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Role Of Mirna Clusters In Epithelial To Mesenchymal Transition In Cancer, Vaibhav Shukla, Divya Adiga, Padacherri Vethil Jishnu, Vinay Koshy Varghese

Open Access archive

Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including …

Solitary Solidarity: Vignettes Of The Appalachian Trail, Noah L. Booth

Undergraduate Theses, Professional Papers, and Capstone Artifacts

This past Summer, I spent two months solo-hiking the first third of the Appalachian Trail. I completed 737 total miles, starting at Springer Mountain in Georgia and continuing through North Carolina and Tennessee, before finishing my journey in central Virginia. I am no stranger to backpacking, but the rolling Blue Ridge Mountains of the Southeast were completely foreign to me. Throughout this two month excursion I kept a daily journal, logging everything from mileage and geographical features, to encounters with wildlife and humans alike. Over six months have elapsed since I completed my journey and, having had plenty of time …

Cash Reserve And Liquid Asset Requirements, Bank Of Jamaica

Documents

No abstract provided.

Operations, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

Documents

data showing the allotments and auctions results for the BAPF

Transaction-Level Data, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

Documents

data showing the Bankers' Acceptances purchased under the BAPF

Cash Management Bond Buyback Results, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

Documents

data showing the GoC securities purchased and operations conducted under cash management buybacks

Mtm Corporate Bond Index, Thai Bond Market Association (Tbma)

Documents

compiled data summarizing movements in prices of Thai corporate bonds

Thbfix, Bank Of Thailand

Documents

Data showing THBFIX, the Thai overnight index swap rate

Bank Of Israel Balance Sheet 2020, Bank Of Israel

Documents

No abstract provided.

Bank Of Israel Balance Sheet 2021, Bank Of Israel

Documents

No abstract provided.

Covid Corporate Financing Facility (Ccff) Issuer Eligibility Form - Primary Market, Bank Of England/Central Bank Of The United Kingdom

Documents

No abstract provided.

Covid Corporate Financing Facility (Ccff) Issuer Eligibility Form - Secondary Market, Bank Of England/Central Bank Of The United Kingdom

Documents

No abstract provided.

Provincial Money Market Purchase Program (Pmmpp) Transaction Data, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

Documents

No abstract provided.

Contingent Term Repo Facility Results, Bank Of England/Central Bank Of The United Kingdom

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No abstract provided.

Mmlf Request Form, Federal Reserve System: Board Of Governors

Documents

No abstract provided.

Development And Evaluation Of A New Algorithm For Detecting 30m Land Surface Phenology From Viirs And Hls Time Series, Xiaoyang Zhang, Jianmin Wang, Geoffrey Henebry, Feng Gao

Global Land Surface Season Data Sets

These files contain source code and sample data associated with the article, Development and Evaluation of a New Algorithm for Detecting 30m Land Surface Phenology from VIIRS and HLS Time Series.

To run the software, the inputs in both example-1 file and example-2 file should be put to one single directory.

Downloadable files:

1. readme.txt
2. Example-1.zip (994.3 MB)
3. Example-2.zip (902.2 MB)
4. Input_example.txt
5. input_description.txt
6. HLS_VIIRS_shape_fusion.exe
7. HLS_VIIRS_shape_fusion.c
8. makefile

Switch Operation Results, Bank Of Canada/Central Bank Of Canada/La Banque Du Canada

Documents

data showing the GoC securities purchased and operations conducted under switch operations

Modelling Mycorrhizal Fungi Dispersal By The Mycophagous Swamp Wallaby (Wallabia Bicolor) [Dataset], Melissa Danks, Natalie Simpson, Todd F. Elliot, C.E. Timothy Paine, Karl Vernes

Research Datasets

Despite the importance of mammal-fungal interactions, tools to estimate the mammal-assisted dispersal distances of fungi are lacking. Many mammals actively consume fungal fruiting bodies, the spores of which remain viable after passage through their digestive tract. Many of these fungi form symbiotic relationships with trees and provide an array of other key ecosystem functions. We present a flexible, general model to predict the distance a mycophagous mammal would disperse fungal spores. We modelled the probability of spore dispersal by combining animal movement data from GPS-telemetry with data on spore gut-retention time. We test this model using an exemplar generalist mycophagist, …

Human Impact Overrides Bioclimatic Drivers Of Red Fox Home Range Size Globally, Michael Main, Robert Davis, David Blake, Harriet Mills, Tim Doherty

Research Datasets

Aim Identifying the variables that influence animal home range size is important for understanding the biological requirements of individuals and their social interactions. Given their often broad distributions, carnivores are model organisms for studying range-wide determinants of home range size. Here we test predictions about environmental determinants of home range size for one of the world’s most widely distributed carnivores, the red fox (Vulpes vulpes).

Location Global

Methods We compiled a database of 70 mean home range estimates from 62 studies and four continents, which we analysed according to site-based temperature, precipitation, environmental productivity and human influence …

Hybrid Zone Barriers Comparative Data Set, David L. Field

Research Datasets

Many recent studies have addressed the mechanisms operating during the early stages of speciation, but surprisingly few studies have tested theoretical predictions on the evolution of strong reproductive isolation (RI). To help address this gap, we first undertook a quantitative review of the hybrid zone literature for flowering plants in relation to reproductive barriers. Then, using Populus as an exemplary model group, we analysed genome-wide variation for phylogenetic tree topologies in both early- and late-stage speciation taxa to determine how these patterns may be related to the genomic architecture of RI. Our plant literature survey revealed variation in barrier complexity …

Floral Display And Habitat Fragmentation: Effects On The Reproductive Success Of The Threatened Mass-Flowering Conospermum Undulatum (Proteaceae), Nicola Delnevo, Eddie Van Etten, Margaret Byrne, William Stock

Research Datasets

1. Fragmentation of natural vegetation is currently one of the largest threats to plant populations and their interactions with pollinators. Plant reproductive susceptibility to habitat fragmentation has been investigated in many species; however, the response of wild mass-flowering species is poorly known, with research limited to mainly boreal plant species.

2. Here we studied twelve remnant populations of the threatened mass-flowering shrub Conospermum undulatum in the southwest Australian biodiversity hotspot, each presenting different population size, level of isolation, and floral display. We assessed the impact of fragmentation on: 1) fruit and seed production; and 2) seed germination. To gain a …

A Geospatiotemporal And Causal Inference Epidemiological Exploration Of Substance And Cannabinoid Exposure As Drivers Of Rising Us Pediatric Cancer Rates, Albert Stuart Reece

Research Datasets

Background: Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975-2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. We investigated whether cannabis use was related spatiotemporally and causally to TPCIR.

Methods: State-based age-adjusted TPCIR data was taken from the CDC Surveillance, Epidemiology and End Results cancer database 2003-2017. Drug exposure was taken from the nationally-representative National Survey of Drug Use and Health, response rate 74.1%. Drugs included were: tobacco, alcohol, cannabis, opioid analgesics and cocaine. This was supplemented by cannabinoid concentration data from the …

Contemporary Epidemiology Of Rising Atrial Septal Defect Trends Across Usa 1991-2016: A Combined Ecological Geotemporospatial And Causal Inferential Study, Albert Stuart Reece

Research Datasets

Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with a range of data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal?

Methods: Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted …

Broad Spectrum Epidemiological Contribution Of Cannabis, Tobacco And Alcohol To The Teratological Profile Of Northern New South Wales: Geospatial And Causal Inference Analysis, Albert Stuart Reece

Research Datasets

Background: Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) a known cannabis use centre.

Methods: Design: Cohort. 2008-2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, Risky Alcohol, Annual cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial and causal …

Co-Occurrence Across Time And Space Of Drug- And Cannabinoid- Exposure And Adverse Mental Health Outcomes In The National Survey Of Drug Use And Health Dataset 2: Combined Ecological Geotemporospatial And Causal Inference Analysis, Albert Stuart Reece

Research Datasets

Background: Whilst many studies have linked increased drug and cannabis exposure to adverse mental health (MH) outcomes their effects on whole populations and geotemporospatial relationships are not well understood.

Objectives: Determine: (1) if cannabis use is associated with major MH outcomes ascross space and time, (2) if such impacts are robust to multivariable adjustment and (3) if the relationship is causal.

Methods: Ecological cohort study of National Survey of Drug Use and Health (NSDUH) geographically-linked substate-shapefiles 2010-2012 and 2014-2016 supplemented by five-year US American Community Survey. Drugs: cigarettes, alcohol abuse, last-month cannabis use and last-year cocaine use. MH: any mental …

Male Victims Of Female-Perpetrated Partner Violence: A Qualitative Analysis Of Men's Experiences, The Impact Of Violence, And Perceptions Of Their Worth, Andreia Machado, Denise Hines, Emily M. Douglas

Department of Social Work and Child Advocacy Faculty Scholarship and Creative Works

There has been a recent increase in the amount of research on male victims of female-perpetrated partner violence (PV), but research needs to be conducted to understand how the patterns of abuse persist in these relationships. In the current study, the experiences of 59 male PV victims in the United States, recruited through online advertisements in professional networks and websites (e.g., agencies that specialize in male victims of PV), were explored through a thematic analysis. Analyses suggested that the help-seeking process of male PV victims is complex and heterogeneous and can often lead to further negative consequences due to various …

Friction-Free Permanent Magnet Bearings For Rotating Shafts: A Comprehensive Review, Siddappa I. Bekinal, Mrityunjay Doddamani

Open Access archive

This article presents a comprehensive review of modeling, analysis, and development of permanent magnet bearings (PMB) for rotating shafts. The different configurations of PMB are highlighted with relevant approaches to estimate their features. The progress in mathematical approaches adopted and optimization of the static and dynamic bearing characteristics in terms of accuracy are discussed in depth. Further, key developments on instability issues and their realization in combination with other bearings for rotors stability in low and high-speed applications are reviewed. Finally, concluding remarks on key aspects to be followed in the design and development of PMB are presented.

Explicit Evaluation Of Some Of The Theta-Function Identities, Shruthi, B. R.Srivatsa Kumar

Open Access archive

In this paper, we evaluate two parameters hk, n and h'k, n of some P-Q type Theta functions ϕ(q) for any positive real numbers k and n. During this process, we also evaluate Ramanujan's cubic continued fraction.

Intermittent Power Smoothing Control For Grid Connected Hybrid Wind/Pv System Using Battery-Edlc Storage Devices, N. S. Jayalakshmi, D. N. Gaonkar, R. P. Karthik, P. Prasanna

Open Access archive

Wind and solar radiation are intermittent with stochastic fluctuations, which can influence the stability of operation of the hybrid system in the grid integrated mode of operation. In this research work, a smoothing control method for mitigating output power variations for a grid integrated wind/PV hybrid system using a battery and electric double layer capacitor (EDLC) is investigated. The power fluctuations of the hybrid system are absorbed by a battery and EDLC during wide variations in power generated from the solar and wind system, subsequently, the power supplied to the grid is smoothened. This makes higher penetration and incorporation of …

Review On Unconventional Wind Energy, Gaurav Gulabani, Beegum Shahnaz Abdul Karim, Jayakrishnan Radhakrishnan, B. Satish Shenoy

Open Access archive

Fossil fuel is currently the major source of energy but it is a fast depleting resource. The phenomenal increase in fossil fuel consumption over recent times has adversely affected our carbon footprint, severely impacting the environment. With strict environmental regulations in place, the focus towards renewable sources of energy is gaining momentum, supported by recent advancements in technologies in wind, hydro and solar. Wind energy was the first form of clean energy and has seen a major increase in power production. However, site restrictions limit the wind turbine from being used to its maximum potential. In recent years, the concept …