGal-1 to modulate the immune response is particularly promising for therapeutic applications in patients with LGMD2B/R2. In this study, we evaluated the effects of rHsGal-1 in a …

Effect Of Roadway Lighting On Safety In Utah, Samuel Lewis Runyan

Theses and Dissertations

A significant portion of severe crashes and severe crashes involving vulnerable road users, 29 percent and 39 percent respectively, occur at night in Utah, despite roughly only 25 percent of traffic occurring at night. Nighttime crash causes are less understood than daytime crashes as there are fewer nighttime crashes, but it is generally assumed that increasing street lighting can help mitigate these crashes. To test this assumption, the Utah Department of Transportation was interested in developing Crash Modification Factors (CMFs) specific to the state of Utah which correlate the quantity and quality of light to crash outcomes, to observe how …

Aircraft Control, Collision Avoidance, And Remote Autonomy In Scenarios With Ground Radar Information, Jaron Charles Ellingson

Theses and Dissertations

Unmanned aircraft systems (UAS) have become integral to various modern applications, including package delivery, security, medicine, and recreation. The autonomous operation of UAS significantly enhances their utility by improving performance and reducing operator workload, enabling collaborative missions such as boundary detection, border protection, and target tracking. To ensure safe integration of UAS, more work needs to be done in the areas of control, estimation, collision avoidance, path planning, hardware implementation, and autonomous practices in general. For this dissertation we chose to focus on the critical areas of control, collision avoidance, and remote autonomy. Our research is motivated by the need …

Lost, Or Found? Seeking And Preserving The Education Of Artisanal Arts, Jennie Doezie

Theses and Dissertations

Crafts and the artisanal arts have a complex relationship with art and art education. Nevertheless, hands-on crafts have an important and often overlooked contribution to visual art education. In addition to their value as cultural icons, the artisanal arts can contribute to cognitive development, emotional well-being, and mental health. The practice of a craft can balance some of the negative effects of 21st century screen culture. This thesis explores the following regarding crafts education: its value, its relationship to traditional art education, and its future potential. In addition to the traditional elements of literature review and research methodology, this thesis …

Implementing The Safe System Approach At Intersections In Utah, Ian Patrick Macgregor

Theses and Dissertations

This thesis investigates the principles and elements of the Safe System Approach, a new paradigm in roadway safety. A compendium of practice was created to determine recommendations on how to implement the Safe System Approach at intersections and observe how other jurisdictions are implementing it. Several strategies identified include the Safe Systems at Intersections (SSI) methodology, Safe System Alignment Frameworks, Vision Zero communities, incorporating the Safe System Approach into the Strategic Highway Safety Plan (SHSP) or Highway Safety Improvement Program (HSIP), mandating the Safe System Approach be considered in all projects, and the Organizational Safety Culture Self-Assessment. These policies do …

Barbie, Taylor Michelle Gale

Theses and Dissertations

The stereotypes placed over men and women throughout various forms of media, including film and TV, song, printed media, and even through objects like toys, have a large impact on society as a whole. Kumari and Joshi (2015) explain that media plays an important role in sharing information concerning what deems to be the fabric of contemporary culture, which can aid in changing, or perpetuating long standing societal norms. This study identifies how Greta Gerwig's Barbie (2023) approaches the themes of the portrayal of women in the media through the Barbie film, examining themes such as objectification, self-objectification, and the …

Computational Study Of The Evolution Of The Grain Boundary Network During Anisotropic Grain Growth, Jose Nino

Theses and Dissertations

The grain boundary network (GBN) of polycrystalline materials changes during grain growth, affecting the material's properties. This research presents the results of fully anisotropic grain growth simulations. We perform simulations using three GB energy functions: an energy function that considers a GB's 5 degrees of freedom, the Read-Shockley model, and isotropic. We analyze the impact of these energy functions on the morphological evolution and various microstructural statistics, such as crystallographic texture and triple junction distribution. The results demonstrate that while individual grain evolution varies with GB energy function, certain microstructural statistics reach similar steady states across different models. In addition, …

"We Are All About Equality": D/Deaf Inclusivity In Little Wimmin, Ruth Ann Leber

Theses and Dissertations

Figs in Wigs integration of a British Sign Language interpreter in their performance of Little Wimmin is a compelling example of inclusive theatre for D/deaf audiences. By examining the works of foundational D/deaf studies scholars Neil Glickman and Paddy Ladd alongside the works of contemporary D/deaf scholars such as Tom Humphries, Carol Padden, and Michael Richardson we can gain valuable insight into the evolution of the D/deaf culture and identity. This paper will refer to diversity scholar Susanne Ricee when defining the difference between accommodation, access, accessibility, and inclusivity. It will explore the current advantages and limitations of D/deaf accommodations …

Rare Sugars And Dairy Ingredients: A Synergistic Pairing For The Reduction Of Food Waste And Sugar Consumption, Melinda Michelle Moss

Theses and Dissertations

In the future, sustainability in the dairy industry will require creative and scale-able solutions for better utilization of the primary solid component in milk: lactose. One promising avenue of “up-cycling” underutilized lactose is converting it to valuable rare sugars. Rare sugars like D-tagatose and D-allulose are increasing in popularity extremely quickly. D-tagatose and D-allulose are hexose sugars, D-allulose being an epimer of D-fructose and D-tagatose an isomer of D-galactose. They have excellent functional properties in food systems with clean sweetness profiles similar to sucrose. Critically, they also have excellent nutritional characteristics, such as low caloric values and low glycemic indices. …

Compliant Structures Facilitate Less Invasive And Biomechanically Improved Lumbar Spinal Implants, Daniel J. Orr

Theses and Dissertations

Implants used in lumbar spinal fusion and lumbar total disc replacement procedures have improved substantially over the years, however, the opportunity remains to improve either the adjustability, durability, motion, or minimally invasive characteristics which could aid in achieving optimal surgical outcomes. It is hypothesized that the inherent advantages of compliant mechanisms specifically Deployable Euler Spiral Connectors (DESCs) and a new mechanism known as the interior contact aided rolling element (I-CORE) are well suited for each of these applications and will be explored and utilized as the basis of these proposed designs. By addressing these challenges, the research endeavors to improve …

Sound Innovations For Biofabrication And Tissue Engineering, Mengxi Wu, Zhiteng Ma, Zhenhua Tian, Joseph Rich, Xin He, Jianping Xia, Ye He, Kaichun Yang, Shujie Yang, Kam W. Leong, Luke P. Lee, Tony Jun Huang

Faculty Publications

Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently been widely reviewed in the literature, acoustics-based technologies still need to be explored. The rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these technologies. In this review, we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages: noncontact manipulation, biocompatibility, deep tissue penetrability, versatility, precision …

Engaging Families Of Minoritized Bilingual Preschoolers In Designing A Family Literacy Program, Melany Hooker

Theses and Dissertations

The purpose of this qualitative exploratory study was to include culturally and linguistically diverse minoritized parents in the design of a family literacy program. Parents of traditionally marginalized emergent bilingual Spanish-speaking preschoolers provided feedback on family literacy resources generally and specific resources from the Systematic and Engaging Early Literacy (SEEL) family literacy program, including the website, a lesson plan, and a training video. Culturally relevant pedagogy and user experience (UX) design were applied to determine what these families found accessible, instructive, and important. Feedback was collected through individual interviews and focus groups using UX design. Thematic analyses revealed five main …

Implementing Generative Ai In Higher Education, Braden Stephenson

Marriott Student Review

On November 30, 2022, ChatGPT was released to the public. Just days later, one of my professors scratched part of his planned lecture to explore ChatGPT as a class. We gave “Chat” a complex word problem to solve. ChatGPT got the question right and even explained how to get the answer!

Investigating Secondary Metabolites Of Streptomyces And Bacillus Bacteria That Inhibit Colony Growth Of Pathogenic Potato Fungi (Colletotrichum Coccodes, Pythium Ultimum), Jacob R. Henrie

Theses and Dissertations

Potato (Solanum tuberosum) is a crucial global food crop, yet its production is threatened by fungal pathogens such as Pythium ultimum and Colletotrichum coccodes, which cause significant yield losses and impact tuber quality. In this study, we investigated the antifungal properties of various Streptomyces and Bacillus isolates against these pathogens. The Streptomyces isolates, known for their prolific secondary metabolite production, were selected for their varying efficacy against these fungi. Despite the anticipated potential, Streptomyces isolates exhibited limited antifungal activity against Pythium ultimum and only moderate activity against Colletotrichum coccodes. In contrast, Bacillus isolates, particularly B1, demonstrated strong inhibition of C. …

Full Issue

Marriott Student Review

No abstract provided.

Dr. Nelson On His Passion For Finding The Joy In Family, Emily Pomeroy

Marriott Student Review

Recently, “Measuring Success Right,” the official English podcast from the Marriott Student Review, had the pleasure of interviewing Dr. Larry Nelson. Dr. Nelson is a professor at BYU and actively studies emerging adulthood. He believes that the recent changes we have seen in this age group can be attributed to delayed marriage and graduation ages. Additionally, young adults today coin adulthood more as how they handle decisions and self-sufficiency than landing a successful career or being married. Often, in the past, young adults would quickly move to marriage or careers, which gave structure and accountability to their lives.

Byu Marriot School Of Business: Values Through Msr's Eyes, Savannah Pursglove

Marriott Student Review

No abstract provided.

Full Issue

Marriott Student Review

No abstract provided.

Advancements Of A Vibration-Based Sound Power Method For Direct And Indirect Applications, Ian Charles Bacon

Theses and Dissertations

This dissertation advances the Vibration-Based Sound Power (VBSP) method for measuring the sound power of vibrating structures, expanding its applicability to a wider range of geometries and acoustic environments. The research addresses limitations of traditional sound power measurement techniques by developing an alternative method that achieves near Precision (Grade 1) accuracy while maintaining feasibility for in situ testing under uncontrolled acoustic conditions. After reviewing the current VBSP method in Unit 1, Unit 2 introduces stitching techniques for Scanning Laser Doppler Vibrometer (SLDV) measurements, enabling accurate 3D scans and extending the method to complex geometries. Experimental validation is provided for baffled …

Biodegradable Polymeric Microspheres For Magnetically Guided Drug Delivery To Tumors, Tyler Payson Green

Theses and Dissertations

This thesis investigates the feasibility of utilizing biodegradable polymeric microspheres loaded with the anticancer drug 5-fluorouracil (5FU) and superparamagnetic iron oxide nanoparticles (SPIONs) to magnetically deliver the cancer therapeutic 5FU to a target tumor in the human body. The primary method of material loading consisted of a w/o/w double emulsion mechanism which 1) loads and protects 5FU in the inner water phase consisting of distilled water and polyvinyl alcohol (PVA), 2) dispersed SPIONs in the biodegradable polymeric organic phase consisting of methylene chloride (MeCl2) for eventual magnetic transport, and 3) suspended these w/o emulsion droplets in an outer aqueous phase …

A Study Of Fit And Friction Force As A Function Of The Printing Process For Fff 3d-Printed Piston–Cylinder Assembly, Philippe A. Passeraub, Quentin Allen, Elizabeth Clark, Michael Miles, Siddartha Berns, Maija Pearson, Sterling Allred, Jonah Brooks, Sylvain Hugon

ScholarsArchive Data

Dataset DOI: https://doi.org/10.26067/hjm6-3d45

The shared data comprises the experimental measurements performed presented in the figures 5, 6, 7, 9, 10, 11, 12, and in the tables for the following article:

Passeraub, P.A.; Allen, Q.; Clark, E.; Miles, M.; Berns, S.; Pearson, M.; Allred, S.; Brooks, J.; Hugon, S. A Study of Fit and Friction Force as a Function of the Printing Process for FFF 3D-Printed Piston–Cylinder Assembly. J. Manuf. Mater. Process. 2024, 8, 249. https://doi.org/10.3390/jmmp8060249

Ignis: A One-Dimensional Laminar Flame Code, Jansen P. Berryhill, Jacob K. Spinti, David O. Lignell

Faculty Publications

Laminar flame codes have an important role in combustion modeling. They can provide a fundamental understanding of flame dynamics and provide a basis for building subgrid scale models in turbulent flow simulations. This paper presents Ignis, an open-source laminar flame code with the capability to offload submodels, like soot formation and radiation, using external packages and libraries. Ignis is written in C++, is documented with Doxygen, and is available on GitHub. It contains three different flame formulations: diffusion flames, premixed flames, and laminar flamelets solved in the mixture fraction coordinate. An option to facilitate creation of a diffusion flame table …

Podcast Review: Marianna Richardson On Marriott Student Review's Successes, Zoey Diede

Marriott Student Review

One of the most recent Measuring Success Right podcasts, published in February of 2023, was an interview with Dr. Marianna Richardson, MSR’s very own founder. Marianna started the Marriott Student Review six years ago, and she discusses the successes and goals that MSR has accomplished since its birth.

Editor's Letter Embrace, Marianna Richardson

Marriott Student Review

Embracing loved ones after a long absence is a warm greeting that makes us feel welcomed. We clasp our arms around the person we love to make them feel accepted, wanted, and included.

Embrace: Full Issue

Marriott Student Review

No abstract provided.

End Matter

Swiss American Historical Society Review

No abstract provided.

King Lear'S "Poor, Bare, Forked Animal" And The Cross, Paul J. Stapleton

Quidditas

In William Shakespeare’s tragedy, King Lear describes the “unaccommodated man” as a “poor, bare, forked animal.” Lear’s comments are ostensibly about Edgar disguised as Poor Tom, but critics have detected in the passage a more general expression about human nature. The term “forked” is regularly glossed as “two-legged,” but there are philological problems with this reading. This paper, therefore, takes into consideration an alternate meaning for “forked” based on sixteenth-century usages that relate the noun “fork” to instruments of torture. The paper discusses the depiction of the cross as a “fork” (Latin – furca) in the antiquarian Justus Lipsius’s …

Front Matter

Quidditas

No abstract provided.

Full Issue

Quidditas

No abstract provided.

Mobility In The Middle Ages - Literary Evidence As A Mental Map For Travel Imaginations: A Critical Reconsideration Of Modern Myths About The Past, Albrecht Classen

Quidditas

Literary fantasy has often served as a meaningful reflection of historical, material, or political developments, and events. This also applies to many works from the European Middle Ages. While popular opinion continues to assume that most medieval people were home-bound, the very opposite can almost be claimed, especially for the late Middle Ages. After the Crusades, the stream of pilgrims to the Holy Land grew tremendously, but many other people were on the roads as well, whether for economic, religious, or political reasons. Constructive contacts between West and East only developed in the course in time, but the basic foundations …