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Developing A Scheduling Method For Animal-Assisted Therapy In Acute Rehabilitation, Abbegayle Sutterfield Apr 2025

Developing A Scheduling Method For Animal-Assisted Therapy In Acute Rehabilitation, Abbegayle Sutterfield

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Animal-Assisted Therapy (AAT) provides meaningful benefits in rehabilitation, including reduced anxiety and improved motivation and physical outcomes (Burres et al, 2016, Denzer-Weiler & Hreha, 2018). However, barriers such as inconsistent scheduling and limited clinician experience hinder implementation in fast-paced healthcare settings. This project took place at a large inpatient acute care hospital where therapy staff sought to integrate AAT more effectively into rehabilitation sessions.

The purpose of this quality improvement project was to develop a sustainable scheduling method to facilitate coordination between therapy staff and volunteer animal-handler teams. Goals included improving interdisciplinary communication, enhancing patient engagement through AAT, and creating …


What About Participation? Using Key Form Mapping To Emphasize Community Participation In Stroke Survivors, Sarah E. Humphrey Apr 2025

What About Participation? Using Key Form Mapping To Emphasize Community Participation In Stroke Survivors, Sarah E. Humphrey

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

The purpose of this MUSC Occupational Therapy (OT) Doctoral Capstone project was to determine if stroke survivors demonstrate participation gains resulting from Rasch-derived, patient-spectice practice, i.e., “keyform mapping,” program by evaluation participation at 3 levels. Approximately 50% of stroke survivors have participation restrictions that may impact their engagement with fulfilling, meaningful activities. This is a secondary analysis of data collected from a stroke rehabilitation RCT parent study which tested the effect of a tailored. task-practice program using Rasch-derived keyform map of the individual’s FMA-UE item responses. Participation levels were evaluate by the Activity Card Sort Low-Demand Leisure and Social Acitivites …


Ionospheric Evidence Of Lobe Reconnection For Northward Imf, Dora Csonge, Gerard Fasel, John Mann, Audrey Daucher, Owen Bradley, Aidan Hulbert, Thomas Lewer, Sun-Hee Lee, F. Sigernes, D. Lorentzen Apr 2025

Ionospheric Evidence Of Lobe Reconnection For Northward Imf, Dora Csonge, Gerard Fasel, John Mann, Audrey Daucher, Owen Bradley, Aidan Hulbert, Thomas Lewer, Sun-Hee Lee, F. Sigernes, D. Lorentzen

Seaver College Research And Scholarly Achievement Symposium

It is believed that magnetic reconnection is one of the main mechanisms to transfer energy and momentum from the for the solar wind into the terrestrial environment. Dungey suggested that magnetic reconnection occurs on the dayside magnetosphere when the interplanetary magnetic field (IMF) is southward. Poleward moving auroral forms (PMAFs) have been identified in past studies as Ionospheric signatures of magnetic reconnection on the dayside.

However, magnetic reconnection can also occur for other geometrical orientations of the IMF. This presentation presents possible examples, 1 December 2021, for lobe reconnection during periods when the IMF x-component is negative, coupled with a …


Dayside Auroral Oval Expansion, Magnetic Flux Erosion, And Substorms, Dora Csonge, Parker Para, Gerard Fasel, Owen Bradley, Gasia Excel, Makena Swenski, Rachel Rodriguez, Sun-Hee Lee, John Mann, F. Sigernes, D. Lorentzen Apr 2025

Dayside Auroral Oval Expansion, Magnetic Flux Erosion, And Substorms, Dora Csonge, Parker Para, Gerard Fasel, Owen Bradley, Gasia Excel, Makena Swenski, Rachel Rodriguez, Sun-Hee Lee, John Mann, F. Sigernes, D. Lorentzen

Seaver College Research And Scholarly Achievement Symposium

Magnetic flux is eroded from the dayside magnetosphere when the interplanetary magnetic field (IMF) turns southward. During this period, the dayside auroral oval shifts equatorward as magnetic flux is transported anti-sunward to the magnetotail. Poleward-Moving Auroral Forms (PMAFs) are thought to be the ionospheric footprints of the flux tubes which are formed and transported tailward. Afterwards, magnetic reconnection occurs in the magnetotail, resulting in a substorm.

This study looks at the time between the onset of dayside magnetic reconnection and the onset of a substorm. Rates of dayside auroral oval equatorward shifts after southward turnings of the IMF are presented, …


Fitspiration And The Prevalence Of Orthorexia Symptomatology In A Male Population, Avery N. Encalade, Jennifer A. Harriger, Janet P. Trammell Apr 2025

Fitspiration And The Prevalence Of Orthorexia Symptomatology In A Male Population, Avery N. Encalade, Jennifer A. Harriger, Janet P. Trammell

Seaver College Research And Scholarly Achievement Symposium

Orthorexia nervosa (ON) is a condition characterized by an unhealthy obsession with eating healthy food, often leading to psychological impairment (Oberle & Lipschuetz, 2018). Fitspiration is a social media trend that has gained popularity in recent years, showcasing idealized physiques and promoting rigid dietary practices along with intense exercise in pursuit of health. Using Thompson et al.'s (1999) Tripartite Influence Model of the Sociocultural Theory as a framework, the researchers hypothesized that increased viewership of fitspiration content would be associated with higher orthorexia symptomatology and would be moderated by the internalization of sociocultural ideals and physical appearance comparisons. Participants included …


Genome Analysis Of Aeromonas Hydrophila Strain S14-452, Zarin Tasnim Raya Apr 2025

Genome Analysis Of Aeromonas Hydrophila Strain S14-452, Zarin Tasnim Raya

Undergraduate Research Conference

The Aeromonas hydrophila are gram-negative, opportunistic bacteria that can infect many groups of organisms, mainly fish and amphibians. In channel catfish, A. hydrophila causes fatal bacterial septicemia, leading to massive economic losses for catfish farmers. Therefore, an understanding of its genome will aid in identifying its virulence factors, metabolic pathways and survival mechanisms within the host. This study details the draft genome sequence of A. hydrophila strain S14-452, isolated from channel catfish exhibiting bacterial septicemia during a disease outbreak at a catfish farm.

A. hydrophila strain S14-452 was sequenced using the Illumina iSeq 100 System. Assembly was performed with SPAdes, …


Does Awareness Of Behavioral Challenges Impact The Preparedness Of Recent Slp Graduate Students For Their Professional Practice?, Madison K. Jones, Catherine L. Cotton Dr. Apr 2025

Does Awareness Of Behavioral Challenges Impact The Preparedness Of Recent Slp Graduate Students For Their Professional Practice?, Madison K. Jones, Catherine L. Cotton Dr.

Undergraduate Research Conference

This research aims to explore how awareness of behavioral challenges, such as aggression, defiance, and hyperactivity, affects the preparedness of recent Speech-Language Pathology (SLP) graduates. With over 84% of children receiving SLP services also facing emotional or behavioral difficulties, it is crucial to examine whether new SLPs feel prepared to manage these challenges. The study seeks to assess whether increased awareness of behavioral issues correlates with greater confidence and readiness in addressing them during the first year of clinical practice. The study will involve administering a survey to first-year Speech-Language Pathologists. The survey will focus on their preparedness and their …


Does A Sexual Education Intervention Affect Students' Critique Of Hookup Culture?, Isabella Mullin, Steve Rouse, Janet Trammell Apr 2025

Does A Sexual Education Intervention Affect Students' Critique Of Hookup Culture?, Isabella Mullin, Steve Rouse, Janet Trammell

Seaver College Research And Scholarly Achievement Symposium

Hookup Culture has created a pervasive sexual script on college campuses. This dominant culture urges students to hookup frequently and routinely based on several myths, such as the belief that hookups benefit all participants equally or that they give a person an opportunity to express sexual freedom. Studies have emphasized the need for comprehensive sexual education for young adults exposed to or participating in hookup culture. However, to the best of our knowledge, no curriculum has been developed to raise awareness of the detrimental realities of hookup culture. College students at Pepperdine University were randomly assigned to a hookup culture …


Sexual Education Topics Recalled By Students From Public And Private Schools, Olivia Mastalerz, Sarah Lucente, Shane Feins, Steve Rouse Apr 2025

Sexual Education Topics Recalled By Students From Public And Private Schools, Olivia Mastalerz, Sarah Lucente, Shane Feins, Steve Rouse

Seaver College Research And Scholarly Achievement Symposium

This research aimed to determine which comprehensive sex education principles (as recommended by the Sexual Education Information Council of the United States (SEICUS)) were recalled among people who attended private and public schools. We surveyed 80 participants at a private, religiously affiliated university to see what they recalled from their sexual education in public vs. private schools. Only two topics (sexual anatomy and puberty) were recalled by more than 70% of the participants. All other SEICUS standards were recalled by fewer than 30% of the participants, with the fewest recalling sexual fantasies, sexual dysfunction, sex and the law, sex and …


Self-Efficacy As A Moderator Of The Effectiveness Of A Sleep Hygiene Intervention, Sabrina Krebs, Nataria Joseph, Janet Trammell Apr 2025

Self-Efficacy As A Moderator Of The Effectiveness Of A Sleep Hygiene Intervention, Sabrina Krebs, Nataria Joseph, Janet Trammell

Seaver College Research And Scholarly Achievement Symposium

Interventions that address sleep hygiene knowledge and behaviors have yielded inconclusive results. The aim of the current study was to assess the effectiveness of an online sleep hygiene intervention on modifying sleep hygiene behavior and sleep quality, hypothesizing that the use of a sleep hygiene intervention will be more effective at increasing sleep hygiene behaviors and sleep quality compared to the control. In addition, we hypothesized that self-efficacy may moderate this effect, with the intervention being more effective among those with high levels of self-efficacy compared to those with low levels. Participants included 66 college students (78.3% female). Participants were …


The Perception Of Iuds On Social Media, Carlee Griste, Allee Weathers Apr 2025

The Perception Of Iuds On Social Media, Carlee Griste, Allee Weathers

Undergraduate Research Conference

We analyzed YouTube videos about intrauterine devices (IUDs) to evaluate the information being shared. Using Apify, we scraped videos and randomly selected 30 videos and used a random number table to find 5 videos for review using the DISCERN scale. We also assessed interrater reliability to average DISCERN scale across raters. On average, the videos were 5 minutes and 28 seconds long, with varying view counts and low likes. Most videos were positive, despite mentioning negative side effects of IUDs, but none addressed insertion pain, which was a concern of patients in prior studies. The shortest video had the most …


Comprehensive Detection Of Endogenous Cftr Expression In Epithelial Cell Lines: Biochemical And Molecular Approaches, Ethan Wilkins Apr 2025

Comprehensive Detection Of Endogenous Cftr Expression In Epithelial Cell Lines: Biochemical And Molecular Approaches, Ethan Wilkins

Undergraduate Research Conference

Cystic fibrosis (CF), primarily affecting Caucasians of northern European descent, results from mutations in the CFTR gene. DF508, the most common of CFTR mutations, results in dysfunctional Cl- channels in epithelial cells. Detecting CFTR protein expression at endogenous levels poses challenges, prompting this study to employ biochemical and molecular methods for its detection in non-transfected epithelial cell lines. Human pancreatic epithelial cell lines expressing endogenous wild-type CFTR (Capan-1) and DF508-CFTR (CFPAC) were treated with 5mM sodium butyrate for 60h to upregulate the CFTR expression. Additionally, a human lung epithelial cell line stably transfected with wild-type CFTR gene (CFBE-wt) was employed …


Natal And Neonatal Teeth In Mississippi Newborn, Keona Sanders, Anna Mcdowell, Dr. Sarah Mccrary Apr 2025

Natal And Neonatal Teeth In Mississippi Newborn, Keona Sanders, Anna Mcdowell, Dr. Sarah Mccrary

Undergraduate Research Conference

Title: Natal And Neonatal Teeth In Mississippi Newborns

Submission Type: Semester Long Research/ Oral Presentation

Abstract: In recent years, we have seen a growth in Mississippi infants being born with or growing teeth at an earlier stage. This may be caused by several things, like gestational age, maternal age, or possibly the mother’s diet. We are now looking for common similarities between these infants to see what the possible cause may be. Although this may not seem detrimental, this is still very harmful for infants, causing diseases like Riga Fede Disease. This is a disease that is caused by mandibular …


Hb 1557 Impact On Family Functions, Andi Brabham Apr 2025

Hb 1557 Impact On Family Functions, Andi Brabham

Undergraduate Research Conference

Families are often noted as the foundation of this country, so it is important to consider all families when implementing new policies. In 2022, the Parental Rights in Education bill (HB 1557) was approved in Florida. It was put into place with the intention of benefitting children and families, however, not every family was considered. Main points from HB 1557 include giving parents the right to know any information obtained on their children, the right of parents to have more control over decision making for their children, and the prohibition of discussions or teachings on sexuality and gender identity within …


Scrolling Into Selfhood: Youth, Identity, And Influence., Jakaia A. Crockett Apr 2025

Scrolling Into Selfhood: Youth, Identity, And Influence., Jakaia A. Crockett

Undergraduate Research Conference

Social media has become a significant influence in shaping the experiences and identities of young people in emerging adulthood. This presentation will explore the significant impact that social media platforms and influencers have on the youth as they navigate through this crucial stage of life. With constant exposure to curated content and idealized lifestyles, young individuals increasingly turn to social media to explore their identities, understand social concepts, and process emotional changes.

We will examine how social media has redefined traditional coming-of-age experiences, providing a digital space for self-discovery, peer connections, and cultural exploration. The discussion will also address how …


Emma Ody Pohl: The Untold Story Of “Miss Mscw” And Her Influence On Southern White Women, Anna Sandlin Apr 2025

Emma Ody Pohl: The Untold Story Of “Miss Mscw” And Her Influence On Southern White Women, Anna Sandlin

Undergraduate Research Conference

I conducted an in-depth research project on Emma Ody Pohl, the Director of Physical Education at Mississippi University for Women from 1908 to 1955. I wanted to highlight Pohl's significance on her students and the college. I used the records, letters, and documents in the Pohl Papers at the Beulah Culbertson Archives and Special Collections to analyze Pohl's importance and create a biography of her time at the college. I also conducted further research into the idea of Southern White Womanhood throughout the twentieth century. Through this information, it is evident that the life and teaching of Emma Ody Pohl …


Enhancing Mental Health Awareness And Sustainability: A Playbook And Needs Assessment Approach, Kenadee Kline Apr 2025

Enhancing Mental Health Awareness And Sustainability: A Playbook And Needs Assessment Approach, Kenadee Kline

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

The purpose of this capstone project was to promote greater awareness and education regarding mental health resources within a local non-profit organization dedicated to supporting individuals' mental health through recreation, education, and community-building. The project aimed to enhance the visibility and understanding of available mental health services, while also assessing the effectiveness of current initiatives and improving the sustainability of these programs.

To achieve these goals, a comprehensive playbook was designed to serve as an educational tool for the community, which included findings from a needs assessment of existing mental health initiatives. A multifaceted approach was used, incorporating one-on-one interviews, …


Management Of Sensory Processing Differences To Support Children’S Participation In Church, Sarah Allen Apr 2025

Management Of Sensory Processing Differences To Support Children’S Participation In Church, Sarah Allen

OTD Capstone Projects

This doctoral capstone project was completed in partnership with the First Presbyterian Church of Nashville (FPCN), with the shared objective of fostering a more inclusive and sensory-friendly environment within its Children’s Ministry. In alignment with FPCN’s mission to nurture young disciples through holistic, age-appropriate faith formation, this project addressed the growing need to accommodate children’s diverse sensory needs. Key outcomes included improved staff confidence as measured through pre- and post-training surveys, the creation of a resource binder on sensory processing, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD), and concrete changes to curriculum structure and classroom environments to better support …


User Authentication In A Changing Vendor Landscape - Part Two, Tom Tran, Lisa Baures Apr 2025

User Authentication In A Changing Vendor Landscape - Part Two, Tom Tran, Lisa Baures

Library Services Publications

With implementation of Microsoft Multi-Factor Authentication (MFA), the deployment of the SAML protocol improves security, facilitates the enforcement of security policies, improves user experience, and reduces password fatigue. By using a single set of credentials to authenticate, students, faculty and staff now access resources and services with a single sign-on (SSO). This results in some issues associated with IP validation and EZproxy being resolved, but not all. Therefore, presentation identified what has changed, what has not changed, and what are the new challenges to providing access. As in our presentation last year, for illustrative purposes business databases served as a …


Activity Levels Among Older Adults In A Life Plan Community, Emily D. Winters Apr 2025

Activity Levels Among Older Adults In A Life Plan Community, Emily D. Winters

OHSU-PSU School of Public Health Annual Conference

This study aimed to analyze resident's knowledge of the health and wellness programs available to them in their facility. It explored activity levels, preferred activity methods, and health and wellness program utilization among older adults residing in a life-plan community. A total of 166 survey respondents, aged 65 and older, were included in the analysis. Data were collected using a self-administered questionnaire designed to assess physical activity patterns, preferences for activity types, and engagement with the facility’s health and wellness offerings. Open-ended questions were assessed qualitatively through thematic analysis to find common themes within data. Results indicated that the most …


Association Between Arsenic And Other Heavy Metal Exposures Through Drinking Water And Food With Lung Function And Respiratory Symptoms: A Cross-Sectional Study, Sofia I. Chapela Lara, Seth O'Neal Md, Mph For The Cysticercosis Working Group In Peru Apr 2025

Association Between Arsenic And Other Heavy Metal Exposures Through Drinking Water And Food With Lung Function And Respiratory Symptoms: A Cross-Sectional Study, Sofia I. Chapela Lara, Seth O'Neal Md, Mph For The Cysticercosis Working Group In Peru

OHSU-PSU School of Public Health Annual Conference

Impaired lung function is a major health concern, particularly in children, as it increases the risk of chronic respiratory diseases and long-term morbidity. Environmental exposure to heavy metals (HMs) such as arsenic, lead, cadmium, and manganese has been associated with reduced lung function and respiratory symptoms. However, findings vary by exposure context and population, with limited research in pediatric populations and few studies evaluating the combined effects of multiple HMs. These exposures disproportionally affect marginalized rural communities, especially in low and middle-income countries with mining activities. This cross-sectional study investigated the association between exposure to As and other HMs through …


The Relevance Of Gut Microbiota For The Activity Of Herbal Drugs, Rudolf Bauer Apr 2025

The Relevance Of Gut Microbiota For The Activity Of Herbal Drugs, Rudolf Bauer

Oxford ICSB

Despite intensive research, the active principles and mechanisms of action of many herbal drugs are still not clear. Moreover, the bioavailability of many polar plant constituents is rather limited, why they are not likely to act systemically. Therefore, alternative approaches to explain their activity have to be considered. Gut microbiota and the human body form a symbiosis which is essential for our health and well-being. Dysbiosis can lead to various diseases, like inflammation, obesity, asthma, diabetes, and even cancer. Therefore, gut microbiota are a relevant target for herbal drugs, and may help to understand their effects. For example, Faecalibacterium prausnitzii …


Insights From Ethnobotanical Research In North America, Latin America, And West Africa Into The Phytochemical Quality, Pharmacokinetics, Pharmacodynamics, And Toxicology Of Botanicals, Robin Marles Apr 2025

Insights From Ethnobotanical Research In North America, Latin America, And West Africa Into The Phytochemical Quality, Pharmacokinetics, Pharmacodynamics, And Toxicology Of Botanicals, Robin Marles

Oxford ICSB

Insights perhaps worth sharing have been gained over a career spanning 50 years of ethnobotanical and pharmacognostic research on botanicals of Canada, Mexico, Ecuador, and Togo, and the development of standards on the quality, safety, and evidence-based uses of botanicals in health products and foods. Perspectives provided by traditional healers in these countries have informed approaches to a better understanding of, and possible goals for future research on traditionally used plants. This includes their phytochemical quality; absorption, distribution, metabolism, and excretion; possible mechanisms of action; and potential safety concerns. These insights will be illustrated by specific examples from research conducted …


Enhancing Understanding Of Infant Cues And The Role Of Rehabilitative Therapies In The Neonatal Intensive Care Unit, Lexie Jones Apr 2025

Enhancing Understanding Of Infant Cues And The Role Of Rehabilitative Therapies In The Neonatal Intensive Care Unit, Lexie Jones

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Research emphasizes the importance of early rehabilitative therapy involvement in the NICU to improve outcomes for preterm infants. The American Academy of Pediatrics (AAP) recommends the presence of occupational therapy (OT) and speech-language therapy (SLP) services in Level III NICUs to enhance neurodevelopment, promote feeding success, and support interdisciplinary collaboration (AAP, 2020). Cue-based feeding approaches have been linked to improved weight gain, reduced hospital stays, and decreased physiological stress in preterm infants compared to volume-driven approaches (Pados et al., 2020). However, limited staff understanding of infant behavioral cues and the distinct roles of OT and SLP can lead to missed …


Maternal Physical And Mental Health In The State Of South Carolina: Creating High-Quality Educational Materials, Elizabeth Chard Apr 2025

Maternal Physical And Mental Health In The State Of South Carolina: Creating High-Quality Educational Materials, Elizabeth Chard

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

This capstone project, in collaboration with the Empowering Moms team at the Medical University of South Carolina, aimed to establish the foundation for a statewide occupational therapy initiative focused on maternal mental and physical health education as a preventative approach to addressing rising maternal mortality rates. The project involved assessing the needs of mothers, developing evidence-based educational materials, and compiling a comprehensive resource list to enhance access to information for mothers and community health partners (CHPs) across South Carolina. To support this initiative, a website and REDCap surveys were created to facilitate information dissemination and track outcomes. Embedded within the …


Young Children's Responses To Socioeconomic Status In Peer Reward And Punishment, Joshua R. Namingha, Peter Reschke Dr. Apr 2025

Young Children's Responses To Socioeconomic Status In Peer Reward And Punishment, Joshua R. Namingha, Peter Reschke Dr.

FHSS Mentored Research Conference

This research aimed to determine whether children's understanding of socioeconomic status influences their tendency to reward or punish their peers. The experimenters used the "dictator task" to evaluate children's (ages 7-8) assessments of hypothetical scenarios with participants punishing/rewarding poor and rich children. The results indicate no significant difference in punishment based on socioeconomic status, suggesting limited social class bias at this age.


87 - Maternal Dental Status And Caries Among Siblings, Monica Walker, Charity Hammond, Angela Wilson, Denise Mckinney, Katie Protogyrou Apr 2025

87 - Maternal Dental Status And Caries Among Siblings, Monica Walker, Charity Hammond, Angela Wilson, Denise Mckinney, Katie Protogyrou

Undergraduate Research Symposium

Research has suggested that birth order or environmental factors affect siblings' oral health status during childhood. However, more recent research suggests that the strongest predictor of children's oral health status is the mother's oral health status. This project investigated the association between the oral health status of the mother during pregnancy and bacteria (biofilms) identified in cavitated lesions (dental caries) of their children’s exfoliated primary teeth. Five consenting maternal participants anonymously donated their children's primary teeth and completed a questionnaire about their oral health status during each pregnancy. After visually identifying the exfoliated teeth with dental caries, the biofilms were …


Unlocking Nature’S Pharmacy: Using Hidden Secrets From Post Famine Ireland To Direct Modern Scientific Exploration Of Irish Bogland Species., Helen Sheridan Apr 2025

Unlocking Nature’S Pharmacy: Using Hidden Secrets From Post Famine Ireland To Direct Modern Scientific Exploration Of Irish Bogland Species., Helen Sheridan

Oxford ICSB

Boglands are iconic landscapes and important carbon sinks, extending across the northern hemisphere, covering approximately 20% of Ireland's land area. These ancient water-logged ecosystems are reservoirs of a unique biodiversity adapted to survive in nutrient-poor yet strikingly beautiful environments. Irish mythology is deeply connected to boglands, featuring stories about healing plants, fairies, and ancient curses. Irish communities historically used bogland plants for their medicinal properties. Many uses are recorded in the Schools' Manuscript Collection (SMC) (1937-1939), a treasure-trove of Irish folklore, customs, and ethnographic data, collected as part of the Irish Folklore Commission's effort to preserve Ireland’s oral traditions (Dúchas.ie). …


The Contribution Of The European Pharmacopoeia To The Quality Control Of Herbal Medicinal Products, Salvador Canigueral Apr 2025

The Contribution Of The European Pharmacopoeia To The Quality Control Of Herbal Medicinal Products, Salvador Canigueral

Oxford ICSB

The European Pharmacopoeia (Ph. Eur.) is an international regulatory document setting the standards for the quality control of medicinal products. It is elaborated by the European Directorate for the Quality of Medicines & HealthCare (EDQM), a body of the Council of Europe, headquartered in Strasbourg, France. It is mandatory in 39 European countries and the European Union. The Ph. Eur. establishes quality specifications for active ingredients, excipients, dosage forms, and finished products. In relation to herbal medicinal products, the upcoming 12th Edition (effective January 2026) includes: 25 general methods in pharmacognosy, 6 general monographs, 2 information chapters, and 392 individual …


Bioseq: A Molecular Intelligence Platform Based On Organism-On-Chip Technology For Bridging Data Gaps Between C. Elegans And Humans, Hunter Edwards, Adnan Qureshi, Mizanur Rahman, Tyler Chiriboga, Amar Chittiboyina, Ikhlas Khan, Siva Vanapalli Apr 2025

Bioseq: A Molecular Intelligence Platform Based On Organism-On-Chip Technology For Bridging Data Gaps Between C. Elegans And Humans, Hunter Edwards, Adnan Qureshi, Mizanur Rahman, Tyler Chiriboga, Amar Chittiboyina, Ikhlas Khan, Siva Vanapalli

Oxford ICSB

The FDA Modernization Act 2.0, emphasizes the urgent need for New Approach Methodologies (NAMs) to replace conventional animal testing in safety and efficacy assessments. NemaLife’s organism-on-chip platform, utilizing C. elegans, microfluidics and visual AI, provides a high throughput platform for in vivo screening. To enhance human relevance and reduce the inter-species gap between C. elegans and human, we developed BioSeq, a novel discovery workflow, based on high-throughput transcriptomics. Leveraging the 60-80% homology between C. elegans and human genomes, BioSeq translates worm gene expression data to human orthologs. This enables: (i) identification of differentially expressed human-relevant genes triggered by bioactive ingredients …