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The Discovery Of Novel 14-3-3 Binding Proteins Atg9a And Ptov1 And Their Role In Regulating Cancer Mechanisms, Colten Mitchell Mcewan Aug 2022

The Discovery Of Novel 14-3-3 Binding Proteins Atg9a And Ptov1 And Their Role In Regulating Cancer Mechanisms, Colten Mitchell Mcewan

Theses and Dissertations

14-3-3 proteins are among a family of phospho-binding proteins that are known to regulate many essential cellular mechanisms. By binding to sites of phosphorylation, 14-3-3s are integrated into multiple signaling pathways that govern critical processes, such as apoptosis, cell cycle progression, autophagy, glucose metabolism, and cell motility. These processes are crucial for tumorigenesis and 14-3-3 proteins are known to play a central role in facilitating cancer progression. In this study, my colleagues and I discover two novel 14-3-3 interacting proteins, ATG9A and PTOV1, that are both vital to essential cellular functions and describe various mechanisms that these two proteins regulate. …

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Space-Time Block-Encoded 16-Apsk In Aeronautical Mobile Telemetry, Autumn Twitchell Aug 2022

Space-Time Block-Encoded 16-Apsk In Aeronautical Mobile Telemetry, Autumn Twitchell

Theses and Dissertations

The two-antenna problem in aeronautical mobile telemetry is created by the reception of two copies of the same RF waveform with different phases and time delays. Alamouti and Alamouti-like space time block codes can solve the two-antenna problem, but the decoder/detector needs to account for the different time delays between the signals received from the two transmit antennas. In this thesis, a comparison is made between the performance of Alamouti space-time block codes and time-reversed space-time block codes with 16-APSK to solve the two-antenna problem. The maximum likelihood decoder/detector for Alamouti-encoded 16-APSK is a sequence detector operating on a trellis …

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Investigations Into Pressure Profile And Pressure Control In Wrist-Worn Health Monitoring Devices, Roger Mcallister Black Aug 2022

Investigations Into Pressure Profile And Pressure Control In Wrist-Worn Health Monitoring Devices, Roger Mcallister Black

Theses and Dissertations

To aid in the design of future wearable health devices (WHDs), contact pressure between the distal forearm (wrist) and two different wrist-worn devices was investigated in this work. The first device included eight force sensors arranged in series along the length of a wristband to measure the pressure profile. The band also included a tensioner device for manually tightening the band while on a wrist. Testing was done on dummy wrists and the results were statistically significant supporting the hypothesis that areas of the wrist with lower radius of curvature will experience higher contact pressures generally and a faster rate …

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Help-Seeking Experiences As An Individual With Suicide Ideation: A Qualitative Study About Seeking Help For Suicide Ideation, Makaela H. Caldwell Aug 2022

Help-Seeking Experiences As An Individual With Suicide Ideation: A Qualitative Study About Seeking Help For Suicide Ideation, Makaela H. Caldwell

Theses and Dissertations

Suicide ideation and suicide impact a rapidly rising number of individuals each year, however our society has not envisioned a way to increase help-seeking behaviors to decrease these numbers. The literature discusses many barriers and hurdles to help-seeking, but the focus of SI within the context of help-seeking has not been studied in depth. The purpose of this qualitative study was to increase knowledge on the process through which individuals determine how and whom to ask for help when experiencing SI. Two sections of themes were found: things that encourage individuals to seek or continue to seek help, and things …

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Getting Back On Track After Challenges: A Qualitative Analysis Of Repair Efforts In Intimate Relationships, Tiffany Reid Lotulelei Aug 2022

Getting Back On Track After Challenges: A Qualitative Analysis Of Repair Efforts In Intimate Relationships, Tiffany Reid Lotulelei

Theses and Dissertations

All couples confront conflict in their marriage. Finding ways to navigate couple conflict is a topic that has been explored for several decades among marriage researchers (Rollin & Dowd, 1979). Repair, a strategy to help reconcile a situation or conversation that has gone awry, is important in helping couples overcome conflict. When couples are not able to repair and move forward, resentment arises. Unfortunately, the research on repair and resentment is limited, and the complexity of these variables can make it difficult to conceptualize. The present study utilized a qualitative lens (grounded constructivist theory) to explore relational repair and resentment …

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Design And Characterization Of Phased Arrays For Uas Detection And Tracking, David Buck Aug 2022

Design And Characterization Of Phased Arrays For Uas Detection And Tracking, David Buck

Theses and Dissertations

This work continues the development of phased array radar for UAS detection and tracking. The earlier 1D scanning, 4 channel BYU SAA radar is improved upon and replicated to form a network of radars. These are shown to work together for higher level tracking across multiple fields of view. Additionally, a new phased array instrument is designed and constructed with 16 channels, 2D scanning, and improved signal processing algorithms. Preliminary metrics and field results show the operation of this sensor. A new technique for measuring array mutual impedances from embedded element patterns is developed here. This technique uses an antenna …

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Using Imaging To Understand Achilles Tendon Adaptation And Injury In Female Athletes, Aaron W. Johnson Aug 2022

Using Imaging To Understand Achilles Tendon Adaptation And Injury In Female Athletes, Aaron W. Johnson

BYU Research Development Office Research Networking Conference

Musculoskeletal Imaging, Rehabilitation and Function of the Lower Extremity and Spine, Achilles Tendinopathy/Plantar Fasciopathy, Blood Flow and Perfusion of Foot Structures, Foot Morphology and Function, Hamstring Injury, Physical Therapy, Orthopedics

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Using Imaging To Understand Achilles Tendon Adaptation And Injury In Female Athletes, Aaron W. Johnson Aug 2022

Using Imaging To Understand Achilles Tendon Adaptation And Injury In Female Athletes, Aaron W. Johnson

BYU Research Development Office Research Networking Conference

Musculoskeletal Imaging, Rehabilitation and function of the lower extremity and spine, Achilles tendinopathy/plantar fasciopathy, Blood flow and perfusion of foot structures, Foot morphology and function, Hamstring injury, physical therapy, orthopedics

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How A Racial Minority Status Impacts The Feeling Of Safety In Therapy, Bayleigh Serage Aug 2022

How A Racial Minority Status Impacts The Feeling Of Safety In Therapy, Bayleigh Serage

Theses and Dissertations

With the lack of adequate mental health care in racial minority communities (NAMI, 2021), more research is needed for clinicians to understand the racial minority client experience. This study aimed to explore the racial minority client's perception of safety during therapy. The MFT- PRN was utilized in order to assess safety for racial minority clients at the start of therapy and later on as the alliance changes. The study hypothesized that racial minority clients would initially report a lower feeling of safety in therapy and would show lower feelings of safety after four sessions of therapy when compared to demographic …

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In-Situ Chlorine Gas Generation For Chlorination And Purification Of Rare Earth And Actinide Metals, Mark H. Schvaneveldt Aug 2022

In-Situ Chlorine Gas Generation For Chlorination And Purification Of Rare Earth And Actinide Metals, Mark H. Schvaneveldt

Theses and Dissertations

Rare earth and actinide metals, critical to security, medicine, and the economy, have been processed through methods such as solvent extraction and electrorefining. To minimize radiological waste and improve yield, a 'chloride volatility' process--also known as the chlorination and volatilization process (CVP)--has been proposed and demonstrated for processing rare earths. The process takes advantage of the low vapor pressure of rare earth chlorides (<700 >°C), CaCl2 was added to LaCl3 to lower the melting temperature. LaCl3 electrochemical behavior has not previously been studied in CaCl2. Cyclic voltammetry (CV) and square wave voltammetry (SWV) were applied to LaCl3 salts in CaCl2-LiCl …

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Fabrication And Characterization Of Dna Templated Electronic Nanomaterials And Their Directed Placement By Self-Assembly Of Block Copolymers, Dulashani Ruwanthika Ranasinghe Weerakkodige Aug 2022

Fabrication And Characterization Of Dna Templated Electronic Nanomaterials And Their Directed Placement By Self-Assembly Of Block Copolymers, Dulashani Ruwanthika Ranasinghe Weerakkodige

Theses and Dissertations

Bottom-up self-assembly has the potential to fabricate nanostructures with advanced electrical features. DNA templates have been used to enable such self-assembling methods due to their versatility and compatibility with various nanomaterials. This dissertation describes research to advance several different steps of biotemplated nanofabrication, from DNA assembly to characterization. I assembled different nanomaterials including surfactant-coated Au nanorods, DNA-linked Au nanorods and Pd nanoparticles on DNA nanotubes ~10 micrometer long, and on ~400 nm long bar-shaped DNA origami templates. I optimized seeding by changing the surfactant and magnesium ion concentrations in the seeding solution. After successful seeding, I performed electroless plating on …

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Fall Conference 2022 Panel Presentation, Ellen Amatangelo Aug 2022

Fall Conference 2022 Panel Presentation, Ellen Amatangelo

Faculty Publications

This presentation was part of a panel discussing ways in which work done by employees at the Brigham Young University Library focuses on Christ. Collections and articles in BYU's institutional repository that focus on religious topics are highlighted.

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Student Retention And Persistence In University Certificate-First Programs, Troy Martin, Randall Davies Aug 2022

Student Retention And Persistence In University Certificate-First Programs, Troy Martin, Randall Davies

Faculty Publications

While access to higher education has grown over the past few years, significant barriers exist for nontraditional students attempting to prepare for and complete postsecondary education. For these students, the traditional methods for acknowledging student achievement do not always work. This research explored the impact of earning professional certificates on nontraditional students’ confidence, motivation, and persistence. Specifically, this study evaluated the matriculation rates between two cohorts of students who participated in the online PathwayConnect program. The mixed-method study found that matriculation rates for students who were encouraged to earn a certificate increased compared to those who followed a traditional path. …

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Precision Maritime Localization And Landing With Real-Time Kinematic Gnss, Alexander Jordan, Matthew Kent Rydalch, Tim Mclain, Michael Williamson Tabango Jul 2022

Precision Maritime Localization And Landing With Real-Time Kinematic Gnss, Alexander Jordan, Matthew Kent Rydalch, Tim Mclain, Michael Williamson Tabango

Student Works

This paper presents a highly effective method for UAV precision shipboard localization and landing using Real-time Kinematic Global Navigation Satellite System (RTK GNSS). To assess the feasibility of RTK GNSS for this use case we explicitly exclude vision-based localization techniques which are most often presented in the literature. Instead, the methods presented in this paper use only RTK GNSS with an inertial measurement unit aboard the landing pad to estimate the state of the boat and the relative position of the UAV with respect to the boat. We use a continuous-discrete extended Kalman filter combined with a complementary filter for …

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Communication About Pornography And Relationship Quality In Different-Gender Couples, Rachel Ann Augustus Jul 2022

Communication About Pornography And Relationship Quality In Different-Gender Couples, Rachel Ann Augustus

Theses and Dissertations

Scholars have begun to suggest factors that explain and influence the association between pornography use and relationship outcomes but further work is still needed. Communication about pornography is one variable that may be influential but it has yet to be considered in this way. Using a dyadic sample of 713 different-gender couples, I used Actor-Partner Structural Equation Modeling to analyze associations between pornography use (male pornography use, joint pornography use and female pornography use) and relational quality (from the perspective of each partner, respectively), associations between communication about pornography and relationship quality. Communication about pornography was also considered as a …

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The Experience Of Friendship As A Characteristic Of Intimate Relationships: A Grounded Theory Study, Jennifer Griffith Jul 2022

The Experience Of Friendship As A Characteristic Of Intimate Relationships: A Grounded Theory Study, Jennifer Griffith

Theses and Dissertations

The purpose of this study was to gain a greater understanding of the construct of friendship, specifically how intimate partners experience friendship in intimate relationships. 45 participants were interviewed one-time (for a total of 60-90 minutes) and asked about their experience of healthy and unhealthy behaviors, including friendship, in committed relationships. Research questions included: how participants define the concept of friendship, behaviors that perpetuate friendship in intimate relationships, perceived benefits of friendship, and what a lack of friendship in their relationship looks like. Participants were asked about friendship generally with the hope that information on the research questions would be …

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Behavioral Indicators Of The Therapeutic Alliance In Relation To Dropout In Couple Therapy, S. Celeste Esplin Jul 2022

Behavioral Indicators Of The Therapeutic Alliance In Relation To Dropout In Couple Therapy, S. Celeste Esplin

Theses and Dissertations

Almost half of those who start therapy drop out early (Thalmayer, 2018). When therapists work to improve the therapeutic alliance, clients are more likely to stay in treatment and chances of recovery improve (D'Aniello et al., 2018; Escudero & Friedlander, 2017). However, the existing research comes almost entirely from client self-reports of the alliance. Little research has examined what occurs during the session. There has been no research to determine what specific therapeutic alliance behaviors are related to early termination. The current naturalistic study sought to discover if behaviors that strengthen or diminish the therapeutic alliance are related to early …

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Exercise As A Predictor Of Change In Self-Reported Marital Satisfaction And Behaviors Of Couples In Therapy, Emily J. Nelson Jul 2022

Exercise As A Predictor Of Change In Self-Reported Marital Satisfaction And Behaviors Of Couples In Therapy, Emily J. Nelson

Theses and Dissertations

Recent studies looking to link physical exercise with beneficial couple outcomes have had mixed results, showing benefits for females but not males in some instances, and even negative effects for males in one instance. However, these studies used self-report data for exercise which may suffer from reporting errors. This study analyzed how daily exercise, measured by participants wearing accelerometers, impacts marital satisfaction, positive behaviors, and negative behaviors in a clinical population. The data was analyzed using multilevel models to determine how time spent exercising impacted individuals and their partners in terms of relationship outcomes. Results indicated small but significant relationships …

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Selecting And Optimizing Origami-Based Patterns For Deployable Space Systems, Diana Stefania Bolanos Jul 2022

Selecting And Optimizing Origami-Based Patterns For Deployable Space Systems, Diana Stefania Bolanos

Theses and Dissertations

This thesis addresses the design difficulties encountered when designing deployable origami-based arrays. Specific considerations regarding thickness accommodation, deployment, and parameter modifications are discussed. Patterns such as the Miura-ori, flasher, and hexagon are investigated, with emphasis placed on pattern modification from zero-thickness to finite-thickness. Applying origami principles to form engineering solutions is a complicated task. Competing requirements may create confusion around which pattern is most favorable for the space array application. Implementing origami into a finite-thickness, engineered system poses challenges that are not manifest in a zero-thickness model. As such, it is important to understand and address the limitations of the …

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Neuroticism's Ties To Relationship Satisfaction: What Behaviors Matter?, Alexyss M. Lange Jul 2022

Neuroticism's Ties To Relationship Satisfaction: What Behaviors Matter?, Alexyss M. Lange

Theses and Dissertations

In multiple studies, neuroticism and romantic relationship satisfaction are negatively related to one another. Yet, the exact behaviors that link neuroticism to lower relationship satisfaction are unknown. Our seven-day daily diary study (N = 246) identified specific, everyday behaviors that might mediate this association. After establishing positive and negative factors using exploratory factor analysis, we examined whether positive or negative behaviors (and sub-categories of these dimensions) mediate the relationship between neuroticism and relationship satisfaction. Our results showed that negative behaviors mediated the relationship between neuroticism and relationship satisfaction but positive behaviors did not. A subcategory of conflict tactics mediated the …

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Quantifying Protein Quality To Understand Protein Homeostasis, Hsien-Jung Lavender Lin Jul 2022

Quantifying Protein Quality To Understand Protein Homeostasis, Hsien-Jung Lavender Lin

Theses and Dissertations

Proteins are the center of all biochemical reactions in living organisms. Proteins need to be present at the right time, in the right place, with the correct concentration and have the right shape to carry their designated function. Protein homeostasis is when all proteins in the proteome are in functional balance, and such balance is maintained by synthesis, folding, and degradation machinery. When protein homeostasis is lost, organisms start to age and develop diseases. To truly unveil disease mechanisms and provide more efficient means for treatment and prevention, we need a holistic understanding of the mechanism of protein homeostasis. Currently, …

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End Matter, Vol. 82 No. 2 Jul 2022

End Matter, Vol. 82 No. 2

Western North American Naturalist

No abstract provided.

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Enabling Successful Human-Robot Interaction Through Human-Human Co-Manipulation Analysis, Soft Robot Modeling, And Reliable Model Evolutionary Gain-Based Predictive Control (Mega-Pc), Spencer W. Jensen Jul 2022

Enabling Successful Human-Robot Interaction Through Human-Human Co-Manipulation Analysis, Soft Robot Modeling, And Reliable Model Evolutionary Gain-Based Predictive Control (Mega-Pc), Spencer W. Jensen

Theses and Dissertations

Soft robots are inherently safer than traditional robots due to their compliance and high power density ratio resulting in lower accidental impact forces. Thus they are a natural option for human-robot interaction. This thesis specifically looked at human-robot co-manipulation which is defined as a human and a robot working together to move an object too large or awkward to be safely maneuvered by a single agent. To better understand how humans communicate while co-manipulating an object, this work looked at haptic interaction of human-human dyadic co-manipulation trials and studied some of the trends found in that interaction. These trends point …

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Simulation And Localization Of Autonomous Underwater Vehicles Leveraging Lie Group Structure, Easton Robert Potokar Jul 2022

Simulation And Localization Of Autonomous Underwater Vehicles Leveraging Lie Group Structure, Easton Robert Potokar

Theses and Dissertations

Autonomous underwater vehicles (AUVs) have the potential to dramatically improve safety, quality of life and general scientific knowledge. Our coasts, lakes and rivers are filled with various forms of marine infrastructure including dams, bridges, ship hulls, communication lines, and oil rigs. Each of these structures requires regular inspection, and current methods utilize divers, which is dangerous, expensive, and time consuming. AUVs have the potential to alleviate these difficulties and enable more regular inspection of these structures. Furthermore, there are significant scientific discoveries in the fields of geology, marine biology and medicine that AUV exploration of our oceans will enable. Since …

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Trace Elements In Walleye Tissues And Dietary Components From An Impoundment Located Downstream Of The Leadville Mining District, Colorado, I: Hg And Se, Scott J. Herrmann, Del Wayne R. Nimmo, Igor V. Melnykov Jul 2022

Trace Elements In Walleye Tissues And Dietary Components From An Impoundment Located Downstream Of The Leadville Mining District, Colorado, I: Hg And Se, Scott J. Herrmann, Del Wayne R. Nimmo, Igor V. Melnykov

Western North American Naturalist

There is a paucity of studies focusing on how total mercury (THg) and total selenium (TSe) concentrations vary in walleye tissues and prey organisms from a reservoir that is downstream from a major mining district and whose basin consists of Cretaceous sedimentary Se-bearing outcroppings. Pueblo Reservoir in Colorado is fed by water from the upper Arkansas River, which has been polluted by trace metals and metalloids since mining began in 1859. Pueblo Reservoir is the only mainstem impoundment on the Upper Arkansas River and is located about 251 km downstream from the historic Leadville Mining District. Nearly all the contaminated …

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Trace Elements In Walleye Tissues And Dietary Components From An Impoundment Located Downstream Of The Leadville Mining District, Colorado, Ii: Cu, Zn, As, Cd, And Pb, Del Wayne R. Nimmo, Scott J. Herrmann, Igor V. Melnykov Jul 2022

Trace Elements In Walleye Tissues And Dietary Components From An Impoundment Located Downstream Of The Leadville Mining District, Colorado, Ii: Cu, Zn, As, Cd, And Pb, Del Wayne R. Nimmo, Scott J. Herrmann, Igor V. Melnykov

Western North American Naturalist

Trace elements in 15 walleye (Sander vitreus) tissues taken from the Pueblo Reservoir in Colorado corresponded to many metals of worldwide concern and were the same as those released into the Arkansas River from decades of mining at Leadville, Colorado. Therefore, analyses of walleye stomach contents, gizzard shad (Dorosoma cepedianum; a dietary prey item for walleye), and tissues of walleye were compared for an increase in, or a deficiency of, Cu, Zn, As, Cd, and Pb. Tissues were compared as couplets but also evaluated with tissues clustered into 6 functional groups. The trace elements were found …

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E-Pra: Participatory Rural Appraisal Using Satellite Imagery On A Flexi Sheet [Online], Nishant Kumar, Pavan Matham, Shravya False, Peter False Jul 2022

E-Pra: Participatory Rural Appraisal Using Satellite Imagery On A Flexi Sheet [Online], Nishant Kumar, Pavan Matham, Shravya False, Peter False

International Congress on Environmental Modelling and Software

Efficiency of rural infrastructure projects in developing countries is suboptimal. This can be improved through participation of rural communities at every stage of the program i.e. planning, implementation, monitoring and evaluation. Though participation is required at every stage, it is most important at the planning stage. To ensure this, a participatory method known as participatory rural appraisal (PRA) is most often used. A key step is to map and plan resources utilization using as medium either ground, paper, or GIS. However, most often, it only follows the ‘inform’ step in the participatory ladder. In the present paper, an innovative PRA …

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Personality-Dependent Responses Of Elk To Predatory Pursuits, Rob Found Jul 2022

Personality-Dependent Responses Of Elk To Predatory Pursuits, Rob Found

Western North American Naturalist

Personality in wildlife has been linked to several ecological processes including mortality risk, facultative migration, and behavioral plasticity. In this paper I examined the relationship between personality and antipredator tactics exhibited by 20 wild female elk (Cervus canadensis) in Jasper National Park, Alberta. Two observers conducted 106 separate chases designed explicitly to resemble predator pursuits by wolves, the main predator of elk. We quantified and classified elk tactical responses during each chase. Elk with “shy” type personalities responded to 84% of predator-resembling pursuits by employing speed-based tactics to outrun pursuers or rejoin conspecifics. Elk with “bold” type personalities …

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Reconstituting A Pre-Neolithic Territory By Implementing Plant Functional Types: Application To The Roussillon Territory (France), Benoit Gaudou, Zenith Arnejo, Paul Bannwart, Flavien Loup-Hadamard Jul 2022

Reconstituting A Pre-Neolithic Territory By Implementing Plant Functional Types: Application To The Roussillon Territory (France), Benoit Gaudou, Zenith Arnejo, Paul Bannwart, Flavien Loup-Hadamard

International Congress on Environmental Modelling and Software

The study of the impact of human activities on a non-humanly modified landscape is confronted with an essential need to define the initial state before farmers arrived. Particularly, vegetation cover (biomass but also vegetation type distribution) is hard to reconstitute once we postulate there is no such thing as climatic vegetation. Here we present the first steps of a reconstitution of a self-evolving vegetation cover of the French department of Pyrénées-Orientales (also, Roussillon) - an area cultivated since the 5th millennium B.C. To simulate the vegetation state at the neolithic period, we first classify the 94 tree and bush species …

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Ensemble Model-Based Method For Time Series Sensors’ Datavalidation And Imputation Applied To A Real Waste Water Treatmentplant, Josep Pascual-Pañach, Miquel Sànchez-Marrè, Miquel Àngel Cugueró-Escofet Jul 2022

Ensemble Model-Based Method For Time Series Sensors’ Datavalidation And Imputation Applied To A Real Waste Water Treatmentplant, Josep Pascual-Pañach, Miquel Sànchez-Marrè, Miquel Àngel Cugueró-Escofet

International Congress on Environmental Modelling and Software

Intelligent Decision Support Systems (IDSS) integrate different Artificial Intelligence (AI) techniques with the aim of taking or supporting human-like decisions. To this end, these techniques are based on the available data from the target process. This implies that invalid or missing data could trigger incorrect decisions and therefore, undesirable situations in the supervised process. This is even more important in environmental systems. In data-driven applications such as IDSS, data quality is a basal problem that should be addressed for the sake of the overall systems’ performance. In this paper, a data validation and imputation methodology for time-series is presented. This …

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