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Assessing The Influence Of Health Policy And Population Mobility On Covid-19 Spread In Arkansas, Tayden Barretto

Industrial Engineering Undergraduate Honors Theses

The outbreak of COVID-19 has created a major crisis across the world since its start in 2019, and its influence on every realm of society is undeniable. Globally, more than 500 million cases have been recorded since March 2020, with almost 6 million deaths. In the wake of this crisis, many governments and health organizations have taken steps and precautions to mitigate its spread. These steps involve public mandates of information, reducing frequency of personal contact, and use of masks to minimize the risk of transmission. Current access to mobility data released from Google detailing population movements has provided a …

Statistical Methods For Assessing Drug Interactions And Identifying Effect Modifiers Using Observational Data., Qian Xu

Electronic Theses and Dissertations

This dissertation consists of three projects related to causal inference based on observational data. In the first project, we propose a double robust to identify the effect modifiers and estimate optimal treatment. Observational studies differ from experimental studies in that assignment of subjects to treatments is not randomized but rather occurs due to natural mechanisms, which are usually hidden from the researchers. Many statistical methods to identify the treatment effect and select the optimal personalized treatment for experimental studies may not be suitable for observational studies any more. In this project, we propose a exible outcome model to select the …

Association Of Phosphate-Containing Versus Phosphate-Free Solutions On Ventilator Days In Patients Requiring Continuous Kidney Replacement Therapy, Melissa L. Thompson Bastin, Arnold J. Stromberg, Sethabhisha N. Nerusu, Lucas J. Liu, Kirby P. Mayer, Kathleen D. Liu, Sean M. Bagshaw, Ron Wald, Peter E. Morris, Javier A. Neyra

Statistics Faculty Publications

Background and objectives Hypophosphatemia is commonly observed in patients receiving continuous KRT. Patients who develop hypophosphatemia may be at risk of respiratory and neuromuscular dysfunction and therefore subject to prolongation of ventilator support. We evaluated the association of phosphate-containing versus phosphate-free continuous KRT solutions with ventilator dependence in critically ill patients receiving continuous KRT.

Design, setting, participants, & measurements Our study was a single-center, retrospective, pre-post cohort study of adult patients receiving continuous KRT and mechanical ventilation during their intensive care unit stay. Zeroinflated negative binomial regression with and without propensity score matching was used to model our primary outcome: …

An Examination Of The Statistics And Risk Management Concepts Behind The Patient Protection And Affordable Care Act (Ppaca) Of 2010, Scott Sinclair

Undergraduate Honors Thesis Collection

The Patient Protection and Affordable Care Act (PPACA) is the overarching federal law that has impacted the intricacies of the health insurance market for more than a decade. Using the supervised learning method of multiple linear regression, the relationship between the medical loss ratio rebates and predictor variables such as the state, health insurance market, and the number of insurance companies owing rebates will be analyzed, along with the actuarial value of metal tiers and geographic rating area factors in terms of their relationship to the insurance premium for a standard family of four, defined as a forty-year-old couple with …

A Machine Learning Approach To Stochastic Optimal Control, Pablo Ever Avalos

Open Access Theses & Dissertations

Merton's portfolio optimization problem is a well-renowned problem in financial mathematics which seeks to optimize the investment decision for an investor. In the simplest situation, the market consists of a risk-less asset (i.e. a bond) that pays back a relatively low interest rate, and a risky asset (i.e. a stock) that follows a geometric Brownian motion. The optimal allocation strategy of the investor's wealth is found by optimizing the expected utility along the stochastic evolution of the market. This thesis focuses on several different applications of this optimization problem. We look at pre-constructed analytical solutions and showcase the results. We …

Understanding And Improving The System: The Effects Of Weighting On The Accuracy Of Political Polling In Arkansas, Beck Williams

Political Science Undergraduate Honors Theses

In an effort to increase the accuracy of statewide political polling in Arkansas, we explore the statistical strategy of weighting with a focus on one yearly opinion poll: The Arkansas Poll. We conduct over 70 weighting experiments on the 2016 and 2020 Arkansas Polls using a variety of variables and opinion questions. From these experiments, we find that while some weighted variables tend to create larger changes, weighting typically results in a single-digit percentage change that does not substantially shift or “flip” the majorities. Due to a greater rate of change through weighting in the 2020 Poll compared to the …

The Impact Of Social Controls And Vaccination On The Spread Of Covid-19 In New Jersey, Ariel J. Bonneau

Theses, Dissertations and Culminating Projects

The emergence of the novel coronavirus (SARS-CoV-2) in late 2019 has led to a global pandemic (COVID-19) which continues to cause enormous public health and economic challenges around the world. It is therefore important to improve our understanding of the outbreak and spread of COVID-19 as well as to investigate how one might contain or stop the spread of COVID-19 via different control measures. In this thesis, we consider a COVID-19 model based on an SEIR compartmental model. The model includes susceptible, vaccinated, exposed, pre-symptomatic, symptomatic infectious, asymptomatic infectious, hospitalized, recovered, and deceased compartments, each of which is sub-divided into …

Modeling The Dynamics Of Excitable Cells, Asja Alić

Theses, Dissertations and Culminating Projects

We consider an electrical parallel conductance membrane model which is an extension of the classical Hodgkin-Huxley neuronal model of excitability. This extended model describes the formation of the resting membrane potential and conductance, and the formation of action potentials in nodose A-type excitable cells. The model consists of a set of nonlinear ordinary differential equations which are numerically solved using the Python programming language. The results show that the model is capable of accurately describing experimental results including resting membrane potential and conductance, duration and form of action potentials, amplitude of the spike, oscillations, and activitydependent changes in [Ca^{2+ …}

Forecasting Electricity Load In New Jersey With Artificial Neural Networks, Erik W. Raab

Theses, Dissertations and Culminating Projects

Load forecasting is an important tool for both the energy and environmental sectors. It has progressed hand-in-hand with machine learning innovation, where recurrent neural networks, a type of artificial neural network, is primarily used. This thesis compares progressively complex, feed-forward artificial neural networks using a mix of weather and temporal data. We demonstrate that electrical load in New Jersey can be reliably predicted using memory-less algorithms with minimal predictors drawn from preexisting public data sources. The methods used in this thesis could be used to build competitive load forecasting models in other states, and if included in diverse model ensembles, …

A Contribution To The Statistical Analysis Of Climate-Wildfire Interaction In Northern California, Adam Diaz

All Theses

Wildfires are extreme weather events that exist at the interface of atmospheric, ecological, and human processes. Ongoing anthropogenic climate change is expected to impact the distribution, frequency, and behavior of wildfires on a grand scale, however the exact nature of this change remains shrouded in a great deal of uncertainty. This study takes a statistical approach to the question over the fire-prone Northern California region of the western United states. Climate model projections are analyzed to investigate changes in a major driver of fire weather in the region. The relationship between wildfire severity and climate factors is then explored separately, …

Aberrant Responding With Underlying Dominance And Unfolding Response Processes: Examining Model Fit And Performance Of Person-Fit Statistics, Jennifer A. Reimers

Graduate Theses and Dissertations

Researchers have recognized that respondents may not answer items in a way that accurately reflects their attitude or trait level being measured. The resulting response data that deviates from what would be expected has been shown to have significant effects on the psychometric properties of a scale and analytical results. However, many studies that have investigated the detection of aberrant data and its effects have done so using dominance item response theory (IRT) models. It is unknown whether the impacts of aberrant data and the methodology used to identify aberrant responding when using dominance IRT models apply similarly when scales …

Posterior Predictive Model Checking Of The Hierarchical Rater Model, Nnamdi Chika Ezike

Graduate Theses and Dissertations

Fitting wrongly specified models to observed data may lead to invalid inferences about the model parameters of interest. The current study investigated the performance of the posterior predictive model checking (PPMC) approach in detecting model-data misfit of the hierarchical rater model (HRM). The HRM is a rater-mediated model that incorporates components of the polytomous item response theory (IRT) model, such as the partial credit model (PCM) and generalized partial credit model (GPCM), at the second level of the hierarchy, to model examinees’ responses to performance assessments. To date, the HRM has not been rigorously evaluated using PPMC techniques. Monte Carlo …

Penalized Estimation Of Autocorrelation, Xiyan Tan

All Dissertations

This dissertation explored the idea of penalized method in estimating the autocorrelation (ACF) and partial autocorrelation (PACF) in order to solve the problem that the sample (partial) autocorrelation underestimates the magnitude of (partial) autocorrelation in stationary time series. Although finite sample bias corrections can be found under specific assumed models, no general formulae are available. We introduce a novel penalized M-estimator for (partial) autocorrelation, with the penalty pushing the estimator toward a target selected from the data. This both encapsulates and differs from previous attempts at penalized estimation for autocorrelation, which shrink the estimator toward the target value of zero. …

Dataset Evaluation For Data Trading Using Expected Loss And Homomorphic Encryption, Minsung Joo

Senior Honors Papers / Undergraduate Theses

Supervised machine learning suffers from the ``garbage-in garbage-out" phenomenon where the performance of a model is limited by the quality of the data. While a myriad of data is collected every second, there is no general rigorous method of evaluating the quality of a given dataset. This hinders fair pricing of data in scenarios where a buyer may look to buy data for use with machine learning. In this work, I propose using the expected loss corresponding to a dataset as a measure of its quality, relying on Bayesian methods for uncertainty quantification. Furthermore, I present a secure multi-party computation …

Sensory Comparison Of Beer Carbonated Using Forced Carbonation And The Carbo Rock-It, Michala Smith

Biological and Agricultural Engineering Undergraduate Honors Theses

Craft brewing is a growing market which represents over 12% of beer produced in the United States. Dr. G Scott Osborn, PE invented the Carbo Rock-It™ to improve the carbonation process for craft breweries. The invention allows for shorter carbonation time and uses less CO₂, saving companies money and time. Because of the lack of gas losses through bubbling, Osborn theorized that the Carbo Rock-It could also prevent the “stripping of the nose” that can occur in traditional forced carbonation. Existing research supports the mechanism, as beer flavor and aroma volatiles have been detected during the release of …

Attempting To Predict The Unpredictable: March Madness, Coleton Kanzmeier

Theses/Capstones/Creative Projects

Each year, millions upon millions of individuals fill out at least one if not hundreds of March Madness brackets. People test their luck every year, whether for fun, with friends or family, or to even win some money. Some people rely on their basketball knowledge whereas others know it is called March Madness for a reason and take a shot in the dark. Others have even tried using statistics to give them an edge. I intend to follow a similar approach, using statistics to my advantage. The end goal is to predict this year’s, 2022, March Madness bracket. To achieve …

Intraday Algorithmic Trading Using Momentum And Long Short-Term Memory Network Strategies, Andrew R. Whitinger Ii

Undergraduate Honors Theses

Intraday stock trading is an infamously difficult and risky strategy. Momentum and reversal strategies and long short-term memory (LSTM) neural networks have been shown to be effective for selecting stocks to buy and sell over time periods of multiple days. To explore whether these strategies can be effective for intraday trading, their implementations were simulated using intraday price data for stocks in the S&P 500 index, collected at 1-second intervals between February 11, 2021 and March 9, 2021 inclusive. The study tested 160 variations of momentum and reversal strategies for profitability in long, short, and market-neutral portfolios, totaling 480 portfolios. …

Multi-Trophic Biodiversity Increases With Increasing Structural Complexity Of Forest Canopy, Ayanna St. Rose

Graduate Theses and Dissertations

Understanding the effects of forest canopy structural complexity on multi-trophic diversity is critical for conserving biodiversity and managing land sustainably. But multi-trophic diversity is often ignored when making decisions about land management due to lack of cost- and time-effective methods to evaluate it. Here, we explored a new method based on widely available remote sensing data to quantify canopy structural complexity and its relationships with multi-trophic biodiversity at landscape scale using 32 forested sites of the National Ecological Observatory Network. We investigated the influence of vertical and horizontal structural complexity of forest canopy on multi-trophic (primary producers, herbivores (beetles), omnivores …

Deep Depression Prediction On Longitudinal Data Via Joint Anomaly Ranking And Classification, Guansong Pang, Ngoc Thien Anh Pham, Emma Baker, Rebecca Bentley, Anton Van Den Hengel

Research Collection School Of Computing and Information Systems

A wide variety of methods have been developed for identifying depression, but they focus primarily on measuring the degree to which individuals are suffering from depression currently. In this work we explore the possibility of predicting future depression using machine learning applied to longitudinal socio-demographic data. In doing so we show that data such as housing status, and the details of the family environment, can provide cues for predicting future psychiatric disorders. To this end, we introduce a novel deep multi-task recurrent neural network to learn time-dependent depression cues. The depression prediction task is jointly optimized with two auxiliary anomaly …

Finding A Representative Distribution For The Tail Index Alpha, Α, For Stock Return Data From The New York Stock Exchange, Jett Burns

Electronic Theses and Dissertations

Statistical inference is a tool for creating models that can accurately display real-world events. Special importance is given to the financial methods that model risk and large price movements. A parameter that describes tail heaviness, and risk overall, is α. This research finds a representative distribution that models α. The absolute value of standardized stock returns from the Center for Research on Security Prices are used in this research. The inference is performed using R. Approximations for α are found using the ptsuite package. The GAMLSS package employs maximum likelihood estimation to estimate distribution parameters using the CRSP data. The …

Modeling Of Cns Cancer With A Focus On The Immune Component, Daniel Zamler

Dissertations and Theses (Open Access)

The knowledge surrounding cancers of the central nervous system remains poorly developed, in particular with regard to the immune component. The works contained in this thesis look at craniopharyngioma, glioblastoma, and several forms of brain metastasis. While some attention is given to the tumor cells themselves, as well as the patient setting which these studies model, the immune component of disease progression and treatment plays a strong role in each and is the primary focus of the works contained.

Craniopharyngioma is a relatively rare tumor in adults. Although histologically benign, it can be locally aggressive and may require additional therapeutic …

Advancements In Gaussian Process Learning For Uncertainty Quantification, John C. Nicholson

All Dissertations

Gaussian processes are among the most useful tools in modeling continuous processes in machine learning and statistics. The research presented provides advancements in uncertainty quantification using Gaussian processes from two distinct perspectives. The first provides a more fundamental means of constructing Gaussian processes which take on arbitrary linear operator constraints in much more general framework than its predecessors, and the other from the perspective of calibration of state-aware parameters in computer models. If the value of a process is known at a finite collection of points, one may use Gaussian processes to construct a surface which interpolates these values to …

Developing And Applying Computational Algorithms To Reveal Health-Related Biomolecular Interactions, Yixin Xie

Open Access Theses & Dissertations

Computational biology is an interdisciplinary area that applies computational approaches in biological big data, including protein amino acid sequences, genetic sequences, etc., which is widely used to analyze protein-protein interactions, make predictions in drug discovery, develop vaccines, etc. Popular methods include mathematical modeling, molecular dynamics simulations, data science mythology, etc. With the help of computational algorithms and applications, drug development is much faster than traditional processes, as it reduces risks early on in a drug discovery process and helps researchers select target candidates that have the highest potential for success. In my doctoral research, I applied multi-scale computational approaches to …

Some Improved Markov Chain Convergence Rates, Fun Choi John Chan

All Dissertations

Explicit convergence rates to equilibrium are established for non reversible Markov chains not having an atom via coupling methods. We consider two Markov chains having the same transition function but different initial conditions on the same probability space, that is, a coupling. A random time is constructed so that subsequent to the random time the two processes are identical. Exploiting a shadowing condition, we show that it is possible to bound the tail distribution of the random time using only one of the chains. This bound gives the convergence rate to equilibrium for the Markov chain. The method is then …

Groundwork For The Development Of Gpu Enabled Group Testing Regression Models, Paul Cubre

All Dissertations

In this dissertation, we develop novel techniques that allow for the regression analysis of data emerging from group testing processes and set the groundwork for graphic processing units (GPU) enabled implementations. Group testing primarily occurs in clinical laboratories, where it is used to quickly and cheaply diagnose patients. Typically, group testing tests a pooled specimen--several specimens combined into one sample--instead of testing individual specimens one-by-one. This method reduces costs by using fewer tests when the disease prevalence is low. Due to recent advances in diagnostic technology, group testing protocols were extended to incorporate multiplex assays, which are diagnostic tests that, …

An Empirical Investigation Into The Impact Of Automated Grading, Alex James St. Aubin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Context: Computer Science enrollment has seen increases in recent years. At the University of Nevada, Las Vegas we have seen an average year to year growth rate of 17.33% in the spring and 13.71% in the fall over the past 10 years in our entry level programming course. These enrollment increases have led to considerable additional costs for grading course material.Objective: The goal of this study is to determine the impact of automatic grading systems on students. If automatic grading is at least as effective as manual grading in practice, it may reduce cost under the context of at least …

The Effects Of Metronomic And Maximum-Tolerated Dose Chemotherapy In Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy And Mrna Expression, Ariel Isaac Mundo Ortiz

Graduate Theses and Dissertations

Colorectal cancer (CRC) continues to be one of the most incident and deadliest types of cancer worldwide. Chemotherapy has proven effective to reduce tumor burden for CRC patients, but there are several disadvantages associated with the use of mainstay maximtolerated dose (MTD) chemotherapeutic strategies. Metronomic chemotherapy (MET) has been developed as an alternative that addresses the shortcomings of maximum-tolerated dose chemotherapy but so far its effectiveness as a neoadjuvant strategy for CRC has not been explored.

This dissertation uses a combined optics and molecular biology approach (using diffuse reflectance spectroscopy and mRNA expression) to study the changes in angiogenesis and …

On Misuses Of The Kolmogorov–Smirnov Test For One-Sample Goodness-Of-Fit, Anthony Zeimbekakis

Honors Scholar Theses

The Kolmogorov–Smirnov (KS) test is one of the most popular goodness-of-fit tests for comparing a sample with a hypothesized parametric distribution. Nevertheless, it has often been misused. The standard one-sample KS test applies to independent, continuous data with a hypothesized distribution that is completely specified. It is not uncommon, however, to see in the literature that it was applied to dependent, discrete, or rounded data, with hypothesized distributions containing estimated parameters. For example, it has been "discovered" multiple times that the test is too conservative when the parameters are estimated. We demonstrate misuses of the one-sample KS test in three …

To Adopt Blockchain Technology Or Not: Is The Decision-Making Process Immune To Covid-19?, Rebecca Jauch

Thinking Matters Symposium

Blockchain technology has been shown to have advantages in improving the effectiveness of supply chain management. We use the Technology-Organization-Environment (TOE) framework with Threat-Rigidity Theory (TRT) to determine the factors that lead U.S. businesses to adopt blockchain technology, the factors that act as barriers to adoption, and the disruptive effect of COVID-19 on the rate of blockchain adoption

The Biggest Loser: How Tanking In Professional Sports Impacts Fan Perception, Julia Ayres

Honors Projects in Mathematics

Professional sports teams are adored nationwide for their talents and the pride they bring to their city for their efforts. However, not all teams take this responsibility seriously and will lose on purpose, or tank, to gain a higher draft pick in the future. Although the long-term goals of tanking are to help the organization, many people take issue with athletes not putting in their best efforts in every game. Teams in both the NBA and NFL are guilty of tanking to gain better draft picks but not all have found success in this process. This leads to important questions …