Digital Commons Network^™

Steroid Receptor Coactivator 3-Deficient Regulatory T Cells Eradicate Multiple Solid Tumors In Syngeneic Mouse Models, Nuri Sung, Eunsu Kim, Yosef Gilad, Yuri Park, Adam M Dean, Yan Xia, Jianming Xu, Clifford C Dacso, David M Lonard, Sang Jun Han

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is highly expressed in regulatory T cells (Tregs) and is important for their immunosuppressive activity. Recently, we demonstrated that disrupting SRC-3 expression in Tregs eliminates triple-negative breast cancer (TNBC) and prostate cancer in syngeneic animal models by generating an anti-tumor immune microenvironment without inducing immune-related adverse events (irAEs). Further analysis of these mice revealed that SRC-3 knockout (KO) Tregs infiltrated breast tumors and facilitated the infiltration of CD8

When Probiotics Guidelines Differ: A Practical Guide For Clinicians And Researchers, Geoffrey A Preidis, Hania Szajewska, Marla Cunningham, Howard Bauchner, Daniel J Merenstein

Faculty, Staff and Students Publications

Many professional organizations publish clinical practice guidelines for the use of probiotics in gastrointestinal disorders. Generally, no two guidelines align perfectly, and some differ markedly. These discrepancies occur because clinical practice guidelines are not purely mechanical outputs of data synthesis. They are shaped by structured interpretation, value judgments, and predefined thresholds for uncertainty. These elements become particularly visible when effect sizes are small, heterogeneity is high, and outcomes vary in clinical relevance-as is the case with probiotic research. This article examines why discordance among probiotic guidelines is predictable and provides practical guidance for clinicians who must decide among conflicting recommendations …

Reducing The Detrimental Effects Of Post-Stroke Social Isolation Through Inhibition Of Mirna-10a-5p In A Mouse Model, Peijun Zhao

Summer Research Program Abstracts

No abstract provided.

Dysregulation Of Lipid Metabolism In Chronic Hypoxia In Neonates, Mason L. Wong

Summer Research Program Abstracts

No abstract provided.

The Impact Of Sex Hormones On Heritable Thoracic Aortic Disease: A Montalcino Aortic Consortium Study, Catherine E. Wilson

Summer Research Program Abstracts

No abstract provided.

Bacteriophage Encapsulation With Type A And Type B Gelatin Microparticles To Treat Antimicrobial-Resistant Orthopedic Device-Related Infections, Aiden A. Willis

Summer Research Program Abstracts

No abstract provided.

Leveraging Sports Analytics And Intraoperative Video To Improve Surgical Quality And Outcomes, Jasie L. Williams-Roberts

Summer Research Program Abstracts

No abstract provided.

Incidence And Risk Factors For Heterotopic Ossification After Acetabular Fracture Fixation Using A Kocher-Langenbeck Approach: A Single-Center Retrospective Cohort, Weston W. Wilber

Summer Research Program Abstracts

No abstract provided.

The Impact Of Narrative Interventions On Cognitive And Emotional Well-Being In Elders, Jasmine N. White

Summer Research Program Abstracts

No abstract provided.

A New Tool To Improve Prediction Of Clinical Outcomes After Endovascular Therapy For Patients With Large Infarct Core., Demi K. Waworuntu

Summer Research Program Abstracts

No abstract provided.

Surface Imprinting To Enhance Antibiotic Elution Of Bone Cement Spacers Abstract, David Tran

Summer Research Program Abstracts

No abstract provided.

Sleep Respiratory Biomarkers Of Sudden Unexpected Death In Epilepsy (Sudep): A Case Control, Cat Tien Tran

Summer Research Program Abstracts

No abstract provided.

Age And Sex Modulation Of No Signaling In Mouse Brain, Emmaline R. Thorpe

Summer Research Program Abstracts

No abstract provided.

Reducing Acute Healthcare Services With Self-Management Of Blood Pressure Monitoring Through Remote Patient Monitoring For Hypertensive Patients A Quality Improvement Project, Becky J. Wagner

Doctor of Nursing Practice (DNP) Manuscripts

Hypertension (HTN) affects nearly half of U.S. adults and remains a leading cause of preventable emergency department (ED) visits, hospitalizations, and healthcare costs due to poor blood pressure (BP) control (Fryar et al., 2024; Mullins et al., 2019). Traditional care models often lack the continuous monitoring and timely intervention needed for effective chronic disease management. Remote Patient Monitoring (RPM) provides an innovative approach by delivering real-time BP data, enabling early clinical intervention, and encouraging patient engagement in self-management (Omboni et al., 2020).

This Doctor of Nursing Practice (DNP) project evaluated the effectiveness of an RPM intervention in reducing acute healthcare …

Impact Of Implementing Standard Wound Care Guidelines For Patients In The Home Care Setting On Patient Outcomes, Raymond Anthony Flores Jr

Doctor of Nursing Practice (DNP) Projects

Wound care is among the most significant public health concerns, affecting millions of people worldwide. Most individuals with wounds end up self-managing their condition from their homes due to being discharged early from the hospital, owing to various reasons, and the costs associated with health care. Although home wound management offers convenience and lower costs for patients, it is also associated with substantial challenges, including limited access to and use of appropriate care protocols, wound management tools, and sufficient education on the topic, as well as limited professional advice. These limitations contribute to poor outcomes, including slow healing rates, infections, …

Standardizing Ascitic Fluid Panel To Improve Outcomes In A Large State Hospital, Yimei Zhang

Doctor of Nursing Practice Final Project Abstract

Purpose: The purpose of this quality improvement project was to increase provider compliance with evidence-based, hepatology-recommended ascitic fluid studies among inpatient providers from a baseline of 50% to 60% within five months through electronic health record (EHR) standardization.

Background: Delayed or incomplete ascitic fluid analysis can increase the risk of preventable complications. Workflow variability and non-standardized ordering practices contributed to inconsistent adherence to evidence-based recommendations.

Methodology: Using the Institute for Healthcare Improvement (IHI) Model for Improvement with Plan–Do–Study–Act (PDSA) cycles, two paracentesis workflows were redesigned. For the Mobile Procedure Team, a standardized ascitic fluid panel with six defaulted, evidence-based tests …

Improving Adherence To The Ticket-To-Test C. Difficile Protocol In A Medical-Surgical Microsystem, Georgette Marie D. Lim

Master's Projects and Capstones

Problem: Poor adherence to the ticket-to-test protocol on the 3 South unit led to unnecessary C. difficile testing, inappropriate isolation, and workflow variation. These issues mirror national concerns about over-testing and misdiagnosis, which can inflate hospital‑onset C. difficile rates and increase costs.

Context: This project was implemented on a medical‑surgical unit, a team with a strong culture of collaboration, education, and engagement in quality improvement. The unit benefits from structured oversight through the C. difficile committee, which reports to the performance improvement team.

Interventions: The Institute for Healthcare Improvement Model for Improvement guided four PDSA cycles, with …

Is Your Cyst Really A Ganglion Cyst? A Case Report Of Angioleiomyoma Mimicking A Plantar Fascia Cystic Lesion, Christopher Anjorin Ms Dpmc, Joseph Bender Dpm

School of Podiatric Medicine - Student Research

Ganglion cysts are among the most common benign soft tissue masses encountered in podiatric clinical practice, and their diagnosis is often presumed based on location, clinical observation, and transillumination. However, this case highlights a diagnostic idiosyncrasy: a lesion clinically presumed to be a ganglion cyst within the plantar fascia was ultimately identified as an angioleiomyoma following surgical excision and histopathological evaluation. This finding underscores the importance of maintaining a broad differential diagnosis when assessing cystic lesions, particularly those that transilluminate, as benign vascular tumors may closely mimic more common entities in both clinical presentation and imaging. More importantly, what if …

Nourishing Births: A Program Evaluation Proposal For Community-Based Nutrition Education, Food Access, And Garden Engagement Among Black Birthing People, Naa Deedei-Vera Hammond

Master's Projects and Capstones

Black birthing people in the United States continue to experience unequal maternal health outcomes, shaped in part by racism and barriers to nutritious food, culturally relevant health education, and supportive community spaces. While prenatal nutrition education and food assistance programs can provide important resources, information alone cannot address the challenges many people face when trying to access healthy and affordable food during pregnancy. The Nourishing Births Initiative is a proposed community-based maternal health program designed to respond to these needs by bringing together prenatal nutrition education, help connecting to food resources, community gardening, and peer support for Black birthing people …

Adolescent And Young Adult Cancer Survivorship: Supportive Care Needs, Resources, And Barriers, Allison Bryn Koplos

Master's Projects and Capstones

Background: Adolescent and young adult (AYA) cancer survivors experience unique physical, psychosocial, developmental, and healthcare-related challenges that often persist beyond treatment completion. Although survivorship resources have expanded, gaps in supportive care needs persist. This scoping review examined the supportive care needs, survivorship resources, and barriers to accessing supportive care among AYA cancer survivors.

Methods: A scoping review was conducted following the Arksey and O'Malley framework and reported in accordance with the PRISMA-ScR guidelines. Peer-reviewed literature published between 2000 and 2026 was identified through searches in PubMed and Google Scholar. Studies examining supportive care needs, survivorship resources, or supportive care services …

20141218: President Stephen J. Kopp Memorial Materials, 2014-2015, President's Office

Guides to University Archives

These items include materials from the office of the President at Marshall University from 2014-2015. Items were received in that time period and include notable materials from President Kopp's departure from this Earth. Included are newspaper articles, obituary write-ups, copies of his memorial service, and write-ups about his life published in the Herald-Dispatch. Please download the inventory for a complete list of the contents.

Gauging Understanding Of Information In Discharge Education In Trauma And Burn Patients, Marissa N. Thibodeaux

Summer Research Program Abstracts

No abstract provided.

The Cost Of Helping Hand: Lost Revenue On Overnight Hand Call, Tia Taylor

Summer Research Program Abstracts

No abstract provided.

Operating Room Waste Reduction In Watts And Water: Savings Beyond The Shift To Reusable Textiles, Taylor R. Sweeney

Summer Research Program Abstracts

No abstract provided.

The Making Of A Counselor: How My Life Shaped My Purpose, Grace M. Christopherson

Dissertations, Theses, and Projects

This Plan B Project Analysis of Self explores the life experiences of an aspiring school counselor. The goal of a self-analysis project is to further explore the contents of oneself before entering the mental health field. Personal stories and experiences will be debriefed with the purpose of showing what has led to a pursuit in a career as a mental health counselor. Assessment results will also be shown and drawn from further enhancing the analysis of self. Additionally, theoretical orientation will be elaborated on and illustrated. All the different aspects of the analysis of self will reveal development both professionally …

The Hemostatic Properties Of Green Plasma, David J. Sun

Summer Research Program Abstracts

No abstract provided.

Robust Statistical Methods For Microbiome Abundance Data, Yiming Shi

WUSM Theses and Dissertations – All Programs

Differential abundance analysis in microbiome studies aims to identify taxa whose abundance differs across biological or clinical conditions. The observed data are typically taxon-specific sequencing read counts, representing reads assigned to different taxa within each sample. These counts are indirect measurements of the underlying microbial abundance profile and are constrained by sample-specific library sizes. Microbiome count data are also typically sparse, overdispersed, and heteroscedastic. Together, these characteristics create substantial challenges for differential abundance analysis and make the results highly sensitive to normalization procedures, model specification, and the statistical methods used for inference.

Normalization defines the scale on which samples are …

Investigating The Ability Of Presequences To Influence Mitochondrial Protein Import, Youmian Yan

WUSM Theses and Dissertations – All Programs

Mitochondria are essential organelles housing over 1000 proteins, 99% of which are nuclear-encoded and synthesized in the cytosol. Most mitochondrial proteins are targeted by a positively charged sequence called the presequence, which lacks a common sequence motif and is poorly conserved across evolution. Accumulating evidence suggests that presequences encode meaningful information that influences mitochondrial protein uptake. For instance, multiple stress response models propose that stress sensing proteins contain “weak” presequences which allows them to monitor mitochondrial health. However, there is a lack of systematic examination about how presequences influence import kinetics and what constitutes presequence strength. These gaps in knowledge …

Port And Vessel Communication Traffic Intrusion Detection: A Variational Autoencoder‑Enhanced Multilayer Perceptron Approach, Chien-Lin Chiang, Hsien-Cheng Chou, Ming-Yuan Peng, Yi-Yuan Chiang, Yu-Shun Liu

Journal of Marine Science and Technology–Taiwan

Port and vessel networks increasingly operate on IP/Ethernet backbones with high‑noise, high‑dimensional traffic. We present a lightweight hybrid intrusion‑detection model that couples a variational autoencoder (VAE) with a multilayer perceptron (MLP) and augments training with a boundary‑oriented latent‑space mixup strategy. The VAE models the distribution of normal traffic and identifies anomalies through reconstruction errors. Subsequently, it generates robust latent vectors, enabling the MLP to perform highly accurate supervised classification. On the UNSW‑NB15 dataset, the proposed pipeline attains ≥97% accuracy and an outstanding recall of 99.56% in binary intrusion detection, and visualization of the latent space (PCA) together with reconstruction‑error analyses …

Sar Ship Detection Based On Shallow Feature Guidance, Chenxu Xia, Peng Chen, Ya Zhang, Ying Li

Journal of Marine Science and Technology–Taiwan

Maritime ship detection is of great significance for both military security and civilian applications. Synthetic Aperture Radar (SAR), with its all-weather and all-day imaging capability, plays a vital role in maritime surveillance. Nevertheless, SAR ship targets typically appear small in scale, embedded in complex backgrounds, blurred at boundaries, and easily confused with near-shore features, which pose substantial challenges for accurate detection. To address these issues, we propose a SAR ship detection network that integrates dual enhancements of small-object representation and edge information. The network introduces two key components: the Small Target Refine Pyramid (STRP) to strengthen shallow feature representation for …