Digital Commons Network^™

Indian Society For Study Of Pain, Cancer Pain Special Interest Group Guidelines On Pharmacological Management Of Cancer Pain (Part I), Raghavendra Ramanjulu, Raghu S. Thota, Arif Ahmed, Parmanand Jain

Open Access archive

The Indian Society for Study of Pain (ISSP), Cancer Pain Special Interest Group guidelines on pharmacological management of cancer pain in adults provides a structured, step-wise approach which will help to improve the management of cancer pain and to provide the patients with a minimally acceptable quality of life. The guidelines have been developed based on the available literature and evidence, to suit the needs, patient population, and situations in India. A questionnaire based on the key elements of each sub drafts addressing certain inconclusive areas where evidence was lacking, was made available on the ISSP website, and circulated by …

Effect Of Three Silver Diamine Fluoride Application Protocols On The Microtensile Bond Strength Of Resin-Modified Glass Ionomer Cement To Carious Dentin In Primary Teeth, Savil Uchil, Baranyae Suprabha, Ethel Suman, Ramya Shenoy

Open Access archive

Background: Use of silver diamine fluoride (SDF) after selective caries excavation can arrest the further progress of the carious lesion. Application of potassium iodide (KI) can reduce the staining due to SDF.Aim:The aim of the study was to evaluate the effect of the application of SDF, with and without acid etching and KI on the bond strength of resin-modified glass ionomer cement (RMGIC) to the carious dentin of primary teeth. Materials and Methods:In thisin vitro study, caries was induced on the occlusal surface by inoculating Streptococcus mutans strain in 36 extracted primary molars. The teeth were divided into four groups …

Lipidomics And Cognitive Dysfunction – A Narrative Review, Arpita Chakraborty, Samir Kumar Praharaj, R. V. Krishnananda Prabhu, M. Mukhyaprana Prabhu

Open Access archive

Background: More than half portion of the brain is formed by lipids. They play critical roles in maintaining the brain’s structural and functional components. Any dysregulation in these brain lipids can lead to cognitive dysfunction which are associated with neurological disorders such as Alzheimer’s disease, Parkinson’s disease, schizophrenia, vascular dementia etc. Studies have linked lipids with cognitive impairment. But not much has been studied about the complex brain lipids which might play a pivotal role in cognitive impairment. This review aims to highlight the lipidomic profiles in patients with cognitive dysfunction. Results: Forty-five articles were reviewed. These studies show alterations …

Evaluation Of The Relation Between Lens Opacities Classification System Iii Grading And Nuclear Size By Direct Measurement, Chidanand Kulkarni

Open Access archive

CONTEXT: Although relation between Lens Opacities Classification System III (LOCS III) and nuclear density is established, no data are available about nuclear size at different LOCS III grades. AIMS: The aim of this study is to evaluate the relation between LOCS III grading of nuclear opacity obtained preoperatively and the size of the nucleus obtained during cataract surgery. SETTINGS AND DESIGN: This was a prospective observational study carried out in a hospital attached to medical college. MATERIALS AND METHODS: Patients who underwent manual small-incision cataract surgery or extra-large temporal tunnel cataract extraction and gave consent were included in this study. …

Modified Pectins For Colon-Specific Drug Delivery, Aneesh Muvva, Indhu Annie Chacko, Vivek Ghate, Shaila Angela Lewis

Open Access archive

Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained importance as a carrier for colon-specific delivery attributed to swelling nature as well as the ability to resist gastric degradation. This review describes the chemistry of pectin, …

Integrating Concerns Of Gender, Sexuality And Marital Status In The Medical Curriculum, Nikhil Govind, Ketaki Chowkhani

Open Access archive

The introduction of AETCOM (attitude, ethics and communication) (1) is seen as an effort at incorporating Medical Humanities (MH) within the medical curriculum. For the first time, India's medical curriculum includes modules on the patient-doctor relationship, helping doctors to address ethical dilemmas that might arise during medical practice. Despite this progressive step, AETCOM has a number of drawbacks. Gayathri Prabhu (2) has analysed AETCOM as ossified, instrumental, lacking in a critical sensibility and failing to borrow from a humanities methodology. We would like to add to her excellent critique by examining other areas which have been overlooked within AETCOM. Our …

Renal Salvage, An Achievable Goal In Patients With Emphysematous Pyelonephritis: Outcomes Of An Algorithmic Renal Preserving Strategy, Rajeshkumar Reddy Adapala, Ranjit Shetty, P. Venugopal, G. G.L. Prabhu

Open Access archive

Introduction: Emergency nephrectomy has been the time-honored treatment of choice for emphysematous pyelonephritis (EPN), a fatal gas-forming necrotizing infection. Recent years have seen a shift toward nonextirpative approach aimed to achieve higher rates of renal salvage, limiting the indications for nephrectomy to severe grades of the disease. This study aimed at analyzing the role of initial renal preserving measures algorithmically applied across grades of EPN. Materials and Methods: We prospectively analyzed the clinical data and outcome of 36 consecutive patients of EPN in 5 years' study period, treated by renal preserving measures, which include aggressive resuscitation, parenteral antibiotics, effective drainage …

Deciphering The Role Of Uba-Like Domains In Intraflagellar Distribution And Functions Of Myosin Xxi In Leishmania, Rani Bajaj, Bindu Ambaru, Chhitar M. Gupta

Open Access archive

Myosin XXI (Myo21) is a novel class of myosin present in all kinetoplastid parasites, such as Trypanosoma and Leishmania. This protein in Leishmania promastigotes is predominantly localized to the proximal region of the flagellum, and is involved in the flagellum assembly, cell motility and intracellular vesicle transport. As Myo21 contains two ubiquitin associated (UBA)-like domains (UBLD) in its amino acid sequence, we considered it of interest to analyze the role of these domains in the intracellular distribution and functions of this protein in Leishmania cells. In this context, we created green fluorescent protein (GFP)-conjugates of Myo21 constructs lacking one of …

Frequency And Clinical Significance Of Red Cell Antibodies In Pregnancy - A Prospective Study From India, Soumya Das, Shamee Shastry, Lavanya Rai, Poornima Baliga

Open Access archive

Background: For appropriate management of hemolytic disease of the fetus and newborn (HDFN), it is important to detect irregular red cell antibody in the antenatal period. Though it is a simple one-step method, it is not part of routine antenatal screening in many developing countries. To reiterate the importance of antenatal antibody screening, we have assessed the frequency and clinical significance of irregular red cell antibodies in our patient population. Materials and Methods: A prospective study was carried out from October 2013 to May 2015 at a tertiary care center from south India. All antenatal samples received by the laboratory …

Covid 2019 Outbreak: The Disappointment In Indian Teachers, Ritesh Bhat, Varun Kumar Singh, Nithesh Naik, C. Raghavendra Kamath

Open Access archive

No abstract provided.

Second And Third Harmonic Nonlinear Optical Process In Spray Pyrolysed Mg:Zno Thin Films, Krithika Upadhya, U. G. Deekshitha, Albin Antony, Aninamol Ani

Open Access archive

In the present study, Mg-doped ZnO (MZO) nanofilms (NF) were grown by spray pyrolysis technique. X-ray diffraction (XRD) patterns have shown an intense peak oriented along (002) crystalline plane confirming crystalline origin of grown MZO films. Atomic force microscopy (AFM) data revealed that the average roughness decreased significantly upon Mg doping from 20.3 nm to 4.72 nm. Ambient temperature photoluminescence spectra accounted for four emission bands in the visible spectral region due to the presence of various intrinsic defect centres in the films. The non-linear absorption coefficient (βeff) were estimated by open aperture Z-scan technique and found to be in …

Surface Engineered Nanoliposomal Platform For Selective Lymphatic Uptake Of Asenapine Maleate: In Vitro And In Vivo Studies, Renuka S. Managuli, Julie Tzu Wen Wang, Farid Muhammad Faruqu, Abhjieet Pandey

Open Access archive

Asenapine maleate (ASPM) is an antipsychotic drug prescribed for the treatment of schizophrenia and bipolar disorder. ASPM possesses low oral bioavailability due to extensive hepatic metabolism. Therefore, RGD peptide conjugated liposomes loaded with ASPM were prepared to target Peyer's patches in the intestine which in-turn get access into intestinal lymphatic system thereby increasing the oral bioavailability of the drug. Liposomes were evaluated for size, zeta potential, differential scanning calorimetry (DSC), FTIR spectroscopy, X-ray diffraction (XRD), shape and morphology, in vitro drug release, cell line studies, everted intestinal uptake, pharmacodynamics, pharmacokinetics, tissue distribution, targetability and stability studies. In vitro drug release …

Automated Decision Support System For Detection Of Leukemia From Peripheral Blood Smear Images, Roopa B. Hegde, Keerthana Prasad, Harishchandra Hebbar, Brij Mohan Kumar Singh

Open Access archive

Peripheral blood smear analysis plays a vital role in diagnosing many diseases including cancer. Leukemia is a type of cancer which begins in bone marrow and results in increased number of white blood cells in peripheral blood. Unusual variations in appearance of white blood cells indicate leukemia. In this paper, an automated method for detection of leukemia using image processing approach is proposed. In the present study, 1159 images of different brightness levels and color shades were acquired from Leishman stained peripheral blood smears. SVM classifier was used for classification of white blood cells into normal and abnormal, and also …

Diffuse Large B-Cell Lymphoma In Blood And Bone Marrow: A Rare Presentation Of Leukemic Phase At Diagnosis, Pooja K. Suresh, Sridevi Hanaganahalli Basavaiah, Mrigank Goel, Sanyo Dsouza

Open Access archive

No abstract provided.

Final Project Report, Nikhil Menon

CTEDD Final Project Reports - Archive

No abstract provided.

English Proficiency At A Glance: A Literature Review And Qualitative Interview Analysis For First-Time Tesol For First-Time Tesol Volunteers, Molly Bebko

Honors Projects

The purpose of this literature review and these consultations is to present the demands and needs of ESL volunteers in order that they may be effective teachers. These demands of ESL volunteers will be categorized according to the eight domains of the 2008 TESOL International Association Standards for ESL/EFL Teachers of Adults Framework. The literature review comprised of a thematic search of past and current research. The consultation process was semi-structured, phenomenological, and qualitative. The primary investigator interviewed five professionals in the ESL field. After both the literature review and consultation process, themes were identified and results were categorized into …

Indian Society For Study Of Pain, Cancer Pain Special Interest Group Guidelines On Pharmacological Management Of Cancer Pain (Part Ii), Raghu S. Thota, Raghavendra Ramanjulu, Arif Ahmed, Parmanand Jain

Open Access archive

The Indian Society for Study of Pain (ISSP), Cancer Pain Special Interest Group (SIG) guidelines on pharmacological management of cancer pain in adults provide a structured, stepwise approach, which will help to improve the management of cancer pain and to provide the patients with a minimally acceptable quality of life. The guidelines have been developed based on the available literature and evidence, to suit the needs, patient population, and situations in India. A questionnaire, based on the key elements of each sub draft addressing certain inconclusive areas where evidence was lacking, was made available on the ISSP website and circulated …

'The Miracle Mothers And Marvelous Babies': Psychosocial Aspects Of Surrogacy - A Narrative Review, Ansha Patel, Pratap Kumar, P. S.V.N. Sharma

Open Access archive

Surrogates are described in literature as true angels 'who make dreams happen.' On the other hand, surrogacy has also been surrounded by several psychosocial controversies. In this review, we have made an attempt to encapsulate this topic from the multiple perspectives of individuals who are involved in the surrogacy cycle. We present to the readers the various outlooks and dilemmas of the clinicians, patient parties contracting for surrogacy, the child born out of surrogacy, and the intricate role of the mental health professionals in surrogacy arrangements. The review also throws light upon the psychosocial issues in connection to the evolving …

Is Cytology Of Purulent Aspirates Imperative?: An Instance Of A Periappendicular Abscess, P. V. Santosh Rai, Saraswathy Sreeram, Ayush M. Goel, Akshatha Bhat

Open Access archive

No abstract provided.

Correction To: Algebraic Construction Of Near-Bent And Apn Functions (Advances In Applied Clifford Algebras, (2019), 29, 5, (93), 10.1007/S00006-019-1012-X), Prasanna Poojary, Harikrishnan Panackal, Vadiraja G.R. Bhatta

Open Access archive

Remark 4.1 and Remark 4.5 in Section 4 will be true only if a is a power of two. Hence, the proofs of Theorem 4.2 and Theorem 4.6 hold in the case of a being a power of 2.

Ohpl Implementation - Two Stage Learning Strategy, Bob Vanderheyden, Ying Xie

OHPL Software

No abstract provided.

Ohpl Application: Ordinal Sentiment Analysis On Amazon Review - Lstm + Ohplall, Ying Xie

OHPL Software

No abstract provided.

In-Class Activities For Openstax Astronomy, Rosa Williams, Kimberly Shaw

Physics and Astronomy Ancillary Materials

This set of in-class activities in Microsoft Word format are intended to supplement OpenStax Astronomy. Topics include:

• Atmospheric Gas
• Celestial Sphere
• Dwarf Planets
• Earth Size
• Earth Impact
• Greenhouse Gases and Climate Change
• Jovian Planet
• Jovian Moon and Ring
• Mars Atmosphere and Climate
• Solar System Formation and Scale
• Sunspots
• Terrestrial Planet and Lunar Features
• Venus Atmosphere and Climate

Closing Yield Gaps In Oil Palm Production Systems In Ghana Through Best Management Practices, Tiemen Rhebergen, Shamie Zingore, Ken E. Giller, Charles Adu Frimpong, Kwame Acheampong, Francis Tetteh Ohipeni, Edward Kofi Panyin, Victor Zutah, Thomas Fairhurst

All Peer-Reviewed Publications

The area under oil palm in Ghana has expanded but average fruit bunch yields remained low, resulting in large yield gaps. This study assessed the potential for increasing yield with 'Best Management Practices (BMP)' on plantations and smallholder farms in southern Ghana, compared with current standard practices, i.e. reference (REF) yield. We evaluated short-term (≤1 year) yield increases with 'yield taking' (improved crop recovery), and long-term increases (>1 year) with 'yield making' (better agronomy) practices and identified the factors that contributed most to yield improvements. Average fruit bunch yield increases with BMP were 2.1 t ha−1 (+19%) and 4.7 …

Modelling The Effect Of Temperature On The Biology And Demographic Parameters Of The African Coffee White Stem Borer, Monochamus Leuconotus (Pascoe) (Coleoptera: Cerambycidae), Abdelmutalab G.A. Azrag, Abdullahi A. Yusuf, Christian W.W. Pirk, Saliou Niassy, Ephantus K. Guandaru, Guillaume David, Régis Babin

All Peer-Reviewed Publications

The African coffee white stem borer Monochamus leuconotus (Pascoe) (Coleoptera: Cerambycidae) is a destructive insect pest of Arabica coffee trees in African highlands. Our study aims to provide information on the pest biology as influenced by temperature, determine thermal thresholds, and provide life table parameters for M. leuconotus reared in the laboratory. The life cycle of M. leuconotus was studied at seven constant temperatures in the range 15–35 °C, with 80 ± 5% RH and a photoperiod of L:D 12:12. Linear and nonlinear models were fitted to laboratory data to describe the impact of temperature on M. leuconotus development, mortality, …

Performance Of Elite Maize Genotypes Under Selected Sustainable Intensification Options In Kenya, Leonard Rusinamhodzi, Dan Makumbi, James M. Njeru, Fred Kanampiu

All Peer-Reviewed Publications

Combining different cropping and tillage systems with different genotypes across several cropping seasons can reveal opportunities for sustainable intensification (SI). The objective of this study was to assess the performance of six maize genotypes under intercropping with conservation tillage (no-till) – two promising options for SI. The experiment was carried out over three years (or six cropping seasons) at Kiboko Research Station, Kenya with sole cropping and mouldboard ploughing as baseline production systems. Results showed that maize genotypes and cropping systems had a significant effect on yield, but the effect of tillage was not significant. Moreover, there was no significant …

Science-Based Decision Support For Formulating Crop Fertilizer Recommendations In Sub-Saharan Africa, Jairos Rurinda, Shamie Zingore, Jibrin M. Jibrin, Tesfaye Balemi, Kenneth Masuki, Jens A. Andersson, Mirasol F. Pampolino, Ibrahim Mohammed, James Mutegi, Alpha Y. Kamara, Bernard Vanlauwe, Peter Q. Craufurd

All Peer-Reviewed Publications

In sub-Saharan Africa, there is considerable spatial and temporal variability in relations between nutrient application and crop yield, due to varying inherent soil nutrients supply, soil moisture, crop management and germplasm. This variability affects fertilizer use efficiency and crop productivity. Therefore, development of decision systems that support formulation and delivery of site-specific fertilizer recommendations is important for increased crop yield and environmental protection. Nutrient Expert (NE) is a computer-based decision support system, which enables extension advisers to generate field- or area-specific fertilizer recommendations based on yield response to fertilizer and nutrient use efficiency. We calibrated NE for major maize agroecological …

Temperature-Dependent Development And Survival Of Immature Stages Of The Coffee Berry Borer Hypothenemus Hampei (Coleoptera: Curculionidae), A. G.A. Azrag, A. A. Yusuf, C. W.W. Pirk, S. Niassy, K. K. Mbugua, R. Babin

All Peer-Reviewed Publications

Although the coffee berry borer, Hypothenemus hampei (Ferrari) (Coleoptera: Curculionidae: Scolytinae) is the most destructive insect pest of coffee worldwide, there is much to learn about its thermal biology. This study aimed to develop temperature-based models for H. hampei development and to provide the thermal requirements of immature stages in the laboratory. Using a new observation method, larval development and survival were monitored daily on fresh Arabica coffee seeds, under seven constant temperatures in the range 15-35°C, with 80 ± 5% RH and 12:12 L:D photoperiod. Linear and non-linear functions were fitted to the development data plotted against temperature, using …

Primates On The Farm – Spatial Patterns Of Human–Wildlife Conflict In Forest-Agricultural Landscape Mosaic In Taita Hills, Kenya, Mika Siljander, Toini Kuronen, Tino Johansson, Martha Nzisa Munyao, Petri K.E. Pellikka

All Peer-Reviewed Publications

Human–wildlife conflict (HWC) is a growing concern for local communities living in the vicinity of protected areas. These conflicts commonly take place as attack by wild animals and crop-raiding events, among other forms. We studied crop-raiding patterns by non-human primates in forest–agricultural landscape mosaic in the Taita Hills, southeast Kenya. The study applies both qualitative and quantitative methods. Semi-structured questionnaire was used in the primary data collection from the households, and statistical tests were performed. We used applied geospatial methods to reveal spatial patterns of crop-raiding by primates and preventive actions by farmers. The results indicate most of the farms …

The Woman's Role In Human Reproduction And Generation According To Ancient Greek And Roman Philosophers, Olivia Miller

Honors Program: Senior Projects (Public)

From the Greek archaic period to the end of the Roman Empire, theories of reproduction and inheritance developed as new philosophers and medical practitioners tackled fundamental issues of generation and sex. Without tools to help them see the complex chemical and cellular processes of the body, ancient thinkers relied on their own observations and commonly-held beliefs about sex and gender to understand the human body. Until the Roman Empire, dissections and similar forms of clinical study were strictly taboo, with the result that the Greek philosophers could not conduct close investigations into human anatomy. Instead, they relied on their own …