Digital Commons Network^™

Associations Between Longer Leukocyte Telomere Length And Increased Lung Cancer Risk Among Never Smokers In Urban China, Jason Y Y Wong, Xiao-Ou Shu, Wei Hu, Batel Blechter, Jianxin Shi, Kevin Wang, Richard Cawthon, Qiuyin Cai, Gong Yang, Mohammad L Rahman, Bu-Tian Ji, Yutang Gao, Wei Zheng, Nathaniel Rothman, Qing Lan

Faculty, Staff and Student Publications

BACKGROUND: The complex relationship between measured leukocyte telomere length (LTL), genetically predicted LTL (gTL), and carcinogenesis is exemplified by lung cancer. We previously reported associations between longer pre-diagnostic LTL, gTL, and increased lung cancer risk among European and East Asian populations. However, we had limited statistical power to examine the associations among never smokers by gender and histology.

METHODS: To investigate further, we conducted nested case-control analyses on an expanded sample of never smokers from the prospective Shanghai Women's Health Studies (798 cases and 792 controls) and Shanghai Men's Health Studies (161 cases and 162 controls). We broke the case-control …

Neutrophil To Lymphocyte Ratio (Nlr) In Captive Olive Baboons (Papio Anubis): The Effects Of Age, Sex, Rearing, Stress, And Pregnancy, Sarah J. Neal, Angela M. Achorn, Steven J. Schapiro, William D. Hopkins, Joe H. Simmons

Anthropology Faculty Publications

In apes and humans, neutrophil to lymphocyte ratio (NLR) can be used as a predictive indicator of a variety of clinical conditions, longevity, and physiological stress. In chimpanzees specifically, NLR systematically varies with age, rearing, sex, and premature death, indicating that NLR may be a useful diagnostic tool in assessing primate health. To date, just one very recent study has investigated NLR in old world monkeys and found lower NLR in males and nursery-reared individuals, as well as a negative relationship between NLR and disease outcomes. Given that baboons are increasingly used as research models, we aimed to characterize NLR …

A Dual-Angle Exploration Towards Understanding Lapses In Covid-19 Social Responsibility, Sean T. H. Lee, Jerome J. X. Mah, Angela K. Y. Leung

Research Collection School of Social Sciences

Breaking infection chains requires not just behaviours that allow individuals to stay healthy and uninfected (i.e. health protective behaviours) but also for those who are possibly infected to protect others from their harboured infection risk (i.e. socially responsible behaviours). However, socially responsible behaviours entail costs without clear, immediate benefits to the individual, such that public health-risking lapses occur from time to time. In this important yet understudied area, the current exploratory study sought to identify possible psychological factors that may affect people's likelihood of engaging in socially responsible behaviours. Assuming that self-perceived infection should provide an impetus to engage in …

The Role Of Micrornas On Systemic And Central Nervous System- Inflammation In Aged Mice, Anik Banerjee

Dissertations and Theses (Open Access)

MicroRNAs play a crucial role in multiple biological processes, including development, cell differentiation, proliferation, metabolism, and cell death. Aberrant regulation of microRNAs is seen in many diseases, such as sepsis, cardiovascular disease, neurological diseases such as stroke, and metabolic disorders. Because of their involvement in disease processes, microRNAs have been investigated as both potential biomarkers, and as therapeutic targets. Age-related inflammatory diseases including diabetes, obesity, and atherosclerosis are important risk factors for infection and sepsis. Intestinal barrier impairment occurs with aging and after brain injuries, including stroke. Both aging and stroke increase the risk of infection and sepsis and are …

A Cost-Effectiveness Analysis Of Telehealth Vs. Office-Based Delivery Of Buprenorphine At The Addiction And Substance Abuse Program (Asap) Clinic - University Of New Mexico Hospital: A Societal Perspective, Rana Alkhafaji

Pharmaceutical Sciences ETDs

This study evaluates the cost-effectiveness of office-based versus telehealth delivery of buprenorphine treatment for opioid use disorder (OUD). A retrospective chart review of 135 patients at the University of New Mexico Hospital's Addiction and Substance Abuse Program compared retention rates and costs between the two settings. Retention was defined as continuous treatment for at least six months. No statistically significant difference in retention rates was found, with 51% for office-based and 42% for telehealth. However, office-based treatment had higher total costs, with an incremental cost-effectiveness ratio of $3,750 per 1% increase in retention. The findings suggest telehealth is a cost-effective …

Depressive Symptoms And Substance Use Behaviors Among Young Adults Before And During Covid-19, Sarah Chun

Clinical Psychology Dissertations

Exposure to previous public health disasters have been found to have a significant negative impact on young adult mental health. Thus, it is important to examine the effect that COVID-19 had on young adult mental health. The current study examined differences in depressive symptoms as well as frequency and impairment of substance use in two cross-sectional samples of undergraduate students, one before COVID-19 and one during COVID-19. This study also examined the moderating effects of religiosity on the association between COVID-19 status and both depressive symptoms and substance use behaviors. Participants were 898 young adults (M_age = 19.83, …

Management Overview Of The Lung Tuberculosis Control Program At The Dki Jakarta Provincial Health Office In 2023, Mutiara Kiranti, Helen Andriani

Journal of Indonesian Health Policy and Administration

Tuberculosis is one of the infectious diseases that is fatal if not cured immediately. In 2022, the success rate of tuberculosis treatment in DKI Jakarta Province is 81%, while the national target is 90%. In the field, the number of cadres to carry out contact investigations is still insufficient, so that in 2022 the coverage of contact investigations in DKI Jakarta Province will only reach 25%, while the national target is 90%. To increase the scope of successful treatment, the government should try to overcome tuberculosis, which is needed. Proper program management is required to run effectively and efficiently for …

Island Health Crisis: Bridging Gaps In Indonesia's Healthcare Deserts, Joyce Mangoma, Wahyu Sulistiadi

Journal of Indonesian Health Policy and Administration

This narrative literature review examines critical healthcare challenges in Indonesia's island communities, focusing on workforce shortages, inadequate health infrastructure, and the profound impact of geographical and socioeconomic factors. Drawing from eight studies published between January 2000 and December 2023, the discussion highlights both the strengths and weaknesses of existing research. The studies were selected based on their relevance to healthcare issues in island communities, rigorous methodological approaches, and significant insights into healthcare challenges and solutions. This time frame was chosen to encompass a comprehensive evolution of healthcare challenges and responses, particularly considering the effects of the COVID-19 pandemic. Grounded in …

Effectively Managing Communication After A Crisis: A Phenomenographic Study On Public Health Crises In The Country Of Jamaica, Jehan Donnique Wilson

Walden Dissertations and Doctoral Studies

Effectively managing communication after a crisis is the starting point of successful public policy and administration when handling a public health crisis. Jamaica has dealt with several public health crises over the span of its existence; this study compared SARS-CoV-2 (COVID-19) and influenza, two major Jamaican public health crises during the period from 2019 to 2022. This study’s research questions addressed (a) what specific communication strategies were used by Jamaica during the influenza outbreak as compared to the COVID-19 pandemic and (b) how the specific communications strategies used during the influenza outbreak and COVID-19 pandemic contributed to the development of …

Exploring The Lived Experience Of Counseling Leaders And Professionals In The East African Community Transitioning Through The Covid-19 Pandemic: A Phenomenological Study, Daniel Muthini Kimony

Doctoral Dissertations and Projects

The East African Community (EAC) is a regional intergovernmental assembly, currently comprising seven member states including Burundi, the Democratic Republic of Congo (DRC), Kenya, Rwanda, South Sudan, Tanzania, and Uganda. This transcendental phenomenological study examined the lived experiences of counseling leaders and professionals in the EAC as they transitioned through the COVID-19 global pandemic. Grounded in Schlossberg’s transition theory, the study explored participants’ experiences as they moved into, moved through, and moved out of the pandemic in the period between January 2020 and May 2023. Triangulated, qualitative data, assessed through transcendental and heuristic methodology, was collected from 10 participants representing …

Changing The Narrative: Developing Evidence-Based, Communication Strategies To Address Health Disparities Of Black Women In The United States, Emmerline Francesca Nelson-Rogers

Doctoral Dissertations and Projects

Black women experience health issues at disparate rates when compared to their racial counterparts. Although these health disparities can be linked to health behaviors, they are deeply rooted in historic, racial systems that govern our lives today. More often than not, changes in health behaviors are at the forefront of addressing these health disparities rather than historical health trends of Black women in the U.S. This study aims to discuss why the change needed is a change in the narrative for why these health disparities exist and persist as well as a change in narrative about the role Black women …

Effects Of Covid-19 On Mental Health Workers' Job Satisfaction, Employee Burnout, And Intent To Leave, Colton Jacobs

Doctoral Dissertations and Projects

The COVID-19 disease emerged in December 2019 and created a worldwide pandemic. As the COVID-19 virus spread, healthcare workers faced increased workloads and burnout due to increased stress. With a current abundance of research to better understand how the pandemic affected healthcare workers, minimal research has been conducted to investigate the effects on mental health workers. It is imperative to better understand how the consequences of the pandemic affected mental health workers due to their importance in supporting the mental well-being of our communities. This study focused on how the COVID-19 pandemic influenced job satisfaction, burnout syndrome, and intent to …

Assessing Health Needs In A Dominican Republic Community During An Interprofessional Service-Learning Trip, Gabriela Andonie, Hanna Rotundo, Ashanti Jones, Logan Dugas, Shylon Francis

Journal of Interprofessional Practice and Collaboration

Purpose: International medical missions may increase access to medicines and care, but international teams must understand local needs to implement appropriate services. In 2023, a multidisciplinary team from our institution partnered with a nonprofit organization in the barrio of Cienfuegos, Dominican Republic with the goal of strengthening local health services. The primary objective of this study was to identify health-related needs in Cienfuegos from the perspective of community members and local health care workers.

Methods: A qualitative study was conducted as part of a service-learning initiative. After obtaining informed consent, the investigators conducted individual semi-structured interviews facilitated by multi-lingual interpreters. …

Policy Practices And Countermeasures Analysis On Deep Integration Of Technological Innovation And Industrial Innovation, Defang He, Tao Chen, Hui Liu, Fangjuan Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Technological innovation serves as the strategic foundation for driving high-quality development and building a modern industrial system. To compete for global leadership in science, technology, and industrial advancement, major economies worldwide are reshaping their policy frameworks to accelerate the development of cutting-edge technologies and future industries. This study analyzes the intrinsic mechanisms and policy evolution of the integration between technological innovation and industrial innovation. By examining domestic and international case studies—such as integrated circuits, mRNA vaccines, new energy vehicles, and photovoltaics—it reveals how strategic guidance and policy coordination facilitate the convergence of innovation chains and industrial chains. Furthermore, the study …

Deconstructing Drugs: Addressing The Stigma, Harm Reduction, And Policy Solutions, Charlotte Theriault

Themis: Research Journal of Justice Studies and Forensic Science

Black and homeless people who struggle with substance use disorder (SUD), especially opioid use disorder (OUD), have experienced unique obstacles due to inequalities relating to their social determinants of health (SDOH). Historical context and peer-reviewed research were used to evaluate racial bias and expand upon the factors that contributed to the opioid crisis, the effects of COVID-19 on drug overdoses, and the presence of fentanyl in illicit drug supplies. Various studies combat the stigma surrounding substance use disorder (SUD) by acknowledging the disease as a chronic health condition. Research showed that the most effective way to combat these inequalities and …

U.S. International Climate Finance: An Analysis Of Historical Shortfalls And A Proposal For More Equitable Distribution, Maria-Cristina Kealey

Master's Projects and Capstones

Least-developed countries experienced 69% of deaths from climate disasters over the past 50 years despite comprising only 13% of the world’s population. Low-income and climate vulnerable nations around the world are suffering disproportionately as wealthy, high-emitting countries, such as the U.S., profit from the climate crisis. This research provides a comprehensive overview of past U.S. contributions to international climate finance efforts, assesses the climate finance deficit globally and specifically for developing countries, and proposes a more equitable share of U.S. funding from a quantitative and restorative climate justice approach. The primary analyses included quantifying the U.S. share of global greenhouse …

When The Fear Sinks In: The Politics Of Paranoia In The Wake Of Covid-19, Samantha G. Minear

Senior Theses

This project begins in January 2021 – a period henceforth known as ‘post-pandemic’ – following the release of the first COVID-19 vaccines in Europe (AstraZeneca) and the United States (Pfizer). While the pandemic is still ongoing as of December 2023, the release of vaccines heralded a new era more reminiscent of a time before March 2020: less (or no) mask mandates, a reduced emphasis on social distancing, and a positive shift in social opinion towards prophylactic vaccination. During my time as an American studying international politics, I have observed a positive correlation between time passed since January 2021 and the …

Managing The Environmental And Socio-Economic Impacts Of Rohingya Refugees In Bangladesh, Mousume Azad

Master's Projects and Capstones

In August 2017, nearly 1 million Rohingya people fled to Bangladesh to save their lives from the genocide inflicted by the military of Myanmar. At present, over 1.3 million Rohingyas are staying at Cox’s Bazar, Bangladesh, in 34 overcrowded refugee camps. This research examined the environmental impacts especially the change in vegetation cover and land surface temperature as well as the socioeconomic alteration of the host country after the refugee influx. The research found a 5488 ha or 9.58% decrease in forest area, accompanied by an 8.25% increase in refugee settlement areas, an increase in average land surface temperature within …

Secrets Of The Medicine Cabinet: How Big Pharma's Information Monopoly Influences Federal Public Health Regulations, Kyle James

Culture, Society, and Praxis

Pharmaceutical companies are the largest industry contributor to political activities in the United States. Instead of pursuing traditional routes of political influence, these firms concentrate their efforts within federal public health agencies. By directly intervening in the regulatory process, Big Pharma assumes control of the drug approval process, dictating the means by which pharmaceutical products enter the marketplace. This scheme is designed to strip agencies of their public interest mandate. The resulting political phenomenon, known as regulatory capture, creates a symbiotic relationship where federal agencies and industry mutually benefit from the swift commercialization of drugs. This thesis examines "how" Big …

Perceived Stress From Covid-19 On High School Students With Previous Trauma In A Rural County In The Southeastern United States, Kari Anne Russell

Doctoral Dissertations and Projects

The COVID-19 pandemic created historical trauma that will be felt for years to come. As the world begins sifting through the impacts, adolescents with previous trauma could be among the greatest sufferers. Rooted in trauma theory, this study aimed to examine the effects on high school students with previous trauma in a rural county in the southeastern United States. Variables such as previous mental health or counseling services, gender, socioeconomic status, race or ethnicity, and number of generations living in the home were all examined for those students having four or more ACEs. Through a quantitative design and with passive …

Women, War And Reproductive Health: An Analysis Of Afghanistan 1980-2023, Behishta Sadaat

Dartmouth College Master’s Theses

As an Afghan woman who lived through decades of conflict, experienced motherhood, and advocated for women’s rights, I have witnessed firsthand the profound impact of war on reproductive health. Despite the significance of this issue, there exists a dearth of essential data and research, particularly in the context of armed conflict. Drawing from my academic background in the health sector and my activism for women’s rights, my thesis aims to fill this gap by examining how war has shaped Afghan women’s reproductive health needs and experiences between 1980 and 2023.

This research explores the evolving socio-political landscape of the country …

Racial Stressors, Resiliency, And African American Women Counselors, Barbara Ann Bazemore

Walden Dissertations and Doctoral Studies

African American women therapists are the second largest group of counseling providers, with many displaying behavioral health symptoms differently than other cultures. This quantitative correlational cross-sectional study explored the resiliency of African American women counselors related to racial-specific stressors inclusive of self-identity, COVID-19 anxiety, and daily discrimination. Initially, three research questions were selected to investigate the relationship between demographic factors (age, education level, active years as a counselor), racial-specific stressors (self-identity, COVID-19 pandemic anxiety, and everyday discrimination), and resiliency in 112 African American women counselors. Emails and an online survey were sent to collect data to answer the research hypotheses. …

Physician Burnout And The Marital Relationship: Spouse Perspective, Lisa Anne Muehlenbein

Walden Dissertations and Doctoral Studies

Physician burnout rates have consistently been higher than the general working population; however, recent literature suggested that after a steady decline in physician burnout rates, the COVID-19 global pandemic and additional organizational factors have caused physician burnout to reach an all-time high. Substantial research is available on physician burnout; however, little is known about how a physician’s burnout is experienced in the marital relationship through the spouse’s perspective. This basic qualitative study used purposive, convenience, and snowball sampling methods to recruit 10 female spouses of male physicians to participate in semi-structured interviews. The research question investigated the participants’ perceptions of …

The Impact Of Turnover And Turnover Intentions On Nigeria's Public Health Administration, Albert Abani Uduma

Walden Dissertations and Doctoral Studies

High turnover creates a vicious cycle that affects employees with further shortages and turnover. This study explored the lived experiences and perceptions of a government employer and employees about turnover, turnover intentions, and the government’s leadership effectiveness using Heidegger’s phenomenological research methods. The theoretical frameworks that grounded the study were Herzberg’s motivation-hygiene theory, public service motivation theory, and corporate social responsibility theory. The study questions focused on stakeholders’ perceptions and lived experiences of the government’s leadership effectiveness in addressing the impacts of high turnover, as well as the employees’ consequent reactions to the government’s leadership approach. Participant data were collected …

Using Digital Twins To Protect Biomanufacturing From Cyberattacks, Brenden Fraser-Hevlin, Alec W. Schuler, B. Arda Gozen, Bernard J. Van Wie

Military Cyber Affairs

Understanding of the intersection of cyber vulnerabilities and bioprocess regulation is critical with the rise of artificial intelligence and machine learning in manufacturing. We detail a case study in which we model cyberattacks on network-mediated signals from a novel bioreactor, where it is important to control medium feed rates to maintain cell proliferation. We use a digital twin counterpart reactor to compare glucose and oxygen sensor signals from the bioreactor to predictions from a kinetic growth model, allowing discernment of faulty sensors from hacked signals. Our results demonstrate a successful biomanufacturing cyberattack detection system based on fundamental process control principles.

Investigating Risk Factors Contributing To The High Incidence Of Covid-19 Among The Diné People Of The Navajo Nation, Elizabeth Lila Reynolds

Rowan-Virtua Research Day

Background: COVID-19 became international news in December 2019 and subsequently impacted global health. The research shows that the Diné people of the Navajo Nation were one of the most severely impacted populations¹. The Navajo Nation is a region spanning Arizona, New Mexico, and Utah that is composed of North American indigenous people known as the Diné. Purpose: To explore the risk factors contributing to the increased rates of COVID-19 infection and severity of infection among the Diné people. Methods: This literature review research process utilized PubMed and JAMA to find scholarly articles on this topic. Search terms …

Rapid Increase Of Female But Not Male Obesity: Analysis Of The 2023 Vanuatu Health Transition Project Survey On Aneityum, Matthew Christian, Olivia Lasalle, Zhiqiao Huang, Hannah Chen, Ricky Chen, J. Koji Lum

Binghamton University Undergraduate Journal

Globally, obesity rates are continuing to increase and countries in the midst of modernization are most vulnerable. Developing nations are undergoing a health transition alongside rapid economic modernization. The nation of Vanuatu, like other Pacific island countries, is experiencing such a transition marked by decreased cases of infectious disease and increased incidence of chronic and non-communicable diseases. Aneityum is a small and sparsely populated island in Vanuatu and is behind more developed islands in its transition. This present study is the latest in a multi-year project examining health in Vanuatu as it undergoes a health transition with an increased prevalence …

Water Justice And Equity: The Disproportionate Effects Of Pollution On Black, Indigenous, And Other Communities Of Color, Rae Cade

Theses, Dissertations and Culminating Projects

Access to clean drinking water is a basic human right, regardless of an individual’s background. Yet, discriminatory practices in the United States have disproportionately burdened Black, Indigenous, and other people of color (BIPOC) with contaminated sources of water. Understanding how and why water is disproportionately contaminated in areas with increased diversity, and identifying and targeting areas of environmental injustice, are essential steps for ensuring future water equity. Here, I examine the drivers of inequitable access to clean drinking water within the northeastern United States. In chapter one, I look at the historical drivers of land inequity within the United States. …

State Policies On Maternal And Infant Health In The United States, Heeun Kim

Legacy Theses & Dissertations (2009 - 2024)

In the United States (US), state-level policies are critical structural determinants of maternal and infant health outcomes. State policies profoundly affect prenatal care utilization and pregnancy outcomes, particularly among marginalized pregnant persons with stigmatized health conditions. In this three-paper dissertation, I focus on two closely interrelated policies that aim to address significant public health concerns in the US: prenatal syphilis screenings and the criminalization of prenatal substance use. My research revolves around two central questions: First, do these policies effectively improve the pregnancy outcomes of high-risk populations, or do they cause unintended consequences? Second, if challenges in policy design and …

An Examination Of Missing Person Social Media Engagement Through Data Mining And Experimentation: An Application Of The Crisis And Emergency Risk Communication Model, Cailin M. Kuchenbecker

Communication (PhD) Dissertations

According to the Federal Bureau of Investigation (FBI), approximately 600,000 individuals are reported missing each year in the United States (2022). When missing person cases do not meet alert (e.g., AMBER) criteria, law enforcement often utilize social media to crowdsource information to ultimately return the missing home. Therefore, guided by the crisis and emergency risk communication model (CERC; Reynolds & Seeger, 2005) and its recently clarified propositions (Miller et al., 2021), the purpose of this dissertation was to (a) identify strategies law enforcement use to crowdsource missing person information and (b) experimentally test message characteristics that facilitate prosocial sharing of …