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’Turn It Into An “A,”’ Or ‘Turnitin To An “F”’: A Small Sample Study Of Plagiarism Analysis As A Tool For Both Formative And Summative Assessment, Scot Boeringer Nov 2020

’Turn It Into An “A,”’ Or ‘Turnitin To An “F”’: A Small Sample Study Of Plagiarism Analysis As A Tool For Both Formative And Summative Assessment, Scot Boeringer

Southeast ICAI Sharing Conference

This presentation will discuss the debate about using an algorithm to identify academic dishonesty and present an argument for a mixed formative feedback/summative evaluation role, which is completely student-initiated and does not require significant knowledge of the Turnitin platform, nor requires a greatly increased percentage of effort by the instructor.


2020-11-06_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Nov 2020

2020-11-06_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


Replication Data For: Comparing Teamwork & Collaboration Competencies Between A Technology In Art Education Course And An Engineering Project Management Course, Martin Wallace, Ryan Hulla Nov 2020

Replication Data For: Comparing Teamwork & Collaboration Competencies Between A Technology In Art Education Course And An Engineering Project Management Course, Martin Wallace, Ryan Hulla

UTA Libraries Datasets - Archive

This data was collected over two academic years, 2018/19 and 2019/20 from students enrolled in two courses at UTA: ART 4365 Technology in Art Education and IE 4340 Engineering Project Management. The data collection instruments were pre- and post-self assessment surveys, distributed at the beginning and end of the semester. The data includes student-self reported competencies for Maker Competencies 9 and 10, "Assembles Effective Teams" and "Collaborates Effectively" on a range of 1 (low) to 5 (high).


Genetic Variation At The Species And Population Levels In The Rocky Mountain Ridged Mussel (Gonidea Angulata) – Supplementary Material, James A. Walton, Karen E. Mock, Steven F. R. Brownlee, Jon H. Mageroy, Greg Wilson, Ian R. Walker Nov 2020

Genetic Variation At The Species And Population Levels In The Rocky Mountain Ridged Mussel (Gonidea Angulata) – Supplementary Material, James A. Walton, Karen E. Mock, Steven F. R. Brownlee, Jon H. Mageroy, Greg Wilson, Ian R. Walker

Browse all Datasets

Freshwater mussels in western North America are threatened by water diversions, climate change, loss of required host fish, and other factors, and have experienced marked decline in the past several decades. All four of the primary lineages (potentially species) of freshwater mussels in the western U.S. and Canada are widespread and have somewhat generalist host fish requirements. Of these lineages, perhaps the most poorly understood and of greatest conservation concern is Gonidea angulata (Rocky Mountain ridged mussel). Gonidea is a monotypic genus occurring only in the western continental U.S. and southern Canada. Here we describe the patterns of genetic variation …


2020-11-05_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Nov 2020

2020-11-05_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


Multi-Omics Analysis To Characterize Cigarette Smoke Induced Molecular Alterations In Esophageal Cells, Aafaque Ahmad Khan, Krishna Patel, Shankargouda Patil, Niraj Babu Nov 2020

Multi-Omics Analysis To Characterize Cigarette Smoke Induced Molecular Alterations In Esophageal Cells, Aafaque Ahmad Khan, Krishna Patel, Shankargouda Patil, Niraj Babu

Open Access archive

Though smoking remains one of the established risk factors of esophageal squamous cell carcinoma, there is limited data on molecular alterations associated with cigarette smoke exposure in esophageal cells. To investigate molecular alterations associated with chronic exposure to cigarette smoke, non-neoplastic human esophageal epithelial cells were treated with cigarette smoke condensate (CSC) for up to 8 months. Chronic treatment with CSC increased cell proliferation and invasive ability of non-neoplastic esophageal cells. Whole exome sequence analysis of CSC treated cells revealed several mutations and copy number variations. This included loss of high mobility group nucleosomal binding domain 2 (HMGN2) and a …


Changes In Tinnitus Experiences During The Covid-19 Pandemic, Eldré W. Beukes, David M. Baguley, Laure Jacquemin, Matheus P.C.G. Lourenco Nov 2020

Changes In Tinnitus Experiences During The Covid-19 Pandemic, Eldré W. Beukes, David M. Baguley, Laure Jacquemin, Matheus P.C.G. Lourenco

Open Access archive

Introduction: The COVID-19 pandemic has disrupted delivery of healthcare, economic activity, and affected social interactions. Identifying and supporting those most affected by the pandemic is required. The purpose of this study was to determine the impact of the pandemic on individuals with tinnitus and to identify mediating factors. Methods: This is a mixed-methods exploratory cross-sectional study, using data collected via an online survey from 3,103 individuals with tinnitus from 48 countries. The greatest representation was from North America (49%) and Europe (47%) and other countries were only marginally represented. Results: Although the study was aimed at those with pre-existing tinnitus, …


Documents From The November 05, 2020 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students Nov 2020

Documents From The November 05, 2020 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Documents from the November 05, 2020 meeting of the Associated Students of the University of Montana (ASUM). The following resolutions were discussed during the meeting:

SB 38_20/21- Resolution Revising ASUM Bylaws Article VI, Section 3.F.6; Allowing Candidates to Hand Out Campaign Flyers

SB 42_20/21- Resolution Amending the Threshold for Primary Elections in Article VI, Section 4 of the ASUM Bylaws

SB 43_20/21- Resolution Endorsing the Inclusion of Major Repairs Funding for “Music Building Infrastructure” in HB05

SB 44_20/21- Resolution Proposing a Constitutional Referenda to Strike the Petition Signature Requirement


Implementing Dysphagia Screenings In Stroke Patients, Meredith Buller Nov 2020

Implementing Dysphagia Screenings In Stroke Patients, Meredith Buller

Scholars Week

Dysphagia screenings are important to be done for all stroke patients in order to prevent aspiration, pneumonia, and other complications. All patients should be screened regardless of severity of stroke. Many policies outline that all patients should be screened, but many floors are not implementing the policy on all patients. This article reviews research associated with dysphagia screenings and how to properly perform one. Dysphagia screenings should be performed on all stroke patients at the hospital to achieve the best outcomes post-stroke.

Keywords: Stroke, aspiration, screening, dysphagia


2020-11-04_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Nov 2020

2020-11-04_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


Motors Liquidation Company Dockets (All Documents In The General Motors Bankruptcy Case), United States: Courts: Bankruptcy Court: Southern District Of New York, General Motors Company Nov 2020

Motors Liquidation Company Dockets (All Documents In The General Motors Bankruptcy Case), United States: Courts: Bankruptcy Court: Southern District Of New York, General Motors Company

Documents

Excel sheet containing links and descriptions for every document filed in the GM bankruptcy case.


2020-11-03_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Nov 2020

2020-11-03_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


2020-11-03_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Nov 2020

2020-11-03_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …


Csci 49380/79526: Fundamentals Of Reactive Programming - Assignment 5, Raffi Khatchadourian Nov 2020

Csci 49380/79526: Fundamentals Of Reactive Programming - Assignment 5, Raffi Khatchadourian

Open Educational Resources

No abstract provided.


2020-11-02_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Nov 2020

2020-11-02_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


2020-11-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Nov 2020

2020-11-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …


2020-11-02_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services Nov 2020

2020-11-02_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.


Behavioral Changes During Covid-19 Confinement In France: A Web-Based Study, Hélène Rossinot, Romain Fantin, Julien Venne Nov 2020

Behavioral Changes During Covid-19 Confinement In France: A Web-Based Study, Hélène Rossinot, Romain Fantin, Julien Venne

Open Access archive

Background: A global pandemic due to COVID-19 emerged in November 2019 and hit France in early March 2020. It not only resulted in a loss of lives, but also in very strict confinement measures. The objective of this study was to understand what the determinants of the changes in participants’ behavior and mental state were during the confinement. Methods: An online survey was launched on 23 April 2020 and closed on 7 May 2020. The final sample included 1454 participants from 24 to 65 years old. Descriptive and multivariate analyses were then performed. Results: In total, 28.7% reported having a …


Surface Engineering Of Titanium Using Anodization And Plasma Treatment, Manjaiah Mallaiah, Ravi Kumar Gupta Nov 2020

Surface Engineering Of Titanium Using Anodization And Plasma Treatment, Manjaiah Mallaiah, Ravi Kumar Gupta

Open Access archive

Ti64 alloy is a well-known material for biomedical applications due to high corrosion resistance and biocompatibility properties. Surface properties of implants plays a vital role in bone and cell growth in the human body. With the anodization process, we can increase the surface porosity, which will be adequate for surface fascination of the implant screw to the bone and appropriate mechanical properties. Hence, the present study attempted to improve the surface properties of Ti64 by anodization and plasma treatment that may be promising method to increase the biocompatibility of Ti materials. Anodization process is the cheapest one to improve the …


Targeting Glutathione With The Triterpenoid Cddo-Im Protects Against Benzo-A-Pyrene-1,6-Quinone-Induced Cytotoxicity In Endothelial Cells, Halley Shukla, Ho Young Lee, Ashkon Koucheki, Humaira A. Bibi, Gabriella Gaje, Xiaolun Sun, Hong Zhu, Y R. Li, Zhenquan Jia Nov 2020

Targeting Glutathione With The Triterpenoid Cddo-Im Protects Against Benzo-A-Pyrene-1,6-Quinone-Induced Cytotoxicity In Endothelial Cells, Halley Shukla, Ho Young Lee, Ashkon Koucheki, Humaira A. Bibi, Gabriella Gaje, Xiaolun Sun, Hong Zhu, Y R. Li, Zhenquan Jia

Osteopathic Medicine, Jerry M. Wallace School of

Epidemiological studies have exhibited a strong correlation between exposure to air pollution and deaths due to vascular diseases such as atherosclerosis. Benzo-a-pyrene-1,6-quinone (BP-1,6-Q) is one of the components of air pollution This study was to examine the role of GSH in BP-1,6-Q mediated cytotoxicity in human EA.hy96 endothelial cells and demonstrated that induction of cellular glutathione by a potent triterpenoid, CDDO-Im (1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole), protects cells against BP-1,6-Q induced protein and lipid damage. Incubation of EA.hy926 endothelial cells with BP-1,6-Q caused a significant increase in dose-dependent cytotoxicity as measured by LDH release assay and both apoptotic and necrotic cell deaths as measured …


Species-Specific Holistic Assessment Of Tree Structure And Defects In Urban Hong Kong, N. L. Chau, C. Y. Jim, H. Zhang Nov 2020

Species-Specific Holistic Assessment Of Tree Structure And Defects In Urban Hong Kong, N. L. Chau, C. Y. Jim, H. Zhang

Faculty of Design & Environment (THEi)

© 2020 Elsevier GmbH Sustainable urban forests require healthy trees with stable structures to improve provision of ecosystem services including air purification and climate mitigation to urban areas. Trees in compact residential areas are particularly prone to development of defects and unstable tree structures. We assessed in detail tree species, key structural and physiological defects, tree dimensions, growing habitats and planting site conditions of 38,156 trees in 102 sampled public housing estates (PHEs) in Hong Kong. The open spaces in PHEs allowed trees to grow in representative urban habitats. PHE attributes including estate age, number of trees, species richness and …


2020-11-01_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Nov 2020

2020-11-01_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …


Personal Protective Equipment Availability And Usage Amongst Pediatric Otorhinolaryngologists During The Covid-19 Pandemic: An International Survey, Dong Hyun Kim, Neil K. Chadha, Lily Hp Nguyen, Murad Husein Nov 2020

Personal Protective Equipment Availability And Usage Amongst Pediatric Otorhinolaryngologists During The Covid-19 Pandemic: An International Survey, Dong Hyun Kim, Neil K. Chadha, Lily Hp Nguyen, Murad Husein

Paediatrics Publications

Objectives: To survey a group of global pediatric otolaryngology specialists to assess their usage and access to personal protective equipment during the COVID-19 pandemic. Methods: A survey of 13 questions was created collecting information on: basic demographics of practice, types of PPE used for procedures of varying aerosolization risk, access to positive air-purifying respirator (PAPR) and patient testing for SARS-CoV-2. Pediatric otolaryngologists were invited to complete the survey via Whatsapp™. Results: 96 responses were collected from 17 different countries. N95 was the most commonly utilized PPE when dealing with COVID-19 patients (64.2%–81.9% depending on aerosolization risk of the procedure). Significantly …


The Marine Compound And Elongation Factor 1a1 Inhibitor, Didemnin B, Provides Benefit In Western Diet-Induced Non-Alcoholic Fatty Liver Disease, Rachel B. Wilson, Yun Jin Chen, Brian G. Sutherland, Cynthia G. Sawyez, Richard Zhang, Taylor Woolnough, Alexandra M. Hetherington, Kia M. Peters, Krisha Patel, John P. Kennelly, Kelly Ann Leonard, Meg Schuurman, René L. Jacobs, Rennian Wang, Nica M. Borradaile Nov 2020

The Marine Compound And Elongation Factor 1a1 Inhibitor, Didemnin B, Provides Benefit In Western Diet-Induced Non-Alcoholic Fatty Liver Disease, Rachel B. Wilson, Yun Jin Chen, Brian G. Sutherland, Cynthia G. Sawyez, Richard Zhang, Taylor Woolnough, Alexandra M. Hetherington, Kia M. Peters, Krisha Patel, John P. Kennelly, Kelly Ann Leonard, Meg Schuurman, René L. Jacobs, Rennian Wang, Nica M. Borradaile

Paediatrics Publications

Inhibition of eukaryotic elongation factor 1A1 (EEF1A1) with the marine compound didemnin B decreases lipotoxic HepG2 cell death in vitro and improves early stage non-alcoholic fatty liver disease (NAFLD) in young genetically obese mice. However, the effects of didemnin B on NAFLD in a model of long-term diet-induced obesity are not known. We investigated the effects of didemnin B on NAFLD severity and metabolic parameters in western diet-induced obese mice, and on the cell types that contribute to liver inflammation and fibrosis in vitro. Male 129S6 mice were fed either standard chow or western diet for 26 weeks, followed by …


Academic Procrastination And Self-Efficacy Among A Group Of Dental Undergraduate Students In Malaysia, Eswara Uma, Chia Lee, Siti Shapiai, Anis Binti Mat Nor Nov 2020

Academic Procrastination And Self-Efficacy Among A Group Of Dental Undergraduate Students In Malaysia, Eswara Uma, Chia Lee, Siti Shapiai, Anis Binti Mat Nor

Open Access archive

BACKGROUND: Undergraduate dental students have to do multiple tasks as part of their extensive curriculum in order to achieve the proficiencies expected of them. During the course of their study, a tendency to procrastinate and question their self-efficacy is detrimental for the students. The aim of this study was to evaluate the level of procrastination and self-efficacy and its related factors among dental undergraduate students. SUBJECTS AND METHODS: This cross-sectional study was conducted among all (n = 361) consented dental undergraduate students of our dental school. A twenty-item Lay's Procrastination Scale for student population and a ten-item General Self-Efficacy Scale …


Detection Of Tor Traffic Using Deep Learning, Debmalya Sarkar, P. Vinod, Suleiman Y. Yerima Nov 2020

Detection Of Tor Traffic Using Deep Learning, Debmalya Sarkar, P. Vinod, Suleiman Y. Yerima

Open Access archive

Tor, originally known as The Onion Router, is a free software that allows users to communicate anonymously on the Internet. This makes Tor attractive to cyber criminals, and the anonymity provided can be misused by hackers to enable remote control of victim systems. Indeed, a large volume of Tor traffic is used for malicious purposes such as fast port scans, hacking attempts, ex-filtration of stolen credentials, etc. This makes Tor traffic detection an important component of intrusion detection and prevention systems. Hence, in this paper we present a deep neural network (DNN) based system for the detection and classification of …


'Motor Band Sign' In Susceptibility-Weighted Imaging In Motor Neuron Disease, Arvind N. Prabhu, Lakshmi Manasa Sajja Nov 2020

'Motor Band Sign' In Susceptibility-Weighted Imaging In Motor Neuron Disease, Arvind N. Prabhu, Lakshmi Manasa Sajja

Open Access archive

No abstract provided.


Mental Health Research On Scheduled Tribes In India, S. Devarapalli, Sudha Kallakuri, Abdul Salam, Pallab Maulik Nov 2020

Mental Health Research On Scheduled Tribes In India, S. Devarapalli, Sudha Kallakuri, Abdul Salam, Pallab Maulik

Open Access archive

Background: The burden of mental illness among the scheduled tribe (ST) population in India is not known clearly. Aim: The aim was to identify and appraise mental health research studies on ST population in India and collate such data to inform future research. Materials and Methods: Studies published between January 1980 and December 2018 on STs by following exclusion and inclusion criteria were selected for analysis. PubMed, PsychINFO, Embase, Sociofile, Cinhal, and Google Scholar were systematically searched to identify relevant studies. Quality of the included studies was assessed using an appraisal tool to assess the quality of cross-sectional studies and …


A Case Report Of Androgen Receptor Inhibitor Therapy In Recurrent High-Grade Serous Ovarian Cancer, Sewanti Limaye, Prashant Kumar, Ramya Pragya, Janani Sambath Nov 2020

A Case Report Of Androgen Receptor Inhibitor Therapy In Recurrent High-Grade Serous Ovarian Cancer, Sewanti Limaye, Prashant Kumar, Ramya Pragya, Janani Sambath

Open Access archive

Ovarian cancer is common gynaecological malignancy and a leading cause of death among women. Despite the advances in treatment strategies, majority of patients present with recurrence after first- or second-line treatment. Targeted therapy that has proven to be effective in other advanced or metastatic solid tumors have also demonstrated its efficacy in ovarian cancer. Recent studies have shown that the androgen receptor (AR) signalling is involved in pathogenicity and progression of cancer. Current observations suggest AR could be a potential target in managing the disease. In this case report we present a patient with high grade serous ovarian cancer (HGSOC) …


In Silico Drug Repurposing Of Penicillins To Target Main Protease Mpro Of Sars-Cov-2, Krishnaprasad Baby, Swastika Maity, Chetan Mehta, Akhil Suresh Nov 2020

In Silico Drug Repurposing Of Penicillins To Target Main Protease Mpro Of Sars-Cov-2, Krishnaprasad Baby, Swastika Maity, Chetan Mehta, Akhil Suresh

Open Access archive

Background: SARS coronavirus-2 (SARS-CoV-2) infection causes Novel Coronavirus Disease (COVID-19). It is a respiratory tract infection and currently becoming pandemic worldwide affecting more than 50 lakh people. As of now, there is no treatment or vaccine developed for disease management. The main protease, Mpro in SARS-CoV-2 is a druggable target explored by many scientists. We targeted this with the well-known approach of drug repurposing by using computational tools. Methods: Schrödinger software was used for the study. Ligands were prepared from US-FDA drug-bank by importing it to Maestro graphical user interphase, optimised using LigPrep, and molecular geometry minimized using OPLS3e force-field. …